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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hepatocellular Carcinoma: From Pathophysiology to Innovative Therapeutic Approaches
edited by Andrea Martini
submission deadline 20 Jun 2026 | Viewed by 545 | Submission Open
Keywords: liver carcinogenesis; tumor microenvironment; immune surveillance; fibrogenesis; inflammation
(This special issue belongs to the Section Molecular Oncology)
The Chitosan Biomaterials: Advances and Challenges, 3rd Edition
edited by , and Cristina Elena Dinu-Pirvu
submission deadline 20 Jun 2026 | 1 articles | Viewed by 526 | Submission Open
Keywords: chitosan; chitosan biomaterials; chitosan derivatives; drug delivery; wound healing; tissue regeneration; dentistry; smart biomaterials
(This special issue belongs to the Section Materials Science)
Cancer-Associated Stromal Cells
edited by Krisztián Németh and Balazs Mayer
submission deadline 20 Jun 2026 | 1 articles | Viewed by 456 | Submission Open
Keywords: cancer; microenvironment; tumor-associated stromal cells; cancer-associated fibroblast; mesenchymal stem cell; tumor-associated adipocyte; pericyte; cancer immunology; angiogenesis; metastasis; targeted cancer therapy; checkpoint inhibitor; CAR T cells; immunotherapy; signal transduction; small molecules
(This special issue belongs to the Section Molecular Oncology)
Brain Stroke Across the Lifespan: Mechanisms, Models, Translational Advances and Impacts Beyond the Brain
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 430 | Submission Open
Keywords: stroke; brain; cerebral injury; post-stroke recovery; systemic physiology; models; therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Unveiling the Functional Microbiomes of the Ocean: From Genes to Ecosystem Services submission deadline 20 Jun 2026 | 1 articles | Viewed by 416 | Submission Open
Keywords: microbiome; symbiosis; community organization; functional diversity; communication; microbial functions; metagenomics; metabolomics; transcriptomics; proteomics; biogeochemical cycling; biofouling; ocean health; marine biotechnology; microbial ecology
(This special issue belongs to the Section Molecular Microbiology)
Machine Learning Approaches in Drug Molecule Design
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 400 | Submission Open
Keywords: machine learning; drug design; deep learning; virtual screening; QSAR; molecular property prediction; de novo drug design; pharmacokinetics; computational chemistry; drug discovery
(This special issue belongs to the Section Molecular Informatics)
Molecular and Cellular Aspects of Autoimmune and Inflammatory Rheumatic Diseases: Second Edition
edited by Marzena Helena Olesińska and Magdalena Szmyrka
submission deadline 20 Jun 2026 | Viewed by 393 | Submission Open
Keywords: autoimmune rheumatic diseases; inflammatory rheumatic diseases; arthritis; connective tissue diseases
(This special issue belongs to the Section Molecular Immunology)
Allosteric Modulation of Kinases in Cancer Therapeutic Strategies and Challenges
edited by
submission deadline 20 Jun 2026 | Viewed by 361 | Submission Open
Keywords: kinase signaling; allosteric modulators; cancer therapy; drug resistance; molecular mechanisms; protein– protein interactions; targeted therapy; conformational changes; ATP-competitive inhibitors; drug design
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Aging: How Can We Live Beyond 100 Years?
edited by
submission deadline 20 Jun 2026 | Viewed by 351 | Submission Open
Keywords: aging; biomarkers; centenarians; longevity interventions; stress resistance and metabolism; age-related diseases
(This special issue belongs to the Section Molecular Biology)
Toxicity of Animal Venoms and the Components: Molecular Mechanisms of Action
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 342 | Submission Open
Keywords: venom toxicity; biochemical activity; toxin biology; cellular targets; peptide; protein; structure– function relationships
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into the Pathophysiology of Placenta Accreta Spectrum
edited by Jessian L. Munoz
submission deadline 20 Jun 2026 | Viewed by 341 | Submission Open
Keywords: placenta accreta; invasive placenta; trophoblasts; placenta; high-risk pregnancy; placenta previa; in vitro fertilization; biomarkers; multi-omics research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metabolic Reprogramming in Health and Aging-Related Diseases
edited by
submission deadline 20 Jun 2026 | Viewed by 340 | Submission Open
Keywords: aging; degenerative diseases; lifestyle intervention; metabolic reprogramming; metabolic syndromes; metabolome; metabolomics; neurodegenerative diseases; omics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Bioactive Compounds in Cancers: Second Edition submission deadline 20 Jun 2026 | Viewed by 328 | Submission Open
Keywords: anticancer strategies; bioactive compounds; natural products; synthetic products; medicinal chemistry; drug repurposing; drug delivery systems
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Telomeres in Development, Senescence and Genome Instability: 2nd Edition
edited by Michal Zalzman
submission deadline 20 Jun 2026 | Viewed by 311 | Submission Open
Keywords: telomere disorders and cell death; telomere factors as therapeutic targets in cancer; telomeres and genome stability; telomeres in aging and senescence
(This special issue belongs to the Section Molecular Genetics and Genomics)
Urothelial Cancer: From Translational Medicine to Recent Innovations in Therapeutic Management
edited by Alessio Bruni
submission deadline 20 Jun 2026 | Viewed by 307 | Submission Open
Keywords: urothelial cancer; bladder cancer; radiation therapy; trimodality approach; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
New Insights into Intercellular Communication and Signal Transduction
edited by
submission deadline 20 Jun 2026 | Viewed by 300 | Submission Open
Keywords: intercellular communication; signal transduction; extracellular vesicles (EVs); exosomes; tunneling nanotubes (TNTs); cytokines; hormonal signaling; neurotransmitters; mechanotransduction; immune signaling
(This special issue belongs to the Section Molecular Biology)
Innovations in Photodynamic Therapy: New Horizons in Breast Cancer Care
edited by Sandeep Surendra Panikar
submission deadline 20 Jun 2026 | Viewed by 288 | Submission Open
Keywords: noninvasive therapy; tumor targeting; breast cancer therapy; oncology; photosensitizers; theranostics; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Macrophage Plasticity: Beyond the M1–M2 Paradigm
edited by
submission deadline 20 Jun 2026 | Viewed by 286 | Submission Open
Keywords: macrophage; plasticity; microenvironment; polarization; epigenetic modulation; phagocytosis
(This special issue belongs to the Section Molecular Immunology)
Valorization of Lignocellulosic Biomass: 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 283 | Submission Open
Keywords: lignocellulosic biomass; biorefinery; biomass conversion; bioenergy; biofuels; bioproducts; platform chemicals; cellulose nanomaterials; lignin nanoparticles; functional materials
(This special issue belongs to the Section Materials Science)
Computational Cancer Genomics and Molecular Profile in Breast Cancer
edited by Daniel Guimarães Tiezzi and
submission deadline 20 Jun 2026 | 1 articles | Viewed by 279 | Submission Open
Keywords: breast cancer; computational biology; genomics; molecular biology
(This special issue belongs to the Section Molecular Informatics)
Structural and Functional Insights into Chemokines and Chemokine Receptors in Immune Pathologies
edited by
submission deadline 20 Jun 2026 | Viewed by 272 | Submission Open
Keywords: chemokines; chemokine receptors; immune pathologies; signaling mechanisms; therapeutic targeting
(This special issue belongs to the Section Molecular Immunology)
Innovative Advances and Applications in Medical and Molecular Virology
edited by and
submission deadline 20 Jun 2026 | Viewed by 271 | Submission Open
Keywords: medical virology; molecular virology; molecular diagnostics; genomics; metagenomics; interactomics; integrative omics
(This special issue belongs to the Section Molecular Microbiology)
Regulation of Brown Adipose Function submission deadline 20 Jun 2026 | Viewed by 266 | Submission Open
Keywords: brown adipose tissue; metabolic disorders; thermogenesis; endocrine function; cellular signaling
(This special issue belongs to the Section Biochemistry)
Molecular Characterization of Glioblastoma: Implications for Diagnosis and Personalized Treatment
edited by Madan Mohan Kwatra
submission deadline 20 Jun 2026 | Viewed by 241 | Submission Open
Keywords: glioblastoma; diagnosis; molecular characterization; personalized treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lectins: Structural Diversity, Molecular Recognition and Emerging Applications submission deadline 20 Jun 2026 | Viewed by 233 | Submission Open
Keywords: lectins; structural diversity; molecular recognition; bioactivities; biomedical applications
(This special issue belongs to the Section Biochemistry)
Contemporary Perspective of Cardio-Kidney Metabolic Syndrome: From Prevention to Management
edited by Alberto Palazzuoli, and
submission deadline 20 Jun 2026 | Viewed by 229 | Submission Open
Keywords: cardiovascular risk factors; metabolic syndrome; chronic kidney disease; heart failure; endothelial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthesis, Modification, and Functional Characterization of Advanced Biomaterials for Bone Tissue Engineering
edited by
submission deadline 20 Jun 2026 | Viewed by 226 | Submission Open
Keywords: material functionalization; bioactive materials; antimicrobial; antibiofilm; coatings; scaffolds; bone cements; metal nanoparticles; controlled release; biocompatibility
(This special issue belongs to the Section Materials Science)
Molecular Horizons in Pain Therapeutics
edited by Alaa Abd-Elsayed
submission deadline 20 Jun 2026 | Viewed by 220 | Submission Open
Keywords: spinal cord stimulation; peripheral nerve stimulation; stem cell therapy; platelet-rich plasma (PRP) injections; chronic pain management; interventional pain procedure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genomics and Epigenetics of Stem Cell: An Update
edited by
submission deadline 20 Jun 2026 | Viewed by 220 | Submission Open
Keywords: stem cells; epigenetics; genomics; cell fate; self-renewal; differentiation; regenerative medicine; transcription factors
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advanced Research on the Major Histocompatibility Complex (MHC): From Bench to Bedside
edited by Antonio Arnaiz-Villena
submission deadline 20 Jun 2026 | Viewed by 219 | Submission Open
Keywords: HLA; immunology; HLA genetics and pharmacogenetics; immune and other functions of the MHC; classical and nonclassical MHC class I HLA genes; HLA-G; HLA-E; HLA-F; MHC evolution; complement; autoimmunity; immunodeficiency; cancer; HIV
(This special issue belongs to the Section Molecular Immunology)
Antimicrobial Nanoparticles: Mechanisms, Applications, and Future Directions submission deadline 20 Jun 2026 | Viewed by 219 | Submission Open
Keywords: antimicrobial activity; nanoparticles; biofilm nano-modulators; antibiotic resistence; wastewater treatment; preservative properties of nanoparticles
(This special issue belongs to the Section Molecular Microbiology)
Molecular Design and Engineering of Carbon-Based Materials for Environmental Remediation and Bioenergy
edited by Hilda Elizabeth Reynel-Ávila
submission deadline 20 Jun 2026 | Viewed by 214 | Submission Open
Keywords: adsorption; catalysis; functionalization; molecular design; environmental; sustainable energy; tailoring
(This special issue belongs to the Section Materials Science)
Molecular Interplay Between Aging, Dementia and Renal Function: Mechanisms, Biomarkers and Therapeutic Targets
edited by
submission deadline 20 Jun 2026 | Viewed by 210 | Submission Open
Keywords: aging; dementia; neuroinflammation; kidney– brain axis; translational research; biomarkers; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cell and Molecular Biology of Archaea
edited by
submission deadline 20 Jun 2026 | Viewed by 208 | Submission Open
Keywords: archaea; molecular biology; translation; gene expression regulation; biofilm; metabolism
(This special issue belongs to the Section Molecular Microbiology)
Sustainable Material Development Through Waste Utilization: From Molecular Insights to Functional Applications
edited by
submission deadline 20 Jun 2026 | Viewed by 206 | Submission Open
Keywords: sustainable materials; waste-derived materials; biodegradable polymers; green chemistry; functionalization; structure– property relationships; chemical modification; recycling; valorization; circular economy; composites; analytical techniques; industrial waste; agricultural waste
(This special issue belongs to the Section Materials Science)
New Insights into Environmental Stresses and Plants: Second Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 205 | Submission Open
Keywords: abiotic stress; biotic stress; adaptation; gene function; omics; metabolic regulation; stress signal; molecular mechanism
(This special issue belongs to the Section Molecular Plant Sciences)
Graphene-based Nanocomposites
edited by
submission deadline 20 Jun 2026 | Viewed by 205 | Submission Open
Keywords: graphite intercalates; graphene; reduced graphene oxide; grafting; vertical heterostructures; nanocomposites; covalent organic frameworks (COFs); 2D nanomaterials; biomimetic interfaces; interfacial engineering
(This special issue belongs to the Section Molecular Nanoscience)
Sphingolipids in Infections, Disorders and Diseases
edited by Elita Avota
submission deadline 20 Jun 2026 | Viewed by 202 | Submission Open
Keywords: sphingolipids; sphingolipid biosynthesis; sphingolipidoses; metabolic disorders; infections; lipidomics; sphingolipid targeting drugs
(This special issue belongs to the Section Biochemistry)
Unraveling Bioactive Peptides: Structure, Function, and Applications
edited by
submission deadline 20 Jun 2026 | Viewed by 196 | Submission Open
Keywords: bioactive peptides; peptide structure– activity relationship; peptidomics; bioactivity assays; human health
(This special issue belongs to the Section Macromolecules)
Natural Bioactive Compounds for Human Health, 3rd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 195 | Submission Open
Keywords: natural bioactive plant products; biological and pharmacological activity; natural plant drug discovery and development; nutraceuticals; botanical dietary supplement
(This special issue belongs to the Section Molecular Pharmacology)
Infectious Diseases and Infection Models in Laboratory Animals
edited by and Fumio Ike
submission deadline 20 Jun 2026 | Viewed by 195 | Submission Open
Keywords: infection model; Infectious diseases in laboratory animals; bacterial infection; viral infection; parasitic infection; molecular diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Endometriosis: Current Trends and Research Developments submission deadline 20 Jun 2026 | Viewed by 193 | Submission Open
Keywords: endometriosis; molecular mechanisms; pathophysiology; hormonal regulation; immune response; epigenetics; inflammation; biomarkers; transcriptomics; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Exploring Recent Research on Natural Compounds: From Biosynthesis to Application
edited by
submission deadline 20 Jun 2026 | Viewed by 192 | Submission Open
Keywords: proteins like antibodies and enzymes; small molecules; plant extracts; biosynthesis; nanodelivery; drug discovery
(This special issue belongs to the Section Biochemistry)
Advances in Tau Protein Research submission deadline 20 Jun 2026 | Viewed by 187 | Submission Open
Keywords: tau biology; disease model systems; protein aggregation; tauopathies; neurodegeneration; Alzheimer’ s disase; seeded aggregation; amyloid filaments; tau propagation; antibodies; targeted protein degradation; tau therapeutics
(This special issue belongs to the Section Molecular Biology)
Molecular Informatics and AI in Cancer Research
edited by and
submission deadline 20 Jun 2026 | Viewed by 187 | Submission Open
Keywords: molecular informatics; artificial intelligence (AI); cancer research; personalized medicine; high-throughput data; biomarkers; clinical applications; longitudinal data
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanisms of Parasitic Diseases
edited by Rajendranath Ramasawmy
submission deadline 20 Jun 2026 | Viewed by 186 | Submission Open
Keywords: parasites; molecular mechanisms; pathogenesis; genetics; symptomatics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement
edited by
submission deadline 20 Jun 2026 | Viewed by 184 | Submission Open
Keywords: genetics; GWAS; genome; abiotic and biotic stress; transcriptomic analysis; fruit crop germplasm; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Modeling in Pharmaceutical Sciences
edited by
submission deadline 20 Jun 2026 | Viewed by 182 | Submission Open
Keywords: molecular modeling; computer-aided drug design; molecular docking; drug discovery; quantum chemistry; molecular dynamics simulations; virtual screening; computational pharmacology; pharmacy; in silico methods
(This special issue belongs to the Section Molecular Pharmacology)
Combined and Mixture Exposure Toxicology of Cancer and Chronic Diseases
edited by and Quentin Felty
submission deadline 20 Jun 2026 | Viewed by 180 | Submission Open
Keywords: combined exposure; mixture exposure; toxicology of cancer; omics of cancer; AI in carcinogenesis; machine learning use in cancer; cancer biomarkers; pollutants of cancer; agrochemicals; endocrine-disruptive chemicals
(This special issue belongs to the Section Molecular Oncology)
Precision Medicine for Cancer-Associated Thrombosis: The Role of Biomarkers
edited by Darko Antic
submission deadline 20 Jun 2026 | Viewed by 178 | Submission Open
Keywords: biomarkers; precision medicine; cancer-associated thrombosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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