Role of MicroRNAs in Cancer Development and Treatment 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 May 2024 | Viewed by 1254
Special Issue Editor
Interests: identification of cancer-related miRNAs and their targets; role of ncRNA in molecular oncology; personalized medicine; non-coding RNAs; transcriptomics; cancer pathobiology; head and neck cancer; colorectal cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
MicroRNAs (miRNAs) represent a prominent part of the non-coding landscape of the human genome. Their role is performed on the post-transcriptional level, and is accomplished by base pairing with the 3′-UTR of target messenger RNAs (mRNAs). As a consequence, mRNA degradation or translational inhibition occurs, which finally leads to the absence of a protein product. Being part of the human non-coding transcriptome, miRNAs reside in regions that frequently undergo alterations in malignancies. As a consequence, the specific deregulation of miRNAs that control genes involved in the cell cycle, senescence, and apoptosis is observed in all human cancers. Therefore, the specific expression profile of miRNA in different cancers, together with their stability and easy detection, provides excellent biomarker properties of miRNAs that can be used for diagnoses and staging, and may have wide clinical applications.
This Special Issue focuses on information regarding the potential of miRNAs to regulate protein-coding gene expression at the post-transcriptional level in cancer development and treatment. Authors are encouraged to submit their original research studies concerning this topic. Review articles will also be taken into consideration. We hope that this Special Issue, regarding the identity, biological role, and/or clinical utility of miRNAs, will arouse the interest of the readers of this journal.
Dr. Nikolay Mehterov
Guest Editor
Manuscript Submission Information
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Keywords
- microRNAs (miRNAs)
- transcriptomics
- functional studies
- cancer pathobiology
- solid tumors
- hematological malignancies
- molecular biomarkers
- therapeutic targets
- apoptosis
- anticancer drugs radiotherapy
- chemotharapy failure
