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Open AccessArticle

Correlation between Choriocapillaris Density and Retinal Sensitivity in Stargardt Disease

Ophthalmology Clinic, University of Marche, 60126 Ancona, Italy
Vitreoretinal Unit, Bristol Eye Hospital, University of Bristol, Bristol BS8 1TH, UK
Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D’Annunzio Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy
Duke Eye Center, Duke University, Durham, NC 27705, USA
Department of Medical, Oral and Biotechnological Sciences, Laboratory of Biostatistics, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy
National Center for Services and Research for the Prevention of Blindness and Visual Rehabilitation of the Visually Impaired, 00100 Rome, Italy
Ophthalmology Department, San Raffaele University Hospital, 20132 Milan, Italy
Author to whom correspondence should be addressed.
These authors contributed equally to this work and should be considered as co-first authors.
J. Clin. Med. 2019, 8(9), 1432;
Received: 20 August 2019 / Accepted: 27 August 2019 / Published: 10 September 2019
(This article belongs to the Special Issue Application of Retinal and Optic Nerve Imaging in Clinical Medicine)
The aim of this work was to characterize the choriocapillaris (CC) in patients with Stargardt disease (STGD) using the swept source widefield optical coherence tomography angiography (SS WF OCTA) and to compare CC perfusion density to retinal sensitivity, analyzed using microperimetry (MP). This cross-sectional study included 9 patients (18 eyes) with STGD and central CC atrophy (stage 3 STGD). The CC was analyzed using SS WF OCTA and areas of different CC impairment were quantified and correlated with retinal sensitivity analyzed using MP. The main outcome measures were the percent perfused choriocapillaris area (PPCA), retinal sensitivity, and correlation between PPCA and retinal sensitivity. Seventeen eyes of 9 patients suffering from stage 3 STGD were analyzed. SS WF OCTA revealed a vascular rarefaction in central atrophic zones and a near atrophy halo of choriocapillaris impairment. In all eyes were noticed a central atrophy (CA) area with absolute absence of CC that corresponded to 0 dB points at MP, a near atrophy (NA) zone of PPCA impairment that included points with decreased sensitivity at MP and a distant from atrophy (DA) zone with higher PPCA and retinal sensitivity values. The mean difference of PPCA and retinal sensitivity between NA and CA and DA and CA was statistical significantly different (p < 0.01), the latter showing higher values. A direct relationship between PPCA and retinal sensitivity was found (p < 0.001). Choriocapillaris damage evaluated using SS WF OCTA correlates with MP, these data suggest that CC impairment may be a predictor of retinal function in patients with STGD. View Full-Text
Keywords: retina; Stargardt disease; OCTA; choriocapillaris; microperimetry retina; Stargardt disease; OCTA; choriocapillaris; microperimetry
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Mastropasqua, R.; Senatore, A.; Di Antonio, L.; Di Nicola, M.; Marchioni, M.; Perna, F.; Amore, F.; Borrelli, E.; De Nicola, C.; Carpineto, P.; Toto, L. Correlation between Choriocapillaris Density and Retinal Sensitivity in Stargardt Disease. J. Clin. Med. 2019, 8, 1432.

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