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Special Issue "Chiari 1 Malformation, Syringomyelia and Related Disorders: Advances in Diagnosis and Treatment for Adults and Children"
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".
Deadline for manuscript submissions: 20 September 2023 | Viewed by 7028
Special Issue Editor
Interests: rare diseases; Chiari malformation; syringomyelia; clinical neurophysiology; neuropathic pain; disability
Special Issue Information
Chiari 1 Malformation (CM1) is classically defined as a caudal displacement of the cerebellar tonsils through the foramen magnum into the spinal cord, but modern imaging techniques and experimental studies disclose a different aetiology. Other disorders, such as syringomyelia, hydrocephalus, craniocervical instability can be associated at the time of the diagnosis or appear secondarily. Syringomyelia (Syr) is morphologically defined at magnetic resonance imaging (MRI) as the presence of a single or multiple fluid-filled cavities within the spinal cord and/or the bulb (Syringobulbia) and classified as a neurological rare disease (ORPHA3280). CM1 is classified as a rare disease (ORPHA268882), but epidemiology has been scarcely investigated. When CM1 is defined by cerebellar tonsil position 5 mm or more below the foramen magnum, MRI prevalence studies estimate prevalence at between 0.24 and 3.6% of the population; the discrepancy between these estimates is a result of the different age groups analysed, as the prevalence is substantially higher in children and young adults compared with older adults. Chiari can present with a wide variety of symptoms, also non-specific, with consequent controversies on diagnosis and surgical decision-making. The potential anatomy changes during maturation influence the decision to treat a younger versus an older patient with Chiari, particularly in asymptomatic o minimally symptomatic.
In this background, the aim of this Special Issue of Journal of Clinical Medicine is to attract high-quality studies covering pathogenesis, diagnosis and management of Chiari and Syringomyelia.
Contributors are encouraged to submit articles describing novel results, models, methodological innovations or reviews. We will strive to ensure that the articles of the Special Issue collectively present a cohesive picture of the state-of-the-art in the field and help to advance our understanding and management of these conditions.
The topics we wish to cover include but are not limited to:
- Epidemiology of Chiari Malformation, syringomyelia and related disorders
- Pathophysiology of Chiari: Hydrodynamics of Cerebro-Spinal Fluid flow
- Pathogenesis of Syringomyelia: lessons from observations in dogs
- The role of genetics in Chiari Malformation and Syringomyelia
- Clinical phenotypes in Chiari and in Syringomeylia
- Diagnostic investigations: old and new neurophysiological methods
- Neuroradiological definitions of Chiari Malformation, Syringomyelia and related disorders
- Advances in neuroradiological techniques in the diagnosis of Chiari Malformations and Syringomyelia
- Surgery in Chiari 1 Malformation with and without Syringomyelia
- Surgical strategies in isolated Syringomyelia
- Outcome measures in Chiari and Syringomyelia long-term follow up
Dr. Palma Ciaramitaro
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- chiari maformation
- epidemiology genetics
- cerebro-spinal fluid
- outcome measures
- clinical outcome