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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Newest Antibacterial Applications of Metal Nanoparticles

edited by

Serhat Keser

submission deadline 30 Nov 2026 | Viewed by 245 | Submission Open

Keywords: metal oxides; hydroxyapatites; antibacterial; gram positive; gram negative; nanoparticles; antibacterial; antibacterial resistance; bioactivity; biocompatibility; metal-based nanoparticles

(This special issue belongs to the Section Molecular Nanoscience)

Advances in the Integrin System: Relevance of Receptors, Ligands, and Counter-Receptors in Signaling and Pathophysiology

edited by

Carlos Cabañas

and

Carmelo Bernabeu

submission deadline 30 Nov 2026 | Viewed by 234 | Submission Open

Keywords: integrin function; integrin signalling pathways; integrin conformational changes; integrin disease and therapeutic strategies; integrin-ligand interactions; integrin counter-receptors (ICRs); extracellular matrix (ECM) integrin ligands

(This special issue belongs to the Section Molecular Biology)

Natural Bioactives Targeting Molecular Mechanisms in Neurological Disorders: From Pathophysiology to Therapy

edited by Jinatta Jittiwat

submission deadline 30 Nov 2026 | Viewed by 233 | Submission Open

Keywords: natural bioactives; molecular mechanisms; neurological disorders; oxidative stress; neuroinflammation; therapeutic targeting; neuroprotection; mitochondrial dysfunction; apoptosis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Diagnosis and Treatments of Diabetes Mellitus: 3rd Edition

edited by

Mihail Virgil Boldeanu

submission deadline 30 Nov 2026 | Viewed by 231 | Submission Open

Keywords: metabolic disorders; diabetes mellitus; inflammation; neurotransmitter; inflammatory biomarkers; molecular target; molecular diagnostics; therapeutics; insulin resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Mechanisms in Fibrotic Interstitial Lung Diseases

edited by Eirini Vasarmidi

submission deadline 30 Nov 2026 | Viewed by 226 | Submission Open

Keywords: interstitial lung diseases; rare lung diseases; autoimmune lung diseases; pulmonary fibrosis; molecular pathways; biomarkers; bronchoalveolar lavage; genetics in lung fibrosis; familial fibrosis; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Leveraging Multiomics for Resilient Crop Development and Food Security

edited by Niharika Sharma

submission deadline 30 Nov 2026 | Viewed by 221 | Submission Open

Keywords: multiomics; crop resilience; climate smart crops; stress tolerance; sustainable crop improvement; genotype‑by‑environment interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Regulatory Networks and Gene Expression Pathways in Bacteria

edited by Miguel A. Ares

submission deadline 30 Nov 2026 | Viewed by 215 | Submission Open

Keywords: bacterial gene expression; regulatory networks; transcription factors; sigma factors; two-component systems; quorum sensing; non-coding RNAs; host–pathogen interactions; bacterial adaptation; RNA-seq

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights Through Bioinformatics and Machine Learning: Precision-Driven Discovery of Drugs, Nutraceuticals, and Insecticides

edited by

Cleydson Breno Rodrigues dos Santos

submission deadline 30 Nov 2026 | Viewed by 212 | Submission Open

Keywords: computational bioactive compound discovery; density functional theory (DFT); antioxidant mechanisms; natural product-based drug discovery; AI-driven molecular modeling

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms Regulating Plant Growth, Development, and Stress Adaptation

edited by

Asma Ayaz

submission deadline 30 Nov 2026 | Viewed by 205 | Submission Open

Keywords: plant growth; plant development; molecular mechanisms; phytohormone signaling; abiotic stress; biotic stress; molecular cloning; plant–microbe interactions; omics approaches; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Diabetes: Molecular Perspectives—from Genetic Risk to Precision Therapy

edited by Suma Elumalai

submission deadline 30 Nov 2026 | Viewed by 199 | Submission Open

Keywords: diabetes mellitus; insulin signaling; β-cell dysfunction; insulin resistance; genomics; epigenetics; multi-omics; inter-organ communication; molecular therapeutics; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Molecular Mechanisms of Lead-Induced Neurotoxicity

edited by

Irena Baranowska-Bosiacka

and

Magdalena Gąssowska-Dobrowolska

submission deadline 30 Nov 2026 | Viewed by 196 | Submission Open

Keywords: lead; neurogenesis and neuronal development; intracellular signaling pathways; synaptic protein function; synaptic transmission and plasticity; neuroinflammation and inflammatory signaling; astrocyte–neuron metabolic cooperation; disturbances in vitamin and micronutrient metabolism; lead-induced alterations of the gut microbiota and gut–brain axis; molecular mechanisms underlying cognitive impairment; pathways contributing to the progression of neurodegenerative disorders following lead exposure

(This special issue belongs to the Section Molecular Toxicology)

Advances in Research on Neurotransmitters (Second Edition)

edited by

Mario Manto

Hiroshi Mitoma

and Jing-Ning Zhu

submission deadline 30 Nov 2026 | Viewed by 195 | Submission Open

Keywords: neurotransmitters; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut–brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Bioinformatics and Phylogenetics of Molecular Pathways and Human Diseases

edited by

Yang Yang

submission deadline 30 Nov 2026 | Viewed by 193 | Submission Open

Keywords: bioinformatics; phylogenetics; molecular pathways; human disease; multi-omics integration; biomarker discovery; disease knowledge graph

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms of Nerve Injury and Regeneration

edited by Barbara Hausott

submission deadline 30 Nov 2026 | Viewed by 192 | Submission Open

Keywords: nerve injury; regeneration; sensory neuron; motoneuron; Schwann cell; macrophage; neutrophin; cytokine; transcription factor; microrna

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Addiction and Substance Abuse Disorders

edited by Martin O. Job

submission deadline 30 Nov 2026 | Viewed by 190 | Submission Open

Keywords: psychostimulant use disorders; opioid use disorders; addiction; biomarkers; phenotypes; heterogeneity; genomics; epigenetics; metabolomics; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Abiotic Stresses in Plants: An Update

edited by Krzysztof Michał Tokarz

submission deadline 30 Nov 2026 | Viewed by 185 | Submission Open

Keywords: extreme temperatures; floods; photosynthetic apparatus; salinity; secondary metabolites; UV radiation; water shortages

(This special issue belongs to the Section Molecular Plant Sciences)

The Effects of Natural Products on Neurological Disorders

edited by Erika Monserrat Estrada-Camarena,

María Eva González Trujano

and Carolina López-Rubalcava

submission deadline 30 Nov 2026 | Viewed by 177 | Submission Open

Keywords: natural products; plants; fungi; vegetables; neurodegeneration; neuroinflammation; mechanism of action; neurodegenerative disorders; mental disorders; animal models; bioactive compounds; behavior

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Engineering of Photo(electro)catalysts: Rational Design and Electron Transfer

edited by Bingqing Zhang

submission deadline 30 Nov 2026 | Viewed by 176 | Submission Open

Keywords: photocatalysis; photoelectrocatalysis; molecular engineering; semiconductor materials; artificial photosynthesis; (photo)electrochemical sensors; energy materials; electron transfer

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Extraction, Characterization and Application of Bioactive Compounds

edited by

Dorota Gumul

and Marek Kruczek

submission deadline 30 Nov 2026 | Viewed by 174 | Submission Open

Keywords: bioactive compounds; extraction methods; molecular mechanisms; antioxidants; encapsulation; functional foods; bioavailability; food by-products

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into Immune Dysregulation Disorders: Second Edition

edited by

Francesco Saettini

submission deadline 30 Nov 2026 | Viewed by 174 | Submission Open

Keywords: immune dysregulation disorders; autoimmune conditions; primary immunodeficiencies; autoinflammatory disorders

(This special issue belongs to the Section Molecular Immunology)

A New Perspective on Fruit Quality: From Molecular Regulatory Mechanisms to Nutritional Value

edited by Xuelian Zhang

submission deadline 30 Nov 2026 | Viewed by 174 | Submission Open

Keywords: fruit quality; color regulation; texture; flavor; bioactive compounds; anthocyanins; carotenoids; human nutrition; CRISPR/Cas9; multi omics; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Endocrine Disruptors and the Nervous System: From Neurodevelopment to Neurotoxicity

edited by

Eui-Bae Jeung

submission deadline 30 Nov 2026 | Viewed by 172 | Submission Open

Keywords: endocrine disruptors; neurodevelopment; neurotoxicity; neuroendocrine; behavior; cognitive function; molecular mechanisms; alternative testing methods; developmental toxicity; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Advancements in Antimicrobial Agents: Focus on Biofilm Eradication

edited by

Marcus Vinícius Dias-Souza

submission deadline 30 Nov 2026 | Viewed by 169 | Submission Open

Keywords: antibiofilm plant extracts; antibiofilm phytomolecules; antibiofilm nanoparticles; antibiofilm liposomes; biofilm physiology; biofilm biochemistry; molecular biology of biofilms; biofilm eradication; biofilm growth control; structure of biofilms

(This special issue belongs to the Section Molecular Microbiology)

ABA Mediated Plant Growth and Development, and Response to Drought and Salt Stress

edited by

Kun Li

and Fengbo Yang

submission deadline 30 Nov 2026 | Viewed by 167 | Submission Open

Keywords: ABA; drought; salt stress; osmotic stress; signal transduction; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Plant Sciences)

Reproductive Toxicity of Chemicals: 2nd Edition

edited by

Maria Laura Zenclussen

submission deadline 30 Nov 2026 | Viewed by 164 | Submission Open

Keywords: reproductive health; fertility; anthropogenic chemicals; impaired fertility; reproductive toxicity; embryo; toxicants; hormone disruption; chemical exposure

(This special issue belongs to the Section Molecular Toxicology)

Molecular Studies of Neurocognitive Disorders

edited by

Cristián Sandoval

and Edgar Vásquez Carrasco

submission deadline 30 Nov 2026 | Viewed by 164 | Submission Open

Keywords: neurocognitive disorders; mild cognitive impairment; Alzheimer’s disease; neuroinflammation; biomarkers; oxidative stress; neurodegeneration; multi-omics; precision medicine; cognitive decline

(This special issue belongs to the Section Molecular Neurobiology)

Tumor Immunology: Molecular Research and Advances

edited by Elizabeth Cristina Perez Hurtado

submission deadline 30 Nov 2026 | Viewed by 162 | Submission Open

Keywords: tumor microenvironment; tumor evasion; immune checkpoint inhibitors; macrophages; biomarkers in cancer; CAR cell therapy; cancer vaccines; lipid metabolism in cancer; metabolic reprogramming of immune response

(This special issue belongs to the Section Molecular Immunology)

Role of Angiotensin II in Cardiac Fibrosis and Heart Failure

edited by

Nancy Martínez-Rodríguez

submission deadline 30 Nov 2026 | Viewed by 159 | Submission Open

Keywords: angiotensin II; cardiac fibrosis; heart failure; renin–angiotensin–aldosterone system (RAAS); extracellular matrix remodeling; myofibroblast activation; cardiovascular genomics; molecular biomarkers

(This special issue belongs to the Section Molecular Biology)

Biological and Mechanistic Insights in Frontotemporal Dementia and Related Disorders

edited by Barbara Borroni and

Daniela Crescenti

submission deadline 30 Nov 2026 | Viewed by 158 | Submission Open

Keywords: frontotemporal dementia; early-onset dementia; biomarkers; neuroimaging; molecular mechanisms; therapeutic approaches; differential diagnosis; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Carbohydrate-Based Materials: Self-Assemblies and Applications

edited by

Redouane Borsali

and

Hong Li

submission deadline 30 Nov 2026 | Viewed by 155 | Submission Open

Keywords: carbohydrate-based materials; sustainable polymers; self-assembly; structure–property–function relationships; functional materials

(This special issue belongs to the Section Materials Science)

Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment—2nd Edition

edited by Manuel Morales-Ruiz and

Jordi Ribera

submission deadline 30 Nov 2026 | Viewed by 155 | Submission Open

Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling cell-to-cell interactions; fibrosis complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Microbiome Research: Multi-Omics Integration for Uncovering Molecular Mechanisms, Functional Pathways, and Microbial Interactions

edited by

Manik Prabhu Narsing Rao

and

Arinthip Thamchaipenet

submission deadline 30 Nov 2026 | Viewed by 153 | Submission Open

Keywords: bioinformatics; metagenomics; comparative genomics; multi-omics integration

(This special issue belongs to the Section Molecular Microbiology)

Secondary Metabolites of Pathogenic Fungi: From Mechanism to Medicine

edited by

Kritsada Pruksaphon

and

Nopawit Khamto

submission deadline 30 Nov 2026 | Viewed by 152 | Submission Open

Keywords: fungal secondary metabolites; mycotoxins; fungal virulence and fungal pathogenesis; biosynthetic gene clusters (BGCs); one strain–many compounds (OSMAC); metabolomics; host–pathogen interaction; ribotoxic stress; one health and climate change; diagnostic biomarkers; antifungal therapeutics; medicinal chemistry; structural biology

(This special issue belongs to the Section Molecular Microbiology)

Probiotics in Metabolism, Inflammation and Nervous System Disorders

edited by Subramanian Thangaleela

submission deadline 30 Nov 2026 | Viewed by 143 | Submission Open

Keywords: probiotics; gut–brain axis; metabolic diseases; neurological disorders; inflammation; secondary metabolites

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research Advances in HIV Infection

edited by

Sıla Akhan

submission deadline 30 Nov 2026 | Viewed by 142 | Submission Open

Keywords: HIV-1; CAR-T therapy; late HIV diagnosis; viral transmission; immune exhaustion; antiretroviral therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress of Biopolymers in Drug Delivery Systems

edited by

Narendra Kale

submission deadline 30 Nov 2026 | Viewed by 137 | Submission Open

Keywords: biopolymers; biomaterials; drug delivery systems; nanomedicine; targeted delivery; polymer therapeutics; bioengineering; quantitative imaging; stimuli-responsive drug delivery; biomedical polymers

(This special issue belongs to the Section Macromolecules)

Unraveling the Mechanistic Pathways of Immune Cell Engagers in Lymphoproliferative Diseases

edited by

Stella Bouziana

submission deadline 30 Nov 2026 | Viewed by 131 | Submission Open

Keywords: lymphoproliferative diseases; immune cell engagers; BiTEs; molecular pathways; next-generation T cell engagers

(This special issue belongs to the Section Molecular Immunology)

Neuropharmacology of Pain: From Molecular Mechanisms to Clinical Translation

edited by

Carlos-Alberto Calderon-Ospina

submission deadline 30 Nov 2026 | Viewed by 128 | Submission Open

Keywords: neuropharmacology; chronic pain; molecular mechanisms; neuroinflammation; neuropathic pain; pharmacological targets; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Multi-Omics and Computational Simulation Approaches: Unraveling Novel Antibacterial Mechanisms of Natural Products

edited by Lili Li

submission deadline 30 Nov 2026 | Viewed by 121 | Submission Open

Keywords: natural products; antibacterial mechanism; anti-biofilm; multi-omics; computational simulation; drug-resistant pathogens

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Diabetes and Metabolic Dysfunction (Second Edition)

edited by

Vasilis K. Tsimihodimos

submission deadline 30 Nov 2026 | Viewed by 120 | Submission Open

Keywords: diabetes; metabolic dysfunction; glucose metabolism; metabolic disturbances; complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Leveraging Novel Insights from Basic Science to Improve Hepatocellular Carcinoma Management in the Era of Precision Medicine

edited by

Hikmet Akkız

submission deadline 30 Nov 2026 | Viewed by 116 | Submission Open

Keywords: hepatocellular carcinoma; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Biology and Therapeutic Applications of Medicinal Plants

edited by Gothai Sivapragasam and Nanthiney Ragavan

submission deadline 30 Nov 2026 | Viewed by 114 | Submission Open

Keywords: medicinal plants; molecular biology; phytochemicals; wound healing; oxidative stress; inflammation; molecular pharmacology; regenerative medicine; bioactive compounds

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Viper Envenomation: From Molecular Mechanisms to Treatment

edited by

Svjetlana Karabuva

submission deadline 30 Nov 2026 | Viewed by 112 | Submission Open

Keywords: snake envenomation; viper envenomation; antiviper serum; Europe; guidelines

(This special issue belongs to the Section Molecular Toxicology)

Molecular Design, Stabilization, and Controlled Delivery of Probiotics and Bioactive Compounds

edited by Chuang Zhang

submission deadline 30 Nov 2026 | Viewed by 108 | Submission Open

Keywords: probiotics; bioactive compounds; functional foods; microencapsulation; controlled delivery; food biopolymers; molecular interactions; bioavailability; gut microbiota; powder-based delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mesenchymal Stromal Cells Within the Tissue Microenvironment: Translational Research and Therapeutic Perspectives

edited by Francesco Agostini

submission deadline 30 Nov 2026 | Viewed by 66 | Submission Open

Keywords: mesenchymal stem cells; microenvironment; stem niche; cancer; drug delivery; good manufacturing practice; cell therapy; medium additive substitutes; microfluidic conditions; homing; migration; gene editing by (non-)viral methods

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Bladder Cancer

edited by

Hironobu Yamashita

submission deadline 1 Dec 2026 | 1 articles | Viewed by 830 | Submission Open

Keywords: urothelial carcinoma; molecular subtypes; tumor microenvironment (TME); epigenetics; precision medicine; chemoresistance

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Inflammation in Neurodegenerative Diseases

edited by

Selçuk Özdemir

submission deadline 1 Dec 2026 | Viewed by 196 | Submission Open

Keywords: neuroinflammation; neurodegenerative diseases; molecular pathways; neuronal cell death; mitochondrial dysfunction; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Stem Cells, Biomaterials, and Molecular Therapies in Plastic Surgery

edited by

Stefan D. Momčilović

submission deadline 5 Dec 2026 | 1 articles | Viewed by 558 | Submission Open

Keywords: stem cells; tissue engineering; biomaterials and bioactive scaffolds; hydrogels; 3D bioprinting; regenerative medicine and surgery; molecular therapies; growth factors; scar modulation; skin repair

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biological Applications, Theoretical Studies, Nanomedicine and Molecular Docking Studies in Drug Discovery

edited by

Moragot Chatatikun

submission deadline 10 Dec 2026 | 1 articles | Viewed by 1092 | Submission Open

Keywords: drug discovery; molecular docking; molecular dynamics; QSAR; nanomedicine; nanoparticles; virtual screening; natural products; in vivo validation; ADMET

(This special issue belongs to the Section Molecular Pharmacology)

Bioactivity of Resveratrol and Flavonoids as Antioxidant and Anti-Inflammatory Compounds: Molecular Insights

edited by

José Díaz-Chávez

submission deadline 10 Dec 2026 | 1 articles | Viewed by 991 | Submission Open

Keywords: resveratrol; flavonoids; polyphenols; antioxidant; anti-inflammatory; molecular mechanism; signal transduction; oxidative stress; gene expression; therapeutic agent

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 1701-1750 on page 35 of 64.

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