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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Diagnosis, Treatment and Prognosis of Coronary Heart Disease

edited by

Simona Giubilato

submission deadline 30 Jun 2025 | 9 articles | Viewed by 13289 | Submission Open

Keywords: coronary heart disease; acute coronary syndrome; chronic coronary syndrome; ischemia with no obstructive coronary arteries (INOCA); guideline-directed optimal medical therapy; precision medicine; artificial intelligence; interventional cardiology; percutaneous coronary intervention (PCI)

(This special issue belongs to the Section Cardiology)

Chronicity, Multimorbidity, and Medication Appropriateness

edited by

Ignatios Ioakeim-Skoufa

Mercedes Aza-Pascual-Salcedo

and Helena Coelho

submission deadline 30 Jun 2025 | 9 articles | Viewed by 12287 | Submission Open

Keywords: multimorbidity; chronic diseases; drug utilization; polypharmacy; medication appropriateness; medication adherence; drug interactions; care models; chronic inflammation; interventions

(This special issue belongs to the Section Pharmacology)

Updates on Neurostimulation: From Mechanistic Principles to Clinical Applications

edited by

Jose Gomez Tames

and

Mariano Fernández-Corazza

submission deadline 30 Jun 2025 | 5 articles | Viewed by 12056 | Submission Open

Keywords: brain stimulation; non-invasive brain stimulation; deep brain stimulation; neuroimaging; computational modelling; therapy

(This special issue belongs to the Section Clinical Neurology)

Current Trends and Innovations in Coronary Artery Disease and Myocardial Ischemia

edited by

Edoardo Conte

submission deadline 30 Jun 2025 | 5 articles | Viewed by 11368 | Submission Open

Keywords: coronary artery disease; fractional flow reserve; invasive coronary angiography; cardiac CT; cardiac MRI

(This special issue belongs to the Section Cardiovascular Medicine)

Early Clinical Diagnosis of and Intervention in Pediatric Cerebral Palsy

edited by

Ann Kristin G. Elvrum

and

Ann-Christin Eliasson

submission deadline 30 Jun 2025 | 8 articles | Viewed by 10467 | Submission Open

Keywords: cerebral palsy; early diagnosis; family factors; associated impairments; outcome measures; intervention; mental health

(This special issue belongs to the Section Clinical Pediatrics)

Vitreoretinal Disease: Clinical Insights and Treatment Strategies

edited by

Makoto Inoue

submission deadline 30 Jun 2025 | 8 articles | Viewed by 10195 | Submission Open

Keywords: vitreoretinal disease; age-related macular degeneration; diabetic retinopathy; retinal detachments; retinitis pig-mentosa; flashes and floaters; macular holes

(This special issue belongs to the Section Ophthalmology)

Clinical Advances in Vascular and Endovascular Surgery

edited by Toshifumi Kudo

submission deadline 30 Jun 2025 | 9 articles | Viewed by 9620 | Submission Open

Keywords: aortic aneurysm; peripheral arterial disease; chronic limb-threatening ischemia; endovascular aneurysm repair; endovascular treatment; non-invasive blood flow measurements; varicose veins; deep venous thrombosis

(This special issue belongs to the Section Vascular Medicine)

Advances in Orthopedic Trauma Surgery in Geriatrics

edited by Ulrich Christoph Liener

submission deadline 30 Jun 2025 | 7 articles | Viewed by 9316 | Submission Open

Keywords: geriatric fractures; orthogeriatric care; osteoporosis; frailty; fragillity fractures; multidisciplinary care

(This special issue belongs to the Section Orthopedics)

Sepsis and Organ Dysfunction: New Insights into Diagnosis and Treatment

edited by

Barbara Adamik

submission deadline 30 Jun 2025 | 7 articles | Viewed by 8817 | Submission Open

Keywords: intensive care; sepsis; septic shock; biomarkers; multiorgan dysfunction syndrome; ex-tracorporeal methods; mortality

(This special issue belongs to the Section Intensive Care)

Treatment of Atopic Dermatitis

edited by

Francisco José Navarro-Triviño

and Ricardo Ruíz-Villaverde

submission deadline 30 Jun 2025 | 4 articles | Viewed by 8588 | Submission Open

Keywords: atopic dermatitis; eczema; topical treatment; systemic treatment; biological therapy; JAK inhibitor; antipruritic treatment

(This special issue belongs to the Section Dermatology)

Clinical Advances in Traumatic Brain Injury

edited by

Abhijit V. Lele

submission deadline 30 Jun 2025 | 4 articles | Viewed by 7327 | Submission Open

Keywords: traumatic brain injury; guideline/recommendations; concordant care; resource limited clinical setting; multimodal monitoring; neuroprognostication; safe/effective/patient-centered/timely/efficient/equitable care; quality improvement

(This special issue belongs to the Section Clinical Neurology)

Microsurgery: Current and Future Perspectives

edited by

Pier Camillo Parodi

, Michele Riccio, Luca Vaienti,

Francesco De Francesco

and

Nicola Zingaretti

submission deadline 30 Jun 2025 | 5 articles | Viewed by 6940 | Submission Open

Keywords: plastic surgery; reconstructive surgery; microsurgery; free flap; free tissue transfer

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Oral and Maxillofacial Surgery: Recent Advances and Future Directions

edited by

Tomasz Gredes

and

Ute Ulrike Botzenhart

submission deadline 30 Jun 2025 | 5 articles | Viewed by 6779 | Submission Open

Keywords: orthodontics; dentofacial orthopedics; bone regeneration; oral health; dentistry; digital technologies; virtual care

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Insights into Corneal Regeneration and Transplantation

edited by

Zala Lužnik Marzidovšek

and

Rohan Bir Singh

submission deadline 30 Jun 2025 | 4 articles | Viewed by 6414 | Submission Open

Keywords: cornea; corneal surface disease; corneal transplantation; eye banking; corneal stem cells; corneal immunology

(This special issue belongs to the Section Ophthalmology)

Polycystic Ovary Syndrome (PCOS): State of the Art: 2nd Edition

edited by

Enrico Carmina

submission deadline 30 Jun 2025 | 4 articles | Viewed by 5701 | Submission Open

Keywords: polycystic ovary syndrome; hirsutism; obesity; insulin resistance; amenorrhea; adult acne; female pattern hair loss; polycystic ovaries; anti-Mullerian hormone

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Aortic Disease and Revascularization

edited by Andrej Udelnow

submission deadline 30 Jun 2025 | 6 articles | Viewed by 5648 | Submission Open

Keywords: aortic disease; aortic aneurysm; endovascular aortic repair; atherosclerosis; aortic dissections; overall survival; quality of life; intravascular ultrasound

(This special issue belongs to the Section Vascular Medicine)

Clinical Application of Physical Therapy in Neurorehabilitation: 2nd Edition

edited by

‪Sofia Straudi

and

Roberto Cano de la Cuerda

submission deadline 30 Jun 2025 | 3 articles | Viewed by 5623 | Submission Open

Keywords: physical therapy; technology-aided rehabilitation; exercise; neurorehabilitation; neuroplasticity; engagement; self-management

(This special issue belongs to the Section Clinical Rehabilitation)

Cardiac Electrophysiology: New Insights and Future Directions

edited by

Michael Spartalis

submission deadline 30 Jun 2025 | 4 articles | Viewed by 5109 | Submission Open

Keywords: cardiac arrhythmias; atrial fibrillation; ventricular arrhythmias; remote monitoring; implantable cardioverter– defibrillators; cardiac resynchronization therapy; catheter ablation; channelopathies

(This special issue belongs to the Section Cardiology)

New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias

edited by

Simone Savastano

submission deadline 30 Jun 2025 | 3 articles | Viewed by 5010 | Submission Open

Keywords: cardiac arrest; defibrillation; ventricular tachycardia; ventricular fibrillation; catheter ablation; non-invasive ablation; neuromodulation; stellate ganglion block

(This special issue belongs to the Section Cardiology)

Clinical Epidemiology in Chronic Kidney Disease

edited by

Vincenzo Antonio Panuccio

and Claudia Torino

submission deadline 30 Jun 2025 | 5 articles | Viewed by 4860 | Submission Open

Keywords: chronic kidney disease; end-stage kidney disease; dialysis; hypertension; renal disease; clinical nephrology; chronic renal failure

(This special issue belongs to the Section Nephrology & Urology)

State-of-the-Art Innovations in Oral and Maxillofacial Surgery

edited by Marcin Kozakiewicz and Katarzyna Bogusiak

submission deadline 30 Jun 2025 | 6 articles | Viewed by 4472 | Submission Open

Keywords: oral surgery; maxillofacial surgery; traumatology; orthognatic surgery; infections; oncology; diagnostics; treatment; implantology; augmentation; imaging; computer-assisted techniques

(This special issue belongs to the Section Otolaryngology)

Trauma and Acute Care Surgery Research: Innovations, Challenges, and Future Directions

edited by Frederick Rogers

submission deadline 30 Jun 2025 | 3 articles | Viewed by 4328 | Submission Open

Keywords: trauma care; best practices; clinical care; trauma system development; optimal trauma care

(This special issue belongs to the Section Intensive Care)

Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges

edited by

Grzegorz Zieliński

and

Eiji Tanaka

submission deadline 30 Jun 2025 | 4 articles | Viewed by 4254 | Submission Open

Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Cardiac Resynchronization Treatment

edited by

George Leventopoulos

, Konstantinos A. Gatzoulis and

Nikolaos K. Fragakis

submission deadline 30 Jun 2025 | 4 articles | Viewed by 4114 | Submission Open

Keywords: conduction system; risk stratification; resynchronization; cardiac pacing; sudden cardiac death

(This special issue belongs to the Section Cardiology)

Targeted Treatment of Kidney Stones

edited by Carmen Gonzalez-Enguita and

Alberto Budía-Alba

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3901 | Submission Open

Keywords: shockwave lithotripsy; ureteroscopy; percutaneous nephrolithotomy; laser lithotripsy; minimally invasive techniques; stone recurrence prevention

(This special issue belongs to the Section Nephrology & Urology)

Inflammatory Bowel Diseases in 2024 and Beyond: From Diagnosis to Treatment

edited by

Amalia Di Petrillo

and Sara Onali

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3744 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; target therapy; nutrition; early diagnosis; inflammatory biomarkers

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Influence of Laparoscopic and Robotic Surgery on Abdominal Diseases and Current Clinical Treatments

edited by

Gianluca Costa

, Maurizio De Maria and Niccolò Petrucciani

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3693 | Submission Open

Keywords: laparoscopic surgery; robotic surgery; minimally invasive surgery; upper GI surgery; colorectal surgery; HBP surgery; transplantation; urology; obstetrics and gynecology

(This special issue belongs to the Section General Surgery)

Thoracic Surgery: Current Challenges and Future Perspectives

edited by

Jon Zabaleta

and José Luis Campo-Cañaveral de la Cruz

submission deadline 30 Jun 2025 | 4 articles | Viewed by 3540 | Submission Open

Keywords: minimally invasive surgery; robotic-assisted thoracic surgery; lung cancer management; esophageal surgery; pleural diseases and interventions; thoracic trauma surgery; tracheal and bronchial surgery; thoracic endoscopy; lung transplantation; lung segmentectomy; 3D printing; pneumothorax; surgical planification; education; simulation; artificial intelligence

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Cardiac Anesthesia and Critical Care

edited by

Marc Licker

and Tiziano Cassina

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3442 | Submission Open

Keywords: cardiac anesthesia; critical care; perioperative organ protection; multimodal analgesia; regional anesthesia; spinal analgesia; perioperative imaging; 3D transesophageal echocardiography

(This special issue belongs to the Section Anesthesiology)

Male Infertility Update: Current Knowledge on Etiology, Comorbidities, Diagnosis and Treatment: Clinical Topics

edited by

Francesco Lotti

and

Mario Maggi

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3311 | Submission Open

Keywords: male infertility; diagnosis; treatment; etiology; pre-testicular/testicular/post-testicular causes; genetic causes; seminal parameters; hormonal parameters; ultrasound; general health; azoospermia

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Innovations in Preeclampsia

edited by Jeffrey M. Denney and

Liliya Yamaleyeva

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3072 | Submission Open

Keywords: preeclampsia; pathophysiology; renin; SFlt-1; PlGF; hypertensive disorders of pregnancy; imitators of preeclampsia; vascular reactivity

(This special issue belongs to the Section Obstetrics & Gynecology)

New Insights in the Endovascular Treatment of Aortic Type A Dissection

edited by

Markus Kofler

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2969 | Submission Open

Keywords: aortic dissection; endovascular treatment; type A dissection; thoracic aorta; stent graft; minimally invasive surgery; hybrid procedures; complications; long-term outcomes; patient selection

(This special issue belongs to the Section Cardiology)

Clinical Perspectives for Headache and Neuropathic Pain

edited by Soo-Jin Cho

submission deadline 30 Jun 2025 | 4 articles | Viewed by 2959 | Submission Open

Keywords: headache; migraine; reversible vasoconstrictino syndrome; calcitonine-gene-related peptide; neuropathic pain; chemothera-py-induced peripheral neuropathy; central sensitization

(This special issue belongs to the Section Clinical Neurology)

Targeted Diagnosis and Treatment of Dementia: Current Concepts and New Horizons

edited by Eli Wertman

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2857 | Submission Open

Keywords: dementia; pre-dementia; diagnosis; targeted therapies; cognitive assessment; behavioral syndromes neuroimaging; multimorbidity; pharmacological interventions; non-pharmacological approaches; case management; supportive care; remediability

(This special issue belongs to the Section Mental Health)

Causes and Advanced Treatments of Macular Edema

edited by

Gawęcki Maciej

and

Slawomir Teper

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2774 | Submission Open

Keywords: macular edema; laser photocoagulation; subthreshold laser; anti-VEGF; optical coherence tomography; fluorescein angiography; angio-OCT

(This special issue belongs to the Section Ophthalmology)

Diagnosis and Treatment of Rheumatic Diseases

edited by Răzvan Gabriel Drăgoi and

Codrina Ancuta

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2731 | Submission Open

Keywords: rheumatic diseases; patient-reported outcomes; assessment; arthritis; impairment; connective tissue diseases; biological and targeted synthetic therapies; impairment

(This special issue belongs to the Section Immunology)

Clinical Trends and Prospects in Urology Surgery

edited by

Lazaros Tzelves

Bhaskar K. Somani

and Patrick Juliebø-Jones

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2696 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; endourology; minimally invasive surgery; artificial intelligence

(This special issue belongs to the Section Nephrology & Urology)

Chronic Pain: Non-Pharmacological Treatments and Rehabilitation Strategies

edited by Matteo Ponzano

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2669 | Submission Open

Keywords: pain; neuropathies; musculoskeletal health; biopsychosocial management; physical therapy; cognitive behavioral therapies

(This special issue belongs to the Section Clinical Rehabilitation)

Cerebral Palsy: Clinical Rehabilitation and Treatment

edited by Joav Merrick and

Dilipkumar R. Patel

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2584 | Submission Open

Keywords: cerebral palsy; physiotherapy; occupational therapy; orthopedic management; medical management; rehabilitation approaches

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Urinary Surgery

edited by Nir Kleinmann and

Asaf Shvero

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2571 | Submission Open

Keywords: endourology; laparoscopic urology; urologic oncology; urolithiasis; robot-assisted surgery; endoscopic surgery

(This special issue belongs to the Section Nephrology & Urology)

Perspectives on Congenital Heart Disease from Children to Adults

edited by

Raffaele Giordano

submission deadline 30 Jun 2025 | 4 articles | Viewed by 2408 | Submission Open

Keywords: congenital heart disease; pediatric cardiac surgery; pediatric cardiology; children; adult congenital heart disease

(This special issue belongs to the Section Cardiology)

Current Challenges in the Management of Vitreoretinal Conditions: 2nd Edition

edited by

Georgios Panos

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2271 | Submission Open

Keywords: retina; anti-VEGF; implants; macular degeneration; diabetic retinopathy; vein occlusions; retinal detachments; vit-reoretinal surgery; COVID-19 impact

(This special issue belongs to the Section Ophthalmology)

Pelvic Organ Prolapse: Current Challenges and Future Perspectives

edited by Marco Soligo

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2160 | Submission Open

Keywords: pelvic organ prolapse; urinary incontinence; lower urinary disorders; quality of life; patient-reported outcomes

(This special issue belongs to the Section Obstetrics & Gynecology)

Current Practice and Future Perspectives of Neurological Conditions Caused by Neurodegeneration, 2nd Edition

edited by

Lilla Bonanno

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1992 | Submission Open

Keywords: neurodegenerative diseases; amyotrophic lateral sclerosis; multiple sclerosis; Parkinson's disease; Alzheimer's disease; Huntington's disease; multiple-system atrophy; prion diseases; stroke

(This special issue belongs to the Section Clinical Neurology)

New Insights into Orthopedic Trauma Surgery—Pelvic and Acetabular Fracture Management

edited by Vera Jaecker and

Sven Märdian

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1983 | Submission Open

Keywords: acetabular fractures; pelvic fractures; trauma surgery; intrapelvic approaches; fragility fractures of the pelvis; minimally invasive approaches; new implants; innovations

(This special issue belongs to the Section Orthopedics)

Advances in Echocardiography and Its Clinical Applications

edited by

Simona Sperlongano

submission deadline 30 Jun 2025 | 3 articles | Viewed by 1949 | Submission Open

Keywords: Doppler imaging; speckle tracking echocardiography; myocardial work; intracardiac flow dynamics; three-dimensional echocardiography; stress echocardiography; transoesophageal echocardiography; contrast echocardiography; artificial intelligence

(This special issue belongs to the Section Cardiovascular Medicine)

Recent Advances in Glaucoma Management

edited by Bogomil Voykov

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1852 | Submission Open

Keywords: glaucoma; MIGS; microinvasive glaucoma surgery; quality of life; sustained-release drugs; wound healing modula-tion; intraocular pressure; intraocular pressure-lowering medication; microstent-supported bleb surgery; MIBS; neuroprotection

(This special issue belongs to the Section Ophthalmology)

Traumatic Brain Injury: Current Treatment and Future Options

edited by

Ismail Zaed

submission deadline 30 Jun 2025 | 3 articles | Viewed by 1826 | Submission Open

Keywords: traumatic brain injury; trauma; biomarkers; post-traumatic outcome; epidemiology

(This special issue belongs to the Section Clinical Neurology)

Emerging Therapies for Multiple Myeloma

edited by Brea C. Lipe

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1821 | Submission Open

Keywords: multiple myeloma; immunotherapy; targeted therapy; CAR-T cell therapy; new drugs; transplant

(This special issue belongs to the Section Hematology)

Gastroesophageal Cancer: Outcomes and Therapeutic Management

edited by Michael K. Gibson

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1801 | Submission Open

Keywords: gastroesophageal cancer; targeted therapy; circulating tumor DNA; precision medicine; immune checkpoint inhibitors; esophageal cancer; gastric cancer; biomarkers; molecular characterization

(This special issue belongs to the Section Oncology)

Displaying special issue 251-300 on page 6 of 27.

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