Chronic Skin Wounds – New Insights in Underlying Pathophysiological Processes, Current Treatment Strategies and Advanced Clinical Approaches

Dear Colleagues,

Chronic wounds are an ulcerative skin defect that fails to proceed through the normal skin repair response. Demographically, the incidence of chronic wounds has reached epidemic levels. On the other hand, current clinical strategies are still limited and often less effective. This highlights the urgent need for new treatment options that require a further understanding of the underlying pathophysiological processes of poor wound healing.

Skin wound healing is a multistage and tightly regulated process. The healthy skin repair response requires spatio-temporal communication between skin-resident cells, invading immune cells and its surrounding extracellular compartment. Failures within this complex communication network results in poor wound healing. Various clinical condition, including vascular diseases and diabetes, compromised immunological status, advanced age or mechanical stress and pressure effects are associated with poor wound healing. However underlying cellular and molecular mechanisms which link these conditions with failures in the various phases of the wound healing response are far from being understood.   

This Special Issue of the Journal of Clinical Medicine on chronic skin wounds is intended to present cutting-edge original research and topical reviews on concepts of chronic wound healing, on existing strategies and on emerging advanced clinical approaches for the prevention and therapy of chronic wounds. Clinical studies on current management strategies of chronic wounds but also dermatoepidemiological studies and lab-based and pre-clinical translational research that increase the knowledge on molecular pathogenesis of chronic wounds and/or may shed light on new therapeutic approaches are welcome.

Dr. Sandra Franz
Guest Editor

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