ijms-logo

Journal Browser

Journal Browser

Molecular Insight into Plant Bioactive Compounds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 1428

Special Issue Editor


E-Mail Website
Guest Editor
Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
Interests: antioxidants; free radicals; secondary plant metabolites; functional food; neurodegeneration; biological activities
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plants are an inexhaustible source of active compounds that have been used in medicine and pharmacy for thousands of years. The bioactive compounds are regarded as significant alternatives for disease prevention and treatment. The pro-health activity of plants results from their bioactive compounds, called secondary metabolites, which include polyphenols, flavonoids, lignins, alkaloids, terpenoids, and carotenoids. These molecules with well-defined functional roles, produced to defend plants from abiotic and biotic stresses, have complex molecular structures, revealing several diversified biological activites. There is a Huge pool of compounds with multidirectional pro-health effects such as antioxidant, antibacterial, anti-viral, normalizing blood pressure, antifungal, and many more.

In this Special Issue, articles (original research papers and reviews) that focus on secondary plant metabolites, methods used for their qualitative and quantitative analyses, the bioactivity of the compounds, both in vitro and in vivo, and newly identified secondary plant metabolites are most welcome. This Special Issue is a call for researchers representing multiple disciplines, including pharmacy, chemistry, biology, etc., from around the world to share their findings on plant bioactive compounds and their pro-health significance.

Dr. Karolina Wojtunik-Kulesza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactivity
  • disease prevention
  • herbal medicines
  • antioxidants
  • qualitative analysis

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

20 pages, 6878 KiB  
Article
Expanding Knowledge about the Influence of Citral on Cognitive Functions—In Vitro, In Vivo and Ex Vivo Studies
by Karolina Wojtunik-Kulesza, Monika Rudkowska, Katarzyna Klimek, Monika Agacka-Mołdoch, Jarosław Mołdoch and Agnieszka Michalak
Int. J. Mol. Sci. 2024, 25(13), 6866; https://doi.org/10.3390/ijms25136866 (registering DOI) - 22 Jun 2024
Viewed by 160
Abstract
Citral, a common monoterpene found in numerous plants, is an interesting compound that has been shown to have various biological activities. Although it is widely distributed in nature and there are many studies presenting its biological activities, its anti-neurodegenerative activity, especially under in [...] Read more.
Citral, a common monoterpene found in numerous plants, is an interesting compound that has been shown to have various biological activities. Although it is widely distributed in nature and there are many studies presenting its biological activities, its anti-neurodegenerative activity, especially under in vivo conditions, is very poorly understood. Thus, this paper aimed to deepen knowledge about citral activity towards factors and symptoms of neurodegeneration. To accomplish this, several comprehensive tests were conducted, including the estimation of butyrylcholinesterase inhibition, the evaluation of hepatotoxicity and the detection of oxidative stress and lipid peroxidation in vitro, as well as an in vivo behavioral assessment using mice models. Additionally, ex vivo determination of level of the compound in the brain and blood of a tested animal was undertaken. The results obtained revealed that citral is able to inhibit butyrylcholinesterase activity and protect hepatic cells against oxidative stress and lipid peroxidation in vitro. Moreover, behavioral tests in vivo indicated that citral (50 mg/kg) improves memory processes associated with acquisition (passive avoidance test), both in acute and subchronic administration. Additionally, we found that the administration of citral at 25 mg/kg and 50 mg/kg did not significantly affect the locomotor activity. Beyond the aforementioned, gas chromatography-mass spectrometry analysis revealed the presence of the compound in the blood and brain after subchronic administration of citral. Taken together, the results obtained in vitro, in vivo and ex vivo clearly indicate that citral is a promising monoterpene that can potentially be used towards cognition improvement. Full article
(This article belongs to the Special Issue Molecular Insight into Plant Bioactive Compounds)
Show Figures

Figure 1

19 pages, 8522 KiB  
Article
Preventive Effect of the Total Polyphenols from Nymphaea candida on Sepsis-Induced Acute Lung Injury in Mice via Gut Microbiota and NLRP3, TLR-4/NF-κB Pathway
by Chenyang Li, Xinxin Qi, Lei Xu, Yuan Sun, Yan Chen, Yuhan Yao and Jun Zhao
Int. J. Mol. Sci. 2024, 25(8), 4276; https://doi.org/10.3390/ijms25084276 - 12 Apr 2024
Viewed by 687
Abstract
This study aimed to investigate the preventive effects of the total polyphenols from Nymphaea candida (NCTP) on LPS-induced septic acute lung injury (ALI) in mice and its mechanisms. NCTP could significantly ameliorate LPS-induced lung tissue pathological injury in mice as well as lung [...] Read more.
This study aimed to investigate the preventive effects of the total polyphenols from Nymphaea candida (NCTP) on LPS-induced septic acute lung injury (ALI) in mice and its mechanisms. NCTP could significantly ameliorate LPS-induced lung tissue pathological injury in mice as well as lung wet/dry ratio and MPO activities (p < 0.05). NCTP could significantly decrease the blood leukocyte, neutrophil, monocyte, basophil, and eosinophil amounts and LPS contents in ALI mice compared with the model group (p < 0.05), improving lymphocyte amounts (p < 0.05). Moreover, compared with the model group, NCTP could decrease lung tissue TNF-α, IL-6, and IL-1β levels (p < 0.05) and downregulate the protein expression of TLR4, MyD88, TRAF6, IKKβ, IκB-α, p-IκB-α, NF-κB p65, p-NF-κB p65, NLRP3, ASC, and Caspase1 in lung tissues (p < 0.05). Furthermore, NCTP could inhibit ileum histopathological injuries, restoring the ileum tight junctions by increasing the expression of ZO-1 and occludin. Simultaneously, NCTP could reverse the gut microbiota disorder, restore the diversity of gut microbiota, increase the relative abundance of Clostridiales and Lachnospiraceae, and enhance the content of SCFAs (acetic acid, propionic acid, and butyric acid) in feces. These results suggested that NCTP has preventive effects on septic ALI, and its mechanism is related to the regulation of gut microbiota, SCFA metabolism, and the TLR-4/NF-κB and NLRP3 pathways. Full article
(This article belongs to the Special Issue Molecular Insight into Plant Bioactive Compounds)
Show Figures

Figure 1

Back to TopTop