Next Article in Journal
Chimeric Antigen Receptor T-Cell Therapy for Colorectal Cancer
Previous Article in Journal
Genome-Wide Association Study of Opioid Cessation
Previous Article in Special Issue
Nocturnal Hypoxemia Impacts Right Ventricle Diastolic Function in Obstructive Sleep Apnea: A Retrospective Observational Study
Open AccessReview

Continuous Positive Airway Pressure Treatment in Patients with Alzheimer’s Disease: A Systematic Review

1
Department of Nursing and Physiotherapy, University of Cadiz, 11009 Cadiz, Spain
2
Department of Physiotherapy, University of Seville, 41009 Seville, Spain
3
Department of Physiotherapy, University of Malaga, 29071 Malaga, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 181; https://doi.org/10.3390/jcm9010181
Received: 8 December 2019 / Revised: 23 December 2019 / Accepted: 7 January 2020 / Published: 9 January 2020
Background: Epidemiological studies have suggested a pathophysiological relationship between obstructive sleep apnea syndrome (OSAS) and Alzheimer’s disease (AD). The aim of this study is to evaluate the treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in AD and its relationship with neurocognitive function improvement. Methods: Systematic review conducted following PRISMA’s statements. Relevant studies were searched in MEDLINE, PEDro, SCOPUS, PsycINFO, Web of Science, CINAHL and SportDicus. Original studies in which CPAP treatment was developel in AD patients have been included. Results: 5 studies, 3 RCTs (Randomized controlled trials) and 2 pilot studies. In all RCTs the CPAP intervention was six weeks; 3 weeks of therapeutic CPAP vs. 3 weeks placebo CPAP (pCPAP) followed by 3 weeks tCPAP in patients with AD and OSA. The two pilot studies conducted a follow-up in which the impact on cognitive impairment was measured. Conclusions: CPAP treatment in AD patients decreases excessive daytime sleepiness and improves sleep quality. There are indications that cognitive deterioration function measured with the Mini Mental Scale decreases or evolves to a lesser extent in Alzheimer’s patients treated with CPAP. Caregivers observe stabilization in disease progression with integration of CPAP. More research is needed on the topic presented. View Full-Text
Keywords: continuous positive airway pressure; Alzheimer disease; neurocognitive function continuous positive airway pressure; Alzheimer disease; neurocognitive function
Show Figures

Figure 1

MDPI and ACS Style

Perez-Cabezas, V.; Ruiz-Molinero, C.; Jimenez-Rejano, J.J.; Gonzalez-Medina, G.; Galan-Mercant, A.; Martin-Valero, R. Continuous Positive Airway Pressure Treatment in Patients with Alzheimer’s Disease: A Systematic Review. J. Clin. Med. 2020, 9, 181.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop