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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nanoparticle-Based Biosensors and Their Applications
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 959 | Submission Open
Keywords: biosensors; metal nanoparticles (MNPs); synthesis methods; molecular spectroscopy characteristics; molecular medicine; molecular biology
(This special issue belongs to the Section Molecular Nanoscience)
Insights into the Pathogenesis, Molecular Landscape and Therapeutics of Triple-Negative Breast Cancer
edited by Rebecca Chin
submission deadline 20 Jul 2026 | 2 articles | Viewed by 622 | Submission Open
Keywords: breast cancer; cancer stemness; therapeutic resistance; brain metastasis; epigenetic mechanisms; chromatin remodeling; multi-omics approaches; high-throughput screening; patient-derived organoids
(This special issue belongs to the Section Molecular Oncology)
Neuronal Differentiation: From Pathology to Therapeutic Strategies
edited by
submission deadline 20 Jul 2026 | Viewed by 342 | Submission Open
Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells
(This special issue belongs to the Section Molecular Neurobiology)
G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 177 | Submission Open
Keywords: GPCR; cell signaling; small-molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode
(This special issue belongs to the Section Molecular Pharmacology)
Recent Molecular Research on Photocatalytic Applications
edited by Hassan Ait Ahsaine
submission deadline 20 Jul 2026 | Viewed by 128 | Submission Open
Keywords: photocatalysis; photocatalytic degradation; molecular catalysts; photocatalysts; functional materials
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Natural Product-Inspired Anticancer Drug Development
edited by
submission deadline 20 Jul 2026 | Viewed by 126 | Submission Open
Keywords: anticancer; antiproliferative; cytotoxic; natural product; drug development; semi-synthesis; total synthesis; structure– activity relationship; computational simulation; enzyme inhibition
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Chronic Airway Diseases: Molecular Basis and Advanced Therapeutics
edited by
submission deadline 20 Jul 2026 | Viewed by 79 | Submission Open
Keywords: chronic airway diseases; asthma; chronic obstructive pulmonary disease (COPD); cystic fibrosis; bronchiectasis; pulmonary fibrosis; airway remodeling; cytokines; inflammation; immune dysregulation; mucociliary clearance; microbiome; epithelial– mesenchymal transition (EMT); molecular mechanisms; biomarkers; proteases; protease inhibitors; precision medicine; targeted therapeutics; RNA-based and gene therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Natural Compounds in the Prevention and Treatment of Human and Veterinary Diseases submission deadline 20 Jul 2026 | Viewed by 38 | Submission Open
Keywords: bioactive natural substances; nutraceuticals; drug discovery; drug resistance; inflammation; antioxidant; health promotion; prevention; treatment; synergistic effect; molecular mechanism; computational analysis; repurposed molecules
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Evolving Landscape of Cardiovascular Pathophysiology
edited by
submission deadline 25 Jul 2026 | Viewed by 42 | Submission Open
Keywords: biomarker discovery in cardiovascular pathophysiology; precision diagnostics-novel contrast agents combined with PET/CT; MRI; machine learning/AI and clinical implementations in cardiology; cardio-metabolic disease; inflammation and immunity in cardiovascular diseases; mechanisms of non-coding RNAs and microRNAs in cardiac diseases; translational research in large animals bridging the rodent re-search with human pathophysiology; targeted therapies- genetic therapies/gene editing approach (CRISPR); stem cell therapies; and therapeutic mRNA and siRNA-based approaches
(This special issue belongs to the Section Biochemistry)
Neurobiology Linking Alcohol Addiction to Psychiatry Symptoms submission deadline 30 Jul 2026 | Viewed by 89 | Submission Open
Keywords: alcohol use disorder (AUD); psychiatry; neurobiology; biomarkers; translational
(This special issue belongs to the Section Molecular Neurobiology)
Cancer Drug Resistance and Therapeutic Targets submission deadline 30 Jul 2026 | Viewed by 89 | Submission Open
Keywords: drug resistance; therapeutic targets; efflux transporters’ oncogenic signaling pathways; tumor microenvironment; dna damage/repair; personalized therapies
(This special issue belongs to the Section Molecular Oncology)
Advances in Bone Homeostasis
edited by
submission deadline 30 Jul 2026 | Viewed by 70 | Submission Open
Keywords: bone remodeling; osteoblasts and osteoclasts; osteoimmunology; osteometabolism; signaling pathways; bone diseases; epigenetic regulation; extracellular vesicles; mechanotransduction; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Phytochemicals and Antioxidants on Health and Disease Modulation
edited by Natalia Kurhaluk
submission deadline 30 Jul 2026 | Viewed by 17 | Submission Open
Keywords: phytochemical bioactive compounds; antioxidant mechanisms; oxidative stress modulation; chronic disease prevention; inflammatory signalling pathways; molecular health effects; bioavailability and metabolism; flavonoid biological activity; polyphenol therapeutic potential; disease modulation strategies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Physiology and Molecular Biology of Plant Stress Tolerance: 3rd Edition
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 445 | Submission Open
Keywords: plant– pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes
(This special issue belongs to the Section Molecular Plant Sciences)
Bioactive Natural Products: From Molecular Mechanisms to Biological Function submission deadline 31 Jul 2026 | Viewed by 7 | Submission Open
Keywords: natural products; molecular mechanism; biological activities; drug discovery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications
edited by Bonghwan Chon
submission deadline 1 Aug 2026 | Viewed by 80 | Submission Open
Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging
(This special issue belongs to the Section Molecular Nanoscience)
Functional Genomics in Translational Medicine
edited by , Oana Zanoaga and
submission deadline 20 Aug 2026 | 2 articles | Viewed by 4606 | Submission Open
Keywords: functional genomics; omics approaches; drug response/resistance; therapeutic targets; genomics and transcriptomic alteration; bioinformatic analysis; data integration; human disease; personalized medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Seed Development and Germination submission deadline 20 Aug 2026 | 3 articles | Viewed by 4152 | Submission Open
Keywords: seed aging; seed development; seed dormancy; seed germination; seed metabolism; seed preservation; seed priming; seed responses to stress
(This special issue belongs to the Section Molecular Plant Sciences)
Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1352 | Submission Open
Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Decoding the Microbial Influence on Host Gene Expression submission deadline 20 Aug 2026 | Viewed by 139 | Submission Open
Keywords: microbiota; host; gene expression; in silico; bioinformatics; in vitro; in vivo
(This special issue belongs to the Section Molecular Microbiology)
Vitamin D in Reproductive Disorders: Determinants, Metabolism, and Downstream Biological Mechanisms submission deadline 20 Aug 2026 | Viewed by 54 | Submission Open
Keywords: vitamin D; perinatal corticosteroids; placental insufficiency; intrauterine growth restriction; cortisol metabolism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities submission deadline 30 Aug 2026 | Viewed by 49 | Submission Open
Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms Fueling Glioblastoma Progression and Resistance: Emerging Therapeutic Opportunities
edited by
submission deadline 30 Aug 2026 | Viewed by 12 | Submission Open
Keywords: glioblastoma; cancer stem cells; radioresistance; chemoresistance; targeted therapies; tumor plasticity; tumor heterogeneity; invasion; immune escape
(This special issue belongs to the Section Molecular Neurobiology)
MiRNA Stromal Interaction in the Tumor Microenvironment
edited by
submission deadline 30 Aug 2026 | Submission Open
Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways
(This special issue belongs to the Section Molecular Oncology)
The Role of Neuropeptides and Their GPCRs in the Neuroendocrine System
edited by
submission deadline 31 Aug 2026 | Viewed by 499 | Submission Open
Keywords: neuropeptides; G-protein-coupled receptors (GPCRs); neuroendocrine system; signal transduction; hypothalamus
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Research in Veterinary Drugs
edited by Jianyong Li
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1519 | Submission Open
Keywords: veterinary drug; target; chemical structure; mechanism; medicinal chemistry; toxicity; pharmacodynamics; pharmacokinetics; residues
(This special issue belongs to the Section Molecular Pharmacology)
Exopolysaccharides of Microbial Origin: Production, Analysis and Modification
edited by Marzena Jedrzejczak-Krzepkowska and
submission deadline 20 Sep 2026 | Viewed by 19 | Submission Open
Keywords: exopolysaccharide; biopolymer; biofilm; microorganism; biosynthesis; genetic engineering; molecular design; modification; analysis
(This special issue belongs to the Section Molecular Microbiology)
Genetic, Functional and Therapeutic Aspects of Procoagulant and Anticoagulant Factors (Third Edition)
edited by and
submission deadline 30 Sep 2026 | Viewed by 543 | Submission Open
Keywords: procoagulant factors; anticoagulant factors; hemostasis; inflammation; genetics; therapeutics; cell signaling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advance in Plant Abiotic Stress: 4th Edition
edited by and
submission deadline 30 Oct 2026 | Viewed by 108 | Submission Open
Keywords: abiotic stress; cold; drought; salt; heat; nutrient deficiency; secondary metabolism; stress resistance; plant
(This special issue belongs to the Section Molecular Plant Sciences)
Research Progress on Disease Models Based on Induced Pluripotent Stem Cells submission deadline 30 Dec 2026 | Submission Open
Keywords: induced pluripotent stem cells; iPSC-derived cells; disease modeling; precision and regenerative medicine; genome editing; CRISP/Cas; organoid; cell sheet; personalized therapeutics; drug discovery
(This special issue belongs to the Section Molecular Biology)
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