Gynecological Cancers: Surgical Treatment and Novel Radiotherapy

Dear Colleagues,

Recent decades have witnessed significant advancements in surgical techniques for the treatment of gynecological cancers, resulting in shorter hospital stays, less blood loss, and lower morbidity levels due to the minimally invasive approach. It is now known that the histological categories of some gynecological tumors do not accurately differentiate the clinical course and response to therapy. Currently, a molecular profile study is being carried out to improve the risk stratification and targeted therapy for endometrial cancer.

Radiotherapy has an important place in the management of gynecological tumors, either as an upfront treatment or as an adjuvant in patients treated with surgery and harboring risk factors for locoregional relapse (e.g., endometrial cancer, early-stage cervical cancer, etc.).

Surgery is the mainstay of the treatment of endometrial cancer. The major evolution in surgical strategy has occurred in lymph node staging. The standard surgical staging includes pelvic and paraaortic lymph node dissection to the level of the left renal vein. Sentinel lymph node dissection has been validated as a less morbid alternative to systematic lymphadenectomy, indicated in patients with low and intermediate risk of lymph node involvement.

In particular, in ovarian cancer treatment, testing for the BRCA and HRD status is expected to further improve the prognosis by combining molecularly targeted agents with different mechanisms of action.

This Special Issue aims to collect original research studies and review articles that add to the current knowledge and showcase the potential future approaches of novel agents for gynecologic cancers.

Dr. Gaspare Cucinella
Guest Editor

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