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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Electrochemical Detection: A Molecular-Level Perspective

edited by Katarzyna Fendrych and

Joanna Smajdor

submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open

Keywords: electrochemical detection; molecular sensing; biosensors; nanostructured electrodes; biomolecular interactions; electroanalytical chemistry; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Radiobiology: New Challenges and Advances

edited by Lorenzo Manti and

Pavel Bláha

submission deadline 30 Apr 2026 | Viewed by 1 | Submission Open

Keywords: strategies for overcoming cancer radioresistance and normal-tissue damage mitigation; combined approaches: BNCT; proton– boron capture therapy; radioimmunotherapy; emerging technologies and novel temporal regimes: FLASH RT mechanisms and radiobiology of laser-accelerated particles; radiobiology of new ions and of novel dose-delivery modalities in particle radiotherapy; limphopoenia in radiotherapy and biomarkers of radiation response; three-dimensional models; microdosimetry: standardising measurements; DNA damage/repair; tumour microenvironment: autophagy; ferroptosis; fibroblast activation protein; non-cancer effects and non-targeted effects

(This special issue belongs to the Section Molecular Biology)

Design, Synthesis and Development of Anticancer Drugs Targeting the Tumor Microenvironment

edited by

Yoshihiro Uto

submission deadline 30 Apr 2026 | Viewed by 1 | Submission Open

Keywords: anticancer drugs; tumor microenvironment; in vivo model; cancer-associated fibroblast; tumor-associated macrophage; tumor hypoxia; tumor endothelial cells

(This special issue belongs to the Section Molecular Oncology)

New Perspectives in Cardiovascular Disease: From Molecular Mechanisms to Clinical Innovations

edited by

Yunglung Chen

submission deadline 30 Apr 2026 | Submission Open

Keywords: cardiovascular disease; molecular mechanisms; biomarkers; atrial fibrillation; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Basis of Plant Traits Associated with Responses to Biotic and Abiotic Stress

edited by Nobuhiro Suzuki

submission deadline 30 Apr 2026 | Submission Open

Keywords: molecular mechanisms ; biotic and abiotic stress ; plant trait ; signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies, 2nd Edition

edited by

Rafał Filip

submission deadline 30 Apr 2026 | Submission Open

Keywords: Crohn’s disease; inflammatory bowel disease; immunologic and molecular mechanisms; therapies in IBD; ulcerative colitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regenerative Medicine: Biomaterials and Stem Cell Research: 2nd Edition

edited by Silvia María Díaz-Prado

submission deadline 30 Apr 2026 | Submission Open

Keywords: regenerative medicine; stem cell; biomaterial; bioprinting; tissue engineering; tissue and organ transplant; organ scarcity

(This special issue belongs to the Section Materials Science)

New Advance in Xenobiotic Toxicology

edited by Marcelo Arbo

submission deadline 30 Apr 2026 | Submission Open

Keywords: xenobiotics; toxicity tests; biotransformation; drug effects; signal transduction; environmental pollutants; chemically induced- injury; toxicogenomics; biomarkers; risk assessment

(This special issue belongs to the Section Molecular Toxicology)

mRNA Vaccines Against Viral Infectious Diseases: Progress and Prospects

edited by

Barbara Ridolfi

, Maria Teresa Maggiorella and

Ivan Schietroma

submission deadline 30 Apr 2026 | Submission Open

Keywords: viruses; mRNA vaccines; mRNA structure; mRNA platform technologies; lipid nanoparticle (LNP) delivery; immunization strategies; adjuvants; preclinical trials; clinical trials; germline-targeting; broadly neutralizing antibodies; humoral immune response; cellular immune response; host– vaccine interactions

(This special issue belongs to the Section Molecular Microbiology)

Composites of Cellulose and Cellulose Derivatives: Engineering and Applications

edited by

Omar A. El Seoud

submission deadline 30 Apr 2026 | Submission Open

Keywords: cellulose composites: engineering and applications; composites of cellulose esters: engineering and applications; composites of cellulose ethers: engineering and applications; molecular interactions within cellulose and its derivatives; molecular interactions within composites of cellulose and its derivatives

(This special issue belongs to the Section Macromolecules)

Bioactive Food Components in Human Health

edited by

Kamila Rachwał

and Klaudia Gustaw

submission deadline 30 Apr 2026 | Submission Open

Keywords: bioactive compounds; functional food; phytochemicals; bioactive peptides; health-promoting foods; food chemistry; polyphenols; natural products; human health; prebiotic compounds; bioavailability; nutraceuticals; bioaccessibility

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Stem Cells for Biomedical Applications

edited by

Sorina Dinescu

submission deadline 30 Apr 2026 | Submission Open

Keywords: stem cells biology; stem cells differentiation; stem cell-based regenerative therapies; stem cells exosomes; personalized medicine; stem cell-based 3D models

(This special issue belongs to the Section Molecular Biology)

The Role of Complement Regulation in Kidney Disease

edited by Jasmina Marković Lipkovski

submission deadline 30 Apr 2026 | Submission Open

Keywords: complement system; kidney disease; glomerulonephritis; C3 glomerulopathy; membranous nephropathy; complement regulation; innate immunity; molecular pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Molecular Insights to Novel Therapies: Neurological Diseases

edited by

Margarita Neganova

submission deadline 20 May 2026 | 17 articles | Viewed by 62346 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; epilepsy; mental illness; transgenic animal models; molecular pathways; metabolism disabilities; mitochondrial dysfunction; oxidative stress; disturbances in epigenetic regulation

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Therapy for Immune Diseases

edited by

Alexey Sarapultsev

submission deadline 20 May 2026 | 15 articles | Viewed by 46534 | Submission Open

Keywords: targeted therapy; immune diseases; biologics; immunotherapy; precision medicine; nanoparticles; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Fascial Anatomy and Histology: Advances in Molecular Biology

edited by

Carla Stecco

submission deadline 20 May 2026 | 4 articles | Viewed by 27465 | Submission Open

Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan

(This special issue belongs to the Section Molecular Biology)

Natural Compounds in Cancer Therapy and Prevention, 2nd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 May 2026 | 6 articles | Viewed by 24248 | Submission Open

Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Anti-Inflammatory Activity of Natural Products of Plant Origin

edited by Radoslaw Zajdel

submission deadline 20 May 2026 | 2 articles | Viewed by 22405 | Submission Open

Keywords: anti-inflammatory; phytochemicals; natural products; medicinal plants; inflammation; cytokines; NF-κ B pathway; cyclooxygenase inhibitors; flavonoids; terpenoids; polyphenols; molecular mechanisms; drug discovery; ethnopharmacology; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innovative Nanomaterials from Functional Molecules

edited by Xiaoming Zhang and

Yi Jia

submission deadline 20 May 2026 | 5 articles | Viewed by 16392 | Submission Open

Keywords: functional materials; molecular design; molecular assembly; medicine; catalysis; battery; supercapacitor; sensing

(This special issue belongs to the Section Molecular Nanoscience)

102nd Anniversary of Neurotransmitter Discovery: Cholinergic Pathways in Physiology and Pathophysiology

edited by

Sumonto Mitra

submission deadline 20 May 2026 | 4 articles | Viewed by 13520 | Submission Open

Keywords: acetylcholine; physiological functions; pathological alterations; cholinergic pathways

(This special issue belongs to the Section Biochemistry)

Advances in Melanoma and Skin Cancers: 2nd Edition

edited by

Domenico Mallardo

Debora Basile

and Maria Grazia Vitale

submission deadline 20 May 2026 | 6 articles | Viewed by 12815 | Submission Open

Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; clinical outcome; prognostic markers; predictive markers; combination immunotherapy

(This special issue belongs to the Section Molecular Oncology)

The Roles of Photodynamic Therapy in Tumors and Cancers

edited by Jianyong Liu

submission deadline 20 May 2026 | 4 articles | Viewed by 10851 | Submission Open

Keywords: photodynamic therapy; PDT; photodetection; photosensitizers; photosensitizing agents; reactive oxygen species; molecular mechanisms; cell necrosis; apoptosis; singlet oxygen; synergetic therapy; combination therapy; delivery vehicles; immunophototherapy; nano-photosensitizer

(This special issue belongs to the Section Molecular Oncology)

The Role of Oxidative Stress and Antioxidants in Human Disease

edited by

Federica Mannino

submission deadline 20 May 2026 | 7 articles | Viewed by 10829 | Submission Open

Keywords: oxidative stress; free radicals; antioxidants; reactive oxygen species (ROS); polyphenols

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment

edited by Manuel Morales-Ruiz

submission deadline 20 May 2026 | 5 articles | Viewed by 10673 | Submission Open

Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways; diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling; cell-to-cell interactions; fibrosis complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenesis and Novel Therapeutic Approaches for Sarcomas

edited by Francisco Giner

submission deadline 20 May 2026 | 4 articles | Viewed by 10542 | Submission Open

Keywords: soft tissue tumors; bone tumors; molecular biology; target therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration

edited by

Sara Cruciani

submission deadline 20 May 2026 | 6 articles | Viewed by 10364 | Submission Open

Keywords: stem cells; differentiation; cell therapy; tissue regeneration; cell mechanisms; regenerative medicine; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Molecular Insights in Antivirals and Vaccines

edited by

Gergana Zahmanova

Ivan Minkov

and

Yoana Dimitrova Kiselova-Kaneva

submission deadline 20 May 2026 | 2 articles | Viewed by 9818 | Submission Open

Keywords: new vaccine platforms; cell cultures; plant molecular farming; vaccines and VLPs; nanoparticle vaccines; emerging viral diseases; novel therapeutics; biologics; antibodies; receptor modulators; plant-based compounds with antiviral activity; medicinal plant-derived products; bioactive proteins from plants

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms and Therapies of Colorectal Cancer: 4th Edition

edited by

Donatella Delle Cave

submission deadline 20 May 2026 | 7 articles | Viewed by 9774 | Submission Open

Keywords: transforming growth factor beta (TGF-β ) signaling; genetic alterations; molecular targeted therapy precision medicine

(This special issue belongs to the Section Molecular Oncology)

New Cardiovascular Risk Factors: 2nd Edition

edited by

Antonio Barbato

submission deadline 20 May 2026 | 4 articles | Viewed by 9272 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Biology)

Plant-Derived Bioactives: Antioxidant Mechanisms and Preventive Health Strategies

edited by

Charles Manful

submission deadline 20 May 2026 | 3 articles | Viewed by 9223 | Submission Open

Keywords: antioxidant; plant-derived bioactive compounds; flavonoids; oxidative stress; mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cutting-Edge Methods for Exploiting Bioactive Compounds in Biomasses: From the Plant Matrix to Molecular Function

edited by Chiara Magni

submission deadline 20 May 2026 | 5 articles | Viewed by 8558 | Submission Open

Keywords: plant matrix; agri-food biomasses; biochemistry; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Impact of Mitochondria on Human Disease and Health

edited by

Martina Semenzato

submission deadline 20 May 2026 | 5 articles | Viewed by 8552 | Submission Open

Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer

(This special issue belongs to the Section Biochemistry)

Fish Immunology, 5th Edition

edited by

Alberto Cuesta

and

Elena Chaves-Pozo

submission deadline 20 May 2026 | 4 articles | Viewed by 8015 | Submission Open

Keywords: fish immunology; innate immunity; acquired immunity; leucocytes; disease; immunostimulants; immunodepression; inflammation

(This special issue belongs to the Section Molecular Immunology)

Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy

edited by

Tetiana Zaǐchuk

submission deadline 20 May 2026 | 5 articles | Viewed by 7575 | Submission Open

Keywords: tumor microenvironment; immune response modulation; signaling pathways; extracellular matrix components; tumor evolution

(This special issue belongs to the Section Molecular Oncology)

Macrophages and Inflammation

edited by

Julia Kzhyshkowska

submission deadline 20 May 2026 | 2 articles | Viewed by 7442 | Submission Open

Keywords: innate immunity; transcriptional programs; epigenetics; immunometabolism; receptors; scavenging; cytokines; ROS

(This special issue belongs to the Section Molecular Immunology)

Antimicrobial and Antiviral Peptides: 2nd Edition

edited by

Tecla Ciociola

submission deadline 20 May 2026 | 4 articles | Viewed by 7380 | Submission Open

Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications

(This special issue belongs to the Section Biochemistry)

Effects of Stressors During Pregnancy and Breastfeeding on the Child: Molecular Perspectives

edited by

Anna Weronika Sobańska

submission deadline 20 May 2026 | 1 articles | Viewed by 7349 | Submission Open

Keywords: xenobiotics; drugs; gestation; breastfeeding; fetus; placenta; child’ s development; teratogenicity; central nervous system

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Treatment of Migraine

edited by Noboru Imai

submission deadline 20 May 2026 | 1 articles | Viewed by 7297 | Submission Open

Keywords: migraine; nitric oxide synthase (NOS); neuropeptides; calcitonin gene-related peptide (CGRP); pituitary adenylate cyclase activating polypeptide (PACAP); molecular pathways; therapeutic targets; neurovascular condition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compound Delivery Systems and Microbiome Interactions

edited by

Ramona Suharoschi

Adriana Fodor

and

Oana Lelia Pop

submission deadline 20 May 2026 | 2 articles | Viewed by 7278 | Submission Open

Keywords: bioactive compounds; delivery systems; gut microbiome; personalized nutrition; bioavailability; encapsulation technologies; microbiome– bioactive interactions; targeted delivery; precision nutrition; synergistic interactions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Bioprinting: Progress and Challenges

edited by

Rui Vitorino

submission deadline 20 May 2026 | 1 articles | Viewed by 6998 | Submission Open

Keywords: advances in 3D bioprinting technologies; biomaterials for bioprinting; bioprinting applications in tissue engineering and regenerative medicine; cellular and molecular interactions in bioprinted constructs; bio-printed organ and tissue models for disease research

(This special issue belongs to the Section Materials Science)

Advances in G Protein-Coupled Receptor Signaling

edited by

Dariusz Szukiewicz

submission deadline 20 May 2026 | 1 articles | Viewed by 6831 | Submission Open

Keywords: G protein-coupled receptors (GPCRs)G蛋白偶联受体; seven transmembrane domain (7TM) receptors七跨膜结构域受体; metabotropic receptors代谢型受体; membrane receptors膜受体; GPCRs signalingGPCR信号; GPCRs signaling pathwaysGPCR信号通路; anti-inflammatory effects抗炎作用; inflammatory diseases炎性疾病; metabolic diseases代谢疾病; metabolic effects代谢效应; anti-inflammatory treatment抗炎治疗

(This special issue belongs to the Section Molecular Immunology)

Molecular Ecology, Physiology and Biochemistry of Insects, 5th Edition

edited by

Klaus H. Hoffmann

submission deadline 20 May 2026 | 4 articles | Viewed by 6790 | Submission Open

Keywords: insect development and reproduction; molecular endocrinology/neuropeptides; insect immunity; photoperiodism; cold hardiness; global climate change; insect aging; insect– plant interactions; molecular interactions of insects with microorganisms; chemical communication; biochemistry of insect venoms; insect genomics and proteomics; genetic engineering; molecular; volution/population genetics; insect biotechnology

(This special issue belongs to the Section Molecular Immunology)

The Role of Natural Compounds in Cancer and Inflammation, 2nd Edition

edited by

Elia Ranzato

submission deadline 20 May 2026 | 4 articles | Viewed by 6197 | Submission Open

Keywords: natural compounds; oxidative stress; anti-cancer; anti-inflammatory; natural product synthesis; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Vascular Protection by Means of Nutraceuticals

edited by

Roberta Macri

submission deadline 20 May 2026 | 2 articles | Viewed by 6071 | Submission Open

Keywords: cardiovascular disease; drugs; nutrients

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Opioid Research

edited by Matthew E. Layton

submission deadline 20 May 2026 | 5 articles | Viewed by 6053 | Submission Open

Keywords: methadone; buprenorphine; hyperbaric oxygen; complementary/alternative/integrative treatments; patient-centered outcomes

(This special issue belongs to the Section Molecular Pharmacology)

Exploring Cannabinoids: Molecular Mechanisms and Potential Therapeutic Applications

edited by

Grace Blest Hopley

submission deadline 20 May 2026 | 4 articles | Viewed by 6021 | Submission Open

Keywords: cannabinoids; endocannabinoid system; δ 9-tetrahydrocannabinol (THC); cannabidiol (CBD); inflammation; chronic pain; neurodegenerative disorders; epilepsy; psychosis; cancer-related symptoms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Periodontal Disease: From Molecular Pathogenesis to Precision Diagnostics and Innovative Therapeutics

edited by

Elisabetta Ferrara

submission deadline 20 May 2026 | 2 articles | Viewed by 5983 | Submission Open

Keywords: periodontitis; gingivitis; oral microbiome; host– pathogen interactions; periodontal immunology; systemic inflammation; salivary diagnostics; periodontal regeneration; precision dentistry; oral-systemic connections; inflammatory biomarkers; antimicrobial peptides; peri-implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Technical Developments and Recent Applications of Cellular Molecular Imaging

edited by Hanae Sato

submission deadline 20 May 2026 | 3 articles | Viewed by 5774 | Submission Open

Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging

(This special issue belongs to the Section Molecular Biology)

Molecular Studies of Monogenic Diseases: Diagnostics, Mechanisms and Therapeutics

edited by

Ivano Condò

submission deadline 20 May 2026 | 2 articles | Viewed by 5718 | Submission Open

Keywords: cell death pathways; DNA sequencing; drug discovery; gene expression; gene mutation; genetic diagnosis; molecular signaling; molecular therapy; monogenic disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Biological and Molecular Targets in Schizophrenia

edited by Jacopo Sapienza

submission deadline 20 May 2026 | 4 articles | Viewed by 5512 | Submission Open

Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 2851-2900 on page 58 of 66.

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