Advances in Spermatogenesis and Male Infertility
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 10291
Special Issue Editor
Special Issue Information
Dear Colleagues,
Sperm provides the zygote with genetic material from the father and is essential for reproduction. Throughout biological evolution, spermatogenesis has been a precise and conserved process which occurs in the male testis but is regulated by the hypothalamic–pituitary–gonadal axis. The blood–testis barrier, as the histological barrier of the testis, prevents the stimulation of spermatogenesis and ensures the process runs smoothly. A variety of signaling molecules are involved in various stages of and at different points in spermatogenesis, and studying its related functions may provide us with a new therapeutic direction for male reproductive diseases. However, at present, more and more environmental factors impair this process, impeding spermatogenesis and as a result decreasing male fertility rates.
The purpose of this Special Issue is to summarize and expand on the molecular mechanisms that ensure successful spermatogenesis and to explore the key processes in male reproduction, providing an effective platform on which new insights into male reproductive diseases to be described.
We welcome submissions of original research articles and comprehensive reviews.
The specific topics include, but are not limited to, the following:
- The role of hormone regulation in spermatogenesis;
- How somatic cells maintain spermatogenesis in the testis;
- The maintenance mechanism ensuring the integrity of the blood–testis barrier and its role in spermatogenesis;
- The multiple signaling pathways that synergistically regulate spermatogenesis;
- New discoveries of molecules involved in spermatogenesis and fertility;
- How cell fate is involved in spermatogenesis (e.g. cell self-renewal and repair, apoptosis, proliferation, autophagy, etc.);
- Molecular mechanisms that disrupt spermatogenesis via environmental toxicology and stimulation.
Prof. Dr. Wanxi Yang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- male reproduction
- hormone regulation
- blood–testis barrier
- male reproductive diseases
- male infertility
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
