Endometrial Cancer: From Pathobiology to Treatment

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 2736

Special Issue Editors


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Guest Editor
Department of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, University of Palermo, 90146 Palermo, Italy
Interests: laparoscopy; obstetric; infertility; gynecological malignancies; ultrasound

Special Issue Information

Dear Colleagues,

Endometrial cancer (EC) is the fifth most common cancer in women worldwide. Global estimates show rising incidence rates in both developed and developing countries. The utilization and choice of ART for patients interested in fertility preservation depends on the type and stage of cancer, the treatment plan, the time available until the cancer treatment has to start, and whether the patient has a committed partner. For patients who have a committed male partner, embryo cryopreservation has a long track record of being a very successful procedure for fertility preservation. A fertility-sparing approach for grade 1 endometrioid adenocarcinoma limited to the endometrium is feasible and can be considered in premenopausal patients with plans to conceive in the near future. Fertility-sparing treatment predominantly involves the use of oral progestins and levonorgestrel-releasing intrauterine devices, which have been shown to be feasible and safe in women with early stage EC and minimal or no myometrial invasion.

This Special Issue aims to provide an update about the current state of the art in the diagnosis management, treatment and outcomes of endometrial cancer in reproductive age regarding fertility, from basic science to translation approach.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Etiology and pathogenesis of endometrial cancer in fertile women;
  • Biomolecular and genetic prognostic factors of endometrial cancer (EC);
  • Fertility-sparing approach in EC;
  • Oocyte vitrification and fertility preservation;
  • Stem cells as therapy for EC;
  • Fertility preservation approach in women affected by endometriosis.

Dr. Giuseppe Gullo
Dr. Gaspare Cucinella
Dr. Valentina Billone
Guest Editors

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Keywords

  • endometrial cancer
  • fertility preservation
  • ovarian reserve

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Published Papers (1 paper)

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Review

17 pages, 306 KiB  
Review
Endometrial Cancer in Reproductive-Aged Females: Etiology and Pathogenesis
by Emma Bassette and Jennifer A. Ducie
Biomedicines 2024, 12(4), 886; https://doi.org/10.3390/biomedicines12040886 - 17 Apr 2024
Cited by 1 | Viewed by 1748
Abstract
Endometrial cancer is the most common gynecologic malignancy in developed countries, and the incidence is rising in premenopausal females. Type I EC is more common than Type II EC (80% vs. 20%) and is associated with a hyperestrogenic state. Estrogen unopposed by progesterone [...] Read more.
Endometrial cancer is the most common gynecologic malignancy in developed countries, and the incidence is rising in premenopausal females. Type I EC is more common than Type II EC (80% vs. 20%) and is associated with a hyperestrogenic state. Estrogen unopposed by progesterone is considered to be the main driving factor in the pathogenesis of EC. Studies show that BMI > 30 kg/m2, prolonged duration of menses, nulliparity, presence of polycystic ovarian syndrome, and Lynch syndrome are the most common causes of EC in premenopausal women. Currently, there are no guidelines established to indicate premenopausal patients who should be screened. This review aims to synthesize current data on the etiology, risk factors, presentation, evaluation, and prognosis of endometrial cancer in this population. Full article
(This article belongs to the Special Issue Endometrial Cancer: From Pathobiology to Treatment)
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