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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multi-Target and Synergistic Therapeutic Strategies in Modern Drug Discovery

edited by

Vincenzo Piccolo

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: multi-target and synergistic therapeutic strategies; drug design; combination therapy; polypharmacology; drug re-purposing

(This special issue belongs to the Section Molecular Pharmacology)

Machine Learning Applications in Bioinformatics and Biomedicine: 4th Edition

edited by Hao Lv

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetic marker discovery for diseases; molecular network marker; early screening of diseases

(This special issue belongs to the Section Molecular Informatics)

3D Printing and Biomaterials for Hearing and Balance Restoration

edited by

Chenkai Dai

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: hearing; balancing; 3D printing; biomaterial

(This special issue belongs to the Section Materials Science)

Emerging Metabolomics Techniques and Applications

edited by Jun Han

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: metabolomics; lipidomics; bioinformatics; micro-extraction; chemical derivatization; liquid chromatography-mass spectrometry (LC-MS); matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS); gas chromatography-mass spectrometry (GC-MS); metabolic profiling; biomarker assay

(This special issue belongs to the Section Molecular Informatics)

The Role of Fibroblasts in the Regulation of Tissue Inflammation and Repair

edited by Rebeca Illescas Montes

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: fibroblast; wound healing; inflammation; tissue repair; immune– stromal crosstalk; extracellular matrix remodeling; myofibroblast; regenerative medicine; exosomes; biomaterials

(This special issue belongs to the Section Molecular Immunology)

Involvement of Connexin-, Pannexin-, and Innexin-Based Hemichannels in Physiological Functions of Diverse Tissues

edited by

Juan Carlos Saéz

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: connexin; pannexin; innexin; hemichannel; permeant ions

(This special issue belongs to the Section Molecular Biology)

Preservation of Testicular Function: From Andrological Pathologies to Testis Cancer

edited by

Elisa Dalla Pozza

and

Ilaria Dando

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: testicular function; male infertility; fertility preservation; spermatogenesis; oxidative stress; cell death; testicular cancer; testosterone

(This special issue belongs to the Section Molecular Pharmacology)

Application of Germplasm Innovation Technology in Aquactic Genetic Breeding

edited by

Hui Qiao

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: aquaculture; biotechnology; germplasm improvement; genetic breeding; gene function; genomics; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Multi-Omic Data Integration in Oncology

edited by Hung-Yu Lin and

Hsing-Ju Wu

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: bioinformatics; multi-omics at bulk level; single-cell omics; spatial multi-omics; metabolomics; proteomics; pharmacogenomics; tumor microenvironment; tumor molecular profiling; therapy resistance

(This special issue belongs to the Section Molecular Informatics)

New Insight Into Pathogen Stress Effects on Plant Structure and Metabolism

edited by

Edmund Kozieł

and

Katarzyna Otulak-Kozieł

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: plant– pathogen interaction; innate immunity; ultrastructure; plant defense systems; plant physiology; signal transduction; resistance genes

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Heredity and Metabolism of Osteosarcoma

edited by

Hiroki Kuniyasu

and

Kanya Honoki

submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open

Keywords: osteosarcoma; clinical imaging; genetics; epigenetics; metabolism; signal transduction; stemness; pathology; metastasis; novel druggable target

(This special issue belongs to the Section Molecular Oncology)

Precision Nutrition and Cancer: Molecular Insights Into Cancer Prevention and Development

edited by

Da Pan

submission deadline 30 Apr 2026 | Viewed by 52 | Submission Open

Keywords: precision nutrition; cancer prevention; cancer development; nutrigenomics; personalized diets; tumor metabolism; dietary interventions

(This special issue belongs to the Section Molecular Oncology)

Exploring the Chemistry of 2D Transition Metal Carbides and Nitrides (MXenes): Synthesis Methods and Surface Chemistry

edited by

Hyunho Kim

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: synthesis optimization of non-Al MAX phase; wet chemical etching of non-Al MAX phase; molten salt etching of non-Al MAX phase; surface modification of MXenes; colloidal stability of MXenes; solution process of MXenes

(This special issue belongs to the Section Materials Science)

The Structure, Function, and Application of Zinc Finger Proteins

edited by

Sabrina Esposito

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: zinc finger proteins: structure; function and properties; applications; protein folding and dynamics; environmental contaminants and metal ions exposure; uptake; toxicity; molecular recognition and signal transduction; mechanisms of action and effects of abnormal zinc finger proteins on human health; zinc finger proteins as drug targets

(This special issue belongs to the Section Molecular Biology)

Tumor Organoids in Translational Cancer Research: Mechanisms and Applications

edited by Yong-Jun Kwon

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: tumor organoids; tumor heterogeneity; multi-omics profiling; drug resistance; tumor microenvironment; patient-derived models; organoid biobank; high-throughput drug screening; personalized therapy; translational research

(This special issue belongs to the Section Molecular Oncology)

Mechanobiology of the Cell

edited by

Zbigniew Baster

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: nuclear and chromatin mechanics; mechanobiology; mechanotransduction pathways

(This special issue belongs to the Section Molecular Biology)

Micro- and Nanoplastics: Molecular Insights from the One Health Perspective

edited by

Magdalena Zemelka-Wiacek

submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open

Keywords: microplastics; nanoplastics; One Health; molecular toxicology; oxidative stress; inflammation; microbiome; bioaccumulation; environmental exposure

(This special issue belongs to the Section Molecular Toxicology)

Phage Therapy: Breakthroughs and Challenges

edited by

Spyridon Megremis

and

Anisha Mahendra Thanki

submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open

Keywords: phage therapy; phage production; phage engineering; phage genomics; phage evolution; phage structural biology

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights in Women’s Health: Advances in Gynecological Disease Mechanisms and Therapeutics

edited by Tsung-Hsuan Lai

submission deadline 30 Apr 2026 | Viewed by 48 | Submission Open

Keywords: ART and IVF; prenatal diagnosis; infertility; minimally invasive surgery; robotic surgery; PCOS; endometriosis; menopause; AI

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Tumor Microenvironment in Hepatocellular Carcinoma: Mechanistic Insights and Future Therapeutic Approaches

edited by

Agnes Chan

submission deadline 30 Apr 2026 | Viewed by 47 | Submission Open

Keywords: advance or metastatic hepatocellular carcinoma; liver disease; radiotherapy; transarterial chemoembolization (TACE) or SBRT; immune checkpoint inhibitors; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Decoding the Pediatric Brain Tumor Microenvironment: A Molecular Perspective

edited by

Samuele Tardito

submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open

Keywords: pediatric brain tumor; precision immunotherapy; pediatric neuro-oncology; tumor microenvironment (TME); single-cell RNA sequencing; whole transcriptomics; mass spectrometry-based proteomics; mass cytometry; cellular and molecular architecture; organoid

(This special issue belongs to the Section Molecular Oncology)

Nanoparticles in Nanobiotechnology and Nanomedicine: 3rd Edition

edited by

Costica Caizer

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: nanoparticles; properties of nanoparticles; methods of obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Toxicology of Cyanobacterial Toxins

edited by

Carlos García

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: toxicology; cyanotoxins; cyanobacteria; harmful effects; health risk

(This special issue belongs to the Section Molecular Toxicology)

Natural Compounds: Impact on Health and Diseases

edited by

Charles Benneh

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: natural compounds; bioactive compounds; efficacy; toxicity; mechanism; compound isolation; chemical characterisation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Effects of Natural Bioactive Compounds on Cellular Responses

edited by

Amélia M. Silva

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: cellular targets; cell proliferation; cell death mechanisms; cell signalling; cytokines; vitamins; phytochemicals; venoms; peptides; pharmacological effect

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Allergy and Asthma: 4th Edition

edited by

Daniel P. Potaczek

submission deadline 30 Apr 2026 | Viewed by 38 | Submission Open

Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology

(This special issue belongs to the Section Molecular Biology)

Advanced Silica-Based Materials: From Molecular Design to Sustainable Applications

edited by Marius Rǎdulescu

submission deadline 30 Apr 2026 | Viewed by 38 | Submission Open

Keywords: silica-based materials; molecular design; hybrid nanomaterials; surface chemistry; structure– property relationships; functionalized silica; sol– gel processes; molecular interactions; green synthesis; sustainable applications; nanostructured systems; catalysis and adsorption; biomedical interfaces; energy and environmental materials; molecular modeling

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Pathology, Diagnosis and Therapeutic Strategies of Thrombotic Diseases

edited by Emanuele Valeriani

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: anticoagulants; cardiovascular diseases; diagnosis; platelet aggregation inhibitors; venous thromboembolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

KRAS-Associated Cancer Signaling

edited by Sang Hun Lee

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: KRAS signaling; receptor tyrosine kinases; EGFR; c-MET; PI3K– MAPK pathways; tumor microenvironment; drug resistance and adaptive rewiring; combination therapy; biomarker stratification; prion protein (PrPC)

(This special issue belongs to the Section Molecular Oncology)

State-of-the-Art Immunotherapy for Non-Small-Cell Lung Cancer

edited by

Haris Charalambous

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: immunotherapy; checkpoint inhibitors; vaccines; cellular therapies; predictive biomarkers; chemotherapy; angiogenesis inhibitors; radiotherapy; modulation microbiome

(This special issue belongs to the Section Molecular Oncology)

Modern Synthetic Pathways for Anticancer Drug Discovery

edited by

Łukasz Struk

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: new anticancer agents; bioactive molecules; drug design; drug synthesis; cancer therapy; medicinal chemistry

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Zoonoses and Vector-Borne Diseases

edited by Ravi Durvasula

submission deadline 30 Apr 2026 | Viewed by 28 | Submission Open

Keywords: malaria; leishmaniasis; soil-transmitted helminths; one health; cryptosporidiosis; trypanosomiasis; mosquito-borne infections; arboviral diseases; paratransgenesis; drug discovery; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Smart Biomolecular Nanocarriers for Precision Cancer Therapy and Diagnosis

edited by

Atul Garkal

submission deadline 30 Apr 2026 | Viewed by 28 | Submission Open

Keywords: nanobiotechnology; anti-cancer agents; nanocarrier; targeted drug delivery

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Biomarkers in Mood Disorders

edited by Lionella Palego and

Valerio Dell’Oste

submission deadline 30 Apr 2026 | Viewed by 26 | Submission Open

Keywords: mood disorders; etiopathogenesis; genetics/epigenetics; RNA analyses; neuroendocrinology; inflammation; molecular markers

(This special issue belongs to the Section Molecular Neurobiology)

Progress in Photobiomodulation Therapy

edited by

Amílcar Sabino Damazo

submission deadline 30 Apr 2026 | Viewed by 22 | Submission Open

Keywords: photobiomodulation (PBM); low-level light therapy (LLLT); light-emitting diodes (LEDs); mitochondrial photostimulation; anti-inflammatory effects; tissue regeneration; neuromodulation; biostimulation; clinical applications; pain management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrative Regenerative Medicine: Bridging Molecular Mechanisms and Therapeutic Applications

edited by Jerran Santos

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: regenerative medicine; stem cells; molecular mechanisms; tissue engineering; organoids; biomaterials; biofabrication; clinical translation; cell therapy; integrative biology

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Brucella Research

edited by

Angel Oñate

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: Brucella abortus; molecular pathogenesis; host– pathogen interaction; virulence factors; oxidative stress response; intracellular survival; immune evasion; exosomes; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Assisted Reproductive Technology

edited by Nuria Marti-Gutierrez

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: cytoplasm maternal factors; mitochondrial replication; meiosis; chromosome pairing; recombination; gene editors

(This special issue belongs to the Section Molecular Biology)

Research on New Targets and New Drugs for Dementia

edited by

Jianrong Xu

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: Alzheimer’ s disease; disease-modifying therapy; neuroinflammation; monoclonal antibodies; natural products

(This special issue belongs to the Section Molecular Neurobiology)

Nanoscale Materials for Advanced Electrocatalysts

edited by

Safia Khan

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: nanomaterials; electrocatalysis; electrocatalysts; energy conversion; fuel cells

(This special issue belongs to the Section Molecular Nanoscience)

Mechanistic Insights into the Ubiquitin System’s Role in Cellular Signal Transduction and Homeostasis

edited by Michael Massiah

submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open

Keywords: ubiquitination; protein homeostasis; deubiquitinases; E3-associated diseases; autophagy; ubiquitin dysregulation; proteasome-targeting; protac

(This special issue belongs to the Section Molecular Biology)

Exploring the Gut-Brain Axis: Mechanisms and Implications for Health and Disease

edited by

Martina Vincenzi

submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open

Keywords: gut– brain axis; enteric nervous system; dysbiosis; gut microbiota; neuroinflammation; one health; microbiota– immune crosstalk; metabolic syndromes; cardiovascular diseases; neurodegenerative diseases; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neurorepair and Regeneration

edited by

Andrei Gresita

and Tiago Santos

submission deadline 30 Apr 2026 | Viewed by 18 | Submission Open

Keywords: neurorepair; regeneration; neuroplasticity; cellular reprogramming; biomaterials; stroke; spinal cord injury; traumatic brain injury; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Medicinal Fungi and Plants: From Bioactive Compounds to Therapeutic Mechanisms

edited by

Jasmina Glamočlija

and

Ana Ćirić

submission deadline 30 Apr 2026 | Viewed by 18 | Submission Open

Keywords: medicinal fungi; medicinal plants; molecular mechanisms; bioactive compounds; metabolomics; phytochemistry; natural products; network pharmacology; molecular docking; functional foods; therapeutic development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

From Molecule to Mind: Neuropharmacology of Psychoactive Alkaloids and Next-Generation Neuroactives

edited by Kyoko Koshibu

submission deadline 30 Apr 2026 | Viewed by 18 | Submission Open

Keywords: psychoactive alkaloids; neuropharmacology; bioactive compounds; performance enhancement; addiction; translational research; cognitive modulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Emerging Targeted Therapies and Evolving Treatment Paradigms in Non-Small Cell Lung Cancer

edited by Luis E. Raez

submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); targeted therapies; human epidermal growth factor receptor 2 (HER2); mesenchymal-epithelial transition factor (MET); anaplastic lymphoma kinase (ALK); C-ROS oncogene 1 receptor tyrosine kinase (ROS1); rearranged during transfection (RET); neurotrophic tyrosine receptor kinase (NTRK); B-Raf proto-oncogene serine/threonine kinase V600 mutation (BRAFv600); Kirsten rat sarcoma viral oncogene homolog (KRAS); epidermal growth factor receptor (EGFR)

(This special issue belongs to the Section Molecular Oncology)

Genomic and Epigenetic Determinants of Circulating Cell-Free DNA Release in Cancer

edited by

Federica Maione

submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open

Keywords: genomic alterations; epigenetic modifications; chromosomal instability; aneuploidy and DNA fragmentation; tumor cell-derived cell-free DNA release; chromosome methylation; liquid biopsy; gene-gene interactions; cell death

(This special issue belongs to the Section Molecular Oncology)

Biomass as Feedstock for the Production of High Value-Added Chemicals by Heterogeneous Catalysis

edited by

Cristina García-Sancho

submission deadline 30 Apr 2026 | Viewed by 15 | Submission Open

Keywords: biomass; heterogeneous catalysts; biofuels; bioproducts; platform molecules

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Bioactive Phenolic Compounds in Human Health and Disease: Second Edition

edited by

Andrei Lobiuc

submission deadline 30 Apr 2026 | Viewed by 15 | Submission Open

Keywords: novel sources; synthesis; biological activity; molecular interactions; pharmacodynamics; pharmacokinetics; assay development; microbiota; sources and intake

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Sperm Physiology and Genetics

edited by Jordi Ribas-Maynou and Ariadna Delgado Bermudez

submission deadline 30 Apr 2026 | Viewed by 14 | Submission Open

Keywords: sperm; DNA; chromatin; physiology; reproduction

(This special issue belongs to the Section Molecular Genetics and Genomics)

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