New Therapeutic Strategies for Cystic Fibrosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 136
Special Issue Editor
Special Issue Information
Dear Colleagues,
The goal of this Special Issue on New Therapeutic Strategies for Cystic Fibrosis is to stay aligned with the rapidly evolving landscape of CF treatments, with a focus on developing universal therapies for all patients. More than 100,000 people are affected by CF worldwide. While 80–90% of individuals with CF currently qualify for CFTR modulator therapies, the remaining 10–20% still lack effective treatment options. This underscores the urgent need to expand therapeutic strategies beyond lifelong pharmacological correction, which relies heavily on patient adherence. Access, cost, and tolerance to medication are the additional factors that affect actual treatment rates. Some patients are not eligible due to rare mutations, age restrictions, or post-lung transplant status. Key areas of innovation to develop alternative therapies include the identification of novel molecular targets, advancements in gene and mRNA therapies, mutation-specific treatments, and personalized medicine approaches.
Dr. Kavisha Arora
Guest Editor
Manuscript Submission Information
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Keywords
- cystic fibrosis
- CFTR
- modulator therapy
- non-responder mutations
- mRNA therapy
- gene editing
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