Oncologic Outcomes of Patients with Early-Stage Cervical Cancer after Minimally Invasive Radical Hysterectomy and Sentinel Lymph Node Biopsy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Diagnosis and Adjuvant Therapy
2.3. SNB Procedure
2.4. Radical Hysterectomy Procedure
2.5. Evaluation of Lymph Nodes
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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SNB | PLD | p Value | |
---|---|---|---|
Number of patients | 52 | 52 | |
Age *, years old | 46 (41–70) | 45 (36–51) | 0.3 |
FIGO staging | 0.03 | ||
1A2 | 8 | 3 | |
1B1 | 43 | 43 | |
2A1 | 1 | 6 | |
Pathological analysis | |||
Histological type | 0.5 | ||
Squamous cell carcinoma | 24 | 27 | |
Adenocarcinoma | 28 | 25 | |
Tumor size, mm * | 12 (7–20) | 20 (13–25) | 0.001 |
Large tumor size (>4 cm) | 0 | 1 | 0.5 |
Lymph node metastasis | 1 | 9 | 0.001 |
Parametrial invasion | 0 | 2 | 0.5 |
Deep stromal invasion | 7 | 17 | 0.02 |
Lymphovascular space invasion | 5 | 13 | 0.03 |
Positive vaginal cut end | 0 | 1 | 0.5 |
No adjuvant therapy | 45 | 28 | <0.001 |
Adjuvant RT or CCRT | 6 | 16 | |
Adjuvant chemotherapy | 1 | 12 | |
Follow-up, months * | 42 (24–60) | 82 (19–101) | <0.001 |
Recurrence | 0 | 4 | 0.04 |
3-year DFS | 100 | 91.5 | 0.04 |
3-year OS | 100 | 100 | 0.5 |
Case 1 | Case 2 | Case 3 | Case 4 | |
---|---|---|---|---|
Age, years old | 68 | 45 | 46 | 52 |
FIGO staging | 1B1 | 1B1 | 1B1 | 1B1 |
Pathological analysis | ||||
Histological type | SCC | AD | SCC | AD |
Tumor size, mm | 18 | 14 | 20 | 11 |
Large tumor size (>4 cm) | - | - | - | - |
Lymph node metastasis | - | - | - | - |
Parametrial invasion | - | - | - | - |
Deep stromal invasion | + | - | - | - |
Lymphovascular space invasion | + | - | - | - |
Positive vaginal cut end | - | - | - | - |
Adjuvant therapy | CCRT | - | - | - |
DFS, months | 9 | 6 | 8 | 10 |
OS, months | 84 | 49 | 104 | 22 |
Recurrent site | Lung | Lung | Pelvis | Vagina |
Outcome | Alive | Died | Alive | Alive |
SNB | PLD | p Value | |
---|---|---|---|
Number of patients | 44 | 30 | |
Age *, years old | 47 (42–55) | 45 (35–50) | 0.2 |
FIGO staging | 0.2 | ||
1A2 | 8 | 2 | |
1B1 | 35 | 26 | |
2A1 | 1 | 2 | |
Pathological analysis | |||
Histological type | 0.7 | ||
Squamous cell carcinoma | 20 | 15 | |
Adenocarcinoma | 24 | 15 | |
Tumor size, mm * | 10 (7–17) | 15 (10–18) | 0.08 |
Large tumor size (>4 cm) | 0 | 0 | |
Lymph node metastasis | 0 | 4 | 0.01 |
Parametrial invasion | 0 | 2 | 0.5 |
Deep stromal invasion | 4 | 7 | 0.1 |
Lymphovascular space invasion | 4 | 6 | 0.2 |
Positive vaginal cut end | 0 | 1 | 0.2 |
No adjuvant therapy | 41 | 20 | 0.02 |
Adjuvant RT or CCRT | 2 | 4 | |
Adjuvant chemotherapy | 1 | 6 | |
Follow-up, months * | 43 (24–60) | 84 (62–105) | <0.001 |
Recurrence | 0 | 4 | 0.02 |
3-year DFS | 100 | 86.4 | 0.02 |
3-year OS | 100 | 100 | 0.4 |
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Tanaka, T.; Nishie, R.; Murakami, H.; Tsuchihashi, H.; Toji, A.; Ueda, S.; Morita, N.; Hashida, S.; Terada, S.; Maruoka, H.; et al. Oncologic Outcomes of Patients with Early-Stage Cervical Cancer after Minimally Invasive Radical Hysterectomy and Sentinel Lymph Node Biopsy. J. Clin. Med. 2024, 13, 3981. https://doi.org/10.3390/jcm13133981
Tanaka T, Nishie R, Murakami H, Tsuchihashi H, Toji A, Ueda S, Morita N, Hashida S, Terada S, Maruoka H, et al. Oncologic Outcomes of Patients with Early-Stage Cervical Cancer after Minimally Invasive Radical Hysterectomy and Sentinel Lymph Node Biopsy. Journal of Clinical Medicine. 2024; 13(13):3981. https://doi.org/10.3390/jcm13133981
Chicago/Turabian StyleTanaka, Tomohito, Ruri Nishie, Hikaru Murakami, Hiromitsu Tsuchihashi, Akihiko Toji, Shoko Ueda, Natsuko Morita, Sousuke Hashida, Shinichi Terada, Hiroshi Maruoka, and et al. 2024. "Oncologic Outcomes of Patients with Early-Stage Cervical Cancer after Minimally Invasive Radical Hysterectomy and Sentinel Lymph Node Biopsy" Journal of Clinical Medicine 13, no. 13: 3981. https://doi.org/10.3390/jcm13133981
APA StyleTanaka, T., Nishie, R., Murakami, H., Tsuchihashi, H., Toji, A., Ueda, S., Morita, N., Hashida, S., Terada, S., Maruoka, H., Taniguchi, K., Komura, K., & Ohmichi, M. (2024). Oncologic Outcomes of Patients with Early-Stage Cervical Cancer after Minimally Invasive Radical Hysterectomy and Sentinel Lymph Node Biopsy. Journal of Clinical Medicine, 13(13), 3981. https://doi.org/10.3390/jcm13133981