Next Article in Journal
Characterization of Bacteria and Inducible Phages in an Intensive Care Unit
Next Article in Special Issue
Aiding the Diagnosis of Diabetic and Hypertensive Retinopathy Using Artificial Intelligence-Based Semantic Segmentation
Previous Article in Journal
The Risk for Glucose Intolerance after Gestational Diabetes Mellitus since the Introduction of the IADPSG Criteria: A Systematic Review and Meta-Analysis
Previous Article in Special Issue
Multimodal Imaging Assessment of Vascular and Neurodegenerative Retinal Alterations in Type 1 Diabetic Patients without Fundoscopic Signs of Diabetic Retinopathy
Open AccessArticle

Correlation between Choriocapillaris Density and Retinal Sensitivity in Stargardt Disease

1
Ophthalmology Clinic, University of Marche, 60126 Ancona, Italy
2
Vitreoretinal Unit, Bristol Eye Hospital, University of Bristol, Bristol BS8 1TH, UK
3
Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D’Annunzio Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy
4
Duke Eye Center, Duke University, Durham, NC 27705, USA
5
Department of Medical, Oral and Biotechnological Sciences, Laboratory of Biostatistics, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy
6
National Center for Services and Research for the Prevention of Blindness and Visual Rehabilitation of the Visually Impaired, 00100 Rome, Italy
7
Ophthalmology Department, San Raffaele University Hospital, 20132 Milan, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work and should be considered as co-first authors.
J. Clin. Med. 2019, 8(9), 1432; https://doi.org/10.3390/jcm8091432
Received: 20 August 2019 / Accepted: 27 August 2019 / Published: 10 September 2019
(This article belongs to the Special Issue Application of Retinal and Optic Nerve Imaging in Clinical Medicine)
The aim of this work was to characterize the choriocapillaris (CC) in patients with Stargardt disease (STGD) using the swept source widefield optical coherence tomography angiography (SS WF OCTA) and to compare CC perfusion density to retinal sensitivity, analyzed using microperimetry (MP). This cross-sectional study included 9 patients (18 eyes) with STGD and central CC atrophy (stage 3 STGD). The CC was analyzed using SS WF OCTA and areas of different CC impairment were quantified and correlated with retinal sensitivity analyzed using MP. The main outcome measures were the percent perfused choriocapillaris area (PPCA), retinal sensitivity, and correlation between PPCA and retinal sensitivity. Seventeen eyes of 9 patients suffering from stage 3 STGD were analyzed. SS WF OCTA revealed a vascular rarefaction in central atrophic zones and a near atrophy halo of choriocapillaris impairment. In all eyes were noticed a central atrophy (CA) area with absolute absence of CC that corresponded to 0 dB points at MP, a near atrophy (NA) zone of PPCA impairment that included points with decreased sensitivity at MP and a distant from atrophy (DA) zone with higher PPCA and retinal sensitivity values. The mean difference of PPCA and retinal sensitivity between NA and CA and DA and CA was statistical significantly different (p < 0.01), the latter showing higher values. A direct relationship between PPCA and retinal sensitivity was found (p < 0.001). Choriocapillaris damage evaluated using SS WF OCTA correlates with MP, these data suggest that CC impairment may be a predictor of retinal function in patients with STGD. View Full-Text
Keywords: retina; Stargardt disease; OCTA; choriocapillaris; microperimetry retina; Stargardt disease; OCTA; choriocapillaris; microperimetry
Show Figures

Figure 1

MDPI and ACS Style

Mastropasqua, R.; Senatore, A.; Di Antonio, L.; Di Nicola, M.; Marchioni, M.; Perna, F.; Amore, F.; Borrelli, E.; De Nicola, C.; Carpineto, P.; Toto, L. Correlation between Choriocapillaris Density and Retinal Sensitivity in Stargardt Disease. J. Clin. Med. 2019, 8, 1432.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop