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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oxidative Stress and Glutathione Content in Liver Diseases: Innovative Signaling Pathways and Molecular Mechanisms submission deadline 31 Mar 2026 | Viewed by 126 | Submission Open
Keywords: oxidative stress; glutathione; MASLD; MASH; hepatic infections
(This special issue belongs to the Section Molecular Biology)
Exploring Natural Products for Cancer
edited by Ana Carolina Gonçalves
submission deadline 31 Mar 2026 | Viewed by 115 | Submission Open
Keywords: natural products; plant-derived compounds; phenolic compounds; pharmacodynamics; pharma-cokinetics; antioxidant capacities; cancer; oxidative stress-related disorders; in vivo assays; in vitro assays; clinical assays; mechanisms of differentiation; tissue homeostasis
(This special issue belongs to the Section Molecular Oncology)
Pain Pathways Rewired: Moving past Peripheral Ion Channel Strategies
edited by
submission deadline 31 Mar 2026 | Viewed by 112 | Submission Open
Keywords: central mechanism of action; central terminal; chronic pain; multichannel block; NaV channel; non-neuronal cell; novel analgesics; pain transduction; subthreshold membrane potential oscillation; TRP channel
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Rheumatic Diseases and Rheumatoid Arthritis
edited by
submission deadline 31 Mar 2026 | Viewed by 110 | Submission Open
Keywords: rheumatoid arthritis; systemic lupus erythematous; systemic sclerosis; Sjö gren’ s syndrome; psoriatic arthritis; rare autoimmune rheumatic diseases; vasculitis; biological therapies
(This special issue belongs to the Section Molecular Immunology)
New Insights into Neuroproteins
edited by
submission deadline 31 Mar 2026 | Viewed by 110 | Submission Open
Keywords: neuroproteins; S100B; glial fibrillary acidic protein; neuron-specific enolase; alpha-synuclein; amyloid proteins
(This special issue belongs to the Section Molecular Neurobiology)
New Insight into Non-Coding RNAs (ncRNAs) in Human Research
edited by
submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open
Keywords: lncRNA; therapy; cancer; SLNCR; tumor suppressor; SINE; estrogen; ERRL01
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Nutritional Neuroscience: Diet, Microbiota, and Brain Function submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open
Keywords: nutritional neuroscience; gut– brain axis; diet; microbiota; molecular mechanisms; neuroinflammation; cognitive function; neurodegeneration; omics; biomarkers
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Biomaterials for Neural Regeneration and Axogenesis: From Cellular Support to Functional Recovery
edited by Noela Rodríguez-Losada
submission deadline 31 Mar 2026 | Viewed by 103 | Submission Open
Keywords: neural regeneration; axogenesis; neurorepair; neuroprotection; biocompatible materials; extracellular matrix mimetics; graphene-based scaffolds; conductive polymers; hybrid hydrogels; carbon nanomaterials; neuroengineering
(This special issue belongs to the Section Molecular Neurobiology)
Genetic and Molecular Basis of Diseases in Preterm Infants
edited by Dawid Szpecht
submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open
Keywords: genetic factors; prematurity complications; gene variants; inflammatory response; preterm infants
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Amyotrophic Lateral Sclerosis
edited by
submission deadline 31 Mar 2026 | Viewed by 99 | Submission Open
Keywords: amyotrophic lateral sclerosis; proteomics; protein aggregation; mitochondria; neurodegeneration; RNA metabolism; oxidative stress; neuroinflammation; systems biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cytomegalovirus: An Unresolved Puzzle in Transplantation
edited by , Zheng Zhang and Lorenzo Gallon
submission deadline 31 Mar 2026 | Viewed by 98 | Submission Open
Keywords: cytomegalovirus; latency; reactivation; transplantation; virus-host interaction; immune evasion; host immune response; omics approaches; high-throughput technologies
(This special issue belongs to the Section Molecular Microbiology)
Advances in Drug Discovery: Emerging Radiotracers and Small Molecule Inhibitors for Cancer and Neurological Disorders
edited by Ramya Tokala
submission deadline 31 Mar 2026 | Viewed by 97 | Submission Open
Keywords: radiotracers; cytotoxic agents; drug discovery; molecular imaging; cancer therapy; neurological disorders; radiochemistry; medicinal chemistry; theranostics; drug development; molecular diagnostics
(This special issue belongs to the Section Molecular Pharmacology)
Metabolic–Epigenetic Interplay in Healthy and Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 96 | Submission Open
Keywords: epigenetics; metabolism; TCA cycle; one-carbon cycle; aging; longevity; cancer; metabolic syndrome; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Skeletal Muscle Aging: Mechanisms, Biomarkers, and Interventions
edited by
submission deadline 31 Mar 2026 | Viewed by 94 | Submission Open
Keywords: skeletal muscle aging; sarcopenia; muscle metabolism; mitochondrial dysfunction; inflammation; exercise adaptation; muscle adaptation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The GPR81 Receptor: Lactate as Signaling Molecule in Health and Disease
edited by
submission deadline 31 Mar 2026 | Viewed by 94 | Submission Open
Keywords: lactate; GPR81 receptor; signaling cascade
(This special issue belongs to the Section Molecular Biology)
T Cell Receptor (TCR) Signaling at the Crossroads of Immunity, Tolerance, and Disease
edited by Amar Singh
submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open
Keywords: T cell receptor (TCR) signaling; immune tolerance; effector T cell differentiation; regulatory T cells (Tregs; Tr1); T cell heterogeneity; metabolic reprogramming; T cell memory and exhaustion; TCR repertoire analysis; autoimmunity and inflammation; TCR-based immunotherapy; CAR-T cells
(This special issue belongs to the Section Molecular Immunology)
Amyloid-β: An Antimicrobial Defense Peptide
edited by
submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open
Keywords: amyloid (Aß ); aggregation prone regions (ARPs); lipopolysaccharide (LPS); amphipathic molecules; LL-37 peptide; neurodegeneration; aggregation inhibition; Alzheimer's disease (AD)
(This special issue belongs to the Section Molecular Biology)
Metabolic Dysfunction and Cardiovascular Disease
edited by
submission deadline 31 Mar 2026 | Viewed by 91 | Submission Open
Keywords: metabolic dysfunction; cardiovascular disease; inflammation; endothelial dysfunction; oxidative stress; biomarkers
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research on Bacteria: 2nd Edition
edited by
submission deadline 31 Mar 2026 | Viewed by 90 | Submission Open
Keywords: bacteria; molecular biology; infections; antimicrobials; bacterial enzymes; bioremediation; enzyme evolution and adaptation
(This special issue belongs to the Section Molecular Microbiology)
Bridging the Omics of Protein Landscape of Aging and Disease: New Insights and Opportunities submission deadline 31 Mar 2026 | Viewed by 89 | Submission Open
Keywords: age-related disease; aging; biomarkers; chronic diseases; neurodegenerative diseases; ocular diseases; proteomics; kidney diseases
(This special issue belongs to the Section Molecular Biology)
PPAR Update: Molecular Mechanisms and Therapeutic Perspectives
edited by
submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open
Keywords: PPAR; PPARα ; SPPARMα ; pemafibrate; lipid metabolism; inflammation; fibrosis; nuclear receptor; translational research; precision medicine
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Plant Molecular Breeding and Molecular Diagnostics
edited by
submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open
Keywords: plant molecular breeding; molecular diagnostics; pathogen detection; disease symptomatology; genetic resources; genetic diversity; phenology; genotype– phenotype integration; genome editing; omics; bioinformatics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Insights into Allergic Asthma
edited by
submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open
Keywords: allergic asthma; molecular mechanisms; allergen exposure; T2 inflammation; inhaler treatment; biological treatment
(This special issue belongs to the Section Molecular Immunology)
Molecular Insights and Novel Therapeutics in Chronic Kidney Disease
edited by
submission deadline 31 Mar 2026 | Viewed by 87 | Submission Open
Keywords: chronic kidney disease (CKD); molecular mechanisms; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Roles of Erythrocytes in Human Health and Disease: 4th Edition
edited by
submission deadline 31 Mar 2026 | Viewed by 86 | Submission Open
Keywords: erythrocytes; red blood cells; red blood functions; vascular function; blood bank storage
(This special issue belongs to the Section Molecular Biology)
Advances in Understanding the Molecular Basis of Antimicrobial Properties in Natural Products, Functional Additives, and Food-Derived Compounds submission deadline 31 Mar 2026 | Viewed by 85 | Submission Open
Keywords: natural antibacterial substances; antibacterial activity; bacterial metabolites; functional additives; antibacterial peptides
(This special issue belongs to the Section Biochemistry)
T Regulatory and NKT Cells as Prognostic Biomarkers in Inflammatory Disorders and Cancers
edited by
submission deadline 31 Mar 2026 | Viewed by 84 | Submission Open
Keywords: immune response; Tregs; NKT; regulation pathways; prognostic biomarkers
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms of RNA Interactions and Biomarker Discovery for Human Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 84 | Submission Open
Keywords: biomarker discovery; RNA interactions; RNA– disease associations; drug– RNA interactions; therapeutic targets
(This special issue belongs to the Section Molecular Informatics)
Molecular Research and Advances in Ear Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 83 | Submission Open
Keywords: vertigo; hearing loss; tinnitus; otosclerosis; Mé niè re’ s disease; middle ear; inner ear; drug therapies; laboratory findings; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Allergic Reactions and Immune Factors submission deadline 31 Mar 2026 | Viewed by 83 | Submission Open
Keywords: allergic reactions; immunity; immunological factors; hypersensitivity; antibody; cytokine; immune response; etiology; pathogenesis; clinical manifestations; diagnostic; therapy
(This special issue belongs to the Section Molecular Immunology)
Non-Coding RNAs, Alarmins, Protein Dynamics, and Therapeutic Targets in Disease submission deadline 31 Mar 2026 | Viewed by 82 | Submission Open
Keywords: non-coding RNAs; alarmins; protein dynamics; therapeutic intervention; inflammatory; cancer; cardiovascular diseases; neurodegenerative diseases
(This special issue belongs to the Section Molecular Biology)
AI-Driven and Physics-Based Modeling in Molecular Engineering Systems
edited by
submission deadline 31 Mar 2026 | Viewed by 82 | Submission Open
Keywords: molecular engineering systems; AI model; physics
(This special issue belongs to the Section Molecular Informatics)
Molecular Research on Endocrine and Metabolic Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 81 | Submission Open
Keywords: systems biology; metabolomics; fluxomics; organoid models; epigenetic regulation; precision medicine; endocrine–metabolic crosstalk
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Rational Design and Advanced Synthesis of Nanomaterials for Electrocatalysis submission deadline 31 Mar 2026 | Viewed by 80 | Submission Open
Keywords: nanocatalysts; supercapacitors; (electro)oxidation of alcohols; oxygen reduction reaction; hydrogenation reactions; hydroformylation; electrochemical sensors
(This special issue belongs to the Section Materials Science)
Beyond Drivers and Suppressors: Investigating Upstream Regulators of Cell Death
edited by Damian Kołat
submission deadline 31 Mar 2026 | Viewed by 80 | Submission Open
Keywords: cell death; driver genes; suppressor genes; upstream regulators; gene expression; in silico; in vitro; in vivo
(This special issue belongs to the Section Molecular Biology)
Advanced Research in Crops: From Physiology to Breeding
edited by and Edyta Zdunek-Zastocka
submission deadline 31 Mar 2026 | Viewed by 80 | Submission Open
Keywords: crops; stress; cultivation measures; molecular mechanisms; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Biology of Hypoxia: 2nd Edition
edited by Yuji Arai
submission deadline 31 Mar 2026 | Viewed by 79 | Submission Open
Keywords: hypoxia; HIFs; normoxic environment
(This special issue belongs to the Section Molecular Biology)
Neural Stem Cells as Tools for Therapies: Challenges and Future Perspectives
edited by
submission deadline 31 Mar 2026 | Viewed by 78 | Submission Open
Keywords: spinal cord injury; spinal muscular atrophy; amyotrophic lateral sclerosis; neurological diseases; neural stem cell differentiation; cellular models; transplantation; trophic factor release
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Strategies for Oral Mucosal Diseases: From Radiotherapy-Induced Damage to Other Pathologies submission deadline 31 Mar 2026 | Viewed by 77 | Submission Open
Keywords: oral mucosal diseases; drug-induced oral lesions; radiotherapy- and chemotherapy-induced oral disorders; targeted therapy- and immunotherapy-induced stomatitis; oxidative stress and inflammation; oral microbiome and immunity; nanomedicine and biomaterials; photobiomodulation and photodynamic therapy; oral potentially malignant disorders; oral oncology; immune modulation; tissue regeneration and repair; translational research; investigational therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbiostatic/Microbicidal Agents and Materials
edited by
submission deadline 31 Mar 2026 | Viewed by 76 | Submission Open
Keywords: antimicrobial resistance (AMR); biofilm; antimicrobial peptides; plant-derived compounds; synergistic therapies
(This special issue belongs to the Section Molecular Microbiology)
Optical, Raman, and Pathological Imaging Biomarkers for Diagnosis and Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 76 | Submission Open
Keywords: optical imaging; Raman spectroscopy; pathological imaging; imaging biomarkers; AI-assisted diagnosis; disease prognosis; therapeutic response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Responses to Environmental Stresses: Physiological and Molecular Mechanisms submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open
Keywords: plant stress; abiotic stress; biotic stress; oxidative stress; antioxidant enzymes; reactive oxygen species (ROS); phytoremediation; biomonitoring; secondary metabolites; molecular mechanisms; omics approaches; bryophytes; heavy metals; plant– microbe interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Synapse: Diversity, Function and Signaling
edited by
submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open
Keywords: synaptic signaling; synaptic plasticity; brain disorders; synapse diversity; molecular composition of synapse
(This special issue belongs to the Section Molecular Neurobiology)
Oxidative Stress and Mitochondrial Dysfunction in Human Diseases
edited by Patrice X. Petit
submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open
Keywords: aging; DAMPs; inflammation; Fenton reaction; ferroptosis; hydroperoxide; mitochondria; mitophagy; NIX; NLRP3; oxidized mtDNA; RIRR; superoxide anions; stem cells
(This special issue belongs to the Section Molecular Biology)
Molecular Insights in Antimicrobial Resistance submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open
Keywords: drug resistance; microorganisms; molecular mechanisms; mobile genetic elements; CRISPR/Cas9; nucleic acid hybriditation; probes; LAMP
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms Underlying Natural Products for Metabolic Disease Treatment submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open
Keywords: metabolic diseases; natural products; MAFLD
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Regulation by Non-Coding RNAs: 2nd Edition
edited by
submission deadline 31 Mar 2026 | Viewed by 73 | Submission Open
Keywords: lncRNAs; circRNAs; miRNAs
(This special issue belongs to the Section Molecular Biology)
Emerging Insights into the Pathobiology and Biomarkers of Traumatic Brain Injury (TBI)
edited by Jessica Gill
submission deadline 31 Mar 2026 | Viewed by 73 | Submission Open
Keywords: traumatic brain injury (TBI); blood-based biomarkers; neuroinflammation; axonal injury; neurodegeneration; precision medicine; omics approaches (genomics; proteomics; metabolomics); translational neuroscience; TBI recovery and outcomes; neurovascular injury
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Spermatogenesis and Male Infertility, 2nd Edition
edited by Wanxi Yang
submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open
Keywords: male reproduction; hormone regulation; blood– testis barrier; male reproductive diseases; male infertility
(This special issue belongs to the Section Molecular Biology)
Advances in Glycoproteomics—Developments in Methodology and Biological Applications
edited by and Jianjun Li
submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open
Keywords: glycoproteomics; glycomics; mass spectrometry; glycobiology; biomarker
(This special issue belongs to the Section Biochemistry)
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