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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Mechanisms of Spinal Cord Injury and Repair

edited by Victoria Moreno-Manzano

submission deadline 20 Feb 2026 | 10 articles | Viewed by 26075 | Submission Open

Keywords: spinal cord injury; molecular changes; neuronal degeneration; circuit regeneration; transcriptomics; cell imaging; single-cell analysis; cell communication; behavior; functional outputs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Probiotics in Health and Disease

edited by

Jasna Novak

submission deadline 20 Feb 2026 | 3 articles | Viewed by 25238 | Submission Open

Keywords: probiotic; microbiota; quality; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites

edited by

Jen-Tsung Chen

submission deadline 20 Feb 2026 | 12 articles | Viewed by 23833 | Submission Open

Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines

(This special issue belongs to the Section Molecular Plant Sciences)

Tumor Microenvironments: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression

edited by Sonam Mittal

submission deadline 20 Feb 2026 | 8 articles | Viewed by 23292 | Submission Open

Keywords: tumor microenvironment; metastasis; metabolism; cytokines; cancer-derived extracellular vesicles; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Advanced Research in Prediction of Protein Structure and Function, 2nd Edition

edited by

Shuai Cheng Li

submission deadline 20 Feb 2026 | 5 articles | Viewed by 22710 | Submission Open

Keywords: prediction; protein structure; protein function; protein complex; machine learning; deep learning; multiple sequence alignment

(This special issue belongs to the Section Molecular Informatics)

Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases

edited by

Niels Schaft

submission deadline 20 Feb 2026 | 7 articles | Viewed by 21494 | Submission Open

Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights in Steroid Biosynthesis and Metabolism

edited by Amanda C. Swart

submission deadline 20 Feb 2026 | 6 articles | Viewed by 19857 | Submission Open

Keywords: steroid biosynthesis; steroid metabolism; aldo-keto reductase (AKR); cytochrome P450; steroid reductase (SRD5A); 17β -hydroxysteroid dehydrogenases (17β HSD); 11β -hydroxysteroid dehydrogenase (11β HSD); reproduction and sexual differentiation; endogenous cardiac steroids; anabolic steroids; prostate cancer; gut microbiome; immune system; inflammation; cardiovascular disease (CVD); kidney function; hormone replacement therapy (HRT)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advancements in Cancer Biomarkers

edited by

Christos Mikropoulos

submission deadline 20 Feb 2026 | 10 articles | Viewed by 17391 | Submission Open

Keywords: biomarkers; ctDNA; mircroRNA; proteomics; gene methylation; TIL; transcriptomics; micro RNA; tumor microenvironment; gene methylation; proteomics

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Alzheimer’s Disease

edited by Sudip Dhakal

submission deadline 20 Feb 2026 | 10 articles | Viewed by 16779 | Submission Open

Keywords: Alzheimer’ s disease; amyloid beta; tauopathy; autophagy; stress response; mitochondrial dysfunction; cognitive decline; biomarkers; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers

edited by Alessandra Bettiol

submission deadline 20 Feb 2026 | 9 articles | Viewed by 16001 | Submission Open

Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Postharvest Biology and Molecular Research of Fruits

edited by

Xiangbin Xu

submission deadline 20 Feb 2026 | 6 articles | Viewed by 15359 | Submission Open

Keywords: postharvest biology; fruit; storage technologies; molecular mechanisms; senescence; chilling injury; browning; nutrition; disease; toxin

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Molecular Trends and Prospects in Kidney Diseases

edited by

Federico Greco

and

Carlo A. Mallio

submission deadline 20 Feb 2026 | 6 articles | Viewed by 15188 | Submission Open

Keywords: nephrology; molecular biology; renal disease; genomic research; kidney molecular pathways; biomarkers in renal disease; transcriptomics of renal dysfunction; omics approaches in kidney research; molecular diagnostics for renal diseases; pharmacogenomics in kidney treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Therapeutic Strategies in Allergic Diseases

edited by

Sylwia Smolińska

submission deadline 20 Feb 2026 | 6 articles | Viewed by 14400 | Submission Open

Keywords: molecular allergy diagnostics; allergen identification; allergen neutralization/elimination strategies; allergen immunotherapy; impact of pollution on allergies; new allergens; cross-reactivity; unexpected allergen sources

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Omics: Sensing, Signaling, Regulation and Homeostasis

edited by

Margherita-Gabriella De Biasi

submission deadline 20 Feb 2026 | 6 articles | Viewed by 14337 | Submission Open

Keywords: plant homeostasis; omics; transcriptomics; metabolomics; proteomics; genomics; ionomics; environmental stress; regulatory mechanisms; metabolic processes; systems biology

(This special issue belongs to the Section Molecular Plant Sciences)

Inflammatory Bowel Diseases: Molecular Mechanism and Therapeutics

edited by

Woon Kyu Lee

submission deadline 20 Feb 2026 | 4 articles | Viewed by 13671 | Submission Open

Keywords: inflammatory bowel disease; IBD; ulcerative colitis; Crohn’ s disease; animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Function in Health and Diseases

edited by Sally P. Wheatley

submission deadline 20 Feb 2026 | 5 articles | Viewed by 13164 | Submission Open

Keywords: mitochondria; metabolism; lipid; ATP; respiration; calcium; iron; inheritance; apoptosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Organoids and Organs-on-Chip for Medical Research

edited by

Miguel Hueso

submission deadline 20 Feb 2026 | 4 articles | Viewed by 13153 | Submission Open

Keywords: organoids; organs-on-chip; tissue engineering; disease modeling; biomarkers; molecular pathways; nanotechnology; preclinical models; artificial organs; artificial intelligence; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Anti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 3rd Edition

edited by

Ming-Ju Hsieh

submission deadline 20 Feb 2026 | 12 articles | Viewed by 12993 | Submission Open

Keywords: anti-inflammatory; anti-cancer; antioxidants; antiproliferative; antiviral; antibacterial; antibodies; molecular mechanism; chemoresistance; molecular biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Bioactive Nutrients Promoting Health Through Gut Microbiota: 3rd Edition

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Feb 2026 | 3 articles | Viewed by 12702 | Submission Open

Keywords: phytochemicals; complex carbohydrates; gut microbiota; prebiotics; probiotics; inflammation; molecular mechanisms; human health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Products from Plants: Association with Human Health and Therapeutic Benefits

edited by

Andrey Marchev

and

Nikolina Mihaylova

submission deadline 20 Feb 2026 | 7 articles | Viewed by 12560 | Submission Open

Keywords: botanical products; phytochemicals; bio/pharmacological compounds; cellular and molecular targets; molecular and physiological mechanism; human health; disease prevention and treatment; inflammatory diseases; age-related disorders; chronic and (auto)immune diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genomics and Proteomics of Cancer

edited by

Raffaella Lazzarini

submission deadline 20 Feb 2026 | 6 articles | Viewed by 12445 | Submission Open

Keywords: cancer; carcinogenesis; genetic; epigenetic modification; protein expression; protein phosphorylation; proteomic

(This special issue belongs to the Section Molecular Oncology)

Antioxidants as Regulators of Metabolic Pathways: Potential and Therapeutic Strategies

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Feb 2026 | 2 articles | Viewed by 12222 | Submission Open

Keywords: antioxidants; metabolic pathways; oxidative stress; cellular homeostasis; redox signaling; energy metabolism; lipid metabolism; therapeutic strategies; chronic diseases

(This special issue belongs to the Section Molecular Biology)

New Insights into Aquaporins: 2nd Edition

edited by

Graça Soveral

and

Inês Vieira Da Silva

submission deadline 20 Feb 2026 | 5 articles | Viewed by 11613 | Submission Open

Keywords: aquaporin; membrane channel; regulation; pathophysiology; drug target

(This special issue belongs to the Section Molecular Biology)

Drug-Induced Modulation and Immunotherapy of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 3 articles | Viewed by 11607 | Submission Open

Keywords: leukemia; dendritic cells; immunotherapy; immune modulation

(This special issue belongs to the Section Molecular Immunology)

New Molecular Mechanisms in the Development of Brain Tumors and Metastases

edited by

Raffaele Addeo

Michele Caraglia

and

Marianna Abate

submission deadline 20 Feb 2026 | 5 articles | Viewed by 10453 | Submission Open

Keywords: brain tumor; brain metastasis; blood– brain barrier; target therapy; cancer molecular biology; brain tumor microenvironment; molecular biomarkers

(This special issue belongs to the Section Molecular Oncology)

Chronic Rhinosinusitis: Aetiology, Immunology and Treatment, 3rd Edition

edited by

Seung-Heon Shin

submission deadline 20 Feb 2026 | 3 articles | Viewed by 10247 | Submission Open

Keywords: innate immunity; adaptive immunity; protease; cytokine; inflammation; epithelial cells; fibroblasts; eosinophils; lymphocytes; biologics

(This special issue belongs to the Section Molecular Immunology)

The Biochemistry, Molecular and Cell Biology Beyond Flowers

edited by

Isabel Marques

submission deadline 20 Feb 2026 | 3 articles | Viewed by 10065 | Submission Open

Keywords: flowers; homeotic genes; MADSBox; molecular expression; pollination; stress; transcription factors

(This special issue belongs to the Section Molecular Plant Sciences)

Machine Learning and Bioinformatics in Human Health and Disease: 2nd Edition

edited by

Andreas Leiherer

submission deadline 20 Feb 2026 | 5 articles | Viewed by 9917 | Submission Open

Keywords: machine learning; bioinformatics; deep learning; multi-omics approaches; genetic risk factors; drug interactions; precision medicine; neurodegenerative diseases; disease diagnosis; epidemic prediction

(This special issue belongs to the Section Molecular Informatics)

Heterocyclic Compounds: Synthesis, Design, and Biological Activity

edited by

Josef Jampilek

submission deadline 20 Feb 2026 | 8 articles | Viewed by 9550 | Submission Open

Keywords: heterocycles; bioactive molecules and materials; pharmacophore; design; targeting; computer studies; synthesis and analysis; natural compounds; carbohydrates; physicochemical properties; biological screening

(This special issue belongs to the Section Biochemistry)

New Insights in Antibody Therapy

edited by

Loredana Frasca

submission deadline 20 Feb 2026 | 3 articles | Viewed by 9232 | Submission Open

Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease

(This special issue belongs to the Section Molecular Immunology)

Advances in Insulin Resistance Research: 2nd Edition

edited by

Byungyong Ahn

submission deadline 20 Feb 2026 | 2 articles | Viewed by 9157 | Submission Open

Keywords: insulin resistance; obesity; metabolic diseases; diabetes; metabolism; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Neurodegenerative Diseases: From Molecular Mechanisms to Pathophysiology (Second Edition)

edited by

Anne Vejux

submission deadline 20 Feb 2026 | 2 articles | Viewed by 9045 | Submission Open

Keywords: neurodegenerative diseases; molecular mechanisms; physiology; cell death; autophagy; oxidative stress; inflammation; genetic factors; diet; cognitive functions; exosomes; blood– brain barrier; immunity

(This special issue belongs to the Section Molecular Neurobiology)

Immunotherapy Versus Immune Modulation of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 5 articles | Viewed by 8750 | Submission Open

Keywords: leukemia; immunotherapy; immune modulation; antileukemic; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Role of MicroRNAs in Human Diseases: 2nd Edition

edited by

Lorenzo F. Sempere

submission deadline 20 Feb 2026 | 7 articles | Viewed by 8351 | Submission Open

Keywords: microRNAs; miRNAs; miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Studies in Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 20 Feb 2026 | 4 articles | Viewed by 7877 | Submission Open

Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Genetics, Epidemiology and Management of Myopathies

edited by

Efthimios Dardiotis

and

Vasileios Siokas

submission deadline 20 Feb 2026 | 1 articles | Viewed by 7786 | Submission Open

Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia

(This special issue belongs to the Section Molecular Biology)

Genes and Human Diseases: 3rd Edition

edited by

Mikhail I. Churnosov

submission deadline 20 Feb 2026 | 6 articles | Viewed by 7657 | Submission Open

Keywords: genes; human diseases; genetic-epidemiological studies; genetic factors; susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

In Silico Methods of Assessing the Therapeutic Potential of Natural Substances

edited by

Radosław Zajdel

and

Anna Merecz-Sadowska

submission deadline 20 Feb 2026 | 4 articles | Viewed by 7614 | Submission Open

Keywords: in silico screening; natural products; molecular docking; computational drug discovery; QSAR modeling; molecular dynamics simulations; natural compounds; drug-target interactions; virtual screening; structure-activity relationships; computational chemistry; cheminformatics; ADMET prediction; bioinformatics; phytochemicals; machine learning in drug discovery; computer-aided drug design; pharmacophore modeling; natural therapeutics; computational pharmacology

(This special issue belongs to the Section Molecular Informatics)

New Advances in Bioactive Compounds in Health and Disease

edited by

Luís Silva

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7554 | Submission Open

Keywords: phenolic compounds; bioactive compounds; health-promoting properties; human diseases; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biocatalysis of Compounds for Pharmaceutical and Biomedical Applications

edited by

Tomasz Siodmiak

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7537 | Submission Open

Keywords: biocatalysis; biomedical application; biotechnology; compounds for pharmacy; compounds for biomedicine; enantiomers; enzyme activity; enzyme engineering; enzyme immobilization; kinetic resolution; pharmaceutical application; supports materials

(This special issue belongs to the Section Molecular Pharmacology)

Health-Promoting Effects of Medicinal and Edible Plants and Their Molecular Mechanism

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Feb 2026 | 5 articles | Viewed by 7470 | Submission Open

Keywords: medicinal plants; edible plants; health-promoting effect; molecular mechanism; phytochemicals; diseases; curing targets; signaling pathway

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease

edited by

Juan Bautista De Sanctis

submission deadline 20 Feb 2026 | 1 articles | Viewed by 7224 | Submission Open

Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition

(This special issue belongs to the Section Molecular Immunology)

Role of Diet and Nutrition in Metabolic Diseases

edited by

Fernando Guerrero-Romero

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7219 | Submission Open

Keywords: nutrients; biomarkers; molecular targets; pahodiagnosis; treatment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Tea Tree Metabolism and Genetics

edited by Xiaoling Sun

submission deadline 20 Feb 2026 | 4 articles | Viewed by 7198 | Submission Open

Keywords: tea tree; secondary metabolite; genetic transformation; genetic breeding; tea germplasm improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Fish Genomics and Developmental Biology, 2nd Edition

edited by

Elena Sarropoulou

and

Jorge Fernandes

submission deadline 20 Feb 2026 | 6 articles | Viewed by 6824 | Submission Open

Keywords: development; teleost; gene regulation; comparative genomics; genomics; aquaculture; transcriptomics; gene expression; environment; genomes; population genomics; selective breeding; biomarker

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms, Pathophysiology and Therapeutic Strategies of Chronic Obstructive Pulmonary Disease (COPD)

edited by

Shih-feng Liu

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6770 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); pathophysiology; novel therapeutic approaches; biomarkers; pulmonary rehabilitation; inflammation; oxidative stress; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition

edited by

Zhidong Zhou

submission deadline 20 Feb 2026 | 2 articles | Viewed by 6672 | Submission Open

Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies

(This special issue belongs to the Section Molecular Neurobiology)

Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis

edited by Alberto Gajofatto

submission deadline 20 Feb 2026 | 4 articles | Viewed by 6594 | Submission Open

Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment

(This special issue belongs to the Section Molecular Neurobiology)

Endothelial Dysfunction and Its Related Cardiometabolic Disorders: From Mechanisms to Targeted Therapies

edited by

Nacci Carmela

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6479 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; endothelial nitric oxide synthase; cardiometabolic disease; vascular inflammation; chemokines; adipocytokines; atherosclerosis; diabetes; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Embryonic Development and Differentiation: 2nd Edition

edited by

László Márk

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6461 | Submission Open

Keywords: blastocyte; embryogenesis; endometrium; implantation; in vitro fertilization (IFV); ICSI; oocyte; pregnancy; seminal plasma; sperm

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1301-1350 on page 27 of 67.

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