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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Therapeutic Approaches and Novel Targets in Fibrosis Treatment

edited by

Akrivi Chrysanthopoulou

submission deadline 31 Dec 2025 | Viewed by 119 | Submission Open

Keywords: organ fibrosis; tissue fibrosis; regenerative medicine; fibroblasts; chronic inflammation; immune mechanisms; wound healing; injured epithelium or endothelium; epithelial– mesenchymal transformation; treatment; therapies; therapeutic approaches; diagnosis; prognosis; antifibrotic agents

(This special issue belongs to the Section Molecular Immunology)

RNA Biology: Unraveling the Complex Interplay Between Proteins and RNAs in Gene Expression and Regulation, 2nd Edition

edited by

Rosemary Kiernan

submission deadline 31 Dec 2025 | Viewed by 119 | Submission Open

Keywords: RNA biology; protein– RNA interplay; gene expression; post-transcriptional modifications; non-coding RNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Endometrial Cancer: From Molecular Insights to Treatment

edited by Giuseppe Angelico

submission deadline 31 Dec 2025 | Viewed by 119 | Submission Open

Keywords: endometrial cancer; molecular classification; TCGA; precision oncology; immunotherapy; targeted therapy; biomarkers; tumor microenvironment; genomics; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Crosstalk in Stress-Induced Psychopathology

edited by Ilaria Demori and

Natalia V. Gulyaeva

submission deadline 31 Dec 2025 | Viewed by 118 | Submission Open

Keywords: Depression; Anxiety; Post-traumatic stress disorder; Early life stress; Microbiota– gut– brain axis; Blood– brain barrier; Neurotransmission; Neuroinflammation; Eating disorders; Addiction; Psychoneuroendocrineimmunology; Allostasis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Skin Allergies: Cross-Disciplinary Approaches to Diagnosis and Therapy

edited by

Montserrat Fernández-Guarino

, Belén De la Hoz and

Javier Martínez-Botas

submission deadline 31 Dec 2025 | Viewed by 116 | Submission Open

Keywords: skin allergy; dermatology; allergy management; allergic reaction; topical immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Underlying the Involvement of Cytomegalovirus in the Progression of Multiple Sclerosis

edited by

Marco Miceli

submission deadline 31 Dec 2025 | Viewed by 116 | Submission Open

Keywords: multiple sclerosis; central nervous system; autoimmune; genetic and environmental factors; herpesviruses; CMV; immunopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Pharmacology for Neuropathic and Chronic Pain Management

edited by

Kuthati Yaswanth

and

Chih-Shung Wong

submission deadline 31 Dec 2025 | Viewed by 113 | Submission Open

Keywords: neuropathic pain; diabetic neuropathy; chronic pain; DPP-4 inhibitors; SGLT2 inhibitors; pain pharmacology; neuroinflammation; glial activation; ion channels; cannabinoids; endogenous peptides; epigenetic modulation; extended-release formulations; drug repurposing; analgesic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Epigenetic Alterations in Hepatocellular Carcinoma

edited by

Yonghwan Shin

submission deadline 31 Dec 2025 | Viewed by 112 | Submission Open

Keywords: hepatocellular carcinoma (HCC); epigenetics; DNA methylation; histone modification; chromatin remodeling; non-coding RNAs epigenetic biomarkers; cancer progression

(This special issue belongs to the Section Molecular Oncology)

Molecular Applications of Microbial and Marine-Derived Natural Products with Health Benefits

edited by Simona Negreş

submission deadline 31 Dec 2025 | Viewed by 111 | Submission Open

Keywords: microbial products; marine-derived products; pharmacological activity; key molecules; molecular mechanisms; drug discovery; nutraceuticals; therapy; prophylaxis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research on Phenolic Profiles and Anti-Inflammatory Activities of Plants

edited by Chi-Rei Wu and Li-Wei Lin

submission deadline 31 Dec 2025 | Viewed by 110 | Submission Open

Keywords: plants; phenolic profiles; inflammation; cardiovascular disorders; cancer; diabetes; neurodegenerative disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Therapeutic Strategies for Cystic Fibrosis

edited by Kavisha Arora

submission deadline 31 Dec 2025 | Viewed by 109 | Submission Open

Keywords: cystic fibrosis; CFTR; modulator therapy; non-responder mutations; mRNA therapy; gene editing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hidradenitis Suppurativa: Molecular Mechanisms and Therapeutic Strategies

edited by

Lucas André Cavalcanti Brandão

submission deadline 31 Dec 2025 | Viewed by 109 | Submission Open

Keywords: hidradenitis suppurativa; molecular mechanisms; therapeutic strategies; pathophysiology; autoinflammatory disorders; immunology; dermatology inflammation; skin disease; molecular pathways; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targets in Brain Tumor Pathogenesis

edited by Mugurel Petrinel Radoi

submission deadline 31 Dec 2025 | Viewed by 108 | Submission Open

Keywords: brain tumors; molecular pathogenesis; glioma biomarkers; tumor microenvironment; neuro-oncology; targeted therapy; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Metabolism of Alzheimer’s Disease

edited by

Rebecca Piccarducci

and Maria Letizia Trincavelli

submission deadline 31 Dec 2025 | Viewed by 107 | Submission Open

Keywords: Alzheimer’ s disease; brain metabolism; insulin resistance; lipid metabolism; APOE ε 4; metabolic targets; insulin-sensitizing drugs; lifestyle and metabolic interventions

(This special issue belongs to the Section Molecular Neurobiology)

Pharmacological Agents for Soft Tissue and Articular Injections: From Mechanisms to Clinical Applications

edited by

Carmelo Pirri

submission deadline 31 Dec 2025 | Viewed by 106 | Submission Open

Keywords: injectable pharmacological agents; musculoskeletal disorders; injection therapies; platelet-rich plasma (PRP); hyaluronic acid

(This special issue belongs to the Section Molecular Pharmacology)

Oxidative–Inflammatory Crosstalk in Retinal Pigment Epithelium: Models, Mechanisms, and Modulators

edited by

Min-Yen Hsu

submission deadline 31 Dec 2025 | Viewed by 105 | Submission Open

Keywords: retinal pigment epithelium (RPE); oxidative stress; inflammation; immunometabolism; mitochondrial dysfunction; inflammasome; IL-8/VEGF signaling; heavy-metal toxicity; extracellular vesicles; antioxidant therapy

(This special issue belongs to the Section Molecular Immunology)

Endocrine–Immune Crosstalk in Human Reproductive Health and Pathology

edited by Juan Pablo Mackern-Oberti

submission deadline 31 Dec 2025 | Viewed by 105 | Submission Open

Keywords: T cells; B cells; autoimmune disease; reproduction; immunemodulation; inflammation; endocrinology; lactation

(This special issue belongs to the Section Molecular Immunology)

RNA-Mediated Post-Transcriptional Regulation in Bacteria Roles of Small RNAs, Small Proteins, and RNA Modifications

edited by Karl M Thompson

submission deadline 31 Dec 2025 | Viewed by 103 | Submission Open

Keywords: bacterial post-transcriptional regulation; small RNAs (sRNAs); small open reading frames (smORFs); RNA modifications; epitranscriptomics

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Underlying the Pathogenesis and Treatment of Gastrointestinal Disorders

edited by

Andrzej Pławski

submission deadline 31 Dec 2025 | Viewed by 102 | Submission Open

Keywords: gastrointestinal disorders; molecular mechanisms; diagnosis; treatment; precision medicine; biomarkers; gastrointestinal cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Perspective of Alzheimer’s Disease

edited by

Philippe Poindron

submission deadline 31 Dec 2025 | Viewed by 102 | Submission Open

Keywords: Alzheimer’ s disease; amyloid peptide (toxic conformation); mutations (gamma-secretase); GWAS; risk factors; new treatment (monoclonal antibodies)

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Environmental Exposures and Molecular Disruption Mechanisms in Human Health

edited by

David Lozano-Paniagua

submission deadline 31 Dec 2025 | Viewed by 98 | Submission Open

Keywords: environmental exposure; epigenetic; exposome; molecular biomarkers; molecular toxicology

(This special issue belongs to the Section Molecular Toxicology)

Next Generation Sequencing in Human Diseases

edited by

Manuel Muro

submission deadline 31 Dec 2025 | Viewed by 97 | Submission Open

Keywords: NGS; single-cell analysis; metagenomics; forensic DNA analysis; precision medicine; genetic diagnostics; transplant monitoring; cell-free DNA; new allele and variant discovery

(This special issue belongs to the Section Molecular Informatics)

Multiple Myeloma: Cancer Therapy and the Tumour Microenvironment

edited by Ruba Al Abdulla

submission deadline 31 Dec 2025 | Viewed by 95 | Submission Open

Keywords: multiple myeloma; cancer resistance; therapeutic strategies; stroma cells; cancer microenvironment; cancer immunity

(This special issue belongs to the Section Molecular Oncology)

Gene Regulation and Neurotoxicity in Alcohol Related Pathologies

edited by

Stefano Casalotti

submission deadline 31 Dec 2025 | Viewed by 95 | Submission Open

Keywords: alcohol; ethanol; gene expression; neurotoxicity; epigenetics; polymorphisms; neu-rons; glial cell; plasticity

(This special issue belongs to the Section Molecular Neurobiology)

Anticancer Drugs: Current Status and Future Directions

edited by

Mariano Martínez-Vázquez

submission deadline 31 Dec 2025 | Viewed by 92 | Submission Open

Keywords: anticancer drugs; hybrids; combinations; nanoparticles

(This special issue belongs to the Section Molecular Pharmacology)

Structural and Functional Analysis of Amino Acids and Proteins: 2nd Edition

edited by

Wenying Yan

submission deadline 31 Dec 2025 | Viewed by 91 | Submission Open

Keywords: protein structure; protein function; amino acids network; deep learning; bioinformatics; protein– protein interaction; drug discovery; biomarker

(This special issue belongs to the Section Molecular Informatics)

Molecular and Adaptive Mechanisms in Plant Genetics

edited by

Gennaro Lettieri

submission deadline 31 Dec 2025 | Viewed by 91 | Submission Open

Keywords: forest genetics; breeding techniques; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Engineering in Insoluble Antibacterial Particle for Medical Devices

edited by Ole T. Jensen

submission deadline 31 Dec 2025 | Viewed by 90 | Submission Open

Keywords: antibacterial; quaternary ammonium silica particles; bactericidal mechanism; antibacterial particle; medical devices

(This special issue belongs to the Section Materials Science)

Gene Variants and Phenotypic Diversity: Insights into CFTR, SLC Transporters and Disease

edited by Veronique Ladeveze

submission deadline 31 Dec 2025 | Viewed by 87 | Submission Open

Keywords: mutations; polymorphisms; alternative splicing; exon skipping; intron retention; CFTR (ABCC7); cystic fibrosis; SLC16a3; Alzheimer’ s disease; pulmonary and brain cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic and Transcriptional Regulation in Aquaculture: Immunity, Stress and Disease Prevention

edited by

Chan-Hee Kim

submission deadline 31 Dec 2025 | Viewed by 86 | Submission Open

Keywords: epigenetics; transcriptional regulation; trained immunity; DNA methylation; histone modifications; non-coding RNAs; disease prevention; aquaculture

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms and Pathways Involved in Toxicant-Induced Stress

edited by

Maria Giulia Lionetto

and

Maria Elena Giordano

submission deadline 31 Dec 2025 | Viewed by 85 | Submission Open

Keywords: oxidative stress; cell death; biomarkers; toxicant exposure; environmental toxicology; cell signaling pathways

(This special issue belongs to the Section Molecular Toxicology)

Genome Editing and Biotechnology in Fruit Improvement

edited by Hongxia Miao

submission deadline 31 Dec 2025 | Viewed by 83 | Submission Open

Keywords: fruit improvement; horticultural crops; genome editing; biotechnology; molecular biology; plant genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Nanomaterials for Cancer Treatment and Translational Medicine

edited by

Mingzhen Zhang

submission deadline 31 Dec 2025 | Viewed by 82 | Submission Open

Keywords: nanozymes; extracellular vesicles; drug delivery systems; cancer treatment; oxidative stress-related diseases; translational medicine

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Advances in Diagnosis and Treatment of Gynaecological Cancers

edited by

Chenhsuan Wu

submission deadline 31 Dec 2025 | Viewed by 78 | Submission Open

Keywords: gynecological oncology; molecular biomarkers; precision medicine; tumor microenvironment; targeted therapy; early detection; immunotherapy; genomic profiling; drug resistance; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Genetic Variants Involved in Breast and Ovarian Cancers

edited by

Chakravarthy Garlapati

submission deadline 31 Dec 2025 | Viewed by 75 | Submission Open

Keywords: breast and ovarian cancers; genetics; genomics; biomarkers; mutations; genetic variants; translational markers

(This special issue belongs to the Section Molecular Oncology)

Cancer Stem Cells as Key Immunotherapy Targets

edited by Cosmin Andrei Cismaru

submission deadline 31 Dec 2025 | Viewed by 50 | Submission Open

Keywords: cancer stem cells; immunotherapy; immune escape; tumor antigens; cancer recurrence

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research on Chronic Heart Failure

edited by

Marco Tana

submission deadline 1 Jan 2026 | 3 articles | Viewed by 6375 | Submission Open

Keywords: chronic heart failure (CHF); cardiovascular medicine; cardiac amyloidosis; biomarkers; translational ap-proaches; molecular approaches; pharmacological treatment; molecular mechanisms; molecular pathways; prognosis; clinical practice in CHF management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Signatures in Overt Neurodegenerative Disease: Toward Precision Diagnosis and Classification

edited by

Jose Miguel Laffita-Mesa

submission deadline 1 Jan 2026 | 1 articles | Viewed by 1302 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; disease stratification; Parkinson’ s disease; Alzheimer’ s disease; spinocerebellar ataxia; precision medicine; digital PCR; circRNA; prognostic biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Poly- and Oligo-Saccharides as Pharmaceutical Agents in Biology and Medicine

edited by

Kevin H. Mayo

submission deadline 1 Jan 2026 | Viewed by 215 | Submission Open

Keywords: polysaccharides; oligosaccharides; isolation and purification; structural and functional analyses; biological mechanisms of action; cellular & molecular targets and interactions; pharmaceutical drug development; cancer; cardiovascular disease; diabetes

(This special issue belongs to the Section Molecular Biology)

Checkpoint Antibodies at the Crossroads: From Mechanisms to Multi-Modal Cancer Therapy

edited by Li Ye and Xuyao Zhang

submission deadline 10 Jan 2026 | 1 articles | Viewed by 1960 | Submission Open

Keywords: immune checkpoint inhibitors; tumor microenvironment; computational immunology; resistance mechanisms; multifunctional antibodies; rational combination design

(This special issue belongs to the Section Molecular Immunology)

From Microbes to Humans: Unveiling the Dynamic World of Carbonic Anhydrases (CAs)

edited by

Clemente Capasso

submission deadline 10 Jan 2026 | Viewed by 697 | Submission Open

Keywords: metalloenzymes; bacteria; pathogens; sulfonamides; inhibitors; activators; anti-infective agents; medicine; anticancer; neurodegenerative diseases; biomedical applications; biotechnology

(This special issue belongs to the Section Biochemistry)

Advances in Allergen Immunotherapy: Current Concepts and Future Directions

edited by

Constantinos Pitsios

submission deadline 10 Jan 2026 | Viewed by 122 | Submission Open

Keywords: allergen immunotherapy; oral immunotherapy; Hymenoptera venom; allergy extracts; adjuvants

(This special issue belongs to the Section Molecular Immunology)

Plant Epigenetic Memory Under Abiotic Stress

edited by

Md Mezanur Rahman

submission deadline 11 Jan 2026 | Viewed by 143 | Submission Open

Keywords: plant epigenetics; epigenetic memory; abiotic stress; DNA methylation; histone modification; chromatin remodeling; transgenerational inheritance; stress-responsive genes

(This special issue belongs to the Section Molecular Plant Sciences)

From Electronic Structure to Application: Computational Insights into Bioactive and Functional Molecules

edited by

Karolina Kula

submission deadline 15 Jan 2026 | 2 articles | Viewed by 1994 | Submission Open

Keywords: molecular design; molecular modeling; substituent effect; reactivity descriptors; biological potential; in silico study; physicochemical properties; ADME; PASS; QSAR

(This special issue belongs to the Section Molecular Informatics)

Natural-Derived Bioactive Compounds in Disease Treatment

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Jan 2026 | 7 articles | Viewed by 26937 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; nutraceuticals; anti-oxidants; gene expression; protein expression; cellular signaling; nanoformulations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms Underlying Vulnerability to Stress-Related Disorders

edited by Marta Pardo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 26022 | Submission Open

Keywords: stress-related disorders; post-traumatic stress disorder; molecular mechanisms; pharmacological targets

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insight into Plant Bioactive Compounds

edited by

Karolina Wojtunik-Kulesza

submission deadline 20 Jan 2026 | 7 articles | Viewed by 20263 | Submission Open

Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation

edited by

Masaru Tanaka

submission deadline 20 Jan 2026 | 4 articles | Viewed by 19938 | Submission Open

Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood– brain barrier; blood– cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Endothelial Dysfunction: Fourth Edition

edited by

Catherine Davis

submission deadline 20 Jan 2026 | 6 articles | Viewed by 19068 | Submission Open

Keywords: vascular permeability; atherosclerosis; blood– brain barrier; endothelial adhesion molecules; vasodilation; thrombosis

(This special issue belongs to the Section Molecular Immunology)

Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment

edited by

Ilaria Mormile

submission deadline 20 Jan 2026 | 8 articles | Viewed by 18392 | Submission Open

Keywords: allergy; autoimmunity; autoimmune diseases; asthma; allergic rhinitis; urticaria; inflammation; molecular pathway; biomarkers; target therapy

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 751-800 on page 16 of 66.

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