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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Nanoparticles-Based Drug Delivery in Cancer Therapy

edited by

André F. Moreira

submission deadline 30 Jun 2025 | Viewed by 206 | Submission Open

Keywords: nanoparticle-based drug delivery; stimuli responsive; cancer targeting; theragnostic nanoparticles; protein corona; combinatorial drug therapies; tumor penetration; cancer cells uptake

(This special issue belongs to the Section Molecular Nanoscience)

Structure, Function and Dynamics in Proteins: 3rd Edition

edited by

Luigi Russo

submission deadline 30 Jun 2025 | Viewed by 201 | Submission Open

Keywords: protein structure and dynamics; protein– protein and protein– DNA interactions; protein folding and misfolding; protein aggregation processes; intermediate/misfolded states; conformational equilibria; DNA and ligand recognition mechanisms; membrane receptors; enzyme dynamics; metal-binding proteins; intrinsically disordered proteins; cell signaling; phase separation mechanims; solution- and solid-state NMR; molecular dynamics simulations; time-resolved X-ray; NMR relaxation; in-/on-cell NMR; cryo-EM; fluorescence polarization; surface plasmon resonance; static and dynamic light scattering; isothermal titration calorimetry; microscale thermophoresis; protein– fragment complementation assay; cross-linking; protein microarray

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into Skeletal Muscle Atrophy and Regeneration, 2nd Edition

edited by

Elena Nebot

Teresa Priego Cuadra

and

Ana Isabel Martín Velasco

submission deadline 30 Jun 2025 | Viewed by 192 | Submission Open

Keywords: muscle atrophy; muscle regeneration; sarcopenia; cachexia; satellite cells; autophagy; proteolytic system; growth factors; myokines; physical exercise; nutrition; bone metabolism

(This special issue belongs to the Section Molecular Biology)

Innovative Research on Nutrition and Epigenetics in Cancer

edited by Marisabel Mecca

submission deadline 30 Jun 2025 | Viewed by 190 | Submission Open

Keywords: diet; nutrition; epigenetics; cancer; cancer therapy; lifestyle

(This special issue belongs to the Section Molecular Oncology)

Microbiome and Bioactive Compounds: Insights into Health, Disease, and Therapeutic Potential

edited by Eui-Jeong Han and

Hea-jong Chung

submission deadline 30 Jun 2025 | Viewed by 184 | Submission Open

Keywords: gut microbiome; bioactive compounds; multi-omics approaches; probiotics

(This special issue belongs to the Section Molecular Microbiology)

New Optical, Electrical, and Thermal Materials: Recent Advances and Challenges

edited by Luyi Zou

submission deadline 30 Jun 2025 | Viewed by 183 | Submission Open

Keywords: optical materials; electrical materials; thermal materials; molecular structure; molecular composition; structural performance

(This special issue belongs to the Section Materials Science)

New Advances in Cancer Genomics

edited by

Yoshihito Kano

submission deadline 30 Jun 2025 | Viewed by 183 | Submission Open

Keywords: cancer genomics; biomarker discovery; precision oncology; KRAS and undruggable targets; artificial intelligence in oncology; multi-omics data integration; drug discovery

(This special issue belongs to the Section Molecular Biology)

Preclinical and Translational Research in Thyroid Cancer

edited by

Marialuisa Appetecchia

and

Giulia Puliani

submission deadline 30 Jun 2025 | Viewed by 180 | Submission Open

Keywords: thyroid cancers; pathogenesis; molecular bases of thyroid cancer; precision medicine; gender medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endometrial Cancer: From Basic Science to Novel Therapeutics

edited by

Hye-Yon Cho

submission deadline 30 Jun 2025 | Viewed by 179 | Submission Open

Keywords: endometrial cancer; molecular tumor pathology; tumor microenvironment; cancer epidemiology and prevention; biomarkers; cancer therapy; genomic and proteomic databases and applications

(This special issue belongs to the Section Molecular Oncology)

Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease

edited by

Consolato M. Sergi

submission deadline 30 Jun 2025 | Viewed by 179 | Submission Open

Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Progress in Adipokines Research in Cardiovascular Health and Diseases

edited by

Morris Karmazyn

submission deadline 30 Jun 2025 | Viewed by 175 | Submission Open

Keywords: adipokine receptors and cell signalling; adipokines and heart failure and hypertrophy; adipokines and myocardial ischemia; adipokines and hypertension; adipokines and thrombosis/atherosclerosis; adipokines and vascular/endothelial function; structure; and integrity; adipokines and cardiovascular inflammation; adipokines; adiposity; and cardiovascular disease in obesity

(This special issue belongs to the Section Molecular Biology)

Phytochemicals: Mechanisms and Applications in Cancer Prevention and Therapy

edited by

Mateusz Kciuk

and

Damian Kołat

submission deadline 30 Jun 2025 | Viewed by 174 | Submission Open

Keywords: phytochemicals; cancer prevention; cancer therapy; molecular mechanisms; signal transduction pathways; anti-oxidant activity; cell death; gene regulation; therapeutic targets

(This special issue belongs to the Section Biochemistry)

Emerging Insights into Phytohormone Signaling in Plants

edited by Meng Zhang

submission deadline 30 Jun 2025 | Viewed by 173 | Submission Open

Keywords: phytohormone; signal transduction; evolutionary and functional diversity; implications for plant science and agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Depression—2nd Edition

edited by

Magdalena Sowa-Kućma

submission deadline 30 Jun 2025 | Viewed by 171 | Submission Open

Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors

(This special issue belongs to the Section Molecular Neurobiology)

Antifungal Potential of Botanical Compounds

edited by Francisca Sempere-Ferre

submission deadline 30 Jun 2025 | Viewed by 168 | Submission Open

Keywords: botanical compounds; antifungal agents; natural products; secondary metabolites; fungal growth inhibition; bioactive plant extracts; eco-friendly antifungals; natural product chemistry; sustainable antifungal solutions; plant-derived bioactives

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Developmental Biology: Computational and Experimental Approaches, 2nd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 30 Jun 2025 | Viewed by 167 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations

(This special issue belongs to the Section Molecular Biology)

Innovations in Organic Framework Materials: Expanding the Horizons of COFs, MOFs, and HOFs for Advanced Applications

edited by Bhausaheb Dhokale

submission deadline 30 Jun 2025 | Viewed by 167 | Submission Open

Keywords: COF; MOF; HOF; synthesis; molecular applications; porous materials; molecular engineering; membranes; theoretical studies; energy

(This special issue belongs to the Section Materials Science)

Organic and Inorganic Active Substances with Antimicrobial, Anti-Inflammatory, Anti-Cancer and Antioxidant Effects

edited by Jebiti Haribabu

submission deadline 30 Jun 2025 | Viewed by 163 | Submission Open

Keywords: organic compounds; metal complexes; nanomedicine; medicinal chemistry; biological applications

(This special issue belongs to the Section Molecular Pharmacology)

Plant-Derived Bioactive Compounds for Pharmacological Applications

edited by

Ilian Badjakov

and

Ivayla Dincheva

submission deadline 30 Jun 2025 | Viewed by 162 | Submission Open

Keywords: plant-derived bioactive compounds; pharmacological applications; antioxidant activity; anti-inflammatory agents; antimicrobial properties; neuroprotective effects; drug discovery; high-throughput screening; extraction and isolation techniques; structural characterization; CRISPR technology; genome editing; bioprocess engineering; bioreactor production; therapeutic potential; metabolite profiling

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mitochondrial Disorders: From Molecular Mechanisms to New Therapies

edited by

Yury Ladilov

and

Muhammad Aslam

submission deadline 30 Jun 2025 | Viewed by 161 | Submission Open

Keywords: mitochondrial disorders; mitochondrial dysfunction; molecular mechanisms; targeted therapeutic approaches; mitochondrial biology regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormone Receptor in Breast Cancer: 2nd Edition

edited by

Rocío García-Becerra

submission deadline 30 Jun 2025 | Viewed by 161 | Submission Open

Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors

(This special issue belongs to the Section Molecular Oncology)

Cell–Cell Communication Through Extracellular Vesicles

edited by Federica Fratini

submission deadline 30 Jun 2025 | Viewed by 161 | Submission Open

Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape

(This special issue belongs to the Section Molecular Biology)

Polyphenol-Based Nanomaterials: Progress and Challenges

edited by

Eliana Capecchi

and

Davide Piccinino

submission deadline 30 Jun 2025 | Viewed by 152 | Submission Open

Keywords: polyphenolic small molecules; polyphenolic macromolecules; organic chemistry

(This special issue belongs to the Section Molecular Nanoscience)

Research on Artificial Intelligence in Plant Biology

edited by Haopeng Yu

submission deadline 30 Jun 2025 | Viewed by 149 | Submission Open

Keywords: artificial intelligence; plant biology; RNA regulation; DNA regulatory elements; plant development; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Research on Alloy Materials Microstructure and Their Functionalization

edited by

Ozkan Gokcekaya

and Celaletdin Ergun

submission deadline 30 Jun 2025 | Viewed by 148 | Submission Open

Keywords: alloy design; microstructure; production methods; additive manufacturing; sol– gel process; biofunctional materials; magnetic properties; nanoparticles; ceramics; composites

(This special issue belongs to the Section Materials Science)

Reactive Oxygen Species (ROS) and Metal Ions in Cellular Systems

edited by

Chryssoula Drouza

and

Debbie C. Crans

submission deadline 30 Jun 2025 | Viewed by 146 | Submission Open

Keywords: reactive oxygen species; reactive oxygen species metabolism; diseases and reactive oxygen species; lipid peroxidation; metal ions and reactive oxygen species; metal based drugs; oxidative stress

(This special issue belongs to the Section Biochemistry)

Recent Advances in 3D Tumor Models for Cancer Research

edited by

Simona Campora

Francesco Lopresti

and Alessandra Lo Cicero

submission deadline 30 Jun 2025 | Viewed by 145 | Submission Open

Keywords: 3D systems; cancer research; spheroids; organoids; organ-on-chip; scaffolds; tissue engineering; biomedical technologies; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Immunotherapy of Breast Cancer

edited by Mariangela Ciccarese, Elisabetta De Matteis and Laura Orlando

submission deadline 30 Jun 2025 | Viewed by 144 | Submission Open

Keywords: subgroups of BC; biomarkers; tumour microenvironment; TIL; PD-1/PD-L1; vaccines

(This special issue belongs to the Section Molecular Oncology)

Advances in Targeted Cancer Therapy and Side-Effect Management

edited by Wei-Min Chang

submission deadline 30 Jun 2025 | Viewed by 142 | Submission Open

Keywords: targeted cancer therapy; novel therapy approaches; personalized treatment; small molecule inhibitors; combination strategies; multi-omics integration; proton therapy; reduced cancer treatment side effects; therapeutic resistance; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Abscisic Acid, a New Old Friend to Regulate Abiotic Stress Tolerance in Plants

edited by Marta Marina Pérez-Alonso and

Miguel González-Guzmán

submission deadline 30 Jun 2025 | Viewed by 138 | Submission Open

Keywords: abscisic acid (ABA); ABA perception; ABA signaling network; abiotic stress; hormonal crosstalk; crop species; stress tolerance; plant productivity; agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Targeted Therapy of Cancer

edited by Da-Liang Ou

submission deadline 30 Jun 2025 | Viewed by 137 | Submission Open

Keywords: pharmacotherapy; targeted therapies; immunotherapy; nanotechnology-based combination therapies; drug repurposing; tumor microenvironment; personalized medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Plant Natural Products

edited by

Noémi Tóth

submission deadline 30 Jun 2025 | Viewed by 136 | Submission Open

Keywords: natural products; plants; molecular mechanism; pharmacokinetics; signaling pathways; metabolites; molecular targets; pharmacodynamics; diseases; anti-inflammation; anticancer; omics; bioactivity; natural compounds; therapeutic

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Tissue Culture-Free Plant Genome Editing and Transgenesis

edited by Degao Liu

submission deadline 30 Jun 2025 | Viewed by 134 | Submission Open

Keywords: CRISPR/Cas; genome editing; plant; tissue culture free; transgenesis

(This special issue belongs to the Section Molecular Plant Sciences)

Biotic and Abiotic Stress Responses of Vegetable Crops

edited by Yongqiang Tian

submission deadline 30 Jun 2025 | Viewed by 132 | Submission Open

Keywords: vegetable crops; biotic stress; abiotic stress; physiological responses; molecular mechanisms; genetic mechanisms; resistance breeding; resistance biotechnology; management strategies

(This special issue belongs to the Section Molecular Plant Sciences)

The Disulfide Stress in Health and Diseases

edited by

Marlena Brzozowa-Zasada

submission deadline 30 Jun 2025 | Viewed by 127 | Submission Open

Keywords: disulfide stress; oxidative Stress; redox metabolism; redox Balance; glutathione; ROS

(This special issue belongs to the Section Biochemistry)

Emerging Molecular Research in Microfluidics

edited by

Guorui Zhu

submission deadline 30 Jun 2025 | Viewed by 127 | Submission Open

Keywords: molecular; microfluidics; single-cell; digital microfluidics; microfluidic sensor

(This special issue belongs to the Section Biochemistry)

Effects of Stressors During Pregnancy and Breastfeeding on the Child: Molecular Perspectives

edited by

Anna Weronika Sobańska

submission deadline 30 Jun 2025 | Viewed by 125 | Submission Open

Keywords: xenobiotics; drugs; gestation; breastfeeding; fetus; placenta; child’ s development; teratogenicity; central nervous system

(This special issue belongs to the Section Molecular Biology)

The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior

edited by

Runxiang Zhang

submission deadline 30 Jun 2025 | Viewed by 125 | Submission Open

Keywords: metabolism pathway; signal pathway; animal development; animal behavior; animal disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Neural Stem Cells: Latest Applications and Future Perspectives

edited by

Evangelos Delivopoulos

submission deadline 30 Jun 2025 | Viewed by 125 | Submission Open

Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease

(This special issue belongs to the Section Molecular Biology)

Benchmarking of Modeling and Informatic Methods in Molecular Sciences

edited by Abby Parrill

submission deadline 30 Jun 2025 | Viewed by 124 | Submission Open

Keywords: modeling; informatics; simulation; benchmarking; performance comparison; modeling method evaluation; informatic method evaluation

(This special issue belongs to the Section Molecular Informatics)

Molecular Pharmacology of Cation-Permeable Ion Channels

edited by

Jian Shi

submission deadline 30 Jun 2025 | Viewed by 124 | Submission Open

Keywords: cation-permeable ion channel structure; cation-permeable ion channel functions; cation-permeable ion channel pharmacology; cation-permeable ion channel and diseases; innovative techniques for cation-permeable ion channel research

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in Plant Breeding Research

edited by Qiang Zhang

submission deadline 30 Jun 2025 | Viewed by 124 | Submission Open

Keywords: crop quality; crop yield; gene editing; excellent germplasm; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and the Link Between Obesity, Diabetes and Inflammation

edited by

Maria Chiara Pelle

and

Arturi Franco

submission deadline 30 Jun 2025 | Viewed by 124 | Submission Open

Keywords: adipose tissue; biomarkers; diabetes; inflammation; obesity; cytokine; insulin resistance; signaling pathways; metabolic diseases

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms of Ozone Therapy

edited by

Francisco Rodríguez-Esparragón

Bernadino Clavo

and

Jacob Lorenzo-Morales

submission deadline 30 Jun 2025 | Viewed by 122 | Submission Open

Keywords: antioxidant response; cellular stress responses; inflammatory signaling; mitochondrial function; molecular pathways; Nrf2; oxidative stress; ozone therapy; redox regulation; antimicrobial resistance; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Developments in Obesity: Metabolism, Pathophysiology and Treatment

edited by

Peteris Tretjakovs

submission deadline 30 Jun 2025 | Viewed by 121 | Submission Open

Keywords: obesity; adipokines; insulin sensitivity; lipid metabolism; pro-inflammatory cytokines; gut microbiota; GLP-1 receptor agonists; personalized nutrition; lifestyle interventions

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Arthritis: Focus on Pathologies, Symptoms and Therapy

edited by

Katarína Bauerová

submission deadline 30 Jun 2025 | Viewed by 121 | Submission Open

Keywords: rheumatoid arthritis; autoimmune; pathogenesis; strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathophysiology and Molecular Therapy of Brain Tumor

edited by Daizo Yoshida and Akira Teramoto

submission deadline 30 Jun 2025 | Viewed by 121 | Submission Open

Keywords: brain tumor; pathophysiology; molecular therapy; signal cascade

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Coagulation Proteins

edited by

Arijit Biswas

submission deadline 30 Jun 2025 | Viewed by 120 | Submission Open

Keywords: coagulation proteins; hemostasis; thrombosis; structural biology; Cryo-EM; inherited coagulation disorders

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Antioxidant and Anti-Inflammatory Properties of Bioactive Compounds

edited by

Gang Ye

submission deadline 30 Jun 2025 | Viewed by 119 | Submission Open

Keywords: antioxidant; anti-inflammatory; bioactive compounds; artificial intelligence; multiomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Electromagnetic Field Interactions with Biomolecules

edited by Samina Masood

submission deadline 30 Jun 2025 | Viewed by 118 | Submission Open

Keywords: magnetic field; biomolecules; medicine; drug delivery; protective methods; disease control

(This special issue belongs to the Section Biochemistry)

Displaying special issue 951-1000 on page 20 of 68.

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