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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Green Gold: Microalgae as a Sustainable Source of Nutrients and Bioactive Compounds

edited by

Blanca Hernández-Ledesma

and Pilar Gómez-Cortés

submission deadline 31 Jan 2027 | 1 articles | Viewed by 930 | Submission Open

Keywords: microalgae; sustainable nutrition; bioactive compounds; functional foods; nutraceuticals; alternative proteins; phycochemistry; circular bioeconomy; biorefinery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Retinal Degeneration: From Pathophysiology to Therapeutic Approaches—4th Edition

edited by

Jan Wijnholds

submission deadline 31 Jan 2027 | 1 articles | Viewed by 925 | Submission Open

Keywords: hereditary retinal disease; retinal inflammation; retinal gene augmentation, editing, optogenetics and splice modulation therapy; natural history studies of the retina; human iPSC-derived retinal organoids and retinal pigment epithelium; retinal iPSC-derived cell therapy; retinal pathology; pre- and clinical gene therapy; animal models for retinal dystrophy; retinal imaging; retina-on-a-chip

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Surfactants: Design, Synthesis and Properties

edited by

Joanna Krawczyk

submission deadline 31 Jan 2027 | 1 articles | Viewed by 914 | Submission Open

Keywords: design and synthesis of surfactants; adsorption and aggregation properties of surfactants; behavior of surfactants at different interfaces; application of biosurfactants and specialist surfactants (industry, agriculture, medicine, pharmacy)

(This special issue belongs to the Section Materials Science)

Latest Advances in Targeted Molecular Therapies for Genetic Disease

edited by Viorica-Elena Rădoi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 908 | Submission Open

Keywords: genetic diseases; precision medicine; gene editing; RNA-based therapeutics; genomic profiling; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Small Molecules in Tissue Repair and Regeneration

edited by

Ildiko Bock-Marquette

submission deadline 31 Jan 2027 | 1 articles | Viewed by 881 | Submission Open

Keywords: small molecules; organ and tissue regeneration; development; aging

(This special issue belongs to the Section Molecular Biology)

Molecular Research and Insights in Rapeseed Abiotic Stress

edited by

Ahsan Ayyaz

submission deadline 31 Jan 2027 | 1 articles | Viewed by 875 | Submission Open

Keywords: rapeseed (Brassica napus); abiotic stress; drought tolerance; salinity stress; heavy metal toxicity; molecular mechanisms; stress signaling; omics (transcriptomics, proteomics, metabolomics); molecular breeding; CRISPR-Cas9; stress-responsive genes; hormone cross-talk; epigenetic regulation; stress resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Materials for Biomedical Applications and Uses

edited by

Magdalena Laskowska

submission deadline 31 Jan 2027 | 1 articles | Viewed by 874 | Submission Open

Keywords: functional materials; nanomaterials; biomedical applications; molecular engineering

(This special issue belongs to the Section Materials Science)

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutic Tools in Chronic Diseases

edited by

Elena Grossini

submission deadline 31 Jan 2027 | 1 articles | Viewed by 839 | Submission Open

Keywords: cell-free therapy; exosomes; immunomodulation; molecular mechanisms; regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Supramolecular Liquid Crystal Compounds—from Molecular Design to Functional Materials

edited by

Katarzyna Merkel

submission deadline 31 Jan 2027 | Viewed by 830 | Submission Open

Keywords: supramolecular; self-assembled; liquid crystal; hydrogen bonding

(This special issue belongs to the Section Materials Science)

Research Progress on Photosensitizers and Photodynamic Therapy

edited by

Michal Heger

submission deadline 31 Jan 2027 | Viewed by 817 | Submission Open

Keywords: photodynamic therapy; photosensitizers; tumor microenvironment; nanotechnology; immunotherapy; targeted drug delivery; reactive oxygen species; hypoxia; combination therapy; molecular mechanisms

(This special issue belongs to the Section Biochemistry)

Vector–Pathogen–Host Interaction, Vaccines and Immunobiologicals

edited by Carlo José Freire Oliveira and

Marcos Vinícius Da Silva

submission deadline 31 Jan 2027 | 1 articles | Viewed by 816 | Submission Open

Keywords: host–pathogen–vector interactions; active biomolecules; immunomodulation; vaccines; binding molecules; immunobiologicals

(This special issue belongs to the Section Molecular Immunology)

Molecular and Systems Mechanisms of Neural Circuit Function and Plasticity

edited by

Hyunjung Oh

submission deadline 31 Jan 2027 | 1 articles | Viewed by 797 | Submission Open

Keywords: neural circuits; neuroplasticity; synaptic organization; brain aging; mood disorders; neurodegenerative disorders; cognitive function

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Stroke: Biomarkers and Mechanisms

edited by Jae Sang Oh

submission deadline 31 Jan 2027 | 1 articles | Viewed by 795 | Submission Open

Keywords: stroke; glymphatic system; biomarkers; human-derived specimens; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Crossroads of Autoimmunity, Inflammatory Diseases, and Cancer

edited by

Xuming Mao

submission deadline 31 Jan 2027 | 1 articles | Viewed by 794 | Submission Open

Keywords: autoimmune disorders; tumor microenvironment; chronic inflammation; immune checkpoint inhibitors; machine learning; epidemiology

(This special issue belongs to the Section Molecular Immunology)

Diverse Molecular Mechanisms of Berberine Action—Identifying Potential Targets and Therapeutic Potential

edited by

Dariusz Szukiewicz

submission deadline 31 Jan 2027 | 1 articles | Viewed by 781 | Submission Open

Keywords: berberine; isoquinoline alkaloid; AMPK activator; natural compound; metabolic syndrome; wieight loss; antioxidant effects; anti-inflammatory effects; antitumor activity; neuroprotection

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Identification of Molecular Biomarkers Through Digital Pathology

edited by

Rafael Parra-Medina

submission deadline 31 Jan 2027 | 1 articles | Viewed by 766 | Submission Open

Keywords: digital pathology; molecular biomarkers; computational pathology; artificial intelligence; deep learning; spatial biology; multi-omics integration; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular Basis of Vascular Pathology: 2nd Edition

edited by

Jolanta Neubauer-Geryk

submission deadline 31 Jan 2027 | 1 articles | Viewed by 742 | Submission Open

Keywords: vascular pathologies; blood vessels; dysfunction; vascular damage; blood flow; biomarkers; biomolecules; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Innovations in Urological Cancers

edited by Michele Marchioni,

Luigi Schips

and Angelo Cafarelli

submission deadline 31 Jan 2027 | 1 articles | Viewed by 715 | Submission Open

Keywords: urological cancers; molecular pathways; precision oncology; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Mechanisms and Therapeutics in Neurological Diseases—5th Edition

edited by

Barbara Mroczko

submission deadline 31 Jan 2027 | 1 articles | Viewed by 693 | Submission Open

Keywords: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Agricultural Hydrology: Plant-Soil-Water Interactions

edited by

Muhammad Bilal Khan

submission deadline 31 Jan 2027 | Viewed by 666 | Submission Open

Keywords: soil–plant–water system; agricultural hydrology; water-use efficiency; root water uptake; rhizosphere interactions; biogeochemical cycling; ecosystem functioning; climate change impacts; wastewater treatment

(This special issue belongs to the Section Molecular Plant Sciences)

Immunoregulatory Mechanisms of Gut Microbiota

edited by

José Fachi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 653 | Submission Open

Keywords: gut microbiota; mucosal immunity; host–microbe interactions; immune homeostasis; dysbiosis; microbial metabolites; short-chain fatty acids; barrier function; colitis

(This special issue belongs to the Section Molecular Microbiology)

Advances in Computational Drug Design and Molecular Modeling

edited by Ana C Stucki-Mafud

submission deadline 31 Jan 2027 | Viewed by 634 | Submission Open

Keywords: preclinical phase of drug development; computer-aided drug design; artificial intelligence; machine learning; deep learning; structure-based drug design; ligand-based drug design; virtual screening; pharmacophore modeling; molecular modeling

(This special issue belongs to the Section Molecular Informatics)

Aptamers in Cancer Therapy: Mechanisms, Applications, and Translational Perspectives

edited by

Gabor István Csonka

submission deadline 31 Jan 2027 | Viewed by 623 | Submission Open

Keywords: aptamers; targeted drug delivery; cancer immunotherapy; molecular imaging; biomarkers; precision oncology; SELEX; theranostics; translational oncology; mechanistic insights

(This special issue belongs to the Section Molecular Oncology)

Progress of Novel Biomarkers and Molecular Targets in Cancer

edited by

Pietro Tralongo

submission deadline 31 Jan 2027 | 1 articles | Viewed by 616 | Submission Open

Keywords: cancer biomarkers; molecular targets; precision oncology; molecular pathology; translational oncology; next-generation sequencing; liquid biopsy; tumor microenvironment; predictive biomarkers; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Translational Pharmacology of GLP-1 Receptor Agonists Beyond Metabolic Diseases

edited by

Carlos-Alberto Calderon-Ospina

submission deadline 31 Jan 2027 | 1 articles | Viewed by 616 | Submission Open

Keywords: GLP-1 receptor agonists; translational pharmacology; neuroprotection; pleiotropic effects; inflammation; neuropsychiatric disorders; addiction; obstructive sleep apnea; energy balance; pharmacokinetics; cardiovascular protection

(This special issue belongs to the Section Molecular Pharmacology)

Valorization of Lignocellulosic Biomass: 2nd Edition

edited by

Haishun Du

submission deadline 31 Jan 2027 | Viewed by 606 | Submission Open

Keywords: lignocellulosic biomass; biorefinery; biomass conversion; bioenergy; biofuels; bioproducts; platform chemicals; cellulose nanomaterials; lignin nanoparticles; functional materials

(This special issue belongs to the Section Materials Science)

Current Research on the Molecular and Cellular Mechanisms of Cancer

edited by Seungbaek Lee

submission deadline 31 Jan 2027 | 1 articles | Viewed by 606 | Submission Open

Keywords: cancer biology; molecular oncology; tumor microenvironment; therapeutic resistance; precision oncology

(This special issue belongs to the Section Molecular Biology)

Cancer Drugs That Target Epigenetic Processes

edited by Eileen Brantley

submission deadline 31 Jan 2027 | 1 articles | Viewed by 602 | Submission Open

Keywords: histone modifications; non-coding RNA; DNA methylation; cancer agents

(This special issue belongs to the Section Molecular Oncology)

Emerging Roles of Extracellular Vesicles in Neurological Diseases

edited by Anudeep Yekula

submission deadline 31 Jan 2027 | Viewed by 602 | Submission Open

Keywords: extracellular vesicles; exosomes; neurological diseases; liquid biopsy; neurodegeneration; neuro-oncology; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Antimicrobial Materials: Molecular Design, Mechanism of Action and Applications

edited by

Katsuaki Dan

submission deadline 31 Jan 2027 | 1 articles | Viewed by 588 | Submission Open

Keywords: bacteria; viruses; antimicrobial materials; molecular design; action mechanism; social implementation; antimicrobial resistance; synergistic effects; infectious diseases; anti-inflammatory diseases

(This special issue belongs to the Section Materials Science)

Nanoparticles in Nanobiotechnology and Nanomedicine: 3rd Edition

edited by

Costica Caizer

submission deadline 31 Jan 2027 | Viewed by 586 | Submission Open

Keywords: nanoparticles; properties of nanoparticles; methods of obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Bioactive Peptides: Microbial Fermentation-Driven Synthesis and Multifunctional Applications in Health and Industry

edited by

Yongjun Wei

submission deadline 31 Jan 2027 | Viewed by 577 | Submission Open

Keywords: bioactive peptides; foods; probiotics; fermentation; pharmaceutical; herbs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Genomics and Genome Editing, 3rd Edition

edited by

Hikmet Budak

submission deadline 31 Jan 2027 | Viewed by 564 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Strategies and Visions for Nano- and Molecular-Design Materials in Future Photovoltaic Applications

edited by

Ivana Validžić

submission deadline 31 Jan 2027 | 1 articles | Viewed by 563 | Submission Open

Keywords: novel photovoltaic materials; semiconductors; perovskites; organic materials; dye-sensitized materials; bio-based materials; advanced materials; innovative energy materials

(This special issue belongs to the Section Materials Science)

Genetic and Molecular Mechanisms in Neurological Diseases

edited by Serena Barral

submission deadline 31 Jan 2027 | Viewed by 549 | Submission Open

Keywords: neurological diseases; genetic mechanisms; molecular pathways; human neuronal models; brain organoids; iPSC-derived neural cells; neurodevelopment and neurodegeneration; disease modeling; human in vitro systems; genotype-phenotype relationships

(This special issue belongs to the Section Molecular Neurobiology)

Maternal–Fetal Immunity and Antibody Transfer: Molecular Mechanisms and Clinical Implications

edited by

Vasileios Giapros

and Aikaterini Nikolaou

submission deadline 31 Jan 2027 | 1 articles | Viewed by 548 | Submission Open

Keywords: maternal immunization; transplacental antibody transfer; neonatal immunity; FcRn; antibody glycosylation; placental immunology; Fc-mediated effector functions; maternal–fetal immunity; passive immunity

(This special issue belongs to the Section Molecular Immunology)

Novel Therapeutic Strategies for Cystic Fibrosis

edited by Hartmut Grasemann and

Dominik Funken

submission deadline 31 Jan 2027 | 1 articles | Viewed by 539 | Submission Open

Keywords: cystic fibrosis; CFTR modulators; gene therapy; airway inflammation; antimicrobial therapy; biomarkers; mucus; extrapulmonary disease; clinical trials; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Kidney Diseases: Molecular Mechanisms and Therapies

edited by

George J. Dugbartey

submission deadline 31 Jan 2027 | 1 articles | Viewed by 535 | Submission Open

Keywords: kidney diseases; pathophysiology; molecular mechanisms; therapeutic targets; acute kidney injury; chronic kidney disease; polycystic kidney disease; end-stage renal disease; IgA nephropathy; diabetic nephropathy; hypertensive nephropathy; renal cancer; kidney infarction; kidney infection; kidney failure; kidney stones; renal tubular acidosis; renal artery stenosis; acute tubular necrosis; glomerulopathy; interstitial nephritis; nephrotic syndrome; simple kidney cyst

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Environmental Contaminants and Health: Biological Effects, Molecular Mechanisms, and Protective Strategies

edited by

Massimo Venditti

and

Gabriella Chieffi Baccari

submission deadline 31 Jan 2027 | 1 articles | Viewed by 532 | Submission Open

Keywords: environmental contaminants; environmental exposure; health effects; cellular responses; oxidative stress; inflammation; epigenetics; non-coding RNAs; biomarkers; protective strategies

(This special issue belongs to the Section Molecular Toxicology)

Physiological and Molecular Responses of Plants to Drought Stress

edited by

Muhammad Waseem

submission deadline 31 Jan 2027 | Viewed by 530 | Submission Open

Keywords: drought stress; photosynthesis; stomatal regulation; signal transduction; phytohormones; anti-oxidants

(This special issue belongs to the Section Molecular Plant Sciences)

Research Advances in Reproductive Biology

edited by Karl Kerns

submission deadline 31 Jan 2027 | 1 articles | Viewed by 529 | Submission Open

Keywords: reproductive biology; fertility; infertility; gametogenesis; fertilization; embryo development; reproductive endocrinology; reproductive health; epigenetics; single-cell omics

(This special issue belongs to the Section Molecular Biology)

Osteoimmunology and Drug Discovery: Molecular Mechanisms, Bone Resorption Pathways and Therapeutic Opportunities

edited by

Vishwa Deepak

submission deadline 31 Jan 2027 | 1 articles | Viewed by 509 | Submission Open

Keywords: osteoimmunology; osteoclasts; bone resorption; drug discovery; inflammation; RANKL; NF-κB; NFATc1; natural products; bone therapeutics

(This special issue belongs to the Section Molecular Immunology)

Recent Progress in Nanomedicine for Cancer Therapy

edited by Peisheng Xu

submission deadline 31 Jan 2027 | Viewed by 506 | Submission Open

Keywords: nanomedicine; cancer-targeted therapy; theragnostic; nanodevice

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Male Infertility and Fertility

edited by

Mariaimmacolata Preianò

submission deadline 31 Jan 2027 | Viewed by 504 | Submission Open

Keywords: male infertility; infertility treatment; omics approaches; proteomics; metabolomics; lipidomics; mass spectrometry; signaling pathways; biomarker discovery; reproductive medicine; precision medicine; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Chronic Obstructive Pulmonary Disease (COPD): From Pathogenesis to Therapeutic Response

edited by

Bassam Redwan

submission deadline 31 Jan 2027 | 1 articles | Viewed by 504 | Submission Open

Keywords: COPD; emphysema; pulmonary endothelium; inhaled corticosteroids; β2-agonists; oxidative stress; efferocytosis; airway inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Eukaryotic Cells Under Stress: Biochemical and Physiological Mechanisms of Resistance and Resilience

edited by

Bruno Hay Mele

and

Carmen Arena

submission deadline 31 Jan 2027 | Viewed by 498 | Submission Open

Keywords: cellular stress response; oxidative stress; bioactive compounds; ROS; DNA damage/repair; environmental stressors; molecular chaperones; antioxidant in human diseases

(This special issue belongs to the Section Molecular Biology)

Transcriptional Reprogramming and Metabolic Plasticity in the Tumor Microenvironment: Implications for Immune Evasion and Therapeutic Resistance

edited by

Inhak Choi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 488 | Submission Open

Keywords: transcriptional reprogramming; epigenetic regulation; metabolic plasticity; immunometabolism; tumor microenvironment; cellular heterogeneity; immune evasion; T cell exhaustion; therapeutic resistance; single-cell omics; spatial transcriptomics; precision immunotherapy; biomarker discovery

(This special issue belongs to the Section Molecular Oncology)

3D Printing in Pharmaceutical Drug Delivery

edited by

Sagar Narala

and

Dinesh Nyavanandi

submission deadline 31 Jan 2027 | Viewed by 485 | Submission Open

Keywords: personalized medication; 3-dimensional printing; solubility and bioavailability enhancement; polymers for 3D printing; bio-inks; 3D-printed implants; additive manufacturing

(This special issue belongs to the Section Molecular Pharmacology)

Stress Signaling and Horticultural Crops Quality Control

edited by