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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cell Biology and Biochemistry of Gynaecological Cancer: Pathways to Discovering Novel Treatments
edited by
submission deadline 31 Aug 2025 | Viewed by 63 | Submission Open
Keywords: gynaecological cancer; ovarian cancer; endometrial cancer; cervical cancer; cell biology; treatment; cell metastasis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Structural and Functional Properties of G-Quadruplexes and Aptamers submission deadline 31 Aug 2025 | Viewed by 63 | Submission Open
Keywords: G-quadruplex structure; aptamer; DNAzyme; catalytic G-quadruplexes
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies submission deadline 31 Aug 2025 | Viewed by 62 | Submission Open
Keywords: anxiety; depression; anxiolytics; antidepressants; animal models
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in Reproduction and Fertility of Aquatic Animals: 3rd Edition
edited by and Hongtuo Fu
submission deadline 31 Aug 2025 | Viewed by 61 | Submission Open
Keywords: reproduction; aquatic animals; sex determination; gonadal development; steroid hormones; sex-related genes; monosex culture
(This special issue belongs to the Section Molecular Biology)
Melanoma: Molecular Diagnosis and Treatment
edited by
submission deadline 31 Aug 2025 | Viewed by 61 | Submission Open
Keywords: molecular pathology; melanoma; skin cancer; molecular pathway; dermatopathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis
edited by
submission deadline 31 Aug 2025 | Viewed by 58 | Submission Open
Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions
(This special issue belongs to the Section Molecular Immunology)
Molecular Techniques to Study Food Safety Challenges
edited by and Micaela Álvarez
submission deadline 31 Aug 2025 | Viewed by 58 | Submission Open
Keywords: food safety; hazards; foodborne pathogens; advanced microbial detection technologies; omics techniques; preventive measures
(This special issue belongs to the Section Molecular Microbiology)
From Pathogenic Mechanisms to Therapy in Retinal Diseases submission deadline 31 Aug 2025 | Viewed by 55 | Submission Open
Keywords: retinal degeneration; oxidative stress; angiogenesis; mitochondria; cellular metabolism; genetic disorders and gene therapy; genes; age-related macular degeneration; inherited retinal dystrophy; diabetic retinopathy; retinal ganglion cells; photoreceptors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbial Metabolism: From Pathway Analysis to Metabolic Engineering and Synthetic Biology
edited by
submission deadline 31 Aug 2025 | Viewed by 55 | Submission Open
Keywords: bacteria; fungi; archeobacteria; metabolic pathways; biodegradation; biosynthesis; biotransformation; omic sciences; metabolic engineering; synthetic regulatory circuits
(This special issue belongs to the Section Molecular Microbiology)
New Advances in Metabolic Engineering and Synthetic Biology of Yeasts
edited by
submission deadline 31 Aug 2025 | Viewed by 54 | Submission Open
Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology
(This special issue belongs to the Section Molecular Microbiology)
Cancer Progression and Therapeutic Resistance Mechanisms
edited by
submission deadline 31 Aug 2025 | Viewed by 53 | Submission Open
Keywords: cancer drug resistance; growth factors; DNA repair; miRNAs; ABC transporters; cancer stem cells; extracellular vesicles; circulating cancer cells; circulating cancer DNA; liquid biopsies; natural anticancer compounds
(This special issue belongs to the Section Molecular Oncology)
Pharmacogenomics: The State of the Art and Future Perspectives
edited by
submission deadline 31 Aug 2025 | Viewed by 52 | Submission Open
Keywords: G-protein-coupled receptors; membrane transporters; drug-metabolizing enzyme; endocytosis receptors; companion diagnostic (CDx); data science in pharmacogenomics; precision medicine with pharmacogenomics; siRNA; microRNA; drug-induced organ injury; drug-induced adverse reactions
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Research Advances in Metabolic Syndrome submission deadline 31 Aug 2025 | Viewed by 52 | Submission Open
Keywords: metabolic syndrome; sepsis; molecular mechanisms; inflammation; insulin resistance; cardiovascular parameters; immune– metabolic crosstalk; experimental models; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications
edited by
submission deadline 31 Aug 2025 | Viewed by 52 | Submission Open
Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Genetics and Genomics of Ruminants—Second Edition
edited by
submission deadline 31 Aug 2025 | Viewed by 51 | Submission Open
Keywords: ruminant genomics; structural genomics; functional genomics; epigenomics; gene expression; genome sequencing; genome evolution; genome-wide association study; genomic selection; marker-assisted selection
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetics and Genomics of Silkworm
edited by
submission deadline 31 Aug 2025 | Viewed by 49 | Submission Open
Keywords: silkworm genome; gene identification; comparative genomics; silkworm domestication; population genetics; functional genomics; insect immunity; genetic manipulation; silkworm breeding
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development
edited by Gabriela Verónica Salamone
submission deadline 31 Aug 2025 | Viewed by 48 | Submission Open
Keywords: gliomas; tumor microenvironment; immune
(This special issue belongs to the Section Molecular Oncology)
Biological and Molecular Aspects of Exercise Adaptation
edited by
submission deadline 31 Aug 2025 | Viewed by 48 | Submission Open
Keywords: exercise; redox homeostasis; metabolic state; biological; physiological
(This special issue belongs to the Section Molecular Biology)
Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment
edited by
submission deadline 31 Aug 2025 | Viewed by 48 | Submission Open
Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion
(This special issue belongs to the Section Molecular Oncology)
Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms
edited by
submission deadline 31 Aug 2025 | Viewed by 48 | Submission Open
Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience
(This special issue belongs to the Section Molecular Plant Sciences)
New Advances in Plant Genetic Research
edited by Ming Chen
submission deadline 31 Aug 2025 | Viewed by 47 | Submission Open
Keywords: plant generative genomics; plant– microbe interaction gene-editing; single-cell omics in plants; plant non-coding RNAs; AI in plant science
(This special issue belongs to the Section Molecular Plant Sciences)
P53 and Tumours: Strategies to Overcome Chemoresistance in a p53-Dependent Way submission deadline 31 Aug 2025 | Viewed by 46 | Submission Open
Keywords: P53; chemoresistant tumours; drug design; regulatory RNAs; drugs targeting; NGS; transcriptional regulation; molecular networks
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Imprinting Technologies for Biological and Biomedical Applications submission deadline 31 Aug 2025 | Viewed by 46 | Submission Open
Keywords: molecularly imprinted polymers; biosensors and diagnostics; biomolecular recognition; molecular imprinting; nanomaterials; molecular biology applications
(This special issue belongs to the Section Molecular Informatics)
Innovative Applications of Topical Probiotics in Dermatology: Addressing Multiple Skin Disorders submission deadline 31 Aug 2025 | Viewed by 45 | Submission Open
Keywords: topical probiotics in dermatology; skin microbiome; skin disorders; therapeutic applications; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Development Biology of Immune Cells
edited by Jacek Z. Kubiak
submission deadline 31 Aug 2025 | Viewed by 45 | Submission Open
Keywords: immune cell development; macrophages; monocytes; B-cells; T-cells; dendritic cells; NK cells
(This special issue belongs to the Section Molecular Immunology)
Epigenetics and RNA Processing Involved in Disease
edited by
submission deadline 31 Aug 2025 | Viewed by 44 | Submission Open
Keywords: RNA processing; RNA splicing; epigenetics; DNA modification; histone modification; RNA modification; RNA diseases; genetic diseases
(This special issue belongs to the Section Molecular Genetics and Genomics)
Focus on the Tryptophan Pathway
edited by
submission deadline 31 Aug 2025 | Viewed by 44 | Submission Open
Keywords: aging; indole-3-propionic acid; kynurenic acid; melatonin; serotonin; tryptophan
(This special issue belongs to the Section Molecular Biology)
Advances in Photobiomodulation Therapy
edited by Maria Fernanda Setúbal Destro Rodrigues
submission deadline 31 Aug 2025 | Viewed by 43 | Submission Open
Keywords: photobiomodulation; dosimetric parameters; human diseases; modulation of inflammation; photobiomodulation therapy; molecular mechanisms; preclinical and clinical studies; therapeutic applications of PBM
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Molecular Research in Neuroimmunology
edited by Mireya Fernández-Fournier
submission deadline 31 Aug 2025 | Viewed by 43 | Submission Open
Keywords: neuroimmunology; antibodies; virus; multiple sclerosis; progression
(This special issue belongs to the Section Molecular Neurobiology)
Natural Products: Potential Anti-Inflammatory or Anti-Oxidative Mechanisms
edited by and Chi-Su Yoon
submission deadline 31 Aug 2025 | Viewed by 42 | Submission Open
Keywords: inflammation; neuroinflammation; neurodegenerative disease; skin inflammation; skin disease; antioxidants; natural products; secondary metabolites
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Regulation of Gene Expression in Cell Differentiation
edited by
submission deadline 31 Aug 2025 | Viewed by 42 | Submission Open
Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling
(This special issue belongs to the Section Molecular Genetics and Genomics)
Ovarian Pathologies: Insights into Mechanisms and Therapeutic Strategy
edited by Anna Ptak
submission deadline 31 Aug 2025 | Viewed by 40 | Submission Open
Keywords: subfertility and infertility; hormonal dysfunction; diminished ovarian reserve (DOR); ovarian cysts; polycystic ovary syndrome (PCOS); primary ovarian insufficiency (POI); ovarian cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Food Allergenicity: From Molecular Mechanisms to Innovative Mitigation Strategies submission deadline 31 Aug 2025 | Viewed by 40 | Submission Open
Keywords: food allergenicity; food allergen detection; biosensors; mass spectrometry; immunoassays; allergen reduction; hypoallergenic food alternatives; personalized nutrition approaches
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research of Cardiovascular Disease
edited by
submission deadline 31 Aug 2025 | Viewed by 39 | Submission Open
Keywords: myocardium; metabolism; ischemia; function; integrity; cardiovascular; disease; infarction; failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Immunotherapy in Cancer
edited by Magdalena Król
submission deadline 31 Aug 2025 | Viewed by 38 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; monoclonal antibodies; cytokine signaling; tumor immune evasion; metabolic regulation in cancer; cell-based therapies
(This special issue belongs to the Section Molecular Immunology)
Advances in Amyloid Aggregation and Its Inhibition: Implementing Insights from Physiological Conditions submission deadline 31 Aug 2025 | Viewed by 36 | Submission Open
Keywords: protein aggregation; amyloid; physiological conditions; aggregation inhibition; neurodegenerative diseases; amyloidosis
(This special issue belongs to the Section Molecular Neurobiology)
New Insights into the Molecular Pathogenesis of Myeloproliferative Neoplasms submission deadline 31 Aug 2025 | Viewed by 35 | Submission Open
Keywords: myeloproliferative neoplasms; molecular diagnostic; targeted therapy; biomarkers; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Multifunctional Antioxidants and Enzyme Inhibitors: Design, Synthesis and Mechanisms of Actions
edited by Choon Young Lee
submission deadline 31 Aug 2025 | Viewed by 34 | Submission Open
Keywords: antioxidant synthesis; multifunctional antioxidants; oxidant-generating enzyme inhibitors; activators of antioxidant-generating enzymes; phenolic antioxidant; thiol-based antioxidant; nitrogen-based antioxidants; anti-inflammatory; oxidative stress; free radical scavenging; reactive oxygen species; reactive nitrogen species; mechanisms of action; metal chelator
(This special issue belongs to the Section Macromolecules)
Molecular and Cellular Neurobiology of Headache and Migraine
edited by
submission deadline 31 Aug 2025 | Viewed by 33 | Submission Open
Keywords: headache; migraine; calcitonin gene-related peptide (CGRP); spreading depolarization/depression; TRP channels; pituitary adenylate cyclase-activating polypeptide; PACAP; cluster headache
(This special issue belongs to the Section Molecular Neurobiology)
Recent Research in Nanoelectrochemistry
edited by
submission deadline 31 Aug 2025 | Viewed by 31 | Submission Open
Keywords: nanoelectrochemistry; single-entity electrochemistry; nanoscale imaging; molecular electronics devices; nanostructured electrodes; electrochemical sensors; energy storage; catalysis; biomedical applications
(This special issue belongs to the Section Materials Science)
Molecular Insights into Heart Failure: From Bench to Bedside
edited by
submission deadline 31 Aug 2025 | Viewed by 29 | Submission Open
Keywords: heart failure; cardiac biomarkers; medical therapy; molecular pathways; prognosis; target therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research
edited by Paola Muggeo
submission deadline 31 Aug 2025 | Viewed by 27 | Submission Open
Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies
(This special issue belongs to the Section Molecular Oncology)
Plant–Rhizobium Interaction
edited by Rujin Chen
submission deadline 31 Aug 2025 | Viewed by 22 | Submission Open
Keywords: legume; rhizobia; symbiotic nitrogen fixation
(This special issue belongs to the Section Molecular Plant Sciences)
Computational, Structural and Spectroscopic Studies of Macromolecules
edited by Sanja Dolanski Babić
submission deadline 10 Sep 2025 | 2 articles | Viewed by 3201 | Submission Open
Keywords: macromolecules; structure DNA; effects on DNA; protein; carbohydrate; lipids; spectroscopic methods; FTIR; NMR; UV; CD; numerical methods
(This special issue belongs to the Section Macromolecules)
Preimplantation Genetic Testing in Assisted Reproductive Technologies
edited by
submission deadline 10 Sep 2025 | Viewed by 75 | Submission Open
Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology
(This special issue belongs to the Section Molecular Genetics and Genomics)
Current Advances in the Pathophysiology and Treatment of Multiple Sclerosis and Related Disorders
edited by Natalia Szejko and
submission deadline 10 Sep 2025 | Viewed by 52 | Submission Open
Keywords: multiple sclerosis; MS; central nervous system; pathophysiology; immunological system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant-Microbe Interaction Studies
edited by
submission deadline 10 Sep 2025 | Viewed by 41 | Submission Open
Keywords: plant-pathogen; plant microorganisms; microbial stress; plant diseases and pests; plant protection
(This special issue belongs to the Section Molecular Microbiology)
Advances in Molecular Research of Facial Adipose Compartments
edited by Marius Valeriu Hînganu
submission deadline 15 Sep 2025 | Viewed by 350 | Submission Open
Keywords: facial fat; facial adipose tissue; molecular markers of facial fat; hormonal environmental; metabolic disorders; facial deformities; single-cell RNA sequencing; CRISPR-Cas9 gene editing
(This special issue belongs to the Section Molecular Biology)
Regulatory Mechanism and Network of Abiotic Stress-Response in Plants 2.0
edited by
submission deadline 20 Sep 2025 | 17 articles | Viewed by 27955 | Submission Open
Keywords: abiotic stress response; osmotic stress; temperature stress; transcriptional regulation; post-transcriptional regulation; regulatory mechanism; gene regulatory network
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights in Tumor Immunity
edited by
submission deadline 20 Sep 2025 | 9 articles | Viewed by 26780 | Submission Open
Keywords: tumor immunity; tumor evolution; tumor antigens; immune surveillance; cancer immunoediting; tumor microenvironment; immunotherapies; immune checkpoints; tumor-specific lymphocytes
(This special issue belongs to the Section Molecular Immunology)
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