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Special Issue "Development and Function of Natural Killer Cells and their Importance in Immunotherapy"
Deadline for manuscript submissions: closed (30 September 2019).
Interests: innate immunity; NK cells; regulation of NK cell activating ligands; anti-tumor immune response; NK cells and multiple myeloma
Major efforts are aimed at developing immunotherapeutic strategies for cancer. Particular attention has been given to the therapeutic potential of natural killer (NK) cells, which are important effectors and regulators of anti-tumor immune response. They exert cytotoxicity against malignant cells, but are also an important source of chemokines and cytokines, which are highly impacting on adaptive immune responses. Increasing evidence shows the extreme heterogeneity and plasticity of NK cell populations, implying that different NK cell subsets, endowed with specific phenotypic and functional features, may be involved and play distinct roles in the tumor context. Indeed, the tumor microenvironment modulates NK cells, rendering them functionally impaired and/or altered.Various strategies have been proposed to exploit or restore NK cell anti-tumor properties, with promising results in clinical trials.
This Special Issue will focus on the relevance of NK cell activity in solid and haematological cancer. We invite authors/investigators to publish original research articles and review articles on the mechanisms impacting the function and development of these innate lymphocytes in the tumor microenvironment. A better understanding of these complex mechanisms will contribute to the development of new NK-cell-based strategies against cancer.
Potential topics include, but are not limited to the following:
- NK cell subsets in cancer
- Impact of tumor microenvironment on NK cell function and/or development
- Plasticity of NK cells in cancer
- NK-cell based immunotherapies against cancer
Dr. Cinzia Fionda
Dr. Helena Stabile
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- NK cells
- Tumor microenvironment