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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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AI-Driven Molecular Discovery and Design for Energy Materials and Applications
edited by Ruijie Zhu
submission deadline 30 Sep 2026 | Viewed by 255 | Submission Open
Keywords: artificial intelligence; machine learning; energy materials; batteries; fuel cells; solar cells; energy storage; computational chemistry; materials design
(This special issue belongs to the Section Molecular Informatics)
Genetics and Molecular Therapies in Common Age-Related and Inherited Retinal Diseases
edited by
submission deadline 30 Sep 2026 | Viewed by 249 | Submission Open
Keywords: inherited retinal diseases; molecular diagnosis; age-related retinal degeneration; genotype–phenotype correlations; gene and cell therapies; early biomarkers of retinal disease; AI‑driven analytics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurochemical and Biochemical Mechanisms of Depressive Disorders
edited by and Mauricio Peña Cunha
submission deadline 30 Sep 2026 | Viewed by 247 | Submission Open
Keywords: neurochemical signaling; molecular psychiatry; biochemical biomarkers; synaptic plasticity; neuroinflammation; oxidative stress; glutamatergic system; proteomics and metabolomics; signal transduction; neuroendocrine
(This special issue belongs to the Section Molecular Neurobiology)
Neuroimmune Interactions: From Physiology to Pathology
edited by
submission deadline 30 Sep 2026 | Viewed by 246 | Submission Open
Keywords: neuroimmune interactions; metabolic and mitochondria reprogramming; sensory neurons; neurodegeneration; neuropathic and nociplastic pain; neuroinflammation cancer neuroimmunology glial cells
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in Human Leukocyte Antigen (HLA)
edited by Inaki Alvarez
submission deadline 30 Sep 2026 | Viewed by 245 | Submission Open
Keywords: HLA; immunopeptidome; antigen presentation; antigen processing; mass spectrometry
(This special issue belongs to the Section Molecular Immunology)
Cardiac Protein Metabolism in Health and Diseases submission deadline 30 Sep 2026 | Viewed by 244 | Submission Open
Keywords: cardiac proteostasis; translational regulation; protein synthesis; ubiquitin–proteasome system; autophagy; cardiac remodeling; cardiomyopathy; RNA biology; protein quality control
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Applicability of Graphene-Based Materials in the Pharmaceutical, Biological and Biomedical Sectors, 2nd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 243 | Submission Open
Keywords: graphene; graphene-based composites; graphene-based sensors; biomedical applications; tissue engineering; drug delivery
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms of Plant Stress Responses: Adaptation and Resilience submission deadline 30 Sep 2026 | Viewed by 241 | Submission Open
Keywords: abiotic stress; phytohormones; molecular breeding; gene expression; osmotic and oxidative stress
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights and Innovative Materials in Prosthodontics and Oral Implantology
edited by Ángel-Orión Salgado-Peralvo
submission deadline 30 Sep 2026 | Viewed by 240 | Submission Open
Keywords: dental implants; dental prosthesis, implant-supported; osseointegration; dental implantation; bone regeneration
(This special issue belongs to the Section Materials Science)
Nuclear Receptor-Mediated Signal Transduction submission deadline 30 Sep 2026 | Viewed by 239 | Submission Open
Keywords: transcriptional regulation; non-genomic signalling; environmental signalling; endocrine disruption; nuclear receptor crosstalk; coregulators; modulators; evolution
(This special issue belongs to the Section Biochemistry)
Metabolic Reprogramming in Cancer: Non-Coding RNAs as Regulators and Biomarkers submission deadline 30 Sep 2026 | Viewed by 239 | Submission Open
Keywords: metabolic enzymes; circulating biomarkers; non-coding RNAs; circulating free DNA; liquid biopsy; metabolic reprogramming; artificial intelligence; biomarker discovery; precision medicine
(This special issue belongs to the Section Molecular Biology)
Development and Application of Novel Bio-Based Food Packaging Materials
edited by
submission deadline 30 Sep 2026 | Viewed by 239 | Submission Open
Keywords: bio-based polymers; active and intelligent packaging; biodegradable materials; food preservation technologies; sustainable packaging systems
(This special issue belongs to the Section Materials Science)
Gut Microbiome in Health and Disease: New Targets for Diagnosis, Prognosis, and Therapy submission deadline 30 Sep 2026 | Viewed by 238 | Submission Open
Keywords: microbiome; microbiomics; dysbiosis; probiotic; microbiome-based intervention; biomarker; nutrition; chronic disease; infection; inflammation
(This special issue belongs to the Section Molecular Microbiology)
Genetic and Genomic Regulation for Plant Nematode Resistance submission deadline 30 Sep 2026 | Viewed by 235 | Submission Open
Keywords: functional genomics; transcriptomics; genetic regulation; phytopathology; molecular plant–microbe interactions; nematodes; genetic resistance; gene pyramiding/stacking; gene discovery; resistance mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Challenges and Innovation in Neurodegenerative Diseases, 3rd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 234 | Submission Open
Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Quantitative Physiology of Mitochondria: Integration of Theory, Computation and High-Throughput Experimentation
edited by
submission deadline 30 Sep 2026 | Viewed by 229 | Submission Open
Keywords: mitochondria; systems biology; quantitative physiology; multi-omics; computational modeling; bioenergetics; thermodynamics and kinetics; metabolic networks; physicochemical modeling; virtual cells
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Obesity and Metabolic Diseases: 2nd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 227 | Submission Open
Keywords: molecular pharmacology; molecular mechanisms; obesity; metabolic diseases; metabolic syndrome; type 2 diabetes; atherosclerosis; cardio-metabolic disorders; metabolic dysfunction-associated steatotic liver disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Mechanisms of Carcinogenesis and Cancer Therapeutic Resistance
edited by Ki Lui
submission deadline 30 Sep 2026 | Viewed by 226 | Submission Open
Keywords: carcinogenesis; therapeutic resistance; tumor microenvironment; cancer genomics; epigenetics; molecular pathways; drug resistance mechanisms; cancer stem cells; targeted therapy; biomarkers
(This special issue belongs to the Section Molecular Oncology)
Arterial Hypertension: Renal Mechanisms, Metabolic Drivers, and Organ-Protective Strategies
edited by Andrea Pio-Abreu
submission deadline 30 Sep 2026 | Viewed by 226 | Submission Open
Keywords: hypertension; arterial hypertension; renal sodium handling; renin–angiotensin–aldosterone system (RAAS); cardio–kidney–metabolic disorder; renal mechanism; SGLT2 inhibition
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Treatment Approaches for EGFR-Mutated Lung Cancers submission deadline 30 Sep 2026 | Viewed by 225 | Submission Open
Keywords: NSCLC; EGFR TKIs; osimertinib; chemotherapy; EGFR–MET bispecific antibodies; immunotherapy; anti-angiogenesis; resistance mechanisms; ctDNA; brain metastases
(This special issue belongs to the Section Molecular Oncology)
The Na, K-ATPase in Health and Disease: 2nd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 222 | Submission Open
Keywords: Na+,K+-ATPase; α-subunit; β-subunit; γ subunits; FXYD
(This special issue belongs to the Section Molecular Biology)
Latest Molecular Research on Solid Electrolytes
edited by
submission deadline 30 Sep 2026 | Viewed by 220 | Submission Open
Keywords: solid-state electrolytes; polymer electrolytes; ion transport mechanisms; electrolyte–electrode interfaces; molecular structure–property relationships; interfacial chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Mechanisms of Heavy Metal Toxicity: 4th Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 219 | Submission Open
Keywords: heavy metal; metal compound; metallothionein; cellular defense mechanism; metal transporter
(This special issue belongs to the Section Molecular Toxicology)
Chemical Bonds and Molecular Shapes submission deadline 30 Sep 2026 | Viewed by 218 | Submission Open
Keywords: chemical bonds; molecular shapes; molecular sciences; atoms and molecules; graphical chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Epigenetic Studies of Mental Illness
edited by
submission deadline 30 Sep 2026 | Viewed by 217 | Submission Open
Keywords: epigenetics; methylation; microRNA; anxiety disorders; schizophrenia; eating disorders; PTSD; affective disorders; psychotic disorders; OCD
(This special issue belongs to the Section Molecular Neurobiology)
Thymus and Its Roles in Immunology
edited by
submission deadline 30 Sep 2026 | Viewed by 214 | Submission Open
Keywords: thymus in health and disease; immunology; T cells; adaptive immunity; age; single-cell RNA sequencing; omics; autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Inside DNA: Bioinformatics for Reading, Re-Reading, Comparing and Rewriting Plant Genomes
edited by
submission deadline 30 Sep 2026 | Viewed by 213 | Submission Open
Keywords: bioinformatics; computational genomics; pan-genomics; population genomics; genetic diversity; predictive breeding; environmental stress; crop improvement; functional genomics; plant biotechnology; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Emerging Topic in Metal–Organic Framework (MOF) Materials
edited by
submission deadline 30 Sep 2026 | Viewed by 211 | Submission Open
Keywords: metal–organic frameworks (MOFs); molecular-level engineering; structure–property relationships; transmetalation and ligand design; post-synthetic modification (PSM); redox-active molecular components; defect chemistry and framework dynamics; electrocatalysis and energy conversion; hybrid MOF-polymer/COF systems; mechanistic understanding; mixed-valence frameworks; operational and chemical stability
(This special issue belongs to the Section Materials Science)
Protease Inhibitors: Their Impact on Inflammatory Pathologies and Cancer submission deadline 30 Sep 2026 | Viewed by 210 | Submission Open
Keywords: protease inhibitors; matrix metalloproteinases (MMPs); cathepsins (cysteine proteases); serine proteases; metastasis and invasion; chronic inflammation; angiogenesis; protease activated receptor (PAR)
(This special issue belongs to the Section Molecular Biology)
Molecular Immunology of Animal Venoms: From Toxin–Receptor Interactions to Immune Response Modulation
edited by
submission deadline 30 Sep 2026 | Viewed by 208 | Submission Open
Keywords: animal venoms; molecular immunology; inflammatory responses; immune signaling pathways; venom-derived molecules; omics approaches
(This special issue belongs to the Section Molecular Toxicology)
Mechanisms of Glucocorticoid Action in Health and Disease
edited by
submission deadline 30 Sep 2026 | Viewed by 204 | Submission Open
Keywords: glucocorticoids; corticosteroids; dexamethasone; prednisolone; triamcinolone acetonide; epigenome; transcriptome; proteome; single cell; epigenetics; chromatin; transcription; RNA decay
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Next-Generation Gene Therapy for Cancer: Oncolytic Viruses, Genome Editing, Targeted Delivery Systems and Preclinical Advances
edited by Maria Veronica López
submission deadline 30 Sep 2026 | Viewed by 203 | Submission Open
Keywords: cancer gene therapy; oncolytic viruses; gene delivery systems; tumor microenvironment; CRISPR and genome editing; biomaterials for gene delivery; hydrogel-based therapeutic platforms; targeted cancer therapies; oncolytic virotherapy; tumor-targeted therapies; translational cancer research
(This special issue belongs to the Section Molecular Oncology)
Plant-Sourced Functional and Bioactive Compounds—Nature’s Blueprint for Improving Human Well-Being (2nd Edition) submission deadline 30 Sep 2026 | Viewed by 203 | Submission Open
Keywords: plants; antioxidants; phytochemicals; phyto-nutrition; natural products; health enhancing
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Natural Macromolecules: Extraction, Characterization, and Advanced Intensification Strategies for Enhanced Production submission deadline 30 Sep 2026 | Viewed by 201 | Submission Open
Keywords: natural macromolecules; molecular characterization; biosynthesis pathways; bioactive compounds; secondary metabolites; metabolic engineering; structural biochemistry; biopolymers; in situ extraction; molecular biotechnology
(This special issue belongs to the Section Macromolecules)
Mesenchymal Stem Cells and Their Derivatives in Tissue Regeneration
edited by Vladislav Volarevic
submission deadline 30 Sep 2026 | Viewed by 201 | Submission Open
Keywords: mesenchymal stem cells; exosomes; extracellular vesicles; immunomodulation; tissue regeneration; stem cell-based therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Melanoma
edited by
submission deadline 30 Sep 2026 | Viewed by 200 | Submission Open
Keywords: pathways; immune resistance; melanoma; circulating biomarkers; vaccines; target therapies
(This special issue belongs to the Section Molecular Oncology)
The Role of Nutritional Physiology in Modulating Microbial and Immune Homeostasis submission deadline 30 Sep 2026 | Viewed by 199 | Submission Open
Keywords: gut microbiome; nutritional physiology; diet–microbiome interactions; mucosal immunity; intestinal barrier; microbial metabolites; host–microbe interactions; inflammation; infectious diseases; microbiota-targeted therapies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Molecular Landscape of Gastroesophageal Cancer: Pathways to Novel Therapies submission deadline 30 Sep 2026 | Viewed by 198 | Submission Open
Keywords: targeted therapy; tumor microenvironment; chemoprevention; signaling pathways; oxidative stress and tumorigenesis
(This special issue belongs to the Section Molecular Oncology)
Advances in Computational Chemistry for Pharmaceutical Applications
edited by
submission deadline 30 Sep 2026 | Viewed by 198 | Submission Open
Keywords: drug discovery; ligand design; therapeutics; disease elucidation; identification of drug targets
(This special issue belongs to the Section Molecular Informatics)
Latest Research in Natural Bioactive Compounds submission deadline 30 Sep 2026 | Viewed by 198 | Submission Open
Keywords: bioactive compounds; natural products; polyphenols; flavonoids; terpenes; alkaloids
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Model for Toxicological Research submission deadline 30 Sep 2026 | Viewed by 195 | Submission Open
Keywords: SABV; rodent models; phenotypic anchoring; multiomics; 3R principles; toxicological profiles
(This special issue belongs to the Section Molecular Toxicology)
Recent Progress on Optical Molecular Sensors
edited by
submission deadline 30 Sep 2026 | Viewed by 195 | Submission Open
Keywords: molecular sensors; chemosensors; luminescence; fluorescence; absorbance; chemometrics; computational studies; sensor arrays; receptors; assays
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Formation of Chiral Supramolecular Assemblies
edited by Dorota Krasowska
submission deadline 30 Sep 2026 | Viewed by 194 | Submission Open
Keywords: chiral macromolecules; supramolecular assemblies; helical chirality; molecular recognition; host–guest systems; self-assembly; self-organization; biomolecules; non-bonding interactions
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Biomarkers for Cardiovascular and Renal Disease Risk Prediction submission deadline 30 Sep 2026 | Viewed by 194 | Submission Open
Keywords: molecular biomarkers; cardiovascular disease; renal disease; risk prediction; multi-omics; artificial intelligence
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Basis of Hepatic Encephalopathy: From Experimental to Translational Research
edited by
submission deadline 30 Sep 2026 | Viewed by 193 | Submission Open
Keywords: hepatic encephalopathy; chronic liver disease; acute liver disease; neurology; ammonia; astroglia; GABA; therapy; manganese
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Computational Research on Pharmacological Structure–Efficacy
edited by
submission deadline 30 Sep 2026 | Viewed by 189 | Submission Open
Keywords: pharmacological efficacy; structure–activity relationship; drug design; molecular modeling; computational pharmacology; medicinal chemistry; target–ligand interactions; multitarget drugs; translational pharmacology
(This special issue belongs to the Section Molecular Informatics)
Advances in Molecular Modeling: Methods, Insights, and Applications
edited by Enrico Pieroni
submission deadline 30 Sep 2026 | Viewed by 188 | Submission Open
Keywords: molecular interactions; binding kinetics and thermodynamics; free energy landscapes; molecular dynamics; enhanced sampling and metadynamics; computational molecular modeling; material science; biological systems
(This special issue belongs to the Section Molecular Biophysics)
Biosynthesis, Regulation and Applications of Plant Secondary Metabolites
edited by Quanliang Xie
submission deadline 30 Sep 2026 | Viewed by 186 | Submission Open
Keywords: plant physiology; plant stress tolerance; biotic/abiotic stresses; secondary metabolites; multi-omics integration; functional genes; plant hormones; plant molecular biology; plant resistant mechanism
(This special issue belongs to the Section Molecular Plant Sciences)
Microbial Biopolymers: Molecular Insights and Functional Innovations submission deadline 30 Sep 2026 | Viewed by 180 | Submission Open
Keywords: microbial biopolymers; functional biomaterials; biosynthesis; optimisation; multi-omics; synthetic biology; characterisation; medical and environmental application; metabolic pathway engineering; machine learning-assisted optimisation
(This special issue belongs to the Section Molecular Microbiology)
Molecular Engineering for Advanced Energy Materials and Catalytic Systems
edited by
submission deadline 30 Sep 2026 | Viewed by 178 | Submission Open
Keywords: molecular engineering; energy materials; catalytic systems; batteries; supercapacitors; energy conversion; self-assembled monolayers; CO2 utilization
(This special issue belongs to the Section Materials Science)
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