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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Advances in Cancer Therapy Through Nano-Based Systems

edited by

Lenuţa-Maria Şuta

and

Claudia Geanina Watz

submission deadline 31 Aug 2026 | Viewed by 250 | Submission Open

Keywords: nano-enabled delivery systems; innovative nanomaterials; smart nanocarriers; cancer nanotherapy; anti-tumorigenic activity

(This special issue belongs to the Section Molecular Nanoscience)

Nanocarrier-Based Drug Delivery Systems: Design, Synthesis and Therapeutic Applications

edited by

Stefania Crispi

and

Carla Serri

submission deadline 31 Aug 2026 | Viewed by 245 | Submission Open

Keywords: nanoparticles; nanomedicine; nanotoxicology; cytotoxicity; oxidative stress; cancer; neurodegenerative disorders; inflammation

(This special issue belongs to the Section Molecular Nanoscience)

Emerging Role of Heterogeneous Catalysis in Materials Science and Application

edited by Alejandro Pérez Larios and

Carlos Soto Robles

submission deadline 31 Aug 2026 | Viewed by 245 | Submission Open

Keywords: heterogeneous photocatalysis; photocatalytic materials; structure–property relationships; catalyst design; surface and interface engineering; operando characterization; charge transfer dynamics; sustainable photocatalysis; CO2 photoconversion; environmental photocatalysis

(This special issue belongs to the Section Materials Science)

The Exhaustive Chase: Investigation of Striated Muscle Regulation in Health and Disease

edited by P. Bryant Chase,

Maicon Landim-Vieira

and Michael Butcher

submission deadline 31 Aug 2026 | Viewed by 241 | Submission Open

Keywords: striated muscle contractility; thin filament regulation; calcium activation; cardiomyopathy; muscle energetics; muscle fiber mechanics; single fiber mechanics; muscle plasticity; muscle functional adaptation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Studies of Endothelial Dysfunction

edited by Alexandru Emil Caraba

submission deadline 31 Aug 2026 | Viewed by 241 | Submission Open

Keywords: atherosclerosis; cardiovascular diseases; chronic kidney disease; endothelial dysfunction; inflammation; inflammatory rheumatic diseases; metabolic syndrome; nailfold capillaroscopy; nitric oxide

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Determinants of Response and Resistance in Cancer Immunotherapy

edited by

Pamela Salman

submission deadline 31 Aug 2026 | Viewed by 240 | Submission Open

Keywords: immune checkpoint inhibitors; adoptive cell therapies; cancer vaccines; tumor microenvironment remodeling; neoantigen dynamics; biomarker discovery; translational approaches to overcome therapeutic resistance

(This special issue belongs to the Section Molecular Oncology)

Multi-Omics Perspectives on Psychiatric Disorders: From Molecular Mechanisms to Clinical Translation

edited by Veronica Sfredel and Madalina Iuliana Mușat

submission deadline 31 Aug 2026 | Viewed by 238 | Submission Open

Keywords: molecular psychiatry; psychiatric multi-omics; neurobiological pathways; psychiatric biomarkers; gene–environment interactions; translational psychiatry; computational psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

DNA Damage, Immune Signaling and Beyond

edited by

Sharbel Weidner Maluf

submission deadline 31 Aug 2026 | Viewed by 237 | Submission Open

Keywords: DNA damage response; immune signaling; genomic instability; cellular senescence; chronic inflammation; cancer and aging

(This special issue belongs to the Section Molecular Immunology)

Transition Metal Complexes: Recent Advances and Future Perspectives

edited by

Leszek Pazderski

submission deadline 31 Aug 2026 | Viewed by 235 | Submission Open

Keywords: transition metal complexes; crystal and molecular structure; spectroscopic properties; magnetic properties; biological activity; pharmacological application; catalysis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Recent Advances in Pathophysiology and Immunology Related to Lung Cancer

edited by

Vito D’Agnano

and Luigi Della Gravara

submission deadline 31 Aug 2026 | Viewed by 231 | Submission Open

Keywords: lung cancer; NSCLC; SCLC; tumor immunology; immune checkpoints inhibitors; targeted therapy; epithelial–immune crosstalk; precision oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research in Nutritional Physiology and Gut Microbiome

edited by

Haiqiang Yao

submission deadline 31 Aug 2026 | Viewed by 226 | Submission Open

Keywords: nutritional physiology; gut microbiome; microbial metabolites; nutrient sensing; metabolic homeostasis; gut–brain axis; prebiotics; probiotics; molecular nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Histamine Receptors: Biology, Pharmacology, and Therapeutic Potential

edited by

Joachim Neumann

submission deadline 31 Aug 2026 | Viewed by 222 | Submission Open

Keywords: histamine; histamine receptor agonist; histamine receptor antagonist; signal transduction; polymorphisms

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Insect-Symbiont Interactions

edited by Chen Luo

submission deadline 31 Aug 2026 | Viewed by 218 | Submission Open

Keywords: insect; endosymbiont; phenotypic effects; molecular mechanisms; immunity; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Photoreceptors and the Optic Nerve

edited by Ruth Estela Rosenstein and Damian Dorfman

submission deadline 31 Aug 2026 | Viewed by 217 | Submission Open

Keywords: photoreceptors; optic nerve; neurodegeneration; neuroprotection; experimental models; retina

(This special issue belongs to the Section Molecular Neurobiology)

Design, Synthesis and Evaluation of Anticancer Agents

edited by

Gourav Kumar

submission deadline 31 Aug 2026 | Viewed by 214 | Submission Open

Keywords: anticancer drug design; structure–activity relationship (SAR); molecular targets in cancer; synthetic antitumor agents; in vitro and ex vivo cancer models; molecular pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Allergen Prediction, Characterization, and Immunoinformatics

edited by

Katarina Smiljanić

submission deadline 31 Aug 2026 | Viewed by 204 | Submission Open

Keywords: allergen prediction; allergen characterization; proteomics; immunoinformatics; environmental allergens; food allergens; IgE epitopes; molecular docking; machine learning; mass spectrometry

(This special issue belongs to the Section Molecular Immunology)

Mechanistics Insights in Antidepressants: Charting New Pathways for Future Research

edited by Lucía Martínez-Mota

submission deadline 31 Aug 2026 | Viewed by 198 | Submission Open

Keywords: antidepressants; neuroplasticity; neurogenesis; neuronal excitability; treatment-resistant depression; major depression disorder

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in Endocannabinoid Research

edited by Elisabetta Murru

submission deadline 31 Aug 2026 | Viewed by 198 | Submission Open

Keywords: endocannabinoid system; N-acylethanolamine (NAE); CB1 and CB2 receptors; lipid mediators; nutrition; dietary fatty acids; energy metabolism; metabolic homeostasis; neuroinflammation

(This special issue belongs to the Section Biochemistry)

Glaucoma: From Molecular Mechanisms to Innovative Therapeutics

edited by Da-Wen Lu

submission deadline 31 Aug 2026 | Viewed by 197 | Submission Open

Keywords: neuroprotection; reinal ganglion cell; therapeutic strategies; Rho kinase inhibitor; molecular research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Deciphering the Cellular Antiviral and Anti-Inflammatory Signalling Orchestrated by Plant-Derived Bioactives

edited by

Maria Teresa Sciortino

submission deadline 31 Aug 2026 | Viewed by 192 | Submission Open

Keywords: immunological aspects of herpesvirus infections; role of PCD in pathogenesis of viral infections; functional studies of UL49 and UL41 structural proteins during HSV replication; involvement of ERK1 pathway in the modu-lation of CCR5 receptor; studies of cyclodextrin carriers as drug or nucleic acid delivery systems for cancer therapy; imaging for antiviral treatment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Human Papillomavirus and Cellular Pathway: Hits and Targets

edited by Elisa S. Gallo

submission deadline 31 Aug 2026 | Viewed by 190 | Submission Open

Keywords: human papillomavirus (HPV); squamous cell carcinoma (SCC); oncogenic HPV; HPV-induced SCC; skin cancer

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases

edited by

Debora Baroni

submission deadline 10 Sep 2026 | 7 articles | Viewed by 11046 | Submission Open

Keywords: genetic diseases; genotype–phenotype correlations; multi-omics approaches; current and investigational therapeutical approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cellular and Molecular Progression of Cardiovascular Diseases: 2nd Edition

edited by

Andrea Borghini

Antonio Rizza

and

Alessandro Tonacci

submission deadline 10 Sep 2026 | 5 articles | Viewed by 4015 | Submission Open

Keywords: cardiovascular diseases; multi-omics data; biomarkers; molecular level

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exercise in Health and Diseases: From the Molecular Perspectives

edited by

Nathalia Bernardes

and Danielle Dias

submission deadline 10 Sep 2026 | 4 articles | Viewed by 3329 | Submission Open

Keywords: exercise physiology; molecular mechanisms of exercise; exercise-induced cellular signaling; metabolic signaling pathways; redox biology and exercise

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Properties and Applications of Nanoparticles and Nanomaterials: 4th Edition

edited by Xiaogang Li

submission deadline 10 Sep 2026 | 1 articles | Viewed by 997 | Submission Open

Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Molecular and Cellular Advances in Coagulation and Bleeding

edited by

Muriel Meiring

submission deadline 10 Sep 2026 | 1 articles | Viewed by 932 | Submission Open

Keywords: thrombosis; haemostasis; inflammation-coagulation cross ralk; proteomics; molecular biomarkers

(This special issue belongs to the Section Molecular Biology)

Nanomaterials for Targeted Therapy and Drug Delivery

edited by Ceren Kimna

submission deadline 10 Sep 2026 | Viewed by 317 | Submission Open

Keywords: nanocarriers ; targeted therapies ; translational nanomedicine ; nano-bio interactions

(This special issue belongs to the Section Molecular Nanoscience)

Pain: From Bench to Bedside

edited by

Christopher Robinson

and Robert J. Yong

submission deadline 20 Sep 2026 | 1 articles | Viewed by 55574 | Submission Open

Keywords: CGRP pathway; chronic pain; drug discovery; ion channels; machine learning; molecular targets; neuroimmune signaling; non-opioid analgesics; translational pain research; Afrikaans; Albanian; Amharic; Arabic; Armenian; Azerbaijani; Bengali; Bulgarian; Catalan; Croatian; Czech; Danish; Dutch; English; Estonian; Finnish; French; German; Greek; Gujarati; Haitian Creole; Hebrew; Hindi; Hungarian; Icelandic; Indonesian; Italian; Japanese; Kannada; Kazakh; Khmer; Korean; Kurdish (Kurmanji); Lao; Latvian; Lithuanian; Malagasy; Malay; Malayalam; Maltese; Maori; Marathi; Myanmar (Burmese); Nepali; Norwegian; Pashto; Persian; Polish; Portuguese; Punjabi; Romanian; Russian; Samoan; Simplified Chinese; Slovak; Slovenian; Spanish; Swedish; Tamil; Telugu; Thai; Traditional Chinese; Turkish; Ukrainian; Urdu; Vietnamese; Welsh

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers

edited by Alessandra Bettiol

submission deadline 20 Sep 2026 | 13 articles | Viewed by 42763 | Submission Open

Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation

edited by

Masaru Tanaka

submission deadline 20 Sep 2026 | 6 articles | Viewed by 39125 | Submission Open

Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood–brain barrier; blood–cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites

edited by

Jen-Tsung Chen

submission deadline 20 Sep 2026 | 13 articles | Viewed by 32420 | Submission Open

Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights in Antibody Therapy

edited by

Loredana Frasca

submission deadline 20 Sep 2026 | 4 articles | Viewed by 20006 | Submission Open

Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease

(This special issue belongs to the Section Molecular Immunology)

Type 2 Diabetes: Molecular Pathophysiology and Treatment

edited by

Edit Szabó

submission deadline 20 Sep 2026 | 6 articles | Viewed by 18358 | Submission Open

Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Sep 2026 | 3 articles | Viewed by 16987 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Understanding Aging in Health and Disease

edited by

Laura Cianfruglia

submission deadline 20 Sep 2026 | 5 articles | Viewed by 16231 | Submission Open

Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging

(This special issue belongs to the Section Molecular Biology)

Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights

edited by

H. Ibrahim Korkmaz

submission deadline 20 Sep 2026 | 2 articles | Viewed by 15735 | Submission Open

Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies

(This special issue belongs to the Section Biochemistry)

Neurological Diseases: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Barbara Miziak

and

Stanisław Jerzy Czuczwar

submission deadline 20 Sep 2026 | 13 articles | Viewed by 14855 | Submission Open

Keywords: Alzheimer's disease; Parkinson's disease; Huntington's disease; epilepsy; stroke; neurological diseases; treatment of neurological diseases

(This special issue belongs to the Section Molecular Neurobiology)

25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics

edited by

Mihai V. Putz

Hyotcherl Ihee

and

Carlos Miguel Costa

submission deadline 20 Sep 2026 | 15 articles | Viewed by 14745 | Submission Open

Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Research of Dystonia and Parkinson’s Disease

edited by

Ryoma Morigaki

submission deadline 20 Sep 2026 | 4 articles | Viewed by 14390 | Submission Open

Keywords: dystonia; Parkinson’s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Computer-Aided Drug Design Strategies

edited by

Alexandre G. De Brevern

submission deadline 20 Sep 2026 | 3 articles | Viewed by 13825 | Submission Open

Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques

(This special issue belongs to the Section Molecular Informatics)

Latest Advances in Diabetes Research and Practice

edited by Ezekiel Uba Nwose

submission deadline 20 Sep 2026 | 9 articles | Viewed by 13694 | Submission Open

Keywords: diabetes mellitus; cardiovascular risk; metabolic syndrome; antioxidants; oxidative stress; antiplatelet monitoring; evidence-based medicine; laboratory medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cancer Drug Treatment and Cancer Cell Drug Resistance

edited by

Juan Sebastian Yakisich

submission deadline 20 Sep 2026 | 3 articles | Viewed by 13580 | Submission Open

Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Genetics, Epidemiology and Management of Myopathies

edited by

Efthimios Dardiotis

and

Vasileios Siokas

submission deadline 20 Sep 2026 | 2 articles | Viewed by 13417 | Submission Open

Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia

(This special issue belongs to the Section Molecular Biology)

Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways

edited by

Nadia Lampiasi

submission deadline 20 Sep 2026 | 4 articles | Viewed by 13232 | Submission Open

Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins, enzymes, ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Antibody Engineering and Therapeutic Applications

edited by

Yong-Seok Heo

submission deadline 20 Sep 2026 | 3 articles | Viewed by 13196 | Submission Open

Keywords: monoclonal antibody (mAb) therapies; antibody engineering; antibody-drug conjugate (ADC); chimeric antigen receptor T cell (CAR-T); bispecific antibody; T-cell engager (TCE); cancer immunotherapy; immunocytokine; AI-driven antibody design; antibody structure and mechanism of action

(This special issue belongs to the Section Molecular Pharmacology)

Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis

edited by Alberto Gajofatto

submission deadline 20 Sep 2026 | 5 articles | Viewed by 13155 | Submission Open

Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment

(This special issue belongs to the Section Molecular Neurobiology)

Inner Ear Disorders: From Molecular Mechanisms to Treatment

edited by

Srdjan Vlajkovic

submission deadline 20 Sep 2026 | 5 articles | Viewed by 13099 | Submission Open

Keywords: hearing loss; balance disorders; stem cell approaches; precision gene therapy; molecular reprogramming; targeted delivery systems; molecular biomarkers; suppression of oxidative stress and inflammation; tissue engineering; immune response and off-target effects

(This special issue belongs to the Section Molecular Immunology)

Inflammation in Pregnancy and Childbirth

edited by

Małgorzata Szczuko

and Maciej Ziętek

submission deadline 20 Sep 2026 | 2 articles | Viewed by 13026 | Submission Open

Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins, resolvins and protectins

(This special issue belongs to the Section Molecular Immunology)

Identification of Novel Biomarkers Towards Improved Diagnosis and Management of Peripheral Vascular Diseases

edited by

Daniel P. Zalewski

submission deadline 20 Sep 2026 | 7 articles | Viewed by 12647 | Submission Open

Keywords: vascular pathophysiology; peripheral atherosclerosis; aneurysm; venous disorders; congenital vascular malformations; molecular biomarkers; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Elucidating How Chondrocytes Maintain Cartilage Stability

edited by James A. Martin

submission deadline 20 Sep 2026 | 7 articles | Viewed by 11827 | Submission Open

Keywords: chondrocytes; articular cartilage; chondrogenesis; osteoarthritis; mechano-transduction; aging; extracellular matrix

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 351-400 on page 8 of 63.

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