Next Article in Journal
Corticospinal Control of Human Locomotion as a New Determinant of Age-Related Sarcopenia: An Exploratory Study
Previous Article in Journal
Biphasic Dose-Response Induced by Phytochemicals: Experimental Evidence
Previous Article in Special Issue
Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter
Open AccessArticle

A Multimodal Eye Assessment in Psoriatic Arthritis Patients sine-Psoriasis: Evidence for a Potential Association with Systemic Inflammation

1
Rheumatology, Allergology and Clinical Immunology, Department of “Medicina dei Sistemi”, University of Rome Tor Vergata, 00133 Rome, Italy
2
Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
3
Rheumatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Short title: Ocular involvement in Psoriatic Arthritis.
Equally contributors.
§
Equally last author contributors.
J. Clin. Med. 2020, 9(3), 719; https://doi.org/10.3390/jcm9030719
Received: 6 February 2020 / Revised: 29 February 2020 / Accepted: 2 March 2020 / Published: 6 March 2020
(This article belongs to the Special Issue Application of Retinal and Optic Nerve Imaging in Clinical Medicine)
Background: Ocular involvement in Psoriatic Arthritis (PsA) patients is mainly associated with uveitis but there remains a paucity of data on dry eye and retinal abnormalities. We aimed to analyze dry eye and subclinical retinal abnormalities in a cohort of PsA patients sine-psoriasis (PsO). Methods: PsA patients sine-PsO were enrolled. Best-corrected-visual-acuity, ocular-surface-disease-index (OSDI), Schirmer test, tear film breakup-time, standard-automated-perimetry (SAP, mean deviation—MD, pattern standard deviation—PSD), fundus-perimetry (FP), and spectral-domain-optical-coherence-tomography (SD-OCT) were performed. Results: A total of 80 eyes from 40 PsA patients with moderate-severe disease activity, and 70 eyes from 35 healthy control (HC) were evaluated. Higher dry eye prevalence occurred in PsA than HC (p < 0.0001). ESR was positively related with OSDI (p < 0.001) and negatively related with Schirmer (p = 0.007). In PsA, SAP registered higher MD (p < 0.0001) and higher PSD (p = 0.005) in comparison with HC. PSD resulted positively correlated with ESR (p = 0.04) and CRP (p = 0.01), while MD showed a negative correlation with CRP (p = 0.01). Both FP mean differential sensitivity and mean defect were lower in PsA then HC (p < 0.0001). In PsA, FP differential sensitivity was directly related with cumulative steroids (p = 0.02). Conclusions: In PsA patients sine-PsO, dry eye and subclinical abnormalities in visual functions occurred being potentially related to systemic inflammation. View Full-Text
Keywords: dry eye; inflammation; microperimetry; psoriatic arthritis; retinal disease; spectral domain-optical coherence tomography; retinal imaging dry eye; inflammation; microperimetry; psoriatic arthritis; retinal disease; spectral domain-optical coherence tomography; retinal imaging
Show Figures

Figure 1

MDPI and ACS Style

Chimenti, M.S.; Triggianese, P.; Salandri, G.; Conigliaro, P.; Canofari, C.; Caso, F.; Costa, L.; Nucci, C.; Aiello, F.; Cesareo, M.; Perricone, R. A Multimodal Eye Assessment in Psoriatic Arthritis Patients sine-Psoriasis: Evidence for a Potential Association with Systemic Inflammation. J. Clin. Med. 2020, 9, 719.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop