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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Updates on Neurosurgical Techniques, Management, and Outcomes for Intracranial Hemorrhages

edited by Bruno Splavski

submission deadline 25 Aug 2025 | Viewed by 115 | Submission Open

Keywords: minimally invasive neurosurgery; neuro-intervention endovascular techniques; intracranial hemorrhage; stroke; hemorrhagic; ischemic; neurosurgical decision-making; long-term outcomes in neurosurgery

(This special issue belongs to the Section Clinical Neurology)

The New Advancements and Clinical Innovations of Electron Microscopy Applied to Dentistry

edited by

Giuseppe Alessandro Scardina

, Pietro Messina and

Enzo Cumbo

submission deadline 25 Aug 2025 | Viewed by 112 | Submission Open

Keywords: electron microscopy; dentistry; implantology; periodontology; surgery; dental prostheses; endodontics; restorative dentistry; orthodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Endocrine Malignancies: Current Surgical Therapeutic Approaches: 2nd Edition

edited by

Mariarita Tarallo

Enrico Fiori

and Marco Bononi

submission deadline 26 Aug 2025 | 1 articles | Viewed by 692 | Submission Open

Keywords: endocrine malignancies; thyroid cancer; adrenocortical cancer; parathyroid; men

(This special issue belongs to the Section Endocrinology & Metabolism)

Pancreatic Cancer: Novel Strategies of Diagnosis and Treatment

edited by

Camelia Cristina Diaconu

and

Gina Gheorghe

submission deadline 26 Aug 2025 | Viewed by 193 | Submission Open

Keywords: pancreatic cancer; chronic pancreatitis; pancreatic intraepithelial neoplasia; gastroenterology; clinical innovative diagnostic; clinical treatment strategies

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Updates in Stem Cell Transplants

edited by Daniele Avenoso and Michele Malagola

submission deadline 26 Aug 2025 | Viewed by 128 | Submission Open

Keywords: AML; CML; lymphoma; allo-HSCT; GVHD; MDS; AA

(This special issue belongs to the Section Hematology)

Clinical Diagnostics and Therapeutics Advances in Acute and Chronic Heart Failure

edited by Ilaria Battistoni and Emilia D'Elia

submission deadline 27 Aug 2025 | 2 articles | Viewed by 1240 | Submission Open

Keywords: acute heart failure; chronic heart failure; gray zones; SGLT2i; cardiogenic shock; cardiopulmonary test; vericiguat; worsening heart failure; advanced heart failure; biomarkers; palliative care

(This special issue belongs to the Section Cardiology)

Clinical Advancements in Foot and Ankle Surgery

edited by

Ho-seong Lee

submission deadline 28 Aug 2025 | 5 articles | Viewed by 4303 | Submission Open

Keywords: flat foot; hindfoot motion; diabetic foot; hallux valgus; foot infection

(This special issue belongs to the Section Orthopedics)

New Trends in Minimally Invasive Thoracic Surgery

edited by Maria Letizia Vita, Leonardo Petracca Ciavarella and Alberto Biondi

submission deadline 28 Aug 2025 | 3 articles | Viewed by 4258 | Submission Open

Keywords: thoracic surgery; minimally invasive surgery; VATS; awake surgery; esophageal cancer

(This special issue belongs to the Section General Surgery)

Future Opportunities in Thoracic Surgery: The Cutting Edge: 2nd Edition

edited by

Giulio Maurizi

submission deadline 28 Aug 2025 | 1 articles | Viewed by 2892 | Submission Open

Keywords: surgical resection; immunotherapy; target therapy; thoracic surgery; thoracic oncology; lung cancer

(This special issue belongs to the Section Respiratory Medicine)

Orthopedic Surgery: Recent Advances and Prospects

edited by Mitchell K. Ng

submission deadline 28 Aug 2025 | 3 articles | Viewed by 2729 | Submission Open

Keywords: orthopedic surgery; clinical updates; joint reconstruction; spine surgery; trauma; elective surgery; peri-operative management

(This special issue belongs to the Section Orthopedics)

Updates on Lumbar Spine Surgery for Degenerative Diseases

edited by

Se-Jun Park

submission deadline 28 Aug 2025 | 3 articles | Viewed by 1859 | Submission Open

Keywords: degenerative disease; lumbar spine surgery; fusion; decompressive surgery; sagittal alignment; complications; outcomes

(This special issue belongs to the Section Orthopedics)

Research Trends and Applications of Hematopoietic Stem Cell Transplantation

edited by David C. Shyr and Robertson Parkman

submission deadline 28 Aug 2025 | 1 articles | Viewed by 1393 | Submission Open

Keywords: hematopoietic stem cell transplant; conditioning regimen; immunology; graft-versus-host disease; gene therapy; transplant-related toxicities; alternative donor stem cell transplant; supportive care

(This special issue belongs to the Section Hematology)

Perioperative Management and Outcome of General and Abdominal Surgery

edited by

Valeriu Surlin

submission deadline 28 Aug 2025 | 1 articles | Viewed by 1156 | Submission Open

Keywords: perioperative management; enhanced recovery after surgery; postoperative recovery; preoperative preparation; surgical outcome

(This special issue belongs to the Section General Surgery)

Systemic Lupus Erythematosus: Current Trends and Therapeutic Innovations

edited by Giuseppe Barilaro

submission deadline 28 Aug 2025 | 2 articles | Viewed by 1104 | Submission Open

Keywords: systemic lupus erythematosus; autoantibodies; biomarkers; therapeutic drugs; lupus nephritis; quality of life; new treatment strategies

(This special issue belongs to the Section Immunology)

Clinical Progress of Mastectomy and Breast Reconstruction Surgery

edited by Antoine L. Carre and Mouchammed Agko

submission deadline 28 Aug 2025 | 1 articles | Viewed by 813 | Submission Open

Keywords: autologous breast reconstruction; reinnervation; mastectomy; robotic DIEP (deep inferior epigastric perforator) flap; rib-sparing DIEP flap; neurotization of DIEP flap; nipple-sparing neurotization; nipple-sparing mastectomy of large breasts; hematoma after mastectomy; robotic mastectomy; pre-pectoral alloplastic reconstruction

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Aspects and Outcomes in Contemporary Colorectal Surgery

edited by

Lior Segev

submission deadline 28 Aug 2025 | 1 articles | Viewed by 508 | Submission Open

Keywords: colorectal surgery; colorectal cancer; Crohn’ s disease; ulcerative colitis; coloproctology; minimally invasive surgery

(This special issue belongs to the Section General Surgery)

Current Trends in Urogynecology: 3rd Edition

edited by

Tomasz Rechberger

submission deadline 28 Aug 2025 | Viewed by 180 | Submission Open

Keywords: urogynecological surgery (uterovaginal prolapse; urinary incontinence; fistulas); OAB; pharmacology; physiotherapy; LUTS

(This special issue belongs to the Section Obstetrics & Gynecology)

The Journey of Hearing and Hearing-Related Disorders over Time—2nd Edition

edited by

Winfried Schlee

and

Jorge Piano Simões

submission deadline 28 Aug 2025 | Viewed by 166 | Submission Open

Keywords: hearing; hearing journey; hearing-related disorders; tinnitus; hyperacusis; digital phenotyping; big data

(This special issue belongs to the Section Otolaryngology)

Neurological Vistas: Cerebrovascular Focus

edited by Latha Ganti

submission deadline 28 Aug 2025 | Viewed by 100 | Submission Open

Keywords: acute stroke; ischemic stroke; traumatic brain injury; intracerebral hemorrhage; cerebrovascular disease

(This special issue belongs to the Section Clinical Neurology)

New Advances in Keratoplasty

edited by Cristina Bovone

submission deadline 29 Aug 2025 | 3 articles | Viewed by 3544 | Submission Open

Keywords: lamellar keratoplasty; descemet stripping endothelial keratoplasty (DSAEK); descemet membrane endothelial keratoplasty (DMEK); deep anterior lamellar keratoplasty (DALK); keratoconus; corneal dystrophies; bullous keratopathy; anterior segment OCT

(This special issue belongs to the Section Ophthalmology)

Clinical Advances in Pain Management

edited by Jamal Hasoon and Omar Viswanath

submission deadline 29 Aug 2025 | 5 articles | Viewed by 3389 | Submission Open

Keywords: postoperative pain; acute pain; chronic pain; nociceptive; analgesia; analgesics; interventional pain procedures

(This special issue belongs to the Section Anesthesiology)

Clinical Updates on Hereditary Hemorrhagic Telangiectasia (HHT) and Other Vascular Diseases

edited by Tamás Major

submission deadline 29 Aug 2025 | 4 articles | Viewed by 3093 | Submission Open

Keywords: hereditary hemorrhagic telangiectasia (HHT); arteriovenous malformations; embolization; VEGF; capillary malformation-arteriovenous malformation

(This special issue belongs to the Section Vascular Medicine)

Knee Osteoarthritis: Clinical Updates and Perspectives

edited by

Yoshitomo Saita

and Shinnosuke Hada

submission deadline 30 Aug 2025 | 12 articles | Viewed by 24911 | Submission Open

Keywords: knee osteoarthritis; diagnosis; cell therapy; platelet-rich plasma; exosome; knee osteotomy; arthroplasty; physiotherapy; conservative treatment; surgical treatment

(This special issue belongs to the Section Orthopedics)

Physical Therapy in Musculoskeletal Disorders: Prevention, Diagnosis, Clinical Management and Treatment

edited by

Rubén Cuesta-Barriuso

submission deadline 30 Aug 2025 | 17 articles | Viewed by 22144 | Submission Open

Keywords: physical therapy; musculoskeletal disorders; prevention; diagnosis; clinical management; treatment

(This special issue belongs to the Section Clinical Rehabilitation)

Review Special Issue Series: Recent Advances in Cardiovascular Medicine, 2nd Edition

edited by

Nandu Goswami

submission deadline 30 Aug 2025 | 2 articles | Viewed by 15204 | Submission Open

Keywords: cardiovascular medicine; recent advances; review articles; diagnostic techniques; therapeutic interventions; emerging trends; cardiovascular health; expert analysis; research

(This special issue belongs to the Section Cardiovascular Medicine)

Targeted Treatment in Head–Neck Cancer

edited by Jacopo Zocchi,

Gerardo Petruzzi

and

Pietro De Luca

submission deadline 30 Aug 2025 | 4 articles | Viewed by 7173 | Submission Open

Keywords: head and neck squamous cell carcinoma; precision medicine; targeted therapies; immunotherapy; tumor heterogeneity; treatment response monitoring

(This special issue belongs to the Section Otolaryngology)

New Progress and Challenges in Clinical Cardiac Surgery

edited by

Giuseppe Nasso

submission deadline 30 Aug 2025 | 4 articles | Viewed by 6502 | Submission Open

Keywords: coronary artery bypass grafting (CABG); mitral valve repair; aortic valve replacement; percutaneous coronary intervention (PCI); heart transplantation; atrial fibrillation ablation; ventricular assist devices (vad); minimally invasive cardiac surgery

(This special issue belongs to the Section Cardiology)

Targeted Treatment of Hematological Malignancy

edited by

Laura Eadie

, Chloe A.L. Thompson-Peach, Elyse C. Page and Deborah White

submission deadline 30 Aug 2025 | 4 articles | Viewed by 5868 | Submission Open

Keywords: leukemia; lymphoma; multiple myeloma; myelodysplastic syndromes; chronic myeloid leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; non-Hodgkin lymphoma; Hodgkin lymphoma

(This special issue belongs to the Section Hematology)

Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions

edited by Mauro Zaccarelli and

Alessandra Latini

submission deadline 30 Aug 2025 | 4 articles | Viewed by 5742 | Submission Open

Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex

(This special issue belongs to the Section Infectious Diseases)

Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era, 3rd Edition

edited by

Adolfo Di Fiore

and

Giulia Brunello

submission deadline 30 Aug 2025 | 5 articles | Viewed by 5681 | Submission Open

Keywords: 3D printing; additive manufacturing; milling technologies; CAD/CAM; digital implant planning; digital workflow; facial scanners; computer-guided implant surgery; intraoral scanners; digital design and fabrication of dental prostheses

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cystic Fibrosis: Diagnosis and Treatment

edited by Corrado Tagliati and Gian Marco Giuseppetti

submission deadline 30 Aug 2025 | 4 articles | Viewed by 5559 | Submission Open

Keywords: cystic fibrosis; diagnosis; treatment; management

(This special issue belongs to the Section Respiratory Medicine)

Recent Advances in Neurorehabilitation: Emerging Techniques and Technologies

edited by

Serena Dattola

and

Lilla Bonanno

submission deadline 30 Aug 2025 | 2 articles | Viewed by 3416 | Submission Open

Keywords: neurorehabilitation; neuroimaging; robotic rehabilitation; virtual reality therapy; neuroprosthetics; brain– computer interfaces; pharmacological interventions; functional recovery; neuroplasticity; cognitive rehabilitation

(This special issue belongs to the Section Clinical Neurology)

Targeted Treatment in Chronic Inflammatory Arthritis

edited by

Cinzia Rotondo

Simone Parisi

and Simone Perniola

submission deadline 30 Aug 2025 | 3 articles | Viewed by 2679 | Submission Open

Keywords: rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; spondyloarthritis; disease-modifying antirheumatic drugs (DMARDs); personalized medicine; immunomodulatory therapies; patient outcomes; combination therapies

(This special issue belongs to the Section Immunology)

Endocrine Surgery: Current Developments and Trends

edited by Leonardo Rossi and Gabriele Materazzi

submission deadline 30 Aug 2025 | 3 articles | Viewed by 2119 | Submission Open

Keywords: thyroid; parathyroid; adrenal gland; minimally invasive surgery; remote-access surgery; robotic surgery; parathyroid fluorescence; adrenal fluorescence

(This special issue belongs to the Section Endocrinology & Metabolism)

Pain Management: Current Challenges and Future Prospects

edited by Gian Marco Petroni

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1621 | Submission Open

Keywords: chronic joint pain; radio frequency ablation; adipose-derived mesenchimal stem cells (ADMScs); intrarticular injection; facet joint injection with ADMScs

(This special issue belongs to the Section Anesthesiology)

Advancements in Cardiac Electrophysiology Through Biomedical Engineering for Abnormality Monitoring and Detection in Clinical Practice

edited by Ilaria Marcantoni and Michela Casella

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1456 | Submission Open

Keywords: electrocardiogram; cardiac electrophysiology; cardiac risk index; cardiac arrhythmias; electrocardiographic alternans; long QT syndrome; heart electrical system anomalies; monitoring of heart electrical system; prevention; biomedical engineering in electrocardiology; cardiac signal processing; cardiac image processing

(This special issue belongs to the Section Cardiology)

Cardiopulmonary Resuscitation in Emergency Care Units

edited by

Stavros Dimopoulos

and

Christos Kourek

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1375 | Submission Open

Keywords: cardiopulmonary resuscitation; emergency care; cardiac arrest; CPR techniques; resuscitation devices; post-resuscitation care; survival outcomes

(This special issue belongs to the Section Emergency Medicine)

Pulmonary Hypertension: Advances in Clinical Diagnosis and Management

edited by Victor F. Tapson

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1346 | Submission Open

Keywords: pulmonary arterial hypertension; pulmonary hypertension; pulmonary vascular disease; chronic thromboembolic pulmonary hypertension; lung disease; left heart disease; functional class; right heart catheterization; prostacyclins; endothelin receptor antagonists; phosphodiesterase inhibitor; soluble guanylate cyclase stimulators; sotatercept

(This special issue belongs to the Section Respiratory Medicine)

The Complex Interplay Between Physical Activity, Sleep, Diet, and Obesity: Clinical Insights for Treatment and Prevention

edited by

Justyna Wyszyńska

and

Piotr Matłosz

submission deadline 30 Aug 2025 | 3 articles | Viewed by 1282 | Submission Open

Keywords: body mass; body composition; nutrition; sleep patterns; weight management; lifestyle interventions; sedentary behavior; adiposity; obesity prevention; dietary habits

(This special issue belongs to the Section Clinical Rehabilitation)

New Advances in Total Knee Arthroplasty

edited by

Carlo Biz

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1153 | Submission Open

Keywords: artificial intelligence; bone tumors; knee joint; knee pain; knee replacement; knee surgery; orthopedic surgery; osteoarthritis; prognostic markers; radiological evaluation

(This special issue belongs to the Section Orthopedics)

Robotic Urological Surgery: Clinical Updates for Better Outcomes

edited by

Shigeo Horie

submission deadline 30 Aug 2025 | 1 articles | Viewed by 984 | Submission Open

Keywords: robotic urological surgery; clinical outcomes; surgical techniques; surgical navigation; patient-reported outcomes; side effects; incident

(This special issue belongs to the Section Nephrology & Urology)

Orthopedic Trauma in Polytraumatized Patients: Current Management Concepts and Innovations

edited by

Thomas Lustenberger

submission deadline 30 Aug 2025 | 1 articles | Viewed by 649 | Submission Open

Keywords: polytrauma; geriatric polytrauma; fracture management; fracture stabilization; damage control orthopedics; early appropriate care; multidisciplinary approach; innovations; minimally invasive surgery

(This special issue belongs to the Section Orthopedics)

Orthopedic Trauma Surgery: Current Challenges and Future Perspectives

edited by Paolo Schiavi, Enrico Vaienti and Francesco Pogliacomi

submission deadline 30 Aug 2025 | Viewed by 558 | Submission Open

Keywords: trauma surgery; politrauma; osteosynthesis; arthroplasty; internal fixation; MIPO; outcome

(This special issue belongs to the Section Orthopedics)

New Clinical Insights into Exercise, Obesity, and Diabetes

edited by

Hugo Louro

Nuno M. Pimenta

, Ana Conceição and

Luis Leitão

submission deadline 30 Aug 2025 | Viewed by 483 | Submission Open

Keywords: diabetes; obesity; physical activity; exercise prescription; physically active learning; tissue oxidation; exercise physiology; physically active senior centres

(This special issue belongs to the Section Sports Medicine)

Thrombosis: Latest Advances and Prospects

edited by Manila Gaddh

submission deadline 30 Aug 2025 | Viewed by 321 | Submission Open

Keywords: thromboembolism; venous thrombosis; arterial thrombosis; anticoagulation

(This special issue belongs to the Section Hematology)

The Role of Bayesian Methods in Clinical Medicine

edited by Nicolas Meyer

submission deadline 30 Aug 2025 | Viewed by 312 | Submission Open

Keywords: bayesian statistics; clinical trials; epidemiology; clinical epidemiology; decision; diagnostic test; master protocol; review; statistical controversies; adaptive design

(This special issue belongs to the Section Clinical Research Methods)

Alcohol-Related Liver Disease: Diagnosis, Treatment, and Management

edited by

Adrian Boicean

and

Cristian Ichim

submission deadline 30 Aug 2025 | Viewed by 226 | Submission Open

Keywords: alcohol-related liver disease; gut– liver axis; hepatic fibrosis; liver cirrhosis; micro-RNA; inflammatory pathways; liver transplantation; steatohepatitis; fecal microbiota transplantation in liver cirrhosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current and Emerging Treatment Options in Atrial Fibrillation: 2nd Edition

edited by

Marco Valerio Mariani

submission deadline 30 Aug 2025 | Viewed by 208 | Submission Open

Keywords: atrial fibrillation; left atrial appendage closure; ablation techniques; personalized medicine in AF treatment; cardioversion methods

(This special issue belongs to the Section Cardiology)

Cardiac Anesthesia: Current Research and Future Prospects

edited by