Advances of Molecular Research in Reproductive Endocrinology

Dear Colleagues,

The increasing utilization of assisted reproductive technology (ART) has allowed many individuals and couples to achieve their dream of starting a family. Since the first birth that used ART over 40 years ago, there have been more than 8 million babies born with the assistance of ART. Recent data have demonstrated that many adult-onset diseases can be traced back to disruptions in early embryonic development or even during gametogenesis; consequently, the concept of the developmental origin of health and disease has been widely accepted. Research on the development, physiology and pathophysiology of reproduction is, therefore, of great importance. A growing body of literature supports the safety and efficacy of fertility preservation in certain patient populations. For example, live birth rates with cryopreserved oocytes in young women are comparable to those with fresh oocytes. Data on the efficacy of ovarian tissue cryopreservation are promising, although still relatively sparse. Additionally, the results of assisted reproductive techniques (ARTs) show evident limitations even in the pre-implantation genetic diagnosis for aneuploidies, prolonged embryo cultures, selection of embryos, etc. Furthermore, there are concerns regarding the obstetric, neonatal and adult health risks of the children conceived via ART. These powerful technologies, such as stem cells and artificial intelligence have led to numerous, important, exciting discoveries on the etiology and molecular mechanisms underlying various reproductive disorders.

This Special Issue is intended to provide an innovative and broad perspective on the research in the field of molecular reproductive biology and medicine, as well as reproductive and developmental biology.

We kindly encourage our colleagues that are involved in all fields of molecular reproduction to make contributions to this Special Issue. High-quality review articles, research articles and communications are all welcome. Potential topics include, but are not limited to, the following:

• Reproductive biology and immunology;
• Endometriosis,
• Thyroid dysfunction and reproductive medicine;
• Reproductive endocrinology;
• Embryo development;
• Stem cells in ART;
• Microbioma in IVF.

Dr. Giuseppe Gullo
Prof. Dr. Antonio Perino
Prof. Dr. Gaspare Cucinella
Guest Editors

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