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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Delivery Systems of Natural and Synthetic Active Compounds

edited by

Aleksandra Gostyńska-Stawna

submission deadline 28 Feb 2026 | Viewed by 41 | Submission Open

Keywords: delivery systems; nanocarriers; natural and synthetic compounds; oral and parenteral administration; molecular mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innate Immune Response in Infectious Diseases

edited by

Julia Fischer

submission deadline 28 Feb 2026 | Viewed by 38 | Submission Open

Keywords: innate immunity; metabolism; bacteria; virus; inflammation; mechanism; immune defense

(This special issue belongs to the Section Molecular Immunology)

The Role of Dietary Fibre, Nutrition in Gastrointestinal Diseases

edited by

Sara Jarmakiewicz-Czaja

submission deadline 1 Mar 2026 | Viewed by 85 | Submission Open

Keywords: dietary fibre; gut microbiome; gastrointestinal disease; inflammatory bowel disease; nutrients; nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advance on Skin Irritation and Inflammation

edited by Nazgol-Sadat Haddadi

submission deadline 12 Mar 2026 | Viewed by 57 | Submission Open

Keywords: photoimmunology; keratinocyte stress; type I interferon; cutaneous lupus erythematosus; der-matomyositis; monocyte-derived dendritic cells; fibroblast heterogeneity; cytokine– chemokine networks; single-cell and spatial omics; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Natural Products in Health and Diseases

edited by

Katarína Bauerová

submission deadline 15 Mar 2026 | 4 articles | Viewed by 12087 | Submission Open

Keywords: natural products; health; chronic diseases; biomolecular research; functional food; oncology; rheumatology; infections; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Pharmacology)

Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies

edited by

Masaru Tanaka

submission deadline 20 Mar 2026 | 10 articles | Viewed by 37909 | Submission Open

Keywords: molecular psychiatry; biomarkers; pharmacogenomics; precision medicine; gene-environment Interaction; neuroinflammation; immune modulation; neuroimaging; molecular imaging; psychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

Kynurenic Acid: Emerging Research Advances and Therapeutic Implications

edited by

Piotr Paluszkiewicz

and Monika Turska-Kozłowska

submission deadline 20 Mar 2026 | 8 articles | Viewed by 36365 | Submission Open

Keywords: kynurenic acid; kynurenine pathway; kynurenine; therapeutic use; supply and distribution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes

edited by

Daniela Miricescu

submission deadline 20 Mar 2026 | 11 articles | Viewed by 30918 | Submission Open

Keywords: cancer; epithelial cells; oncogenic mutations; PI3K/AKT/mTOR; TGF-β ; Ras/Raf/MEK/ERK; Wnt/β -catenin; angiogenesis; invasion; metastasis; inhibitors

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapies of Chronic Obstructive Pulmonary Disease

edited by

Marija Stankovic

submission deadline 20 Mar 2026 | 8 articles | Viewed by 29056 | Submission Open

Keywords: COPD; molecular mechanism; inflammation; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant-Sourced Functional and Bioactive Compounds—Nature’s Blueprint for Improving Human Well-Being

edited by

Dasha Mihaylova

and

Aneta Popova

submission deadline 20 Mar 2026 | 7 articles | Viewed by 22354 | Submission Open

Keywords: plants; antioxidants; phytochemicals; phyto-nutrition; natural products; health enhancing

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Serum Amyloid A (SAA) Family: (Patho)Physiological Functions in (Non)Mammalian Systems

edited by

Ernst Malle

and

János G. Filep

submission deadline 20 Mar 2026 | 6 articles | Viewed by 21901 | Submission Open

Keywords: Serum Amyloid A in (Non)Mammalian systems; phylogenetic overview of different SAA isoforms; expression of SAA1-4 on mRNA and protein level; comparison of SAA with other acute-phase reactants; role of SAA during normal development and inflammation; role of SAA in cancer and other malignancies; potential role of SAA as a suitable biomarker during disease progression

(This special issue belongs to the Section Biochemistry)

Molecular Research and Insights into COVID-19: Third Edition

edited by

Manuela Rizzi

and

Pier Paolo Sainaghi

submission deadline 20 Mar 2026 | 4 articles | Viewed by 21588 | Submission Open

Keywords: SARS-CoV-2; COVID-19; prognostic and diagnostic biomarkers; molecular mechanism of infection; molecular pathophysiology; immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lung Cancers: An Update on Molecular Diagnostics and Therapy

edited by

Mariusz Chabowski

submission deadline 20 Mar 2026 | 6 articles | Viewed by 21031 | Submission Open

Keywords: lung cancer; cancer cachexia; prognosis; anti-lung cancer agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Therapeutic Strategies for Neurodegenerative Disease

edited by

Vasileios Papaliagkas

submission deadline 20 Mar 2026 | 4 articles | Viewed by 20578 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; therapy

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Cell Metabolism in Endocrine Diseases

edited by

Antonella Muscella

submission deadline 20 Mar 2026 | 5 articles | Viewed by 19566 | Submission Open

Keywords: cellular metabolism; homeostasis; endocrine disorders; hormonal signals; dynamic system

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Therapeutics for Diabetes and Related Complications, 2nd Edition

edited by

Kota V. Ramana

submission deadline 20 Mar 2026 | 6 articles | Viewed by 19104 | Submission Open

Keywords: diabetes; diabetes complications; molecular therapeutics; drug development; hyperglycemia; insulin resistance; cell signaling and oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Human Papillomavirus (HPV) Research

edited by

Jane Shen-Gunther

submission deadline 20 Mar 2026 | 3 articles | Viewed by 18360 | Submission Open

Keywords: human papillomavirus (HPV)/genetics; HPV-associated cancers; HPV cell-free DNA (cfDNA); HPV circulating tumor DNA (ctDNA); HPV circulating tumor cells (CTCs); carcinogenesis/genetics; CRISPR-cas systems/genetics; digital PCR; molecular diagnostics/methods; point-of-care diagnostics/methods; next-generation sequencing/methods; single-cell sequencing/methods; genomics; epigenomics; proteomics; metagenomics; phylogenomics; virus evolution; virus– host interactions; virus integration/genetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Perspectives on Wound Healing

edited by

Ermelindo C. Leal

and

Eugenia Carvalho

submission deadline 20 Mar 2026 | 7 articles | Viewed by 18212 | Submission Open

Keywords: chronic wound healing; scarring; biomarkers; inflammation; angiogenesis; infection; extracellular matrix; biomaterials; tissue regeneration; therapeutic targets; innovative therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Beyond Digestion: The Role of Gut Microbiota in Metabolism, Immunity and Brain Function

edited by

Alip Borthakur

submission deadline 20 Mar 2026 | 5 articles | Viewed by 17545 | Submission Open

Keywords: gut dysbiosis; gut microbiota; metabolism

(This special issue belongs to the Section Molecular Immunology)

Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications

edited by Jung-Hyun Lee

submission deadline 20 Mar 2026 | 7 articles | Viewed by 17281 | Submission Open

Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems

(This special issue belongs to the Section Biochemistry)

Viral Infections and Immune Responses

edited by

Alessandra Ruggiero

and

Marco Iannetta

submission deadline 20 Mar 2026 | 6 articles | Viewed by 16582 | Submission Open

Keywords: virus; infections; immune response; T-cells; B-cells; antibodies; neutralizing activity

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in RNA Drug Development

edited by Hidenori Tani

submission deadline 20 Mar 2026 | 3 articles | Viewed by 16343 | Submission Open

Keywords: RNA therapeutics; drug development; antisense oligonucleotides; siRNA; miRNA; aptamers; CRISPR-Cas9; delivery systems; clinical applications; emerging technologies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Product-Based Strategy for Skin Inflammatory Disorders and Regeneration

edited by

Mi Young Lee

submission deadline 20 Mar 2026 | 6 articles | Viewed by 16149 | Submission Open

Keywords: inflammatory skin disorders; skin wound healing and regeneration; skin aging; bioactive natural compound; derivative and conjugate; plant extract; beneficial effect and application; molecular mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition

edited by

Vincent C. Lombardi

submission deadline 20 Mar 2026 | 3 articles | Viewed by 15567 | Submission Open

Keywords: ME/CFS; PASC; long COVID-19; inflammation; innate immunity; adaptive immunity; mast cell activation; post-infection syndrome; metabolism; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Molecular Strategies in Biomedicine

edited by

Rui Vitorino

submission deadline 20 Mar 2026 | 4 articles | Viewed by 15409 | Submission Open

Keywords: bioprinting; organ-on-chip; venom-derived therapeutics; 3D in vitro models; skeletal muscle models; toxic peptides; peptide expression; nanoparticles in medicine; protein and peptide drug delivery; peptide-based biomaterials; self-assembled hydrogels; molecular therapeutics; nanotechnology in drug delivery; regenerative medicine; tissue engineering

(This special issue belongs to the Section Materials Science)

New Insights in Translational Bioinformatics: Second Edition

edited by

Camelia Quek

submission deadline 20 Mar 2026 | 5 articles | Viewed by 15204 | Submission Open

Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology

(This special issue belongs to the Section Molecular Informatics)

Molecular Research in Obesity and Obesity Related Disorders: 3rd Edition

edited by

Grażyna Nowicka

submission deadline 20 Mar 2026 | 7 articles | Viewed by 14143 | Submission Open

Keywords: biochemistry and molecular medicine; molecular and cellular mechanisms of disease pathogenesis; pathogenesis of metabolic disorders; the role of interaction between genetic and environmental factors in the pathogenesis of non-communicable diseases; atherosclerosis; obesity; obesity-related metabolic diseases and cancers

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Zoonotic Diseases

edited by

Vishwanath Venketaraman

submission deadline 20 Mar 2026 | 6 articles | Viewed by 13758 | Submission Open

Keywords: mycobacterial diseases; bubonic and pneumonic plague; Q fever; cat scratch disease; Mediterranean fever; HIV; malaria; ADIS; SARS-CoV-2; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses

(This special issue belongs to the Section Molecular Microbiology)

Latest Advances in Reproduction Biology

edited by Clara Malo

submission deadline 20 Mar 2026 | 8 articles | Viewed by 13588 | Submission Open

Keywords: gamete formation; fertilization; embryo formation; embryo implantation; fertility; infertility; molecular markers; reproductive biology

(This special issue belongs to the Section Molecular Biology)

Zebrafish as a Model in Human Disease: 3rd Edition

edited by

Andrea Vettori

Nicola Facchinello

and

Marco G. Schiavone

submission deadline 20 Mar 2026 | 5 articles | Viewed by 12875 | Submission Open

Keywords: zebrafish; CRISPR/Cas9; transgenic lines; biosensors; endothelial cells; extracellular matrix; genetic mutant for human disease modeling; xenografts

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria: Transport of Metabolites Across Biological Membranes

edited by

Graziantonio Lauria

and

Rosita Curcio

submission deadline 20 Mar 2026 | 3 articles | Viewed by 12707 | Submission Open

Keywords: mitochondria; mitochondrial transporters; mitochondrial metabolism; transport proteins; translocases carriers; mitochondrial carriers; mitochondrial diseases; mitochondrial permeability; apoptosis

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Diabetes and Obesity

edited by

Shin-Da Lee

submission deadline 20 Mar 2026 | 4 articles | Viewed by 12529 | Submission Open

Keywords: obesity; diabetes; hypothalamus; insulin resistance; glucose homeostasis; lipid metabolism; adipose tissue; cardiovascular tissue

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Basis of Pancreatic Secretion and Metabolism

edited by

Dongki Yang

submission deadline 20 Mar 2026 | 5 articles | Viewed by 12239 | Submission Open

Keywords: exocrine of the pancreas; endocrine of the pancreas; acute pancreatitis; chronic pancreatitis; cystic fibrosis; pancreatic metabolic hormones; pancreatic metabolic disease; mechanism of pancreatic bicarbonate secretion; the sodium bicarbonate cotransporter (NBC); cystic fibrosis transmembrane conductance regulator (CFTR); regulators of the ion channels and ion transporters involved in secretion

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Heart Failure: From Molecular Basis to Therapeutic Strategies

edited by

Michele Ciccarelli

submission deadline 20 Mar 2026 | 5 articles | Viewed by 11961 | Submission Open

Keywords: heart failure; cardiac metabolism; mitochondria; inflammatory pathway; neurohormonal system; therapeutical strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

CNS Injuries: 2nd Edition

edited by

Sudhanshu Raikwar

submission deadline 20 Mar 2026 | 1 articles | Viewed by 11957 | Submission Open

Keywords: stroke; TBI; brain edema; SCI; spinal cord edema; neuroinflammation; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Diabetes and Metabolic Dysfunction

edited by

Vasilis Tsimihodimos

submission deadline 20 Mar 2026 | 6 articles | Viewed by 11882 | Submission Open

Keywords: diabetes; metabolic dysfunction; glucose metabolism; metabolic disturbances; complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Unraveling the Molecular Mechanisms of Neurodegeneration

edited by

Michela Ferrucci

submission deadline 20 Mar 2026 | 4 articles | Viewed by 11866 | Submission Open

Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Therapies for Metabolic-Associated Fatty Liver Diseases

edited by Yi-Ming Arthur Chen

submission deadline 20 Mar 2026 | 3 articles | Viewed by 11725 | Submission Open

Keywords: metabolic-associated fatty liver disease; MAFLD; metabolic dysfunction-associated steatohepatitis; MASH; molecular mechanism; genetic polymorphism; individualized medicine; prevention; new drug development; health supplements; diagnosis; epidemiology; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Medical Microbiology

edited by

Alberto Rizzo

submission deadline 20 Mar 2026 | 4 articles | Viewed by 11694 | Submission Open

Keywords: clinical microbiology; clinical virology; SARS-CoV-2; HPV; sexually transmitted infections; respiratory viruses; emerging pathogens; opportunistic infections

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanism and Treatment of Diabetes Mellitus and Its Complications

edited by

Bernd Stratmann

submission deadline 20 Mar 2026 | 6 articles | Viewed by 11673 | Submission Open

Keywords: MODY; LADA; diabetes late complications; molecular mechanisms; omics; polyneuropathy; microvascular disease; macrovascular disease; liver disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Lipid Metabolism in Human Health and Diseases

edited by

Arianna Vignini

submission deadline 20 Mar 2026 | 4 articles | Viewed by 11647 | Submission Open

Keywords: lipids; fatty acids; lipid metabolism; metabolic disorders; cardiovascular diseases; neurodegenerative diseases; cancers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Pathogenesis, Molecular Mechanisms, and Therapeutic Strategies for Neurodegenerative Diseases

edited by

Abdullah Sheikh

submission deadline 20 Mar 2026 | 5 articles | Viewed by 11401 | Submission Open

Keywords: neurodegeneration; molecular pathways; protein aggregation; gene therapy; neuroprotection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular Plasticity and EMT in Cancer and Fibrotic Diseases

edited by

Sabrina Lisi

and

Margherita Sisto

submission deadline 20 Mar 2026 | 5 articles | Viewed by 11205 | Submission Open

Keywords: fibrosis; epithelial– mesenchymal transition; epithelial– mesenchymal plasticity; cancer; fibrotic diseases; inflammation; metastases

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics in Ovarian Cancer

edited by

Bruna Scaggiante

submission deadline 20 Mar 2026 | 6 articles | Viewed by 10737 | Submission Open

Keywords: chemotherapy resistance; differential gene expression; genomic structural variation; ovarian cancer mutations; ovarian cancer metastasis; ovarian cancer treatment; novel molecular targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Inflammatory Bowel Disease and Microbiome

edited by Abigail Raffner Basson

submission deadline 20 Mar 2026 | 4 articles | Viewed by 10731 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; gut microbiota; diet; treatment; pathogenesis; biomarker

(This special issue belongs to the Section Molecular Microbiology)

The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology

edited by

Katarzyna A. Lisowska

submission deadline 20 Mar 2026 | 6 articles | Viewed by 10509 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research on the Diagnosis and Treatment of Chronic Liver Diseases

edited by

Hirayuki Enomoto

submission deadline 20 Mar 2026 | 3 articles | Viewed by 10233 | Submission Open

Keywords: biomarker; genomic research; epigenomic research; molecular mechanisms; viral hepatitis; alcoholic-related liver disease; non-alcoholic fatty liver disease; autoimmune liver diseases; liver cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Vegetable Genetics and Genomics, 3rd Edition

edited by

Yunsong Lai

and

Xixiang Li

submission deadline 20 Mar 2026 | 7 articles | Viewed by 10112 | Submission Open

Keywords: major vegetable crops; genome; variome; genotyping; GWAS; QTL mapping; functional genome; metabolome; breeding target characters; genetic mechanism; functional genes

(This special issue belongs to the Section Molecular Plant Sciences)

Signaling Pathways and Novel Therapies in Heart Disease

edited by

Anindita Das

submission deadline 20 Mar 2026 | 4 articles | Viewed by 10074 | Submission Open

Keywords: heart failure; arrhythmias; ischemic heart disease; myocardial regeneration; inflammation; gene- or cell-based therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Density Functional Theory and Related Methods for Molecular Computational Chemistry

edited by Paolo Umari

submission deadline 20 Mar 2026 | 3 articles | Viewed by 10060 | Submission Open

Keywords: density functional theory; quantum chemistry; algorithms; quantum computing; high-performance computing; machine learning; many-body perturbations theory; quantum Monte Carlo

(This special issue belongs to the Section Molecular Informatics)

Displaying special issue 1851-1900 on page 38 of 65.

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