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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Environmental Contaminants and Health: Biological Effects, Molecular Mechanisms, and Protective Strategies submission deadline 31 Jan 2027 | 1 articles | Viewed by 618 | Submission Open
Keywords: environmental contaminants; environmental exposure; health effects; cellular responses; oxidative stress; inflammation; epigenetics; non-coding RNAs; biomarkers; protective strategies
(This special issue belongs to the Section Molecular Toxicology)
Targeting the Renin–Angiotensin System: A Molecular Strategy for Disease Intervention
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 617 | Submission Open
Keywords: tissue-specific RAS; cardiovascular disease; biomarkers; signal transduction; precision medicine; immune regulation; tubular transport; kidney disease; RAS inhibitors; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Valorization of Lignocellulosic Biomass: 2nd Edition
edited by
submission deadline 31 Jan 2027 | Viewed by 612 | Submission Open
Keywords: lignocellulosic biomass; biorefinery; biomass conversion; bioenergy; biofuels; bioproducts; platform chemicals; cellulose nanomaterials; lignin nanoparticles; functional materials
(This special issue belongs to the Section Materials Science)
Maternal–Fetal Immunity and Antibody Transfer: Molecular Mechanisms and Clinical Implications
edited by and Aikaterini Nikolaou
submission deadline 31 Jan 2027 | 1 articles | Viewed by 606 | Submission Open
Keywords: maternal immunization; transplacental antibody transfer; neonatal immunity; FcRn; antibody glycosylation; placental immunology; Fc-mediated effector functions; maternal–fetal immunity; passive immunity
(This special issue belongs to the Section Molecular Immunology)
Nanoparticles in Nanobiotechnology and Nanomedicine: 3rd Edition
edited by
submission deadline 31 Jan 2027 | Viewed by 595 | Submission Open
Keywords: nanoparticles; properties of nanoparticles; methods of obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms of Chronic Obstructive Pulmonary Disease (COPD): From Pathogenesis to Therapeutic Response
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 594 | Submission Open
Keywords: COPD; emphysema; pulmonary endothelium; inhaled corticosteroids; β2-agonists; oxidative stress; efferocytosis; airway inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Therapeutic Strategies for Cystic Fibrosis
edited by Hartmut Grasemann and
submission deadline 31 Jan 2027 | 1 articles | Viewed by 593 | Submission Open
Keywords: cystic fibrosis; CFTR modulators; gene therapy; airway inflammation; antimicrobial therapy; biomarkers; mucus; extrapulmonary disease; clinical trials; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research Advances in Reproductive Biology
edited by Karl Kerns
submission deadline 31 Jan 2027 | 1 articles | Viewed by 593 | Submission Open
Keywords: reproductive biology; fertility; infertility; gametogenesis; fertilization; embryo development; reproductive endocrinology; reproductive health; epigenetics; single-cell omics
(This special issue belongs to the Section Molecular Biology)
Bioactive Peptides: Microbial Fermentation-Driven Synthesis and Multifunctional Applications in Health and Industry
edited by
submission deadline 31 Jan 2027 | Viewed by 591 | Submission Open
Keywords: bioactive peptides; foods; probiotics; fermentation; pharmaceutical; herbs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Transcriptional Reprogramming and Metabolic Plasticity in the Tumor Microenvironment: Implications for Immune Evasion and Therapeutic Resistance
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 577 | Submission Open
Keywords: transcriptional reprogramming; epigenetic regulation; metabolic plasticity; immunometabolism; tumor microenvironment; cellular heterogeneity; immune evasion; T cell exhaustion; therapeutic resistance; single-cell omics; spatial transcriptomics; precision immunotherapy; biomarker discovery
(This special issue belongs to the Section Molecular Oncology)
Plant Genomics and Genome Editing, 3rd Edition
edited by
submission deadline 31 Jan 2027 | Viewed by 570 | Submission Open
Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Understanding of Horticultural Crops Response to Environmental Stresses
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 543 | Submission Open
Keywords: genome editing; functional genomics; abiotic and biotic stress responses; gene regulatory networks; horticultural crops
(This special issue belongs to the Section Molecular Plant Sciences)
Physiological and Molecular Responses of Plants to Drought Stress
edited by
submission deadline 31 Jan 2027 | Viewed by 542 | Submission Open
Keywords: drought stress; photosynthesis; stomatal regulation; signal transduction; phytohormones; anti-oxidants
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Photodynamic Therapy and Photodetection: Targeted Approaches and Immunological Perspectives submission deadline 31 Jan 2027 | 1 articles | Viewed by 537 | Submission Open
Keywords: photodynamic therapy (PDT); photodetection (PD); photosensitiser; nanoparticles; nanotechnology; targeted therapy; immunotherapy; vaccines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Male Infertility and Fertility submission deadline 31 Jan 2027 | Viewed by 514 | Submission Open
Keywords: male infertility; infertility treatment; omics approaches; proteomics; metabolomics; lipidomics; mass spectrometry; signaling pathways; biomarker discovery; reproductive medicine; precision medicine; diagnostic tools
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Progress in Nanomedicine for Cancer Therapy
edited by Peisheng Xu
submission deadline 31 Jan 2027 | Viewed by 514 | Submission Open
Keywords: nanomedicine; cancer-targeted therapy; theragnostic; nanodevice
(This special issue belongs to the Section Molecular Nanoscience)
Eukaryotic Cells Under Stress: Biochemical and Physiological Mechanisms of Resistance and Resilience
edited by and
submission deadline 31 Jan 2027 | Viewed by 504 | Submission Open
Keywords: cellular stress response; oxidative stress; bioactive compounds; ROS; DNA damage/repair; environmental stressors; molecular chaperones; antioxidant in human diseases
(This special issue belongs to the Section Molecular Biology)
Emerging Technologies Driving New Insights into the Multi-Omic Understanding of Human Disease
edited by and
submission deadline 31 Jan 2027 | 1 articles | Viewed by 499 | Submission Open
Keywords: metabolomic, lipidomic, proteomic, transcriptomic, and genomic analysis; spatial omics; omic analysis applied to human disease; biocomputational approaches for the management of large omic datasets; integration of multi-omic datasets
(This special issue belongs to the Section Molecular Informatics)
Molecular Therapeutic Mechanisms and Drug Discovery for Obesity and Nephropathy
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 495 | Submission Open
Keywords: obesity; diabetes mellitus; kidney injury; treatment and prevention of nephropathy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Stress Signaling and Horticultural Crops Quality Control
edited by and
submission deadline 31 Jan 2027 | Viewed by 492 | Submission Open
Keywords: stress tolerance; molecular mechanisms; quality traits; redox regulation; postharvest physiology; signal transduction
(This special issue belongs to the Section Molecular Plant Sciences)
3D Printing in Pharmaceutical Drug Delivery submission deadline 31 Jan 2027 | Viewed by 489 | Submission Open
Keywords: personalized medication; 3-dimensional printing; solubility and bioavailability enhancement; polymers for 3D printing; bio-inks; 3D-printed implants; additive manufacturing
(This special issue belongs to the Section Molecular Pharmacology)
Fibrosis: Molecular Mechanisms and Targeted Therapy
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 478 | Submission Open
Keywords: fibrosis; myofibroblasts; tissue remodelling; extracellular matrix; wound healing; anti-fibrotic therapy
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Diagnostics in Hereditary Hemolytic Anemias
edited by Joan-Lluís Vives-Corrons
submission deadline 31 Jan 2027 | Viewed by 467 | Submission Open
Keywords: anemia; red blood cell erythropoiesis; membranopathies ; erythro enzymopathies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into T Cell Exhaustion and Tumor Immune Evasion submission deadline 31 Jan 2027 | Viewed by 466 | Submission Open
Keywords: T cell exhaustion; immune evasion; tumor microenvironment; immune checkpoints; immunometabolism; epigenetics; cancer immunology; molecular immunotherapy; single-cell analysis; transcriptional regulation
(This special issue belongs to the Section Molecular Immunology)
Relevant Molecules in the Process of Oxidative Stress submission deadline 31 Jan 2027 | Viewed by 465 | Submission Open
Keywords: oxidative stress; reactive oxygen species; reactive nitrogen species; antioxidant enzymes; non-enzymatic antioxidants; poly(ADPribosyl)ation; transcription factors
(This special issue belongs to the Section Biochemistry)
Cryo-EM and Cryo-Tomography in Macromolecular Structure Analysis
edited by
submission deadline 31 Jan 2027 | Viewed by 463 | Submission Open
Keywords: macromolecular structure; precision nanomedicine; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET); viral capsids; AI/ML in structural analysis; time-resolved imaging; nanoparticle delivery; in-cell tomography; structural dynamics; molecular mechanisms; protein complexes; membrane proteins; macromolecular assemblies; conformational changes; integrative structural biology; cellular structural biology; drug delivery systems; therapeutic design
(This special issue belongs to the Section Macromolecules)
Biomedical Applications of Mesenchymal Stem Cells, 2nd Edition submission deadline 31 Jan 2027 | Viewed by 456 | Submission Open
Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; disease; cartilage
(This special issue belongs to the Section Molecular Biology)
Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement
edited by
submission deadline 31 Jan 2027 | Viewed by 455 | Submission Open
Keywords: genetics; GWAS; genome; abiotic and biotic stress; transcriptomic analysis; fruit crop germplasm; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Biomaterials: From Design, Synthesis and Characterization to Application—2nd Edition
edited by and
submission deadline 31 Jan 2027 | Viewed by 451 | Submission Open
Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis
(This special issue belongs to the Section Materials Science)
Molecular and Biomarker Advances in Gynecologic Oncology
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 451 | Submission Open
Keywords: gynecologic oncology; epithelial ovarian cancer; prognostic biomarkers; tumor microenvironment; systemic inflammation; precision medicine; targeted therapy; clinical risk stratification
(This special issue belongs to the Section Molecular Oncology)
Lysosomal Storage Disorders: Molecular Pathogenesis and Next-Generation Therapeutics
edited by and
submission deadline 31 Jan 2027 | Viewed by 447 | Submission Open
Keywords: lysosomal storage disorders; cellular mechanisms; multi-omics biomarkers; gene therapy; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular Immunotherapy in Cancer: Current Trends and Future Directions
edited by
submission deadline 31 Jan 2027 | Viewed by 443 | Submission Open
Keywords: cellular immunotherapy; CAR-T cells; CAR-NK cells; CAR-macrophages; tumor-infiltrating lymphocytes (TILs); immune receptor signaling; tumor microenvironment; CRISPR/Cas9 genome editing; precision cancer immunotherapy; translational immuno-oncology
(This special issue belongs to the Section Molecular Immunology)
Micro/Nano-Structure Regulation of Two-Dimensional Materials
edited by
submission deadline 31 Jan 2027 | Viewed by 422 | Submission Open
Keywords: 2D materials; micro/nano-engineering; structure–property relationships
(This special issue belongs to the Section Materials Science)
Molecular and Metabolic Mechanisms Regulating Reproduction and Development in Animals
edited by Borhan Shokrollahi and Kimberly M. Davenport
submission deadline 31 Jan 2027 | Viewed by 420 | Submission Open
Keywords: molecular nutrition; metabolic signaling; reproductive physiology; epigenetic programming; placental biology; transcriptomics and metabolomics; mitochondrial function; oxidative stress pathways; developmental programming; ruminant health
(This special issue belongs to the Section Molecular Biology)
Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound
edited by Alicia Paz
submission deadline 31 Jan 2027 | Viewed by 419 | Submission Open
Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives
(This special issue belongs to the Section Molecular Microbiology)
The Relationship Between Cytokines and Autoimmune Diseases: New Insights submission deadline 31 Jan 2027 | Viewed by 413 | Submission Open
Keywords: cytokines; autoimmune diseases; biomarkers; therapeutic targets; etiology; pathophysiology
(This special issue belongs to the Section Molecular Immunology)
Unraveling Bioactive Peptides: Structure, Function, and Applications
edited by
submission deadline 31 Jan 2027 | Viewed by 406 | Submission Open
Keywords: bioactive peptides; peptide structure–activity relationship; peptidomics; bioactivity assays; human health
(This special issue belongs to the Section Macromolecules)
Targeted Cancer Therapeutics: Molecular Pathways and Precision Strategies
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 405 | Submission Open
Keywords: targeted cancer therapy; small molecules; combination therapy; inhibitors; cancer cell death and proliferation
(This special issue belongs to the Section Molecular Oncology)
Interplay of Nanoparticles with Plant Physiology and Molecular Biology: Effects, Mechanisms and Agricultural Applications
edited by
submission deadline 31 Jan 2027 | Viewed by 400 | Submission Open
Keywords: plant nano biology; abiotic stress tolerance; physiological and molecular mechanisms; nanotoxicology; detoxification strategies
(This special issue belongs to the Section Molecular Plant Sciences)
Immuno-Oncology Approaches for Glioblastoma
edited by
submission deadline 31 Jan 2027 | Viewed by 395 | Submission Open
Keywords: GBM pathogenesis; GBM diagnostic; neuro-cancerogenesis; genetics; growth factors; immunotherapy; gene therapy; chemotherapy; radiotherapy; nanotechnology
(This special issue belongs to the Section Molecular Oncology)
Male Reproduction: Unveiling the Molecular Revolution
edited by
submission deadline 31 Jan 2027 | Viewed by 392 | Submission Open
Keywords: testosterone; spermatogenesis; capacitation; acrosome reaction; endocrine disruptors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Antioxidants in Human Health and Disease: Molecular Advances
edited by
submission deadline 31 Jan 2027 | Viewed by 386 | Submission Open
Keywords: antioxidants; immune response; free radicals; mechanism of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Nano-Biomaterials for Biomedicine and Tissue Regeneration
edited by and
submission deadline 31 Jan 2027 | Viewed by 385 | Submission Open
Keywords: nanostructured biomaterials; cell-scaffold interactions; drug delivery systems; tissue engineering; regenerative medicine
(This special issue belongs to the Section Molecular Nanoscience)
Phytochemicals in Cancer Therapy: From Preclinical Studies to Clinical Practice
edited by Mounir Tilaoui
submission deadline 31 Jan 2027 | Viewed by 381 | Submission Open
Keywords: phytochemicals; cancer therapy; molecular mechanisms; signaling pathways; programmed cell death; tumor microenvironment; drug resistance; preclinical models; clinical translation; adjuvant therapy
(This special issue belongs to the Section Molecular Oncology)
Emerging Therapeutic Strategies for Glioblastoma
edited by Inan Olmez
submission deadline 31 Jan 2027 | 1 articles | Viewed by 377 | Submission Open
Keywords: glioblastoma; preclinical; combination therapy; overcoming resistance; translational
(This special issue belongs to the Section Molecular Neurobiology)
Design and Application of Biocatalysts: Emerging Advances and Innovations in Enzyme Immobilization and Technologies submission deadline 31 Jan 2027 | Viewed by 375 | Submission Open
Keywords: low-cost immobilization of enzymes; treatments post-immobilization; enzymatic synthesis of derivatives; polyesters depolymerization; hydroxy-acids polymerization; bioimprinting; post-immobilization treatments; composites
(This special issue belongs to the Section Biochemistry)
Advanced Materials for Next-Generation Energy Storage: Molecular Design, Functional Properties, and Applications submission deadline 31 Jan 2027 | Viewed by 373 | Submission Open
Keywords: energy storage devices; molecular materials; smart functionalities; structure-property relationships; molecular design and engineering; advanced applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Signaling and Stress Adaptation in Plants: 2nd Edition
edited by
submission deadline 31 Jan 2027 | Viewed by 370 | Submission Open
Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Eosinophils: Function and Related Disorders
edited by Giulia Costanzo
submission deadline 31 Jan 2027 | Viewed by 369 | Submission Open
Keywords: eosinophils; polymorphonuclear cells; interleukin; cytotoxic proteins; host defense; tissue remodeling; dysregulation; eosinophilic disorders; therapeutics
(This special issue belongs to the Section Biochemistry)
Calcium Signaling in Human Health and Diseases, 4th Edition
edited by
submission deadline 31 Jan 2027 | Viewed by 368 | Submission Open
Keywords: Ca2+ signalling; intracellular organelles; plasma membrane; inositol-1,4,5-receptors; ryanodine receptors; ionotropic receptors; metabotropic receptors; TRP channels; two-pore channels; STIM and Orai
(This special issue belongs to the Section Biochemistry)
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