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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Telocytes: Unraveling Their Roles in Health and Disease

edited by

Sanda Cretoiu

submission deadline 30 Dec 2025 | Viewed by 160 | Submission Open

Keywords: telocytes; telopodes; intercellular communication; stem cell niche; extracellular vesicles; regenerative medicine; tissue remodelling; stromal cells

(This special issue belongs to the Section Molecular Biology)

Cellular Physiology and Aging: Membrane Dynamics, Intracellular Environment and Signaling Pathways

edited by

Alessia Remigante

Rossana Morabito

and Sara Spinelli

submission deadline 30 Dec 2025 | Viewed by 156 | Submission Open

Keywords: aging; oxidative stress; ion channels; antioxidant molecules; membrane transport systems; redox signaling; cellular senescence; inflammation; intracellular signaling pathways; mitochondrial dysfunction; bioactive compounds; cell physiology; homeostasis; longevity; age-related diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research in RNA–Protein Networks

edited by Hidenori Tani

submission deadline 30 Dec 2025 | Viewed by 147 | Submission Open

Keywords: machine learning; bioinformatics; ribonucleoprotein; RNA– protein complex; alternative splicing; RNA stability; RNA localization

(This special issue belongs to the Section Molecular Biology)

Cellular Mechanisms of Pulmonary Arterial Hypertension

edited by

David P Marciano

and Saurabh Aggarwal

submission deadline 30 Dec 2025 | Viewed by 144 | Submission Open

Keywords: pulmonary arterial hypertension (PAH); pulmonary vascular remodeling; endothelial cells; endothelial dysfunction; smooth muscle cells; hyperplasia; pericytes; fibroblasts; monocytes; macrophage; neutrophil; mechanotransduction; oxidative stress; cytokines; extracellular vesicles; extracellular matrix; epigenetics; metabolism; biomarkers; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products in Immune Regulation

edited by

Wansu Park

submission deadline 30 Dec 2025 | Viewed by 142 | Submission Open

Keywords: natural products; immune responses; immunomodulatory therapies

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Biology of Pregnancy Complications

edited by Elżbieta Poniedziałek-Czajkowska and Radzisław Mierzyñski

submission deadline 30 Dec 2025 | Viewed by 138 | Submission Open

Keywords: molecular biology of pregnancy complications; maternal pregnancy complications; neonatal pregnancy complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Evolutionary Drivers and Adaptive Mechanisms in Algal Organellar Genomes

edited by

Feng Liu

submission deadline 30 Dec 2025 | Viewed by 133 | Submission Open

Keywords: organellar genome of algae; molecular evolution; secondary structure of intron; evolutionary driving force; horizontal gene transfer

(This special issue belongs to the Section Molecular Plant Sciences)

Role of Microorganisms and Their Metabolites in Agriculture, Food and the Environment: 3rd Edition

edited by

Barbara Sokolowska

submission deadline 30 Dec 2025 | Viewed by 128 | Submission Open

Keywords: fermentation; biopreservation; biocontrol; biodegradation; bioremediation; bioaugmentation; omic-technologies

(This special issue belongs to the Section Molecular Microbiology)

New Breakthroughs in Molecular Diagnostic Tools for Human Diseases, 2nd Edition

edited by

Vittorio Fineschi

submission deadline 30 Dec 2025 | Viewed by 122 | Submission Open

Keywords: molecular pathology; molecular diagnostics; genetics; epigenetics; proteomics; immunohistochemistry; thrombo-embolic disease; sudden cardiac death; the molecular pathology of traumatic injuries; hypoxic– ischemic brain damage; the experimental models of injury and diseases; the targeted therapy of injuries and diseases; drug abuse; histological diagnosis; the epigenetics of organs injuries; miRNA and the prognosis of diseases; novel approaches and proofs of principle in therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Crossroads in Cardiac Pathophysiology

edited by

Robert J. Chilton

submission deadline 30 Dec 2025 | Viewed by 114 | Submission Open

Keywords: cardiometabolic disease; cardiac metabolism; heart failure; mitochondrial dysfunction; insulin resistance; cardiometabolic therapies; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Biomarkers and New Therapeutic Options in Neoplastic Diseases

edited by

Maurizio Martini

submission deadline 30 Dec 2025 | Viewed by 106 | Submission Open

Keywords: biomarkers; neoplastic diseases; molecular targets; targeted therapy; precision oncology; signaling pathways; cancer diagnostics; therapeutic options; drug resistance; molecular profiling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Predictive, Prognostic Biomarkers and Therapeutic Targets of Breast Cancer: Second Edition

edited by Antonella Ciabattoni and Fabiana Gregucci

submission deadline 30 Dec 2025 | Viewed by 99 | Submission Open

Keywords: radiotherapy; breast cancer; stereotactic body radiotherapy; brain radiosurgery; target therapy; immunotherapy; tailored systemic therapy

(This special issue belongs to the Section Molecular Oncology)

The Role of Diet in Lipid and Lipoprotein Metabolism

edited by

Kyung-Hyun Cho

submission deadline 30 Dec 2025 | Viewed by 98 | Submission Open

Keywords: dyslipidemia; hypertension; diabetes; dementia

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Unresolved Molecular Bases of Major Histocompatibility Complex (MHC) Function with Transplantation and Diseases Linkage

edited by Antonio Arnaiz-Villena

submission deadline 30 Dec 2025 | Viewed by 81 | Submission Open

Keywords: HLA; disease; autoimmunity; immune deficiency; MHC phylogeny; HLA pharmacogenomics; immune modulatory MHC and HLA genes (G; E; F); transplantation; hemochromatosis; MHC/HLA epithelial interaction; MHC evolution; MHC phylogenetics; Vertebrate MHC; Amimal MHC; Veterinary

(This special issue belongs to the Section Molecular Immunology)

Research on the Key Role of Ubiquitination in Signaling and Cancer

edited by

Bo Zhao

submission deadline 30 Dec 2025 | Viewed by 70 | Submission Open

Keywords: ubiquitin; ubiquitination; E3 ligase; deubiquitinating enzymes; protein degradation; mutations; cancer progression; signal transduction; drug development

(This special issue belongs to the Section Molecular Oncology)

Effects of Bioactive Compounds in Oxidative Stress and Inflammation

edited by

Paul-Mihai Boarescu

and

Raluca Maria Pop

submission deadline 31 Dec 2025 | 9 articles | Viewed by 29237 | Submission Open

Keywords: natural products; antioxidant effects; anti-inflammatory effects; molecular targets; health beneficial effect; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Schizophrenia: From Molecular Mechanism to Therapy

edited by

Yael Abreu-Villaça

submission deadline 31 Dec 2025 | 7 articles | Viewed by 22767 | Submission Open

Keywords: schizophrenia; neurodevelopmental disorders; therapeutic approaches; drug of abuse; mental disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biological Research on Plant Bioactive Compounds

edited by

Adriana Trifan

and

Simon Vlad Luca

submission deadline 31 Dec 2025 | 9 articles | Viewed by 17104 | Submission Open

Keywords: plant bioactive compounds; extraction and analysis of plant bioactive compounds; bioactivity and pharmacokinetics of plant compounds; natural products and modern diseases; plant bioactive compounds and by-products; discovery and development of natural plant drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research Progress of Metabolomics in Health and Disease

edited by

Maria Assunta Acquavia

submission deadline 31 Dec 2025 | 10 articles | Viewed by 16404 | Submission Open

Keywords: metabolomics; health; diseases; target metabolites; mass spectrometry; hyphenated techniques

(This special issue belongs to the Section Molecular Biology)

The Role of Lipids in Health and Diseases

edited by

Yutang Wang

submission deadline 31 Dec 2025 | 5 articles | Viewed by 15946 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

Phyto-Functional Nanomaterials: Synthesis, Characterization and Application

edited by

Maria G. P. M. S. Neves

Carla Isabel Madeira dos Santos

and

Nuno M. M. Moura

submission deadline 31 Dec 2025 | 8 articles | Viewed by 14611 | Submission Open

Keywords: phyto-functional nanomaterials; green synthesis; hydrogen generation; pollutant degradation/removal; fine chemistry; photoinactivation; cancer; microorganisms

(This special issue belongs to the Section Molecular Nanoscience)

Natural Products in Drug Discovery and Development

edited by Tian-Le Gao

submission deadline 31 Dec 2025 | 10 articles | Viewed by 14063 | Submission Open

Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Editorial Board Members’ Collection Series: Cancer Metastasis

edited by

Carlos Cabañas

and

Sung-Hoon Kim

submission deadline 31 Dec 2025 | 5 articles | Viewed by 14035 | Submission Open

Keywords: biomarkers; liquid biopsy; premetastatic niche; angiogenesis; immune evasion and suppression; genetic and epigenetic determinants; chemoresistance; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

The Impact of Natural Bioactive Compounds on Human Health and Disease

edited by

Yeong-geun Lee

submission deadline 31 Dec 2025 | 6 articles | Viewed by 12868 | Submission Open

Keywords: natural product chemistry; nuclear magnetic resonance; structural elucidation; herbal drug

(This special issue belongs to the Section Molecular Pharmacology)

Abiotic Stress Tolerance and Genetic Diversity in Plants, 2nd Edition

edited by

Andrés J. Cortés

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10071 | Submission Open

Keywords: biodiversity; molecular breeding; comparative genomics; abiotic stress adaptation; genetic mapping; predictive breeding; genomic prediction; assisted gene flow; plant breeding; restoration ecology; conservation genetics

(This special issue belongs to the Section Molecular Plant Sciences)

25th Anniversary of IJMS: Updates and Advances in Molecular Neurobiology

edited by

Kiminobu Sugaya

submission deadline 31 Dec 2025 | 7 articles | Viewed by 9498 | Submission Open

Keywords: molecular neurobiology; neural signaling and gene regulation; synaptic plasticity; neurodevelopment; neurodegeneration; neuroregeneration; neuroinflammation; epigenetics in neuroscience; non-coding RNAs; protein misfolding and aggregation; exosomes and extracellular vesicles; stem cells and neural repair; biomarkers of neurological disease; translational neuroscience; neuropharmacology; brain omics (genomics; proteomics; transcriptomics); neuronal-glial interactions; mitochondrial dysfunction in the nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research in Bamboo, Tree, Grass, and Other Forest Products

edited by

Huayu Sun

submission deadline 31 Dec 2025 | 8 articles | Viewed by 9417 | Submission Open

Keywords: bamboo; tree; grass; molecular biology; gene function

(This special issue belongs to the Section Molecular Plant Sciences)

25th Anniversary of IJMS: Updates and Advances in Molecular Oncology

edited by

Peter J. K. Kuppen

submission deadline 31 Dec 2025 | 10 articles | Viewed by 8862 | Submission Open

Keywords: molecular oncology; cancer epigenetics; tumour heterogeneity; tumour microenvironment; precision oncology; liquid biopsy; cancer immunotherapy

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Advances in Molecular Endocrinology and Metabolism

edited by

José L. Quiles

submission deadline 31 Dec 2025 | 5 articles | Viewed by 8681 | Submission Open

Keywords: molecular endocrinology; metabolic diseases; hormonal regulation; systems biology; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Coordination Complexes: From Molecular Design to Functional Applications

edited by

Sanaa Musa

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7715 | Submission Open

Keywords: coordination complexes; organometallic complexes; functional materials; metal– ligand interactions; homogenous catalysis; sensing; magnetic materials; ligand tunability

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

25th Anniversary of IJMS: Updates and Advances in Macromolecules

edited by

Haiyang Gao

Salah-Eddine Stiriba

and

Zhongzhou Chen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6532 | Submission Open

Keywords: macromolecules; monomers; lipids; peptides; proteins; carbohydrates; polysaccharides; nucleic acids; modification; functionalization; structure– property relationship

(This special issue belongs to the Section Macromolecules)

Recent Progress in Metabolic Diseases

edited by

Dariusz Chlubek

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5694 | Submission Open

Keywords: metabolic diseases; enzymes related to metabolic disorders; inborn errors of metabolism; inherited single-gene anomalies; molecular diagnostics in metabolic disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Animal Models for Human Diseases

edited by Yuning Song

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5317 | Submission Open

Keywords: animal models; translational research; preclinical studies; biomedical innovation; reproducibility

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeted Delivery of Nucleic Acids

edited by Yong-Serk Park

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4979 | Submission Open

Keywords: nucleic acid delivery; gene delivery; pDNA delivery; siRNA delivery; miRNA delivery; mRNA delivery; CRISPR-Cas delivery; nanoparticle; lipid nanoparticle; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Advances in Pro-Inflammatory and Anti-Inflammatory Cytokines

edited by

Juliann G. Kiang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4671 | Submission Open

Keywords: pro-inflammation cytokine; anti-inflammation cytokine; chemotherapy; radiotherapy; signal transduction; microbiome– host response; sepsis; bone marrow; GI; brain

(This special issue belongs to the Section Molecular Immunology)

Dietary Supplements: A Delicate Balance Between Benefit and Harm

edited by

Carmen Cantisani

submission deadline 31 Dec 2025 | 1 articles | Viewed by 4568 | Submission Open

Keywords: dietary supplements; antioxidants; skin; ageing; wellness

(This special issue belongs to the Section Bioactives and Nutraceuticals)

25th Anniversary of IJMS: Updates and Advances in Molecular Nanoscience

edited by Qi Zhang,

Marilena Carbone

and

André F. Moreira

submission deadline 31 Dec 2025 | 6 articles | Viewed by 4340 | Submission Open

Keywords: nanotechnology; nanomaterials; nanomedicine; nanostructures; 2D materials; smart nanomaterials; nanocatalysts; nanozymes

(This special issue belongs to the Section Molecular Nanoscience)

Advancements in Diagnostic and Preventive Pharmacogenomics

edited by Alireza Tafazoli

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4328 | Submission Open

Keywords: genome profiling; pharmacogenetic analysis; diagnostic pharmacogenomics; pre-emptive pharmacogenomics; advanced genotyping technologies

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Relationship Between Diet and Insulin Resistance

edited by

Domenico Sergi

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4201 | Submission Open

Keywords: insulin resistance; lipotoxicity; lipid metabolism; type 2 diabetes mellitus; dietary lipids; lipidomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

25th Anniversary of IJMS: Updates and Advances in Molecular Genetics and Genomics

edited by

Francesco Sessa

Lasse Lindahl

and

Apostolos Zaravinos

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4179 | Submission Open

Keywords: molecular genetics; genomics; precision medicine; genetic diagnostics; gene therapy; next-generation sequencing (NGS); pharmacogenomics; epigenetics; forensic genomics; translational genomics; genome replication; gene expression; cell stress; cell cycle; cell signaling; macromolecular surveillance and turnover; molecular evolution

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cutting-Edge Insights into Bacterial Infection and Host Immune Response

edited by

Pablo C. Baldi

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3882 | Submission Open

Keywords: bacteria– host interaction; virulence factors; cellular and molecular immune response; immune evasion mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Advances and Novel Biomarkers in Gastrointestinal Cancers

edited by

Alessandro Mannucci

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3798 | Submission Open

Keywords: gastrointestinal cancers; liquid biopsy; circulating biomarkers; minimal residual disease; early cancer detection; tumor-agnostic assays; molecular diagnostics; precision oncology; predictive biomarkers; translational research

(This special issue belongs to the Section Molecular Oncology)

Functional Food Ingredients in Immunity Improvement

edited by

Prodromos Skenderidis

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3599 | Submission Open

Keywords: functional food ingredients; bioactive compounds; health potentials; food processing and immunomodulation; green extraction techniques; molecular mechanisms; nutritional immunology; dietary intervention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Biomarkers for Targeted Therapies

edited by Vija Lavinia

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3551 | Submission Open

Keywords: biomarkers; molecular targeted radiotherapies; prognostic biomarkers; predictive biomarkers; single or composite biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ion and Molecule Transport in Membrane Systems, 6th Edition

edited by

Victor V. Nikonenko

and

Dmitrii Butylskii

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3274 | Submission Open

Keywords: ion and molecular transport; physical chemistry; chemical physics; transport mechanisms; living systems; biological and artificial membranes; biomimetic structure; structure– property relationships; thermodynamics; irreversible thermodynamics; equilibriums; kinetics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Urologic Cancers: Molecular Basis for Novel Therapeutic Approaches

edited by

Whi-An Kwon

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3159 | Submission Open

Keywords: urologic cancers; prostate cancer; urothelial cancer; renal cell cancer; genomics; proteomics; biomarkers; molecular pathways

(This special issue belongs to the Section Molecular Oncology)

The Biological Activities of Curcumin and Its Analogues

edited by Francis Johnson

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2979 | Submission Open

Keywords: curcumin; analogues; natural compounds; inflammation; tissue reconstruction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism Involved in Cancer Metastasis

edited by

Mohamed Jemaà

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2759 | Submission Open

Keywords: cell motility; cell migration; spheroid; metastasis; extracellular matrix; cell architecture; lamellipodia; epithelial-mesenchymal transition EMT; videomicroscopy; confocal microscopy; animal model

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics

edited by

Mihai V. Putz

Hyotcherl Ihee

and

Carlos Miguel Costa

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2721 | Submission Open

Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Selected Papers from the 5th International Symposium on Frontiers in Molecular Science (ISFMS)

edited by

Yoshinori Marunaka

Masayuki Takahashi

Yusaku Iwasaki

, Atsushi Shiozaki and Akiyuki Taruno

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2579 | Submission Open

Keywords: protein structure and function; multidomain proteins; drug design and drug resistance; enzymes; molecular biology of galectins; glycobiophysics; NMR spectroscopy; specific sensory systems; brain and systemic function

(This special issue belongs to the Section Biochemistry)

Displaying special issue 601-650 on page 13 of 65.

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