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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research on the Adrenal Gland and Hormones

edited by Marcin Ruciński

submission deadline 20 Aug 2025 | 3 articles | Viewed by 5125 | Submission Open

Keywords: bioactive peptides; adrenal gland; adrenocortical carcinoma; HPA axis; G protein-coupled receptor; hormones; steroidogenesis

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Hormones and Nutrients in Health and Disease

edited by

Maria Scuto

submission deadline 20 Aug 2025 | 2 articles | Viewed by 5013 | Submission Open

Keywords: sensory nutrients; steroid hormones; oxidative stress; inflammation; Nrf2 pathway; neurodegenerative disorders; psychiatric diseases; personalized nutritional therapy; organoid technology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Innovative Strategies to Target Metabolism, Inflammation, and Oxidative Stress in Human Diseases

edited by

Kota V. Ramana

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4936 | Submission Open

Keywords: metabolism; inflammation; oxidative stress; diabetes; aging; cardiovascular diseases; gene editing; stem cell therapy; next-generation sequencing; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of MicroRNAs in Cancer Development and Treatment, 2nd Edition

edited by

Nikolay Mehterov

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4894 | Submission Open

Keywords: microRNAs (miRNAs); transcriptomics; functional studies; cancer pathobiology; solid tumors; hematological malignancies; molecular biomarkers; therapeutic targets; apoptosis; anticancer drugs radiotherapy; chemotharapy failure

(This special issue belongs to the Section Molecular Oncology)

Modern Plant Cell Biotechnology: From Genes to Structure, 2nd Edition

edited by

Ewa Kurczyńska

and

Alexander Betekhtin

submission deadline 20 Aug 2025 | 4 articles | Viewed by 4778 | Submission Open

Keywords: genetic engineering techniques; gene modification; gene editing; regulation of gene expression; plant cell biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

New Horizons in Silicon Chemistry

edited by Mitsuo Kira

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4758 | Submission Open

Keywords: synthesis; bonding and structures; reaction mechanism; physical properties; application; germanium; tin

(This special issue belongs to the Section Macromolecules)

New Insights in Translational Bioinformatics: Second Edition

edited by

Camelia Quek

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4721 | Submission Open

Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology

(This special issue belongs to the Section Molecular Informatics)

Molecular Insight into Oral Diseases

edited by Lorenzo Azzi

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4563 | Submission Open

Keywords: dental caries; periodontal disease; oral cancer; oral potentially malignant disorders; salivary gland disease; oral lichen planus; benign mucous membrane pemphigoid; bullous dermatoses; odontogenic cysts; odontogenic tumors; orofacial pain; human papillomavirus; oral diagnosis; oral pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Characterization and Application of Enzymes in Bioprocesses

edited by Loredana Marcolongo

submission deadline 20 Aug 2025 | 4 articles | Viewed by 4559 | Submission Open

Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing

(This special issue belongs to the Section Biochemistry)

Machine Learning and Bioinformatics in Human Health and Disease: 2nd Edition

edited by

Andreas Leiherer

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4530 | Submission Open

Keywords: machine learning; bioinformatics; deep learning; multi-omics approaches; genetic risk factors; drug interactions; precision medicine; neurodegenerative diseases; disease diagnosis; epidemic prediction

(This special issue belongs to the Section Molecular Informatics)

Breakthroughs in Diagnostic Prediction and Fundamental Therapeutics of Dementia and Movement Disorders, 2nd Edition

edited by

Yasemin M. Akay

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4522 | Submission Open

Keywords: Parkinson's disease; dementia with Lewy bodies; Alzheimer's disease; pathogenic protein; biomarker; therapeutic target; drug

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Novel Anti-Alzheimer Drugs: Biological Target, Medicinal Chemistry and Formulation

edited by

Marc Since

and Aurélie Malzert-Fréon

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4475 | Submission Open

Keywords: Alzheimer’ s disease; drug design; amyloid peptide; biological targets; medicinal chemistry; formulation

(This special issue belongs to the Section Molecular Pharmacology)

Using Model Organisms to Study Complex Human Diseases

edited by

Roberto Piergentili

submission deadline 20 Aug 2025 | 4 articles | Viewed by 4460 | Submission Open

Keywords: model organism; Escherichia coli; yeast; Caenorhabditis elegans; Drosophila melanogaster; zebrafish; Arabidopsis thaliana; Xenopus laevis; rat and mouse model; human disease; inherited disease; cancer; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Ligament/Tendon and Cartilage Tissue Engineering and Reconstruction

edited by

Gundula Schulze-Tanzil

submission deadline 20 Aug 2025 | 4 articles | Viewed by 4433 | Submission Open

Keywords: cartilage; tendon; ligament; anterior cruciate ligament; bioprinting; scaffold; bioreactor; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Ocular Ischemic Diseases: From Molecular Mechanisms to Therapeutics

edited by

Deokho Lee

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4400 | Submission Open

Keywords: diabetic retinopathy; retinopathy of prematurity; retinal vein occlusion; retinal artery occlusion; pathologic myopia; age-related macular degeneration; glaucoma; ocular ischemic syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Therapeutic Targets in Acute Settings: Ischemic and Traumatic Brain Injuries

edited by Hylde Zirpoli

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4393 | Submission Open

Keywords: ischemic brain injury; traumatic brain insult; cell-type specific molecular mechanisms; therapy; target discovery; repurposing; efficacy studies; new drug formulations; high-throughput technologies; proteomics; metabolomics; microarray; next-generation sequencing; BBB disruption; gliosis; neuronal loss; neurobehavior; age-related molecular mechanisms in brain injury

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Photosynthesis: Mechanisms of Protein Complex Functioning, Protein Structural Modifications and Protein-Protein Interactions

edited by Ilya B. Kovalenko

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4382 | Submission Open

Keywords: photosynthesis; electron transport; molecular dynamics; proteins; protein-protein interaction; conformational changes; reaction center; mobile electron carrier

(This special issue belongs to the Section Biochemistry)

Induced Pluripotent Stem and Extracellular Vesicles in Biomedicine

edited by

Ylenia Della Rocca

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Aug 2025 | 1 articles | Viewed by 4364 | Submission Open

Keywords: induced pluripotent stem; embryonic stem cells; extracellular vesicles; tissue development; translational medicine

(This special issue belongs to the Section Molecular Biology)

Antioxidants as Regulators of Metabolic Pathways: Potential and Therapeutic Strategies

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4287 | Submission Open

Keywords: antioxidants; metabolic pathways; oxidative stress; cellular homeostasis; redox signaling; energy metabolism; lipid metabolism; therapeutic strategies; chronic diseases

(This special issue belongs to the Section Molecular Biology)

New Molecular Aspects of Colorectal Cancer

edited by

Christos K. Kontos

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4286 | Submission Open

Keywords: colorectal adenocarcinoma; cancer pathobiology; molecular biomarkers; diagnosis and prognosis; prediction of therapy selection; therapeutic targets; RNA molecules; microRNA; long non-coding RNA; circular RNA

(This special issue belongs to the Section Molecular Oncology)

Animal Gut Microbial Metagenome

edited by

Shengguo Zhao

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4272 | Submission Open

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research in Gynecological Diseases—2nd Edition

edited by

David B. Alexander

submission deadline 20 Aug 2025 | 4 articles | Viewed by 4188 | Submission Open

Keywords: malignant gynecological diseases; screening for gynecological cancers; benign gynecological conditions; screening for benign gynecological diseases; endometriosis; polycystic ovaries syndrome; ovarian cysts; uterine fibroids; leiomyomas; adenomyosis; pelvic inflammatory disease; vaginitis; vaginal dysbiosis; treatment targets for gynecological diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria: Transport of Metabolites Across Biological Membranes

edited by

Graziantonio Lauria

and

Rosita Curcio

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4079 | Submission Open

Keywords: mitochondria; mitochondrial transporters; mitochondrial metabolism; transport proteins; translocases carriers; mitochondrial carriers; mitochondrial diseases; mitochondrial permeability; apoptosis

(This special issue belongs to the Section Molecular Biology)

Protein–RNA Interactions: Function, Mechanism, and Identification

edited by

Alessio Colantoni

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4061 | Submission Open

Keywords: RNA-binding protein (RBP); protein– RNA interaction; RNA structure; RNA processing; RNA stability; RNA modification; translation; gene regulatory network

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Tea Tree Metabolism and Genetics

edited by Xiaoling Sun

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4024 | Submission Open

Keywords: tea tree; secondary metabolite; genetic transformation; genetic breeding; tea germplasm improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Products: New Insights into Overcoming Oxidative Stress in Pathological Diseases

edited by

Maria G. Bottone

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3928 | Submission Open

Keywords: natural products; nutraceuticals; oxidative stress; antioxidants; ROS; redox signaling; oxidative stress; pathological diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Therapy Using Human Mesenchymal Stem Cells (MSCs) and MSC Extracellular Vesicles

edited by Tong Ming Liu and Xiaoman Luo

submission deadline 20 Aug 2025 | 1 articles | Viewed by 3913 | Submission Open

Keywords: mesenchymal stem cells; extracellular vesicles; MSCs; MSC-EVs; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Ion Channels in Eye Development, Health, and Disease

edited by Thirumalini Vaithianathan and

T. J. Hollingsworth

submission deadline 20 Aug 2025 | 1 articles | Viewed by 3876 | Submission Open

Keywords: eye development; eye health and disease; ion channels; channelopathies; physiology; computational technology; molecular modeling; molecular biology tools; pharmacology; systems genetics

(This special issue belongs to the Section Molecular Biology)

Functional Analysis and Therapeutic Targets of Long Non-Coding RNAs

edited by Hidenori Tani

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3850 | Submission Open

Keywords: lncRNAs; gene expression; cellular processes; disease dysregulation; therapeutic targets; functional analysis; lncRNA therapeutics; lncRNA modulation; stability; localization

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mitochondrial Respiration and Energy Metabolism in Cancer Cells

edited by

Rasa Banienė

submission deadline 20 Aug 2025 | 3 articles | Viewed by 3848 | Submission Open

Keywords: mitochondria; respiration; cancer; ATP synthesis; mtDNA; oxidative stress; glycolysis; cell death

(This special issue belongs to the Section Molecular Oncology)

New Trends in Biologically Active Compounds in Age-Related Diseases

edited by Celia Andrés Juan

submission deadline 20 Aug 2025 | 1 articles | Viewed by 3701 | Submission Open

Keywords: age-related diseases; oxidative stress and inflammation; energy failure; mitochondrial dysfunction; deregulated autophagy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Research of Phytochemicals in Health and Disease

edited by Sachiko Koyama,

Thomas Heinbockel

and

Vonnie Shields

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3664 | Submission Open

Keywords: phytochemicals with bioactive properties; health; brain function; regeneration; wound healing; treatment; and prevention of diseases; delivery routes and delivery methods; formulation of phytochemicals to overcome their hydrophobic nature and enhance their stability; drugs; supplements to drugs; and supplements for health maintenance; nourishment and phytochemicals; drug side effects; COVID-19

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Tea Tree Genetics and Breeding: 2nd Edition

edited by

Mingzhe Yao

and

Kang Wei

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3651 | Submission Open

Keywords: tea plant (Camellia sinensis); molecular mechanism; secondary metabolites; stress response; quality-related component; genes identification; QTL mapping; molecular functional markers

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Scale Design, Synthesis, and Application of Macroporous, Mesoporous, and Microporous Materials

edited by

María Teresa Colomer

submission deadline 20 Aug 2025 | 3 articles | Viewed by 3648 | Submission Open

Keywords: macro-; meso- and microporous; porous materials; molecular design; adsorption; porous organic frameworks

(This special issue belongs to the Section Materials Science)

Bone Tissue Engineering: Opportunities and Challenges

edited by

Elisa Mazzoni

and

Maria Rosa Iaquinta

submission deadline 20 Aug 2025 | 4 articles | Viewed by 3617 | Submission Open

Keywords: material; biocompatibility; scaffold; regeneration; bone; osteoinductivity; tissue; stem cells; microenvironment processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Diagnosis to Treatment of Haematological Neoplasms

edited by

Magda Zanelli

Francesca Sanguedolce

and

Stefano Ascani

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3545 | Submission Open

Keywords: haematological neoplasms; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Bioactive Polymer-Based Materials Dedicated to Wound Healing

edited by

Sylwia Grabska-Zielińska

and

Marcin Wekwejt

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3519 | Submission Open

Keywords: wound healing; polymer; bioactive materials; tissue engineering; biomaterials; thin films; scaffolds; hydrogels

(This special issue belongs to the Section Materials Science)

Molecular Therapeutic Strategies in Allergic Diseases

edited by

Sylwia Smolińska

submission deadline 20 Aug 2025 | 3 articles | Viewed by 3429 | Submission Open

Keywords: molecular allergy diagnostics; allergen identification; allergen neutralization/elimination strategies; allergen immunotherapy; impact of pollution on allergies; new allergens; cross-reactivity; unexpected allergen sources

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Bioactive Molecules

edited by

Helena P. Felgueiras

submission deadline 20 Aug 2025 | 3 articles | Viewed by 3412 | Submission Open

Keywords: antimicrobial profile; drug discovery; tissue regeneration; analytical techniques; chemical synthesis; high-throughput screening; therapeutic development; surface functionalization; biomaterial integration; bio-based

(This special issue belongs to the Section Molecular Biology)

Stem Cells in Human Health and Diseases

edited by Dana Yehudai-Ofir

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3400 | Submission Open

Keywords: stem cells; stem cell biology; stem-cell-based therapy; stem cell regulation; cancer stem cell; tumor-initiating cell

(This special issue belongs to the Section Molecular Immunology)

Male Genitourinary Tumors: Molecular and Cellular Mechanism

edited by

Ria Winkelmann

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3389 | Submission Open

Keywords: penile carcinoma; tumor biology; immune modulator; HPV TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Engineering in Dental Restorative and Regenerative Materials

edited by

Danijela Marović

submission deadline 20 Aug 2025 | 5 articles | Viewed by 3378 | Submission Open

Keywords: dental composites; ceramics; additive manufacturing; dental adhesives; bioactive; 3D printing; photopolymerization; curing devices; microstructure; degree of conversion; bulk-fill composites; lasers in dentistry; infrared spectroscopy; biocompatibility; bone regeneration; osseointegration; soft tissue regeneration

(This special issue belongs to the Section Materials Science)

Molecular Research Progress of Cereal Crop Disease Resistance

edited by

Hongjie Li

and Zhenqi Su

submission deadline 20 Aug 2025 | 3 articles | Viewed by 3344 | Submission Open

Keywords: cereal crops; disease resistance; resistance genes; breeding; molecular marker-assisted selection; molecular regulatory network

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Liposome-Based Drug Delivery Systems

edited by

Shao-Ling Huang

submission deadline 20 Aug 2025 | 3 articles | Viewed by 3267 | Submission Open

Keywords: liposomes; targeted delivery; controlled release; nanotechnology; drug delivery; diagnostics; therapeutics; multifunctional liposomes; phospholipids

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Pathophysiology and Treatment of Diabetic Retinopathy

edited by Federico Gonzalez-Fernandez and

Andrew Tsin

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3255 | Submission Open

Keywords: diabetic retinopathy; age-related macular degenerations; retinal; vascular endothelial growth factor; visual system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Pathogenesis, Molecular Mechanisms, and Therapeutic Strategies for Neurodegenerative Diseases

edited by

Abdullah Sheikh

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3227 | Submission Open

Keywords: neurodegeneration; molecular pathways; protein aggregation; gene therapy; neuroprotection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research on Cancer Treatments: Apoptosis, Autophagy, and Drug Selection

edited by

Md Ataur Rahman

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3205 | Submission Open

Keywords: autophagy; apoptosis; bioactive natural products; nanoparticles and drug delivery; cancer immunotherapy; in silico and network pharmacology; bioinformatics

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapies of Brain Tumors

edited by Oana Alexandru

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3190 | Submission Open

Keywords: brain tumors; molecular mechanisms; signal transduction; cell proliferation; apoptosis; targeted therapies; chemotherapy; radiotherapy

(This special issue belongs to the Section Molecular Oncology)

Functional Genomics in Translational Medicine

edited by

Cornelia Braicu

, Oana Zanoaga and

Ștefan Strilciuc

submission deadline 20 Aug 2025 | 2 articles | Viewed by 3186 | Submission Open

Keywords: functional genomics; omics approaches; drug response/resistance; therapeutic targets; genomics and transcriptomic alteration; bioinformatic analysis; data integration; human disease; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Regulation and Application of Bioactive Metabolites in Plants

edited by