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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovations and Future Directions in Valvular Heart Disease: Imaging, Technology, and Translational Research

edited by

Mohammad Kassar

, Muhammed Gerçek and Felix Rudolph

submission deadline 25 Dec 2025 | Viewed by 66 | Submission Open

Keywords: prosthetic heart valve; heart valve pathophysiology; structural heart valve interventions; echocardiographic assessment; cardiovascular imaging; valvular heart disease; valvular regurgitation; valvular stenosis; minimally invasive surgery; concomitant valve disease

(This special issue belongs to the Section Cardiology)

IgA Nephropathy: Clinical Updates and Prospects

edited by

Meritxell Ibernon

submission deadline 25 Dec 2025 | Viewed by 60 | Submission Open

Keywords: pathogenesis of IgA nephropathy; novel therapies; role of complement system; risk factors for disease progression; proteomic approach; serologic biomarkers; histological classification

(This special issue belongs to the Section Nephrology & Urology)

Clinical Aspects of Cardiac Arrhythmias and Arrhythmogenic Disorders

edited by

Piotr Bienias

and Jakub Baran

submission deadline 25 Dec 2025 | Viewed by 57 | Submission Open

Keywords: non-invasive arrhythmia assessment; electrocardiography; invasive arrhythmia assessment; invasive electrophysiology; catheter ablation; implantable devices; rare diseases and arrhythmias; arrhythmia risk stratification; genetics aspects of arrhythmogenesis; channelopathy

(This special issue belongs to the Section Cardiology)

Current Clinical Treatments and Challenges for Cardiovascular Diseases

edited by Georgios Bouras and

Christos Kourek

submission deadline 26 Dec 2025 | 4 articles | Viewed by 3983 | Submission Open

Keywords: heart failure; coronary artery disease; atrial fibrillation; cardiomyopathies; hypertension

(This special issue belongs to the Section Cardiovascular Medicine)

New Advances in Extracorporeal Life Support (ECLS)

edited by Robertas Stasys Samalavičius,

Pranas Šerpytis

and

Holger Thiele

submission deadline 26 Dec 2025 | 2 articles | Viewed by 2771 | Submission Open

Keywords: extracorporeal life support (ECLS); extracorporeal membrane oxygenation (ECMO); innovations in ECLS; respiratory failure; cardiogenic shock; eCPR

(This special issue belongs to the Section Emergency Medicine)

Cardiac Rehabilitation: Clinical Challenges and New Insights

edited by Melissa Tracy

submission deadline 26 Dec 2025 | 2 articles | Viewed by 1494 | Submission Open

Keywords: cardiovascular disease; cardiac rehabilitation; atrial fibrillation

(This special issue belongs to the Section Cardiology)

Current Clinical Advances and Challenges for Endourology

edited by

Carlo Giulioni

and

Daniele Castellani

submission deadline 26 Dec 2025 | 1 articles | Viewed by 610 | Submission Open

Keywords: urolithiasis; upper tract urothelial carcinoma; benign prostatic hyperplasia; minimally invasive surgical therapies

(This special issue belongs to the Section Nephrology & Urology)

Multifactorial Causation and Therapies of Myopia: 2nd Edition

edited by

César Villa Collar

Cristina Alvarez-Peregrina

and

David Piñero

submission deadline 26 Dec 2025 | Viewed by 91 | Submission Open

Keywords: epidemiology; genetics; premyopia; simple and pathological myopia; orthokeratology; lenses for myopia control; blue light and red light; binocular vision and ocular optics; artificial intelligence

(This special issue belongs to the Section Ophthalmology)

Clinical Updates on Metabolic and Bariatric Surgery

edited by Maria-Jose Barahona

submission deadline 27 Dec 2025 | Viewed by 250 | Submission Open

Keywords: obesity; bariatric surgery; metabolic surgery; weight loss; obesity treatment; metabolic disorders

(This special issue belongs to the Section General Surgery)

Atrial Fibrillation Rhythm Management: Outcomes, Innovations, and Future Directions

edited by Roberto Scacciavillani and Gemma Pelargonio

submission deadline 28 Dec 2025 | 2 articles | Viewed by 1319 | Submission Open

Keywords: atrial fibrillation; catheter ablation; radiofrequency; cryoablation; pulsed field ablation; cardioneuroablation; left bundle branch area pacing

(This special issue belongs to the Section Cardiology)

Lung Transplantation: Current Strategies and Future Directions

edited by Omer Senbaklavaci and György Lang

submission deadline 28 Dec 2025 | 1 articles | Viewed by 527 | Submission Open

Keywords: lung transplantation; graft optimization; immunosuppression; artificial lung; xenotransplantation; end-stage lung disease; donor lung preservation; chronic lung allograft dysfunction

(This special issue belongs to the Section Respiratory Medicine)

Imaging and Molecular Biomarkers: The New Approach to Degenerative Retinal Diseases

edited by

Giulia Midena

and

Elisabetta Pilotto

submission deadline 28 Dec 2025 | Viewed by 72 | Submission Open

Keywords: ophthalmology; degenerative retinal diseases; imaging biomarkers; multimodal imaging; OCT; OCT angiography; molecular biomarkers; precision medicine; translational ophthalmic research

(This special issue belongs to the Section Ophthalmology)

Pediatric Neurosurgery: Clinical Advances in Diagnostics and Perioperative Management

edited by Kara Leigh Krajewski and Ulrich-Wilhelm Thomale

submission deadline 29 Dec 2025 | Viewed by 321 | Submission Open

Keywords: rapid sequence MRI; intraoperative MRI; perioperative management; neurocritical care; patient selection; M&M conferences; surgical team; rehabilitation

(This special issue belongs to the Section Clinical Pediatrics)

Current Concepts and Clinical Application of Echocardiography

edited by

Marco Solari

submission deadline 29 Dec 2025 | Viewed by 82 | Submission Open

Keywords: echocardiography; clinical echocardiography; advanced echocardiography; cardiovascular disease; clinical cardiology

(This special issue belongs to the Section Cardiology)

Managements of Venous Thromboembolism

edited by

Anabel Franco Moreno

submission deadline 29 Dec 2025 | Viewed by 51 | Submission Open

Keywords: venous thromboembolism; deep vein thrombosis; pulmonary embolism; anticoagulation therapy; direct oral anticoagulants; risk stratification; bleeding risk; artificial intelligence; personalized medicine

(This special issue belongs to the Section Vascular Medicine)

Treatment of Atopic Dermatitis

edited by

Francisco José Navarro-Triviño

and Ricardo Ruíz-Villaverde

submission deadline 30 Dec 2025 | 5 articles | Viewed by 11134 | Submission Open

Keywords: atopic dermatitis; eczema; topical treatment; systemic treatment; biological therapy; JAK inhibitor; antipruritic treatment

(This special issue belongs to the Section Dermatology)

Chronic Pain: Non-Pharmacological Treatments and Rehabilitation Strategies

edited by Matteo Ponzano

submission deadline 30 Dec 2025 | 4 articles | Viewed by 4447 | Submission Open

Keywords: pain; neuropathies; musculoskeletal health; biopsychosocial management; physical therapy; cognitive behavioral therapies

(This special issue belongs to the Section Clinical Rehabilitation)

Recent Advances in Glaucoma Management

edited by Bogomil Voykov

submission deadline 30 Dec 2025 | 3 articles | Viewed by 2581 | Submission Open

Keywords: glaucoma; MIGS; microinvasive glaucoma surgery; quality of life; sustained-release drugs; wound healing modula-tion; intraocular pressure; intraocular pressure-lowering medication; microstent-supported bleb surgery; MIBS; neuroprotection

(This special issue belongs to the Section Ophthalmology)

Current Challenges in Inflammatory Bowel Diseases

edited by

Wesley M. Raup-Konsavage

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1267 | Submission Open

Keywords: ulcerative colitis; Chron’ s disease; inflammatory bowel disease; colitis-associated cancer; novel pharmaceutics

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Perspectives on Women’s Reproductive Health: Challenges and Management Strategies

edited by

Seok Kyo Seo

submission deadline 30 Dec 2025 | 2 articles | Viewed by 895 | Submission Open

Keywords: endometriosis; ovarian endometrioma; polycystic ovary syndrome; reproductive health; cervical; postmenopausal women; hormone replacement therapy; sarcopenia

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Management for Coronary Artery Disease and Revascularization

edited by Mohammad Reza Movahed

submission deadline 30 Dec 2025 | 2 articles | Viewed by 884 | Submission Open

Keywords: coronary artery disease; coronary syndrome; stenting; revascularization; cardiovascular

(This special issue belongs to the Section Cardiovascular Medicine)

Advancements in Emergency Medicine Practices and Protocols

edited by Vincenzo G. Menditto and Beatrice Gasperini

submission deadline 30 Dec 2025 | 1 articles | Viewed by 563 | Submission Open

Keywords: emergency; pulmonary embolism; trauma; management; guidelines; frailty; emergency department observation unit

(This special issue belongs to the Section Emergency Medicine)

Joint Repair and Replacement: Current Challenges and Opportunities

edited by Bartosz Gonera and Kacper Ruzik

submission deadline 30 Dec 2025 | 1 articles | Viewed by 507 | Submission Open

Keywords: orthopedic biomechanics; knee injuries; joint replacement; anterior cruciate ligament; arthroscopy; sports medicine; prosthetic implants

(This special issue belongs to the Section Orthopedics)

Cerebral Palsy: Recent Advances in Clinical Management

edited by Laurie J. Glader and M. Wade Shrader

submission deadline 30 Dec 2025 | Viewed by 442 | Submission Open

Keywords: cerebral palsy; pediatric; neurology; complex care; clinical management

(This special issue belongs to the Section Clinical Pediatrics)

Augmented and Artificial Intelligence in Ophthalmology

edited by Tina Felfeli, Edsel B. Ing, David Jose Mathew and Michael Balas

submission deadline 30 Dec 2025 | Viewed by 376 | Submission Open

Keywords: artificial intelligence; ophthalmology; eye health; vision; teleophthalmology

(This special issue belongs to the Section Ophthalmology)

Regional Anesthesia and Pain Management: Mastering Clinical Art for Optimal Patient Satisfaction

edited by

Min Suk Chae

submission deadline 30 Dec 2025 | Viewed by 166 | Submission Open

Keywords: regional anesthesia; pain management; ultrasound-guided nerve blocks; fascial plane blocks; multimodal analgesia; postoperative analgesia; chronic pain management; opioid-sparing strategies; non-opioid analgesics; patient satisfaction; anesthesia techniques; perioperative care; pain interventions; nerve block techniques; clinical outcomes

(This special issue belongs to the Section Anesthesiology)

Pulmonary Critical Care: Integrating Bedside Physiology and Advanced Monitoring in the Management of Severe Respiratory Diseases

edited by

Gaetano Scaramuzzo

submission deadline 30 Dec 2025 | Viewed by 89 | Submission Open

Keywords: lung monitoring; ARDS; ARF; biomarkers; lung physiology; pneumonia; lung ultrasound; artificial intelligence; COPD; EIT

(This special issue belongs to the Section Respiratory Medicine)

Interventional Cardiology: Recent Developments and Future Challenges

edited by

Andreas Mitsis

and George Kassimis

submission deadline 30 Dec 2025 | Viewed by 89 | Submission Open

Keywords: percutaneous coronary intervention (PCI); drug-eluting stents (DES); high risk percutaneous coronary intervention (CHIP); chronic total occlusions (CTO); intravascular imaging (IVUS; OCT); coronary physiology (FFR; iFR); antiplatelet therapy; complex coronary interventions; mechanical circulatory support (MCS)

(This special issue belongs to the Section Cardiology)

Plastic and Reconstructive Surgery of the Face: Chances and Challenges

edited by

Cristian Trâmbițaș

and Bogdan Andrei Suciu

submission deadline 30 Dec 2025 | Viewed by 86 | Submission Open

Keywords: facial plastic surgery; facial reconstruction procedures; tissue regeneration; esthetic facial procedures; digital imaging and customization; biomaterials in reconstructive surgery; flap surgery innovations; microsurgical precision techniques

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Autoimmune Diseases and Multisystem Inflammation: Pathophysiology and Therapeutic Strategies

edited by

Tsuyoshi Shirai

submission deadline 30 Dec 2025 | Viewed by 74 | Submission Open

Keywords: autoimmune diseases; cardiovascular diseases; cutaneous diseases; gastrointestinal diseases; pulmonary diseases; renal diseases; systemic manifestation; rheumatoid arthritis; systemic lupus erythematosus; vasculitis

(This special issue belongs to the Section Immunology)

Advancing Neonatal Seizures and Epilepsy: New Perspectives and Interventions

edited by

Elena Pavlidis

and Gaetano Cantalupo

submission deadline 30 Dec 2025 | Viewed by 71 | Submission Open

Keywords: neonatal seizures; neonatal epilepsy; neonatal EEG; automated EEG analysis; neonatal brain monitoring; genetic; precision medicine; genetic epilepsies; genome; exome

(This special issue belongs to the Section Clinical Pediatrics)

Cardiovascular Magnetic Resonance Imaging: Precise Diagnosis and Therapeutic Guidance

edited by Radu Andy Sascau and

Carina Gabriela Ureche

submission deadline 30 Dec 2025 | Viewed by 69 | Submission Open

Keywords: cardiac magnetic resonance; cardiomyopathy; tissue characterization; stress perfusion; 4D flow; heart failure; ischemic heart disease; multi-modality imaging; valvular heart disease; T1 mapping; T2 mapping; myocarditis

(This special issue belongs to the Section Cardiovascular Medicine)

New Developments in Hematopoietic Stem Cell Transplantation in Clinical Practice

edited by Mattia Algeri

submission deadline 30 Dec 2025 | Viewed by 60 | Submission Open

Keywords: hematopoietic stem cell transplantation; graft-versus-host disease (GVHD); conditioning regimens; immune reconstitution; donor selection; post-transplant complications; long-term survivorship

(This special issue belongs to the Section Hematology)

Challenges and Opportunities in Colorectal Cancer

edited by

Naim Abu-Freha

submission deadline 30 Dec 2025 | Viewed by 57 | Submission Open

Keywords: colorectal cancer; screening; staging; treatment of colorectal cancer (CRC); high-risk patients; fecal occult testing; colonoscopy; lynch syndrome

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current and Emerging Treatment Options in Colorectal Cancer

edited by Michael Osseis

submission deadline 30 Dec 2025 | Viewed by 56 | Submission Open

Keywords: colorectal cancer (CRC); emerging treatment options; targeted therapies; new surgical technologies; precision medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Shoulder Arthroplasty: Clinical Advance and Future Perspective

edited by Vani J. Sabesan

submission deadline 30 Dec 2025 | Viewed by 55 | Submission Open

Keywords: shoulder arthroplasty; reverse shoulder arthroplasty; perioperative optimization; multimodal pain management; rehabilitation protocols; outpatient shoulder arthroplasty; implant longevity; complication management; disparities in outcomes

(This special issue belongs to the Section Orthopedics)

Ultrasound-Guided Biopsy of Gynecologic Tumors: Technique and Clinical Application

edited by

Athina A. Samara

and Alexandros Daponte

submission deadline 30 Dec 2025 | Viewed by 54 | Submission Open

Keywords: ultrasound-guided biopsy; gynecologic tumors; ovarian cancer; biopsy technique; precision diagnosis; endometrial lesions

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Antiphospholipid Syndrome (APS)

edited by

Ariela Hoxha

submission deadline 30 Dec 2025 | Viewed by 54 | Submission Open

Keywords: thrombosis; pregnancy; antiphospholipid syndrome; lupus anticoagulant; antiphospholipid antibodies

(This special issue belongs to the Section Immunology)

Cutting-Edge Technologies and Unconventional Therapies in Heart Failure

edited by

Gonzalo Luis Alonso Salinas

and Pablo Díez-Villanueva

submission deadline 30 Dec 2025 | Viewed by 40 | Submission Open

Keywords: heart failure; new technologies; artificial intelligence; treatment; advanced heart failure

(This special issue belongs to the Section Cardiology)

Advances in Diagnosis and Treatment of Amyloidosis

edited by Michael Rosenzweig

submission deadline 31 Dec 2025 | 9 articles | Viewed by 14750 | Submission Open

Keywords: amyloidosis; transthyretin (TTR); autologous stem cell transplantation (ASCT); chemotherapy; immunotherapy; cardiomyopathy; nephropathy; neuropathy

(This special issue belongs to the Section Cardiology)

Interdisciplinary Approach on the Oral Cavity Management Due to Musculoskeletal Conditions

edited by Cosmin Sinescu,

Elena Amaricai

and

Virgil-Florin Duma

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11833 | Submission Open

Keywords: rehabilitation medicine; biomechanics; bruxism assessment; general medicine; dental medicine; biomedical imaging; musculoskeletal disorders; shoulder girdle; cervical region; physical therapy; therapeutic exercise; postural correction; dynamic balance; pediatric rehabilitation; sports medicine; quality of life research; general conditions with resonance in the oro-maxillo-facial sphere

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Symptoms and Treatment of Parkinson’s Disease

edited by

Christos Koros

and Nikolaos Papagiannakis

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7153 | Submission Open

Keywords: Parkinson’ s disease; non-motor symptoms; clinical progression; cognitive assessment; genetics; remote monitoring; biomarkers; personalized medicine; device-aided treatments; disease-modifying therapies

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates on Knee and Hip Arthroplasty

edited by Amarildo Smakaj and Elena Gasbarra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1954 | Submission Open

Keywords: knee arthroplasty; hip arthroplasty; total joint replacement; minimally invasive arthroplasty; implant durability; postoperative rehabilitation; revision arthroplasty; prosthesis-related complications; periprosthetic joint infection; implant loosening

(This special issue belongs to the Section Orthopedics)

Acute Kidney Injury: Latest Advances and Prospects

edited by

Emanuele de Simone

and Kianoush Kashani

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1817 | Submission Open

Keywords: acute kidney injury (AKI); sepsis; septic shock; renal replacement therapy; intensive care; specialized interventions; biomarkers; risk factors; “ Green Practice” ; nephrology; epidemiology; multidisciplinary approach

(This special issue belongs to the Section Nephrology & Urology)

Children and Adolescent Mood Disorders: Risks and Treatment

edited by

Angelo Fraschetti

and

Emanuela Mari

submission deadline 31 Dec 2025 | Viewed by 1357 | Submission Open

Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs

(This special issue belongs to the Section Mental Health)

Advances in Gastroenterology and Hepatology: Bridging Basic Science, Clinical Insights, and Translational Medicine

edited by

Abdulrahman Ismaiel

and

Ștefan Lucian Popa

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1265 | Submission Open

Keywords: hepatology; gastroenterology; IBD; IBS; MASLD; liver cirrhosis; artificial intelligence; disorders of gut– brain interaction; cancer; gut microbiota; diagnosis; management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Novel Advanced Imaging in Cardiology: Current Status and Future Directions

edited by

Moshe Rav-Acha

and

Arik Wolak

submission deadline 31 Dec 2025 | 1 articles | Viewed by 954 | Submission Open

Keywords: cardiac imaging; cardiac magnetic resonance; echocardiography; computed tomography; trans-thoracic echocardiography global longitudinal strain (GLS) analyses; radiomics

(This special issue belongs to the Section Cardiovascular Medicine)

New Trends and Challenges in Critical Care Management

edited by

Anna Wrzosek

submission deadline 31 Dec 2025 | 1 articles | Viewed by 821 | Submission Open

Keywords: critical care; intensive care; extracorporeal organ support; mechanical ventilation; personalized medicine; artificial intelligence; infections; antimicrobial resistance; COVID-19

(This special issue belongs to the Section Intensive Care)

Perioperative Management in Thoracic Surgery: Current Advances and Future Perspectives

edited by

Roberto Cascone

and

Alfonso Fiorelli

submission deadline 31 Dec 2025 | 1 articles | Viewed by 451 | Submission Open

Keywords: thoracic surgery; perioperative care; ERAS; minimally invasive surgery; interventional pulmonology; preoperative assessment; postoperative management; surgical outcomes; multidisciplinary approach; technology in surgery

(This special issue belongs to the Section Respiratory Medicine)

Oral Health and Dental Care: Current Advances and Future Options

edited by