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Bioactive Polymer-Based Materials Dedicated to Wound Healing

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 3440

Special Issue Editors


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Guest Editor
Faculty of Chemical Technology and Engineering, Bydgoszcz University of Science and Technology, Seminaryjna 3, 85-326 Bydgoszcz, Poland
Interests: natural polymers; biodegradable polymers; thin films; three dimensional scaffolds; polymers crosslinking; food packaging materials; tissue engineering; biomaterials properties; biopolymers; chitosan; collagen; PLA; silk fibroin
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E-Mail Website
Guest Editor
1. Department of Biomaterials Technology, Faculty of Mechanical Engineering and Ship Technology, Gdańsk University of Technology, Gdańsk, Poland
2. Laboratory for Biomaterials and Bioengineering (CRC-Tier I), Department of Min-Met-Materials Eng & Regenerative Medicine, CHU de Québec, Laval University, Québec City, QC, Canada
Interests: biomaterials; bioactivity; biofunctionality; bone cement; dual-setting materials; magnesium phosphate; natural hydrogels; biocomposite; antibacterial properties
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to a Special Issue concerning “Bioactive Polymer-Based Materials Dedicated to Wound Healing”.

Bioactive polymer-based materials have become a fundamental component in the realm of tissue engineering, capturing widespread attention due to their multifaceted benefits. These materials can be tailored to develop surface characteristics that significantly improve the attachment and growth of essential cells involved in healing wounds. Furthermore, they can incorporate bioactive additives into their structure, which serve as conduits for the delivery of therapeutic substances such as growth factors, antimicrobials, and anti-inflammatory medications. Particularly, certain polymers play a pivotal role in establishing and preserving a moist environment at the wound site, a critical condition that accelerates the healing process by encouraging cell movement, the formation of new blood vessels, and the development of new tissue while simultaneously diminishing scar formation and alleviating pain. In addition to these therapeutic benefits, polymer-based dressings provide vital mechanical support, protecting the wound from additional damage and aiding in the regeneration of tissue. Moreover, these materials are celebrated for their biocompatibility, reducing the chances of unwanted reactions, lowering infection risks, and being easy to apply and remove, which enhances patient comfort and treatment efficacy. Finally, these bioactive dressings can be used to treat clinical problems such as ulcers, deep burns, and cancers or to support the regeneration of hard-to-heal wounds, e.g., in diabetes.

In this Special Issue, we delve into the innovative domain of bioactive polymer-based materials, spotlighting their evolving trends and pivotal role in wound healing applications. It is crucial to explore diverse methodologies to enhance the attributes of these materials, thereby optimizing their therapeutic potential. The scope of research topics includes, but is not limited to, the following areas:

  • Preparation and characterization of bioactive polymer-based materials;
  • Biodegradable polymer materials for biomedical applications;
  • Fabrication of 2D and 3D polymeric or polymer-based materials;
  • Physicochemical properties of biopolymers enhanced with bioactive additives;
  • Biological studies (in vitro and in vivo) of wound dressing;
  • Microbiological activity studies of materials characterized by antimicrobial properties;
  • Studies of wound healing in vivo,
  • Environmental impact and sustainability of bioactive polymers.

It is our pleasure to invite you to submit a manuscript for this Special Issue. Full research papers, communications, and reviews are all warmly welcome.

We look forward to receiving your contributions.

Dr. Sylwia Grabska-Zielińska
Dr. Marcin Wekwejt
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • wound healing
  • polymer
  • bioactive materials
  • tissue engineering
  • biomaterials
  • thin films
  • scaffolds
  • hydrogels

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Published Papers (2 papers)

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Research

17 pages, 8402 KiB  
Article
Two Novel Membranes Based on Collagen and Polyphenols for Enhanced Wound Healing
by Victoria S. Shubina, Margarita I. Kobyakova, Nikita V. Penkov, Gennady V. Mitenko, Sergey N. Udaltsov and Yuri V. Shatalin
Int. J. Mol. Sci. 2024, 25(22), 12353; https://doi.org/10.3390/ijms252212353 - 18 Nov 2024
Cited by 2 | Viewed by 1222
Abstract
Two novel membranes based on collagen and two polyphenols, taxifolin pentaglutarate (TfG5) and a conjugate of taxifolin with glyoxylic acid (DfTf), were prepared. Fourier transform infrared spectroscopy examination confirmed the preservation of the triple helical structure of collagen. A scanning electron microscopy study [...] Read more.
Two novel membranes based on collagen and two polyphenols, taxifolin pentaglutarate (TfG5) and a conjugate of taxifolin with glyoxylic acid (DfTf), were prepared. Fourier transform infrared spectroscopy examination confirmed the preservation of the triple helical structure of collagen. A scanning electron microscopy study showed that both materials had a porous structure. The incorporation of DfTf into the freeze-dried collagen matrix increased the aggregation of collagen fibers to a higher extent than the incorporation of TfG5, resulting in a more compact structure of the material containing DfTf. It was found that NIH/3T3 mouse fibroblasts were attached to, and relatively evenly spread out on, the surface of both newly obtained membranes. In addition, it was shown that the membranes enhanced skin wound healing in rats with a chemical burn induced by acetic acid. The treatment with the materials led to a faster reepithelization and granulation tissue formation compared with the use of other agents (collagen without polyphenols and buffer saline). It was also found that, in the wound tissue, the level of thiobarbituric acid reactive substances (TBARS) was significantly higher and the level of low-molecular-weight SH-containing compounds (RSH) was significantly lower than those in healthy skin, indicating a rise in oxidative stress at the site of injury. The treatment with collagen membranes containing polyphenols significantly decreased the TBARS level and increased the RSH level, suggesting the antioxidant/anti-inflammatory effect of the materials. The membrane containing TfG5 was more effective than other ones (the collagen membrane containing DfTf and collagen without polyphenols). On the whole, the data obtained indicate that collagen materials containing DfTf and TfG5 have potential as powerful therapeutic agents for the treatment of burn wounds. Full article
(This article belongs to the Special Issue Bioactive Polymer-Based Materials Dedicated to Wound Healing)
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18 pages, 11831 KiB  
Article
The Combination of Chitosan-Based Biomaterial and Cellular Therapy for Successful Treatment of Diabetic Foot—Pilot Study
by Filip Humenik, Katarína Vdoviaková, Lenka Krešáková, Ján Danko, Mária Giretová, Ľubomír Medvecký, Peter Lengyel and Ján Babík
Int. J. Mol. Sci. 2024, 25(15), 8388; https://doi.org/10.3390/ijms25158388 - 1 Aug 2024
Cited by 1 | Viewed by 1613
Abstract
Diabetic foot ulceration is one of the most common complications in patients treated for diabetes mellitus. The presented pilot study describes the successful treatment of diabetic ulceration of the heel with ongoing osteomyelitis in a 39-year-old patient after using a combination of modified [...] Read more.
Diabetic foot ulceration is one of the most common complications in patients treated for diabetes mellitus. The presented pilot study describes the successful treatment of diabetic ulceration of the heel with ongoing osteomyelitis in a 39-year-old patient after using a combination of modified chitosan-based biomaterial in combination with autologous mesenchymal stem cells isolated from bone marrow and dermal fibroblasts. The isolated population of bone marrow mesenchymal stem cells fulfilled all of the attributes given by the International Society for Stem Cell Research, such as fibroblast-like morphology, the high expression of positive surface markers (CD29: 99.1 ± 0.4%; CD44: 99.8 ± 0.2% and CD90: 98.0 ± 0.6%) and the ability to undergo multilineage differentiation. Likewise, the population of dermal fibroblasts showed high positivity for the widely accepted markers collagen I, collagen III and vimentin, which was confirmed by immunocytochemical staining. Moreover, we were able to describe newly formed blood vessels shown by angio CT and almost complete closure of the skin defect after 8 months of the treatment. Full article
(This article belongs to the Special Issue Bioactive Polymer-Based Materials Dedicated to Wound Healing)
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