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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research Progress and Therapeutic Targets of Chronic Kidney Disease submission deadline 20 Jan 2026 | 1 articles | Viewed by 1304 | Submission Open
Keywords: blood pressure; cardiovascular disease; chronic kidney disease; diabetes; hypertension; inflammation; oxidative stress; sodium glucose transporter-2; vascular calcification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Immune Mechanisms in Pathogenic Mycobacteria Infections
edited by Fabiana Bigi and Federico Carlos Blanco
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1266 | Submission Open
Keywords: Mycobacterium tuberculosis; virulence; pathogens  
(This special issue belongs to the Section Molecular Microbiology)
Molecular Studies on Oral Disease and Treatment
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1243 | Submission Open
Keywords: oral cancer; oral mucosal lesions; chronic pain; temporomandibular joint disorders; periodontal diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Chronic Inflammatory Demyelinating Polyneuropathy and Neuroimmunological Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1231 | Submission Open
Keywords: chronic inflammatory demyelinating polyneuropathy (CIDP); multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); autoimmune encephalitis; paraneoplastic neurological syndrome; Guillain-Barre syndrome (GBS); myositis; blood-brain barrier; blood-nerve barrier
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Paradigm Iconoclasm
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1201 | Submission Open
Keywords: paradigm shift; biochemistry; cell signaling; coagulation; toxinology
(This special issue belongs to the Section Biochemistry)
Computational Genomics and Bioinformatics in Microbiology submission deadline 20 Jan 2026 | 1 articles | Viewed by 1200 | Submission Open
Keywords: computational microbial genomics; comparative genomics; structural genomics; functional genomics; genomic data bioinformatics
(This special issue belongs to the Section Molecular Informatics)
Unraveling the Enigma of Colorectal Cancer: From Mechanisms to Therapeutic Advances
edited by Valentina Belli and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1199 | Submission Open
Keywords: Colorectal cancer; tumour microenvironment; epigenetics; diagnostic molecules; immune evasion; biomarkers; drug resistance; precision medicine; targeted  
(This special issue belongs to the Section Molecular Oncology)
Tuberculosis: Host Immunity, Diagnosis and Treatment submission deadline 20 Jan 2026 | 1 articles | Viewed by 1191 | Submission Open
Keywords: tuberculosis; immune response; diagnosis; treatment; antibiotics; resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Biomarker Discovery for Rare Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1176 | Submission Open
Keywords: biomarker; rare diseases; pathological processes; cystic fibrosis; Duchenne muscular dystrophy; Ehlers-Danlos syndrome; haemophilia; sickle cell disease; primary biliary cholangitis; fabry disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Radiolabeled Compounds for Theranostic Applications in Oncology
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1158 | Submission Open
Keywords: radiopharmaceuticals; theranostic; cancer therapy; targeted radionuclide therapy; molecular imaging; positron emission tomography; single-photon emission tomography; radiolabeling
(This special issue belongs to the Section Molecular Oncology)
Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1149 | Submission Open
Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology
(This special issue belongs to the Section Molecular Neurobiology)
Hormonal and Metabolic Markers in Health and Disease submission deadline 20 Jan 2026 | 1 articles | Viewed by 1135 | Submission Open
Keywords: hormonal biomarkers; molecular mechanism of endocrine disorders; steroidogenesis; hormonal dysregulation; endocrine disruptors; metabolomics; metabolic regulation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Biotic and Abiotic Stress Responses of Vegetable Crops
edited by Yongqiang Tian
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1112 | Submission Open
Keywords: vegetable crops; biotic stress; abiotic stress; physiological responses; molecular mechanisms; genetic mechanisms; resistance breeding; resistance biotechnology; management strategies
(This special issue belongs to the Section Molecular Plant Sciences)
Progress in Adipokines Research in Cardiovascular Health and Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1033 | Submission Open
Keywords: adipokine receptors and cell signalling; adipokines and heart failure and hypertrophy; adipokines and myocardial ischemia; adipokines and hypertension; adipokines and thrombosis/atherosclerosis; adipokines and vascular/endothelial function; structure; and integrity; adipokines and cardiovascular inflammation; adipokines; adiposity; and cardiovascular disease in obesity
(This special issue belongs to the Section Molecular Biology)
Hearing Loss: Molecular Biological Insights, 2nd Edition
edited by María Beatriz Durán-Alonso
submission deadline 20 Jan 2026 | 1 articles | Viewed by 983 | Submission Open
Keywords: genetics; microRNA; epigenetics; CRISPR; multi-omics; presbycusis; ototoxicity; development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Sarcoma Initiation and Metastasis
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 955 | Submission Open
Keywords: sarcoma; molecular target; metastasis; apoptosis; angiogenesis; microenvironment
(This special issue belongs to the Section Molecular Oncology)
The Role of Bioactive Natural Products in Human Health
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 944 | Submission Open
Keywords: bioactive compound; human health; functional foods; nutraceutical products; food toxicology; antioxidant properties; anti-inflammation; antimicrobial molecules
(This special issue belongs to the Section Molecular Pharmacology)
Microbial Omics: Decoding Microbial Life
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 943 | Submission Open
Keywords: omics technologies; omics methodologies; microorganisms; proteomics; genomics; transcriptomics; bioinformatics; artificial intelligence for omics; microbial physiology; microbial adaptation to environmental challenges; interspecies and host-microbe interactions; environmental monitoring
(This special issue belongs to the Section Molecular Microbiology)
Chemical Tools for Microbial Functionalization: Bridging Organic Chemistry and Biotechnology
edited by Stefania Cicco and
submission deadline 20 Jan 2026 | Viewed by 937 | Submission Open
Keywords: organometallic biochemistry; green chemistry; bioorthogonal; living polymers; living functionalization; hybrid materials
(This special issue belongs to the Section Molecular Microbiology)
The Brain’s Regeneration Potential: The Role of Neural Progenitor Cells in Neuropsychiatric Therapy submission deadline 20 Jan 2026 | 1 articles | Viewed by 902 | Submission Open
Keywords: neural stem cells; neural progenitor cells; neuropsychiatric disorders; neurodegeneration; neurogenesis; neuroplasticity; melatonin; psychoactive drugs
(This special issue belongs to the Section Molecular Neurobiology)
Chitosan: Structural and Chemical Modification, Properties and Application, 2nd Edition
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 858 | Submission Open
Keywords: chitosan modification; adsorption removal; membrane separation; food preservation; environmental remediation; wastewater treatment; disease treatment; agricultural production; tissue engineering
(This special issue belongs to the Section Macromolecules)
Lipid Droplet–Mitochondria Interactions in Health and Disease
edited by Anton Petcherski
submission deadline 20 Jan 2026 | Viewed by 796 | Submission Open
Keywords: mitochondria; lipid droplets; metabolism; lipotoxicity; metabolically active tissue; triacylglycerides; fatty acid oxidation
(This special issue belongs to the Section Biochemistry)
Drug Delivery Systems and Treatment of Human Diseases: Prospects and Challenges
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 760 | Submission Open
Keywords: nanodrug delivery; blood– brain barrier; antibodies therapy; molecular mechanism; neuroprotection
(This special issue belongs to the Section Molecular Pharmacology)
Pathogenesis and Therapy of Oral Carcinogenesis, 3rd Edition
edited by and
submission deadline 20 Jan 2026 | Viewed by 759 | Submission Open
Keywords: oral cancer; oral premalignant disorders; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis
(This special issue belongs to the Section Molecular Oncology)
Molecular Issues in Optic Neuropathy submission deadline 20 Jan 2026 | 1 articles | Viewed by 722 | Submission Open
Keywords: optic neuropathy; neuroprotection; glaucoma induced neuropathy; molecular pathways; novel therapeutics strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Physiopathology of Neurodevelopmental Disorders
edited by Antonio Falace
submission deadline 20 Jan 2026 | Viewed by 712 | Submission Open
Keywords: neuronal development; synaptogenesis; developmental and epileptic encephalopathy; epilepsy; biomarkers; neuroimmunology; translational research; cortical malformation; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Ion Transporter-Based Biomarkers for Sperm Quality
edited by
submission deadline 20 Jan 2026 | Viewed by 705 | Submission Open
Keywords: ion transporters; sperm quality; cryotolerance
(This special issue belongs to the Section Molecular Biology)
Rational Design and Synthesis of Bioactive Molecules, 2nd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 701 | Submission Open
Keywords: synthesis; structure; bonding; reactivity; chemical properties; physical properties; pharmacological activity; structure– activity relationship; applications
(This special issue belongs to the Section Molecular Biology)
Natural Compounds in Neurological Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 696 | Submission Open
Keywords: natural compounds; neuroprotection; neuroinflammation; oxidative stress; mitochondrial dysfunction; autophagy; bioactive molecules (polyphenols; flavonoids; melatonin; etc.); nutraceuticals (bioactive peptides; hydrolysates; etc.); neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Green Chemistry Biocatalysis—Advances in the Use of Sustainable Solvents for Biocatalytic Processes submission deadline 20 Jan 2026 | Viewed by 681 | Submission Open
Keywords: biocatalysts; enzymes; sustainability; green solvents; biotechnology; biochemical process engineering
(This special issue belongs to the Section Biochemistry)
Cell Membrane Electroporation and Electroosmosis Mechanisms
edited by
submission deadline 20 Jan 2026 | Viewed by 626 | Submission Open
Keywords: nanosecond electroporation; calcium electroporation; small-molecule electrotransfer; abscopal effect; bacterial electroporation; irreversible electroporation; electrochemotherapy; immune response; apoptosis
(This special issue belongs to the Section Biochemistry)
The Impact of High-Value Compounds from Agri-Food and Waste Sources on Cellular Metabolism submission deadline 20 Jan 2026 | Viewed by 600 | Submission Open
Keywords: phytochemicals; agri-food waste; nutraceutical; cell metabolism; mitochondria; antioxidants; ROS; anti-cancer
(This special issue belongs to the Section Biochemistry)
Reaction Kinetics in Bioinorganic Systems
edited by Łukasz Orzeł and Maria Oszajca
submission deadline 20 Jan 2026 | Viewed by 591 | Submission Open
Keywords: reaction mechanisms; kinetics; biologically active metal complexes; metalloproteins; reactive oxygen; nitrogen and sulfur species; biocatalysis; inorganic chemotherapy and phototherapy
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Therapies of Gastrointestinal Cancer submission deadline 20 Jan 2026 | 1 articles | Viewed by 584 | Submission Open
Keywords: tumor microenvironment; therapy resistance; genetic mutations; oncogenes; molecular diagnostics
(This special issue belongs to the Section Molecular Oncology)
Phytochemicals: Mechanisms and Applications in Cancer Prevention and Therapy submission deadline 20 Jan 2026 | Viewed by 556 | Submission Open
Keywords: phytochemicals; cancer prevention; cancer therapy; molecular mechanisms; signal transduction pathways; anti-oxidant activity; cell death; gene regulation; therapeutic targets
(This special issue belongs to the Section Biochemistry)
Molecular Research on Skeletal Muscle Metabolism and Diseases
edited by Shen-Liang Chen
submission deadline 20 Jan 2026 | 1 articles | Viewed by 550 | Submission Open
Keywords: muscle; metabolism; mitochondria; peroxisome; stem cell; cahcexia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Molecular Research on Muscle Atrophy
edited by
submission deadline 20 Jan 2026 | Viewed by 507 | Submission Open
Keywords: muscle atrophy; molecular mechanisms; protein degradation; inflammation; oxidative stress; sarcopenia; cachexia; autophagy; therapeutics; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein Structure and Its Interactions
edited by
submission deadline 20 Jan 2026 | Viewed by 497 | Submission Open
Keywords: protein– protein interactions (PPIs); protein– ligand binding; molecular recognition; binding affinity and specificity; molecular interface analysis
(This special issue belongs to the Section Molecular Biology)
Endocannabinoids, Cannabinoids and Psychiatry: Biological Mechanisms—3rd Edition
edited by and Nicholas V. DiPatrizio
submission deadline 20 Jan 2026 | Viewed by 496 | Submission Open
Keywords: endocannabinoids; cannabinoids; psychiatry; neural mechanisms; molecular mechanisms; epigenetics; imaging; psychopathology; stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurological Disorders: From Molecular Mechanisms to Nanomedicine
edited by
submission deadline 20 Jan 2026 | Viewed by 479 | Submission Open
Keywords: stroke; brain and spinal cord trauma; Alzheimer’ s disease; Parkinson’ s disease; nanodrug formulation; stem cells; neuroprotection
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Microglia in Neurological Diseases
edited by
submission deadline 20 Jan 2026 | Viewed by 458 | Submission Open
Keywords: microglia; neuroinflammation; neurodegenerative diseases; molecular signaling; central nervous system (CNS)
(This special issue belongs to the Section Molecular Neurobiology)
Hormone Receptors in Cancer
edited by Rajeshwar R. Tekmal
submission deadline 20 Jan 2026 | Viewed by 452 | Submission Open
Keywords: hormone recptors; hormone-mediated therapies; agonists and antgonists of hormone ligands; coactivators; corepressors  
(This special issue belongs to the Section Molecular Oncology)
Insights into How Electromagnetic Fields Affect Human Immunity and Metabolic Activity
edited by Jolanta Kaszuba-Zwoińska
submission deadline 20 Jan 2026 | Viewed by 426 | Submission Open
Keywords: electromagnetic fields; metabolism; innate and acquired immunity; cell viability; cell secretory activity; cell death types; pathogenesis of diseases
(This special issue belongs to the Section Molecular Biology)
Targeting Epilepsy: Molecular Mechanisms, Neuroinflammation and Emerging Therapies
edited by
submission deadline 20 Jan 2026 | Viewed by 426 | Submission Open
Keywords: epilepsy; molecular targets; antiepileptic drug discovery; neuroinflammation; epileptogenesis; ion channels; pharmacoresistance; translational neuroscience
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Discovery and Development for Renal Disease Treatment
edited by
submission deadline 20 Jan 2026 | Viewed by 424 | Submission Open
Keywords: kidney disease; medicinal chemistry; drug discovery; computer-assisted drug design; drug targets; in vitro assays; epigenetic targets; multi-targeting compounds; biophysical methods; target engagement studies
(This special issue belongs to the Section Molecular Pharmacology)
Synthesis and Application of Organic Antibacterial Agents
edited by
submission deadline 20 Jan 2026 | Viewed by 422 | Submission Open
Keywords: organic antibacterial compounds; synthesis; natural organic compounds; biological activity; active compounds; biological applications
(This special issue belongs to the Section Biochemistry)
DNA Damage and Repair: Current Research
edited by and Emilio Rojas
submission deadline 20 Jan 2026 | 1 articles | Viewed by 414 | Submission Open
Keywords: DNA damage; DNA repair; endogenous compounds; exogenous compounds; therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Metabolomics Research of Environmental Stress in Plants
edited by and Sonika Pandey
submission deadline 20 Jan 2026 | Viewed by 402 | Submission Open
Keywords: agricultural applications of primary and secondary metabolite; ; crop improvement; integration of metabolomics with genomics and transcriptomics; medicinal plants; natural products in agriculture; plant metabolomics; plant biochemistry; primary metabolites; secondary metabolites; tools and techniques of plant metabolites in agriculture research
(This special issue belongs to the Section Molecular Plant Sciences)
Cognitive Aging: Molecular Perspectives
edited by
submission deadline 20 Jan 2026 | Viewed by 395 | Submission Open
Keywords: brain; neuron; aging; neurodegeneration; cognitive neuroscience; inflammation; regeneration; behavioral neuroscience; pharmacology; brain disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Animal Reproduction and Development
edited by
submission deadline 20 Jan 2026 | Viewed by 385 | Submission Open
Keywords: spermatogenesis; oogenesis; fertilization; embryogenesis; cell division; cell differentiation; stem cell; abnormal development; obesity; cancer
(This special issue belongs to the Section Molecular Biology)
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