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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Treatment Strategies in Diabetic Kidney Disease

edited by

Érika Bevilaqua Rangel

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1107 | Submission Open

Keywords: diabetic kidney disease; oxidative stress; autophagy; inflammation; fibrosis; cell therapy; SGLT2 inhibitors and GLP-1 agonists; mesenchymal stem cells; gene therapy; translational nephrology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Food Components in Human Health

edited by

Kamila Rachwał

and Klaudia Gustaw

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1081 | Submission Open

Keywords: bioactive compounds; functional food; phytochemicals; bioactive peptides; health-promoting foods; food chemistry; polyphenols; natural products; human health; prebiotic compounds; bioavailability; nutraceuticals; bioaccessibility

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring Recent Research on Natural Compounds: From Biosynthesis to Application

edited by

Nitin Mantri

submission deadline 25 Dec 2026 | Viewed by 1039 | Submission Open

Keywords: proteins like antibodies and enzymes; small molecules; plant extracts; biosynthesis; nanodelivery; drug discovery

(This special issue belongs to the Section Biochemistry)

Molecular Regulatory Mechanisms of the Tumor Microenvironment in Human Diseases

edited by

Cornelia Amalinei

and

Adriana Grigoraș

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1036 | Submission Open

Keywords: tumor microenvironment; cytokines; exosomes; non-tumor cells; tumor-associated immune cells; cancer prognosis; cancer diagnosis; oncotherapy

(This special issue belongs to the Section Molecular Oncology)

Emerging Strategies in Tuberculosis Drug Discovery

edited by

Parvesh Singh

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1018 | Submission Open

Keywords: anti-tuberculosis agents; MDR-TB; XDR-TB; drug repurposing; hybrid drugs; high-throughput screening; structure-based drug design; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Clinical Advances in Ophthalmic Inflammation, Infection, and Degeneration

edited by Hyun Jin Shin

submission deadline 25 Dec 2026 | 1 articles | Viewed by 997 | Submission Open

Keywords: ophthalmic inflammation; ocular infection; ocular degeneration; molecular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced in In Silico Methods for Rational Drug Design and Predictive Toxicology

edited by

Gnanendra Shanmugam

submission deadline 25 Dec 2026 | 1 articles | Viewed by 993 | Submission Open

Keywords: rational drug design; predictive toxicology; molecular modeling; AI in drug discovery; QSAR; molecular docking; ADMET

(This special issue belongs to the Section Molecular Informatics)

Epilepsy: Molecular Neuropharmacology, Calcium Signalling, Neuroinflammation, and Drug Discovery

edited by Maria F. Cano-Abad

submission deadline 25 Dec 2026 | 1 articles | Viewed by 975 | Submission Open

Keywords: epilepsy receptor pharmacology; neurotransmitter receptor modulation; calcium signaling and homeostasis; therapeutic targets in epilepsy; GABAergic and glutamatergic systems

(This special issue belongs to the Section Molecular Neurobiology)

Unravelling Molecular Pathways in Ocular Disease and Degeneration

edited by

Zala Lužnik Marzidovšek

submission deadline 25 Dec 2026 | 1 articles | Viewed by 916 | Submission Open

Keywords: molecular mechanisms; ocular disease; biomarkers; therapeutic targets; regenerative; gene therapies; corneal degeneration; retinal degeneration; optic nerve pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurological Mechanisms of Action of Natural Products

edited by Damião Pergentino De Sousa

submission deadline 25 Dec 2026 | 1 articles | Viewed by 910 | Submission Open

Keywords: Alzheimer's disease; Parkinson's disease; epilepsy; dementia; pain; essential oils; medicinal plants; alkaloids; flavonoids; natural products

(This special issue belongs to the Section Molecular Neurobiology)

Diversity in Structure, Function, and Regulation of Calcium-Permeable Channels

edited by

Lucie Parent

submission deadline 25 Dec 2026 | Viewed by 873 | Submission Open

Keywords: calcium-permeable channels in health and disease; calcium-permeable channels in calcium cycling; TRP channels; voltage-gated calcium channels; STIM / Orai complexes; intracellular IP3 calcium channels; intracellular RyR calcium channels; posttranslational calcium channel modifications; calcium-permeable channel inhibitors; calcium-permeable channel biophysics; calcium-permeable channel evolution

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Surfactant Sciences: Design, Synthesis, and Applications

edited by Zakaria Hafidi

submission deadline 25 Dec 2026 | 1 articles | Viewed by 869 | Submission Open

Keywords: surfactants; synthesis; biodegradation; catalysis; biological activity; nanoparticles; design; green chemistry; self-assembly; surface chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advanced Research on Antioxidant Activity

edited by Agnieszka Filipek

submission deadline 25 Dec 2026 | 1 articles | Viewed by 853 | Submission Open

Keywords: antioxidants; advanced mechanisms of action; signaling pathways; molecular mechanism; biologically active compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Computational and Molecular Advances in Precision Craniofacial Medicine

edited by

Hsiu-Hsia Lin

submission deadline 25 Dec 2026 | Viewed by 851 | Submission Open

Keywords: precision medicine; craniofacial anomalies; artificial intelligence; 3D morphometrics; genomics; transcriptomics; computational modeling; phenotype–genotype correlation; craniofacial surgery; tissue engineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Research in Neuroinflammation

edited by Reza Khorooshi

submission deadline 25 Dec 2026 | Viewed by 850 | Submission Open

Keywords: neuroinflammation; central nervous system disorders; neuroimmune interactions; inflammation and neurodegeneration; therapeutic strategies in neurology

(This special issue belongs to the Section Molecular Neurobiology)

Curcumin Derivatives and Curcuminoids with Potential Biomedical Applications

edited by

Paola Bonaccorsi

and

Chiara Maria Antonietta Gangemi

submission deadline 25 Dec 2026 | 1 articles | Viewed by 819 | Submission Open

Keywords: curcumin; curcuminoids; synthesis; biomedicine; bioimaging; supramolecular; sensors; photodynamic therapy; antitumor properties; antiviral properties; antibacterial properties; antioxidant properties

(This special issue belongs to the Section Molecular Pharmacology)

Biomolecular Stratification in Antiphospholipid Syndrome

edited by

Cristina Belizna

submission deadline 25 Dec 2026 | 1 articles | Viewed by 816 | Submission Open

Keywords: antiphospholipid syndrome; antiphospholipid; stratification; biomolecular; risk stratification; classification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Inflammasome Signaling

edited by

Soren Hayrabedyan

submission deadline 25 Dec 2026 | 1 articles | Viewed by 803 | Submission Open

Keywords: PANoptosis; NLRP6; NLRP12; CARD8; non-immune cells; viral proteins; gasdermin family; inflammasome-independent signaling; inflammaging; MxA inflammasome

(This special issue belongs to the Section Biochemistry)

Graphene-Based Nanocomposites

edited by

Oleksandr Ivasenko

submission deadline 25 Dec 2026 | 1 articles | Viewed by 795 | Submission Open

Keywords: graphite intercalates; graphene; reduced graphene oxide; grafting; vertical heterostructures; nanocomposites; covalent organic frameworks (COFs); 2D nanomaterials; biomimetic interfaces; interfacial engineering

(This special issue belongs to the Section Molecular Nanoscience)

Host Immunity and Viral Evolution: Dissecting the Molecular Variations of Viral Genomes

edited by Maria Victoria Preciado

submission deadline 25 Dec 2026 | Viewed by 784 | Submission Open

Keywords: virus evolution; immune response; host–virus interaction; vaccine design; antiviral design; virus emergence and reemergence; bioinformatics; immunoinformatics

(This special issue belongs to the Section Molecular Immunology)

Biomass as Feedstock for the Production of High Value-Added Chemicals by Heterogeneous Catalysis

edited by

Cristina García-Sancho

submission deadline 25 Dec 2026 | 1 articles | Viewed by 772 | Submission Open

Keywords: biomass; heterogeneous catalysts; biofuels; bioproducts; platform molecules

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

From ER Stress to Clinical Biomarkers: Integrating Mechanistic Understanding with Diagnostic Innovation

edited by

Maria Francesca Armentano

and

Rocchina Miglionico

submission deadline 25 Dec 2026 | 1 articles | Viewed by 770 | Submission Open

Keywords: unfolded protein response (UPR); circulating biomarkers; extracellular vesicles; translational laboratory medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Growth, Development and Secondary Metabolism in Microorganisms

edited by

Francisco Jose Fernandez

and

Ramón O. García-Rico

submission deadline 25 Dec 2026 | Viewed by 747 | Submission Open

Keywords: secondary metabolites; signal transduction; molecular regulation; microbial growth; morphogenesis; microbial metabolites; biotechnological applications; omics technologies

(This special issue belongs to the Section Molecular Microbiology)

Bioinformatics of Genome Regulation and Structure–2026

edited by

Yuriy L. Orlov

Nikolay A. Kolchanov

and

Anastasia A. Anashkina

submission deadline 25 Dec 2026 | 2 articles | Viewed by 737 | Submission Open

Keywords: bioinformatics; genomics; human genetics; systems biology; AI; e-Health

(This special issue belongs to the Section Molecular Informatics)

Computational Strategies in Toxicology

edited by

Rajesh Kumar Pathak

and

Vikas Kumar

submission deadline 25 Dec 2026 | 1 articles | Viewed by 727 | Submission Open

Keywords: emerging pollutants; environment; molecular docking; molecular dynamics simulations; QSAR; Omics; PBPK model; predictive toxicology; risk assessment

(This special issue belongs to the Section Molecular Informatics)

Perineuronal Nets and Fear Memories Erasure: State of the Art and Future Directions

edited by

Andrea Poli

submission deadline 25 Dec 2026 | Viewed by 648 | Submission Open

Keywords: perineuronal nets (PNNs); extracellular matrix (ECM); fear erasure; traumatic memories; PTSD; translation research; clinical treatment; therapeutical strategies

(This special issue belongs to the Section Molecular Neurobiology)

Alcohol Metabolism: Molecular, Physiological, and Behavioral Consequences from Basic Research to Translational Applications

edited by Analia G. Karadayian

submission deadline 25 Dec 2026 | 1 articles | Viewed by 634 | Submission Open

Keywords: alcohol metabolism; acetaldehyde; mitochondrial dysfunction; oxidative stress; behavioral outcomes; animal models; translational research

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

HPV Infection and Immune Escape Mechanisms

edited by

Vittorio Unfer

and Elisa Lepore

submission deadline 25 Dec 2026 | Viewed by 631 | Submission Open

Keywords: HPV; persistence; natural molecules; vaccination; genotypes; anal infection; oral infection; co-infection

(This special issue belongs to the Section Molecular Immunology)

Atomic-Scale Design of Li-Ion Battery Materials

edited by

Saiful Islam

submission deadline 25 Dec 2026 | Viewed by 628 | Submission Open

Keywords: lithium-ion batteries; atomic-scale design; electrode–electrolyte interface; electrolyte engineering; defect chemistry; solid-state batteries

(This special issue belongs to the Section Materials Science)

Advances in Materials for Water Treatment and Metal/Nutrient Recovery

edited by

Aurora Pat-Espadas

submission deadline 25 Dec 2026 | 1 articles | Viewed by 612 | Submission Open

Keywords: water treatment; wastewater treatment; recalcitrant pollutants; metal recovery; nutrient recovery; molecularly engineered materials; functional materials; adsorption and remediation

(This special issue belongs to the Section Materials Science)

Bioactive Peptides: From Discovery and Characterization to Production, Therapeutic Applications, and Mechanistic Elucidation

edited by

José Thalles Lacerda

Taliana Bezerra

and

Luiz Juliano

submission deadline 25 Dec 2026 | 1 articles | Viewed by 608 | Submission Open

Keywords: bioactive peptides; mass spectrometry; machine learning; molecular dynamics simulation; synthetic biology; enzymology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genomics and Epigenetics of Stem Cell: An Update

edited by

Vikas Malik

submission deadline 25 Dec 2026 | Viewed by 603 | Submission Open

Keywords: stem cells; epigenetics; genomics; cell fate; self-renewal; differentiation; regenerative medicine; transcription factors

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research on the Molecular Mechanisms Related to Exercise

edited by

Kayvan Khoramipour

submission deadline 25 Dec 2026 | Viewed by 599 | Submission Open

Keywords: exercise; molecules; disease

(This special issue belongs to the Section Molecular Biology)

The Next Chapter in HIV: Molecular Pathways and Novel Therapeutic Strategies

edited by

Isabella Abbate

submission deadline 25 Dec 2026 | 1 articles | Viewed by 597 | Submission Open

Keywords: HIV; transcription; provirus; microRNA; epigenetic silencing; reservoir; integration site; latency; immune activation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insight in Reproductive Immunology

edited by Ruben Motrich

submission deadline 25 Dec 2026 | 1 articles | Viewed by 576 | Submission Open

Keywords: reproductive immunology; immune tolerance; male reproductive tract; female reproductive tract; fertility disorders; inflammation; pregnancy complications; immunoregulation

(This special issue belongs to the Section Molecular Immunology)

Molecular Interplay Between Aging, Dementia and Renal Function: Mechanisms, Biomarkers and Therapeutic Targets

edited by

Luca Soraci

submission deadline 25 Dec 2026 | Viewed by 554 | Submission Open

Keywords: aging; dementia; neuroinflammation; kidney–brain axis; translational research; biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanoscale Materials for Advanced Electrocatalysts

edited by

Safia Khan

submission deadline 25 Dec 2026 | Viewed by 521 | Submission Open

Keywords: nanomaterials; electrocatalysis; electrocatalysts; energy conversion; fuel cells

(This special issue belongs to the Section Molecular Nanoscience)

Thyroid Disease: From Molecular Mechanisms to Diagnosis and Therapeutic Advances

edited by

Mariana Lorena Tellechea

and Juan Nicola

submission deadline 25 Dec 2026 | Viewed by 510 | Submission Open

Keywords: thyroid disease; hypothyroidism; hyperthyroidism; autoimmune thyroid disease; thyroid nodules; thyroid cancer

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Characterization and Engineering of Functional Nanomaterials

edited by

Paramasivan Sivaprakash

and Shanmugam Vignesh

submission deadline 25 Dec 2026 | Viewed by 500 | Submission Open

Keywords: functional nanomaterials; molecular-level engineering; engineered materials; materials characterization; energy and environmental applications; materials design and performance

(This special issue belongs to the Section Molecular Nanoscience)

Combined and Mixture Exposure Toxicology of Cancer and Chronic Diseases

edited by

Alok Deoraj

and Quentin Felty

submission deadline 25 Dec 2026 | Viewed by 498 | Submission Open

Keywords: combined exposure; mixture exposure; toxicology of cancer; omics of cancer; AI in carcinogenesis; machine learning use in cancer; cancer biomarkers; pollutants of cancer; agrochemicals; endocrine-disruptive chemicals

(This special issue belongs to the Section Molecular Oncology)

Gene Delivery in Cancer Therapy: Next-Generation Platforms and Translational Advances

edited by

Ksenija Božinović

submission deadline 25 Dec 2026 | Viewed by 487 | Submission Open

Keywords: gene delivery; gene therapy; viral vectors; non-viral vectors; lipid nanoparticles; extracellular vesicles; mRNA therapeutics; CRISPR/Cas genome editing; tumor microenvironment; translational oncology

(This special issue belongs to the Section Molecular Oncology)

Consensus-Based Approaches to Rational Drug Design and Predictive Toxicology

edited by

Fernando Daniel Prieto-Martínez

submission deadline 25 Dec 2026 | Viewed by 482 | Submission Open

Keywords: drug design; bioactive compounds; pharmacophore; molecular dynamics; protein–ligand interactions; activity cliffs; machine learning

(This special issue belongs to the Section Molecular Toxicology)

Molecular Biology, Genetics, Diagnosis, Management and Therapy of Dermatological Diseases

edited by

Elisa Molinelli

and Corrado Tagliati

submission deadline 25 Dec 2026 | Viewed by 480 | Submission Open

Keywords: genodermatoses; hydradenitis suppurativa; inflammatory dermatoses; metabolic disorders; infections; esthetic medicine; neoplastic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Design and Engineering of Carbon-Based Materials for Environmental Remediation and Bioenergy

edited by Hilda Elizabeth Reynel-Ávila

submission deadline 25 Dec 2026 | Viewed by 453 | Submission Open

Keywords: adsorption; catalysis; functionalization; molecular design; environmental; sustainable energy; tailoring

(This special issue belongs to the Section Materials Science)

Molecular Biomarkers for Assessing Marine Ecosystem Health

edited by

Maria Costantini

Valerio Zupo

and

Roberta Esposito

submission deadline 25 Dec 2026 | Viewed by 449 | Submission Open

Keywords: biodiversity; biomarkers; biomonitoring; marine organisms; pollution; metals; microplastics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Biotic and Abiotic Stress Responses in Trees

edited by

Chenghao Li

submission deadline 25 Dec 2026 | Viewed by 442 | Submission Open

Keywords: drought stress; nutrient deficiency; salinity stress; pathogen defense; transcriptional regulation; epigenetic modifications; signal transduction; bioinformatics & multi-omics analysis; breeding for stress resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Decoding the Pediatric Brain Tumor Microenvironment: A Molecular Perspective

edited by

Samuele Tardito

submission deadline 25 Dec 2026 | Viewed by 438 | Submission Open

Keywords: pediatric brain tumor; precision immunotherapy; pediatric neuro-oncology; tumor microenvironment (TME); single-cell RNA sequencing; whole transcriptomics; mass spectrometry-based proteomics; mass cytometry; cellular and molecular architecture; organoid

(This special issue belongs to the Section Molecular Oncology)

New Trends in Green Synthesis of Nanomaterials

edited by Rocío Redón

submission deadline 25 Dec 2026 | Viewed by 431 | Submission Open

Keywords: nanoparticles; cytotoxicity; drug delivery; nanomaterials; green synthesis

(This special issue belongs to the Section Molecular Nanoscience)

Mitochondrial Metabolism in Health and Diseases

edited by

Yongting Luo

and Peng An

submission deadline 25 Dec 2026 | Viewed by 411 | Submission Open

Keywords: mitochondria metabolism; mitochondrial signaling; mitochondrial homeostasis; health and disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

From Molecule to Mind: Neuropharmacology of Psychoactive Alkaloids and Next-Generation Neuroactives

edited by Kyoko Koshibu

submission deadline 25 Dec 2026 | Viewed by 409 | Submission Open

Keywords: psychoactive alkaloids; neuropharmacology; bioactive compounds; performance enhancement; addiction; translational research; cognitive modulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 1701-1750 on page 35 of 62.

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