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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Studies of Endometriosis and Associated Diseases

edited by Sarah J Holdsworth-Carson

submission deadline 21 Aug 2025 | 4 articles | Viewed by 6268 | Submission Open

Keywords: adenomyosis; autoimmune diseases; cardiometabolic conditions; endometriosis; fatigue; heavy menstrual bleeding; irritable bowel syndrome; migraine; painful bladder syndrome; pelvic floor muscle dysfunction; pelvic inflammatory disease; pelvic pain; peritoneal adhesions; polycystic ovarian syndrome; pregnancy complications; ovarian cancer; uterine fibroids

(This special issue belongs to the Section Molecular Biology)

Germline Stem Cells: New Insights

edited by

Thomas Skutella

submission deadline 30 Aug 2025 | 1 articles | Viewed by 4357 | Submission Open

Keywords: signaling pathway; spermatogonia development; oocyte development; microarray analysis; single-cell sequencing; epigenetic mechanisms; germline stem cell

(This special issue belongs to the Section Molecular Biology)

Advances in the Genetics, Epidemiology and Management of Myopathies

edited by

Efthimios Dardiotis

and

Vasileios Siokas

submission deadline 30 Aug 2025 | 1 articles | Viewed by 2798 | Submission Open

Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia

(This special issue belongs to the Section Molecular Biology)

Cellular Plasticity and EMT in Cancer and Fibrotic Diseases

edited by

Sabrina Lisi

and

Margherita Sisto

submission deadline 30 Aug 2025 | 3 articles | Viewed by 2587 | Submission Open

Keywords: fibrosis; epithelial– mesenchymal transition; epithelial– mesenchymal plasticity; cancer; fibrotic diseases; inflammation; metastases

(This special issue belongs to the Section Molecular Biology)

Oral Soft Tissue Repair and Oral Diseases: 2nd Edition

edited by

Jacek Matys

submission deadline 30 Aug 2025 | 2 articles | Viewed by 2333 | Submission Open

Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; implant dentistry

(This special issue belongs to the Section Molecular Biology)

Novel Approaches for Tissue Repair and Tissue Regeneration

edited by Srinivas Madduri

submission deadline 30 Aug 2025 | 1 articles | Viewed by 613 | Submission Open

Keywords: injuries; tissue repair; tissue regeneration; tissue engineering; tissue bioengineering; bioactive biomaterial; cell and gene therapeutics; hydrogel; immune modulation

(This special issue belongs to the Section Molecular Biology)

Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery

edited by

Rosamaria Pennisi

submission deadline 30 Aug 2025 | Viewed by 151 | Submission Open

Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems

(This special issue belongs to the Section Molecular Biology)

Advancements in Pathogen Detection, Microdevice Technologies and AI-Driven Analysis

edited by

Younseong Song

submission deadline 30 Aug 2025 | Viewed by 124 | Submission Open

Keywords: pathogen detection; microfluidic; microdevice; AI analysis; virus; bacteria; point-of-care testing; infectious disease; nanotechnology

(This special issue belongs to the Section Molecular Biology)

Phytochemicals in Health and Disease: From Molecular Mechanisms to Evidence-Based Applications

edited by Olga Silva

submission deadline 30 Aug 2025 | Viewed by 115 | Submission Open

Keywords: phytochemicals; bioactive natural products; medicinal plants; chronic and inflammatory diseases; ethnopharmacology and phytotherapy

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Research on Cardiac Repair and Regeneration

edited by

Francesca Pagano

and

Vittorio Picchio

submission deadline 30 Aug 2025 | Viewed by 112 | Submission Open

Keywords: cardiac repair; cardiomyocyte differentiation; cardiac fibroblast activation; cardiac fibrosis; cardiac tissue microenvironment; cardiac remodeling

(This special issue belongs to the Section Molecular Biology)

Transgenic Mouse Models in Human Disease Research in Epithelial Tissues: Insights and Advances

edited by

Manoocher Soleimani

and

Kamyar Zahedi

submission deadline 30 Aug 2025 | Viewed by 111 | Submission Open

Keywords: transgenic animals; kideny diseases; heart failure; cystic diseases

(This special issue belongs to the Section Molecular Biology)

New Insight into Biomaterials for Tissue Engineering and Regenerative Medicine

edited by

Diana Torge

submission deadline 30 Aug 2025 | Viewed by 87 | Submission Open

Keywords: biomaterials; tissue regeneration; regenerative medicine; bone regeneration; periodontal disease; morphology; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Cellular Pathways and Cytokine Networks in Tuberous Sclerosis: Mechanisms and Therapeutic Targets

edited by Uchenna John Unachukwu

submission deadline 30 Aug 2025 | Viewed by 75 | Submission Open

Keywords: mTOR signaling dysregulation; neurocristopathy; cytokine crosstalk; TSC1/TSC2 complex; epigenetic modifiers; metabolic reprogramming; molecular biomarkers; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

Teleost in Biomedical Research

edited by

Antonino Germanà

and

Marialuisa Aragona

submission deadline 31 Aug 2025 | 2 articles | Viewed by 6991 | Submission Open

Keywords: fish; teleost; experimental model; translational research; biomedicine; comparative studies

(This special issue belongs to the Section Molecular Biology)

Molecular Aspects of Reproductive Medicine

edited by Wei Chen

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1392 | Submission Open

Keywords: spermatogenesis; oogenesis; microenvironment; organ interactions; molecular regulation; gametogenesis; signaling pathways; reproductive disorders

(This special issue belongs to the Section Molecular Biology)

Biological and Molecular Aspects of Exercise Adaptation

edited by

Alessandra Modesti

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1043 | Submission Open

Keywords: exercise; redox homeostasis; metabolic state; biological; physiological

(This special issue belongs to the Section Molecular Biology)

Zebrafish: A Model Organism for Human Health and Disease: 2nd Edition

edited by

Jyotshna Kanungo

submission deadline 31 Aug 2025 | 1 articles | Viewed by 804 | Submission Open

Keywords: zebrafish; drug discovery; high-throughput screens; genome editing/CRISPR mutants; cancer; neuronal disorders; drug toxicity; drug effect mechanisms; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Advances in Structural and Functional Properties of G-Quadruplexes and Aptamers

edited by

Antonella Virgilio

Veronica Esposito

and

Aldo Galeone

submission deadline 31 Aug 2025 | 1 articles | Viewed by 671 | Submission Open

Keywords: G-quadruplex structure; aptamer; DNAzyme; catalytic G-quadruplexes

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Reproduction and Fertility of Aquatic Animals: 3rd Edition

edited by

Hui Qiao

and Hongtuo Fu

submission deadline 31 Aug 2025 | 1 articles | Viewed by 634 | Submission Open

Keywords: reproduction; aquatic animals; sex determination; gonadal development; steroid hormones; sex-related genes; monosex culture

(This special issue belongs to the Section Molecular Biology)

Environmental Influences on Cellular Responses

edited by

Marcus Krüger

submission deadline 31 Aug 2025 | 1 articles | Viewed by 596 | Submission Open

Keywords: cell/environment interaction; cell signaling; mechanobiology; photobiology; thermobiology; enviromics; cell-cell communication; cell-cell interaction

(This special issue belongs to the Section Molecular Biology)

Focus on the Tryptophan Pathway

edited by

Burkhard Poeggeler

submission deadline 31 Aug 2025 | 1 articles | Viewed by 465 | Submission Open

Keywords: aging; indole-3-propionic acid; kynurenic acid; melatonin; serotonin; tryptophan

(This special issue belongs to the Section Molecular Biology)

Multidrug Resistance in Cancer: Molecular Mechanisms and Therapeutic Challenges

edited by

Odília Queirós

and

Patrícia M. A. Silva

submission deadline 31 Aug 2025 | Viewed by 186 | Submission Open

Keywords: cancer therapy; MultiDrug Resistance (MDR); Pgp; efflux pumps; tumor microenvironment; anticancer drug target; combination therapy; novel anticancer agents

(This special issue belongs to the Section Molecular Biology)

Biological Barriers: Consciousness and Mental Illness

edited by

Adonis Sfera

submission deadline 31 Aug 2025 | Viewed by 164 | Submission Open

Keywords: cell membranes; transport protein regulation; blood– brain barrier; epithelial barriers; gut barrier; respiratory barriers; blood– saliva barrier; biological barriers and pathological changes; protection of biological barriers in diseases

(This special issue belongs to the Section Molecular Biology)

Emerging Insights into Lymphoid Organ Development, Regulation and Therapeutic Potential

edited by Hélia Neves

submission deadline 31 Aug 2025 | Viewed by 147 | Submission Open

Keywords: thymus; immune; signaling; molecular; pathways; epigenetics; organoids; bioengineering; regeneration; clinical application

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Angiogenesis: Mechanisms, Signaling, and Therapeutic Horizons

edited by Edgar Delgado-Eckert

submission deadline 31 Aug 2025 | Viewed by 145 | Submission Open

Keywords: angiogenesis; VEGF; intracellular signaling in vascular biology; anti-angiogenic therapy for cancer; artery disease; age-related macular degeneration

(This special issue belongs to the Section Molecular Biology)

Neuroinflammation, and Alcohol Use Disorders: Molecular Mechanisms and Treatment

edited by

Marco Fiore

submission deadline 31 Aug 2025 | Viewed by 127 | Submission Open

Keywords: alcohol; addiction; abuse; inflammation; neurodegeneration; cognition; neuroimmunology; oxidative stress

(This special issue belongs to the Section Molecular Biology)

Purine Signaling as a Therapeutic Target in Human Diseases

edited by

Aránzazu Mediero

submission deadline 31 Aug 2025 | Viewed by 121 | Submission Open

Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Autophagy and Apoptosis in Mammal Cells

edited by Kaja Urbańska and Anna Litwiniuk

submission deadline 31 Aug 2025 | Viewed by 114 | Submission Open

Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death

(This special issue belongs to the Section Molecular Biology)

The Positive Impact of DNA-Derived Substances on Inflammation, Aging and Associated Symptoms

edited by

Mi Young Lee

submission deadline 31 Aug 2025 | Viewed by 102 | Submission Open

Keywords: PDRN; PN; DNA-derived substances; nucleic acid-based therapeutics; inflammation; aging

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Research of Facial Adipose Compartments

edited by Marius Valeriu Hînganu

submission deadline 15 Sep 2025 | Viewed by 397 | Submission Open

Keywords: facial fat; facial adipose tissue; molecular markers of facial fat; hormonal environmental; metabolic disorders; facial deformities; single-cell RNA sequencing; CRISPR-Cas9 gene editing

(This special issue belongs to the Section Molecular Biology)

Novel Biosystems in Toxicology and Pharmacology

edited by

Ricardo Lagoa

Manuel Aureliano

and

Paula A. Videira

submission deadline 20 Sep 2025 | 4 articles | Viewed by 24214 | Submission Open

(This special issue belongs to the Section Molecular Biology)

Oxygen Variations, 2nd Edition

edited by

Costantino Balestra

Simona Mrakic-Sposta

and

Gerardo Bosco

submission deadline 20 Sep 2025 | 9 articles | Viewed by 23933 | Submission Open

Keywords: hypoxia; hyperoxia; normoxia; biochemichal response; integrative approach; normo-hypo-hyperbaric; molecular research; gene expression; adaptive reactions; extreme environments

(This special issue belongs to the Section Molecular Biology)

Recent Research in Gut Microbiota–Gut–Brain Axis

edited by Ying Han

submission deadline 20 Sep 2025 | 3 articles | Viewed by 17580 | Submission Open

Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; short-chain fatty acid; immune pathway; vagus nerve; neuropsychiatric disorders; depression

(This special issue belongs to the Section Molecular Biology)

Advances in Spermatogenesis and Male Infertility

edited by Wanxi Yang

submission deadline 20 Sep 2025 | 8 articles | Viewed by 15406 | Submission Open

Keywords: male reproduction; hormone regulation; blood– testis barrier; male reproductive diseases; male infertility

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into the Processing and Characterization of Animal Fats and Vegetable Oils

edited by

Pavel Mokrejš

submission deadline 20 Sep 2025 | 4 articles | Viewed by 9155 | Submission Open

Keywords: lipid molecules; oils; fats; lipase; interesterification; hydrolysis; phospholipids; fatty acids; molecular research; nutrition; cosmetics matrices; medical applications; food; pharmacy; bioengineering; novel applications; biofuels

(This special issue belongs to the Section Molecular Biology)

Molecular and Physiological Mechanisms of Exercise

edited by Zoran Nikolovski

submission deadline 20 Sep 2025 | 3 articles | Viewed by 8683 | Submission Open

Keywords: molecular biology; biochemistry and exercise; athletic performance; multi-omic

(This special issue belongs to the Section Molecular Biology)

Molecular Biology of Protein Kinases: Regulatory Mechanisms, Therapeutic Targets and Cancer Treatments

edited by Jaw Ji Yang

submission deadline 20 Sep 2025 | 2 articles | Viewed by 7616 | Submission Open

Keywords: protein kinases; signal transduction; cancer therapy; regulatory mechanisms; kinase inhibitors; therapeutic targets; molecular biology; structural biology; translational research; clinical applications

(This special issue belongs to the Section Molecular Biology)

Flow Cytometry: Applications and Challenges

edited by

Alessandra Falda

submission deadline 20 Sep 2025 | 5 articles | Viewed by 6919 | Submission Open

Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress and Cell Damage

edited by Haruhiko Inufusa, Koji Abe and Shigeru Hirano

submission deadline 20 Sep 2025 | 2 articles | Viewed by 6881 | Submission Open

Keywords: oxidative stress; damages on cells; organs; body; prevention damages; parameter of oxidative stress; antioxidants

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Cell Proliferation, Senescence and Apoptosis

edited by

Chuanxi Cai

submission deadline 20 Sep 2025 | 3 articles | Viewed by 5606 | Submission Open

Keywords: biological molecules; cell proliferation; senescence; apoptosis; human diseases

(This special issue belongs to the Section Molecular Biology)

New Advances in Stem Cells in Human Health and Diseases

edited by

Elisaveta N. Voynova

submission deadline 20 Sep 2025 | 4 articles | Viewed by 5538 | Submission Open

Keywords: stem cells biology; iPSCs; hESC

(This special issue belongs to the Section Molecular Biology)

Technical Developments and Recent Applications of Cellular Molecular Imaging

edited by Hanae Sato

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3527 | Submission Open

Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging

(This special issue belongs to the Section Molecular Biology)

Stem Cells and Regenerative Medicine: In Vitro and In Vivo Studies—2nd Edition

edited by

Alessia Peserico

submission deadline 20 Sep 2025 | 1 articles | Viewed by 3202 | Submission Open

Keywords: stem cells; stem cell homing; stem cell tracking; regeneration; tissue injury; immunomodulation; biomaterials; tissue-on-a-chip; organoids; differentiation

(This special issue belongs to the Section Molecular Biology)

New Cardiovascular Risk Factors: 2nd Edition

edited by

Antonio Barbato

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3086 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Biology)

Bilirubin: Health Challenges and Opportunities

edited by

Silvia Gazzin

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2864 | Submission Open

Keywords: bilirubin; biomedical science; neurobiology; Parkinson’ s disease; brain neuroprotection

(This special issue belongs to the Section Molecular Biology)

Molecular Strategies to Overcome Antibiotic Resistance in Carbapenem-Producing Bacteria

edited by

Daniela Calina

and

Ovidiu Zlatian

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2832 | Submission Open

Keywords: antibiotic resistance; antimicrobial agents; bacterial pathogens; carbapenemases; genomics; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

New Insights into Osteoclasts

edited by

David Gyori

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2290 | Submission Open

Keywords: osteoclast; bone remodeling; osteoporosis; inflammatory arthritis; bone tumor

(This special issue belongs to the Section Molecular Biology)

The Molecular Role of Platelets in Human Diseases

edited by

Lukasz Szarpak

and

Michał Pruc

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2181 | Submission Open

Keywords: platelet; biomarkers; platelet membrane proteins; platelet-derived microparticles; platelet-related diseases; thrombosis; inflammatory diseases; cardiovascular disease; cancer; tumor growth and metastasis

(This special issue belongs to the Section Molecular Biology)

Recent Research on Cardiac Troponins

edited by

Chiara Caselli

and

Rosetta Ragusa

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2118 | Submission Open

Keywords: cardiac troponin; gene mutations; post-translational modifications; therapy; high-sensitivity (hs) immunoassays; mechanisms of release; biomarkers; cardiovascular disease

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Oxidative Stress in Health and Disease

edited by

Amelia Maria Găman

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2041 | Submission Open

Keywords: oxidative stress; antioxidants; cancer; redox signalling; reactive oxygen and nitrogen species

(This special issue belongs to the Section Molecular Biology)

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