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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomimetic Materials Applied in the Analytical and Biomedical Fields

edited by

Iacob Bogdan-Cezar

and

Ede Bodoki

submission deadline 20 Dec 2025 | 6 articles | Viewed by 20428 | Submission Open

Keywords: biomimetics; molecular recognition; imprinted polymers; smart materials; molecular complexes; polymeric biomaterials; biomedical materials; analytical methods; molecular interactions; artificial receptors

(This special issue belongs to the Section Materials Science)

Bacteriophages Biology and Bacteriophage-Derived Technologies

edited by Wilfried Moreira

submission deadline 20 Dec 2025 | 5 articles | Viewed by 20314 | Submission Open

Keywords: bacteriophage; antibiotic resistance; biofilm; molecular biology; genetic engineering; synthetic biology

(This special issue belongs to the Section Biochemistry)

Plant Biodiversity and Molecular Marker Technology: Discovery and Application of DNA Polymorphisms

edited by

Luigi De Masi

submission deadline 20 Dec 2025 | 13 articles | Viewed by 20094 | Submission Open

Keywords: plant biodiversity; plant genetic resources; genetic variability; molecular characterization; biomolecular resources; DNA-based molecular markers; DNA sequencing; next generation sequencing; biosequences; DNA polymorphisms; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Basis of Neuropsychiatric Disorders: Recent and Future Developments

edited by

Konstantinos Tsamakis

submission deadline 20 Dec 2025 | 5 articles | Viewed by 19699 | Submission Open

Keywords: molecular; schizophrenia; depression; genetic; autism; mechanisms; genetic

(This special issue belongs to the Section Molecular Neurobiology)

The Relationship, Mechanisms, and Treatment Strategies of Diabetes Mellitus and Related Diseases

edited by Maria Kokozidou

submission deadline 20 Dec 2025 | 6 articles | Viewed by 19635 | Submission Open

Keywords: diabetes mellitus; molecular mechanisms; related diseases; genetic basis; microRNAs; incretins; targeted therapies; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Bioactives and Inflammation, 2nd Edition

edited by

Juan Gambini

submission deadline 20 Dec 2025 | 6 articles | Viewed by 17420 | Submission Open

Keywords: inflammation; bioactive compounds; polyphenols; nutraceutical; diet; nutrition; pharmacology; health; lifespan; healthspan; aging; inflammaging

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Computational Approaches in Drug Design: Novel Methodologies and Applications

edited by

Serena Vittorio

submission deadline 20 Dec 2025 | 7 articles | Viewed by 16863 | Submission Open

Keywords: drug design; computational approaches; molecular docking; molecular dynamics; pharmacophore modeling; homology modeling; computer aided drug design; ADME/Tox predictions; artificial intelligence

(This special issue belongs to the Section Molecular Informatics)

Novel Molecular Mechanisms Underlying Tumorigenesis and Innovative Therapeutic Approaches for Cancer-Fighting, 3rd Edition

edited by

Annapina Russo

, Giulia Russo and

Annalisa Pecoraro

submission deadline 20 Dec 2025 | 8 articles | Viewed by 16617 | Submission Open

Keywords: cancer; nucleolus; nucleolar stress; tumorigenesis; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapeutic Approaches to Osteoarthritis

edited by

Masato Sato

submission deadline 20 Dec 2025 | 8 articles | Viewed by 16474 | Submission Open

Keywords: mode of action; molecular mechanisms; pathogenesis; drug delivery; disease-modifying drug; translational research; cell therapy; regenerative medicine

(This special issue belongs to the Section Molecular Pharmacology)

Impact of Diet on the Endocrine System: Insights into Cellular and Molecular Mechanisms

edited by

Gaia Favero

and

Luca Vanella

submission deadline 20 Dec 2025 | 3 articles | Viewed by 16470 | Submission Open

Keywords: antioxidants; diet; endocrine system; ROS; lifestyle; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights of Fungal and Plant Lipids: Structural Diversity, Metabolism and Applications

edited by

Ekaterina Kotlova

submission deadline 20 Dec 2025 | 7 articles | Viewed by 16350 | Submission Open

Keywords: lipidomics; fatty acids; glycerolipids; sphingolipids; sterols; oxylipins; fungal and plant lipid metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

Updates on Synthetic and Natural Antioxidants

edited by

Izabela Sadowska-Bartosz

and

Grzegorz Bartosz

submission deadline 20 Dec 2025 | 9 articles | Viewed by 16078 | Submission Open

Keywords: antioxidants; synthetic; natural compounds

(This special issue belongs to the Section Biochemistry)

Role of Natural Compounds in Human Health and Disease

edited by Jaewon Shim and

Wook-bin Lee

submission deadline 20 Dec 2025 | 8 articles | Viewed by 16006 | Submission Open

Keywords: natural compound; therapeutic applications; action mechanisms of natural compounds; traditional medicine

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research on HIV Virus and Infection

edited by

Patricia Price

submission deadline 20 Dec 2025 | 5 articles | Viewed by 15869 | Submission Open

Keywords: HIV; viral proteins; immunogenetics; pathogenesis

(This special issue belongs to the Section Molecular Immunology)

The Importance of Molecular Circadian Rhythms in Health and Disease

edited by

Telma Quintela

and

Diana Rita Barata Costa

submission deadline 20 Dec 2025 | 6 articles | Viewed by 15799 | Submission Open

Keywords: molecular clock; circadian dysfunction; health; chronotherapy; circadian rhythms

(This special issue belongs to the Section Molecular Biology)

Recombinant Proteins, Protein Folding and Drug Discovery

edited by

Mohamed Raafat El-Gewely

submission deadline 20 Dec 2025 | 7 articles | Viewed by 15658 | Submission Open

Keywords: heterologous hosts for gene expression; recombinant therapeutic proteins; antigens; and antibodies; large scale production of recombinant proteins; recombinant protein bioreactor; downstream processing of recombinant proteins; codon optimization for protein expression; refolding of misfolded recombinant proteins; solubilization of aggregated and inclusion bodies of recombinant proteins; protein target validation for drug discovery and development; protein target expression for drug discovery and development; metabolic engineering of recombinant protein production; regulatory noncoding RNAs to boost the expression of protein; the use of foldases & conformases in recombinant protein expression; delivery of therapeutic proteins; therapeutic protein Vs mRNA therapeutics

(This special issue belongs to the Section Biochemistry)

Current Research on Bioactives from Natural Products

edited by

Carmen Lizette Del-Toro-Sánchez

submission deadline 20 Dec 2025 | 5 articles | Viewed by 15602 | Submission Open

Keywords: antioxidants; molecular models; natural products; bioactive compounds; food; materials; antimicrobials; mechanisms of action; extraction techniques; health benefits

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapies in Skeletal Muscle Diseases

edited by Valeria Guglielmi

submission deadline 20 Dec 2025 | 4 articles | Viewed by 15477 | Submission Open

Keywords: skeletal muscle; skeletal muscle diseases; pathogenesis; molecular mechanism; muscle degeneration; muscle regeneration; myokines; cell therapy; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mass Spectrometry Approaches as Clinical Diagnostic/Prognostic Tools

edited by

Federica Iavarone

submission deadline 20 Dec 2025 | 2 articles | Viewed by 15412 | Submission Open

Keywords: mass spectrometry; quantitative analysis; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Immunity and Inflammation in Cardiovascular Diseases

edited by

David J. Vigerust

submission deadline 20 Dec 2025 | 6 articles | Viewed by 14980 | Submission Open

Keywords: pathogens; oxidative stress; cytokines; chemokines; immunity; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

(Meta)Genomic, Functional, Structural and Evolutionary Analysis of Transport Systems

edited by

Arturo Medrano-Soto

, Milton Saier and Gabriel Moreno-Hagelsieb

submission deadline 20 Dec 2025 | 3 articles | Viewed by 14610 | Submission Open

Keywords: molecular transport; transport mechanisms; evolution; families and superfamilies; genomics; metagenomics; 3D structural insights; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Molecular Targets for Treatment and Drug Delivery in Tumors

edited by

Emily Capone

submission deadline 20 Dec 2025 | 11 articles | Viewed by 14264 | Submission Open

Keywords: targeted therapy; tumor; molecular target; drug delivery; drug design

(This special issue belongs to the Section Molecular Oncology)

Plant Genome Editing

edited by Lei Gao

submission deadline 20 Dec 2025 | 5 articles | Viewed by 13986 | Submission Open

Keywords: plant genome editing; Cas9/Cas12a; CRISPR/CRISPRa/CRISPRi; anti-CRISPR; gene editing; off target impact; prime editing; bioinformatics/database

(This special issue belongs to the Section Molecular Plant Sciences)

Biomarkers and Early Detection Strategies of Ovarian Tumors

edited by Lukasz Szafron

submission deadline 20 Dec 2025 | 7 articles | Viewed by 13833 | Submission Open

Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment

(This special issue belongs to the Section Molecular Oncology)

Breast Cancer: From Pathophysiology to Novel Therapies

edited by Jennifer Sims-Mourtada

submission deadline 20 Dec 2025 | 7 articles | Viewed by 13646 | Submission Open

Keywords: breast cancer; genetics; tumor microenvironment; model systems; organoids; immune cells; tumor stroma; therapeutic resistance; novel therapies

(This special issue belongs to the Section Molecular Oncology)

In Honor of Elie Metchnikoff, a Nobel Prize Winner, Who Discovered Macrophages as Phagocyte Cells Involved in the Process of Innate Immunity

edited by

Pierre Tennstedt

submission deadline 20 Dec 2025 | 5 articles | Viewed by 12915 | Submission Open

Keywords: macrophages; monocytes; phagocytes; fibroblast; cytokines; chronic disease; autoimmune disease; inflammatory disease; immune response; disease treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Primary and Secondary Bladder Disorders in Neurourology and Inflammatory Diseases

edited by

Wei-Chia Lee

and

Yung-Shun Juan

submission deadline 20 Dec 2025 | 6 articles | Viewed by 12397 | Submission Open

Keywords: bladder ischemia; bladder pain syndrome; interstitial cystitis; irradiation cystitis; ketamine cystitis; microbiota; overactive bladder; underactive bladder; botulinum toxin for bladder disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Natural Products in Drug Discovery

edited by

Luciana Scotti

and

Marcus Tullius Scotti

submission deadline 20 Dec 2025 | 7 articles | Viewed by 11933 | Submission Open

Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry

(This special issue belongs to the Section Molecular Pharmacology)

RNA Vaccines and Therapeutics: Challenges and Opportunities

edited by

Seong-Wook Lee

submission deadline 20 Dec 2025 | 3 articles | Viewed by 11169 | Submission Open

Keywords: RNA-based therapy; RNA vaccine; mRNA; circRNA; saRNA; non-coding RNA/sRNA; microRNA/siRNA/antisense RNA; RNA aptamer; ribozyme; RNA editing/genome editing

(This special issue belongs to the Section Molecular Pharmacology)

Topoisomerase Inhibitors: Future Perspectives and Challenges

edited by

Ben Bax

and Mark Mitton-Fry

submission deadline 20 Dec 2025 | 3 articles | Viewed by 10947 | Submission Open

Keywords: antibiotic; topoisomerase; inhibitor; anticancer; resistance; safety

(This special issue belongs to the Section Molecular Pharmacology)

Targeting Glioblastoma Metabolism

edited by

José M. Matés

and

José Ángel Campos Sandoval

submission deadline 20 Dec 2025 | 4 articles | Viewed by 10888 | Submission Open

Keywords: glioblastoma; metabolic heterogeneity; metabolic reprogramming; cancer stem cells; therapeutic resistance; metabolic vulnerabilities; IDH1/2 mutations; tumor microenvironment; epigenetic regulation

(This special issue belongs to the Section Molecular Oncology)

Phytochemicals of Natural Products: Source, Analysis, and Bioactivities

edited by

Yu-Kuo Chen

, Chi-I Chang and Chi-Chien Lin

submission deadline 20 Dec 2025 | 5 articles | Viewed by 10832 | Submission Open

Keywords: phytochemicals; bioactive compounds; natural products; bioactivities; purification; chemoprevention; chemotherapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genetic Engineering of Plants for Stress Tolerance, Second Edition

edited by

Moxian Chen

submission deadline 20 Dec 2025 | 7 articles | Viewed by 10784 | Submission Open

Keywords: CRISPR-Cas system; RNA interference; abiotic and biotic stresses; transcriptional regulation; post-transcriptional regulation; post-translational modification; genetic evolution; biotechnology; molecular mechanisms; regulatory circuits

(This special issue belongs to the Section Molecular Plant Sciences)

Biomarker Discovery and Validation for Precision Oncology

edited by

Luís Lima

submission deadline 20 Dec 2025 | 5 articles | Viewed by 10733 | Submission Open

Keywords: biomarker discovery; biomarker validation; precision oncology; cancer screening; cancer diagnostics; liquid biopsy; multi-omics integration; targeted therapies; immunotherapy biomarkers; translational cancer research

(This special issue belongs to the Section Molecular Oncology)

Atherosclerosis: From Molecular Mechanisms, Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Antonio Barbato

submission deadline 20 Dec 2025 | 3 articles | Viewed by 10538 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and New Therapy in Melanoma and Other Skin Cancers: 2nd Edition

edited by

Rüdiger Greinert

submission deadline 20 Dec 2025 | 4 articles | Viewed by 10469 | Submission Open

Keywords: epigenetics; cancer stem cells; noncoding RNA (miRNA); personalized diagnostic (medicine); personalized medicine; DNA repair; skin cancer biomarker; skin cancer prevention; genomics; transcriptomics; immunomodulation; ctDNA; circulating tumor cells; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Advances in Molecular Modeling, Docking and Simulations of Protein Structure, 2nd Edition

edited by

Lorant Janosi

submission deadline 20 Dec 2025 | 5 articles | Viewed by 10426 | Submission Open

Keywords: molecular modeling; protein structure; molecular mechanisms; protein interactomics; ligand design; peptides; molecular dynamics; molecular docking

(This special issue belongs to the Section Macromolecules)

Nutrition as a Tool for Modulating Cellular Metabolism

edited by

Francesca Oppedisano

Anna Spagnoletta

and

Salvatore Nesci

submission deadline 20 Dec 2025 | 2 articles | Viewed by 10140 | Submission Open

Keywords: cell metabolism; mitochondria; ROS; RNS; proliferation and cell death; metabolic pathways; transporters; natural compounds; bioactive molecules; novel foods; metabolic diseases; human pathology

(This special issue belongs to the Section Biochemistry)

Molecular Research in Infective Mycobacteria

edited by

Giovanni Stelitano

submission deadline 20 Dec 2025 | 5 articles | Viewed by 10130 | Submission Open

Keywords: infections; mycobacteria; molecular biology; antimicrobials; bacteria biochemistry

(This special issue belongs to the Section Molecular Microbiology)

The Role of Enzymes in Metabolic Processes

edited by

Koichi Fujisawa

submission deadline 20 Dec 2025 | 4 articles | Viewed by 10087 | Submission Open

Keywords: enzyme; metabolism; glycolysis; mitochondria; kinase; cell growth; carcinogenesis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases

edited by

Eugenia Piragine

submission deadline 20 Dec 2025 | 5 articles | Viewed by 9596 | Submission Open

Keywords: sulfur compounds; sulfur metabolism; hydrogen sulfide; H2S-donors; human health; human disease; nutraceuticals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

High Resolution Mass Spectrometry in Molecular Sciences: 2nd Edition

edited by

Laszlo Prokai

submission deadline 20 Dec 2025 | 4 articles | Viewed by 9380 | Submission Open

Keywords: antibodies; astrobiology; biomarkers; drug discovery; drug development; drug metabolism; Fourier transform; glycomics; imaging; ion cyclotron resonance; ion mobility; lipids; lipidomics; mass spectrometry; metabolomics; nucleic acids; Orbitrap; organometallics; polymers; peptides; proteins; proteomics; structural biology; structure elucidation; tandem mass spectrometry; time-of-flight

(This special issue belongs to the Section Biochemistry)

Lymphatic Disorders: From Molecular Mechanisms to Therapies

edited by

Laura Patton

submission deadline 20 Dec 2025 | 4 articles | Viewed by 9300 | Submission Open

Keywords: lymphoedema; lipedema; matrix; vascular disorder; ultrasound; lacteal; microbiota; intersitial fluid

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Recognition and Biosensing

edited by

Longjiao Zhu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 9220 | Submission Open

Keywords: molecular recognition; biosensor; nanomaterials; aptamer; nucleic acids; sensitivity

(This special issue belongs to the Section Biochemistry)

Genetic Research in Neurological Diseases

edited by

Eva Bagyinszky

submission deadline 20 Dec 2025 | 2 articles | Viewed by 9206 | Submission Open

Keywords: neurodegenerative diseases; genetic risk factor; next-genetation sequencing; genome-wide association studies; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Diabetes: Advances in Molecular Research

edited by

Alexandra E. Butler

and

Stephen Atkin

submission deadline 20 Dec 2025 | 3 articles | Viewed by 9174 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; retinopathy; nephropathy; neuropathy; molecular pharmacology; cardiovascular disease; cerebrovascular disease; normal physiology; counter-regulatory hormones; hypoglycemia TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathophysiology of Hair Loss

edited by

Kwang-Hyun Park

submission deadline 20 Dec 2025 | 1 articles | Viewed by 9108 | Submission Open

Keywords: Hair Loss; Pathophysiology; Molecular Mechanisms; Genetic Mutations; Signaling Pathways; Nutrient Interactions; Personalized Therapies; Targeted Drug Delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Nucleic Acids: Therapeutic Potential and Applications, 2nd Edition

edited by

Veronica Esposito

and

Antonella Virgilio

submission deadline 20 Dec 2025 | 5 articles | Viewed by 9088 | Submission Open

Keywords: aptamer; decoy; DNAzyme; ribozyme; siRNA; miRNA; antisense oligonucleotide; antigene strategy; G-quadruplex; triplex

(This special issue belongs to the Section Biochemistry)

Nonalcoholic Liver Disease: Mechanisms, Prevention, and Treatment

edited by

Stefania Grimaudo

and

Rosaria Maria Pipitone

submission deadline 20 Dec 2025 | 3 articles | Viewed by 8785 | Submission Open

Keywords: MAFLD; MASH; metabolic syndrome; steatosis; lipid droplets; SNPs; GWAS; therapeutc target; fatty liver; steatohepatitis; HCC; EpigEnetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into Redox Homeostasis and Oxidative Stress

edited by

Dimitrios Kouretas

, Zoi Vasiliki Skaperda and

Fotios Tekos

submission deadline 20 Dec 2025 | 4 articles | Viewed by 8647 | Submission Open

Keywords: oxidative stress; redox homeostasis; redox signaling; reactive oxygen species; oxidative damage; diseases

(This special issue belongs to the Section Molecular Pharmacology)

Displaying special issue 501-550 on page 11 of 69.

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