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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biology of Oral Cancer

edited by Rafał Pęksa

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1183 | Submission Open

Keywords: oral cancer; molecular mechanisms; biomarkers; tumor microenvironment; therapy resistance; precision medicine; carcinogenesis; oral squamous cell carcinoma; epigenetics; microbiome; immunotherapy; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Biophysical Characterization and Molecular Engineering of Multidomain Proteins (4th Edition)

edited by

Koichi Kato

and

Takayuki Uchihashi

submission deadline 10 Dec 2025 | Viewed by 150 | Submission Open

Keywords: multidomain proteins; protein dynamics; domain interactions; allosteric regulation; protein engineering; SAXS; Cryo-EM; protein NMR; computational modeling; protein design

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms of Obesity and Metabolic Diseases

edited by

Liliya Mihaylova

submission deadline 15 Dec 2025 | 7 articles | Viewed by 25068 | Submission Open

Keywords: molecular pharmacology; molecular mechanisms; obesity; metabolic diseases; metabolic syndrome; type 2 diabetes; atherosclerosis; cardio-metabolic disorders; non-alcoholic fatty liver disease (NAFLD)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Unveiling Mental Disorders: Molecular Mechanisms and Innovative Therapies

edited by Blerida Banushi

submission deadline 20 Dec 2025 | 7 articles | Viewed by 48023 | Submission Open

Keywords: molecular psychiatry; epigenetics; neurobiology; gene– environment interactions; neuroplasticity; psychopharmacology; neuromodulation; personalized medicine; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Reproductive Physiology and Endocrinology

edited by

Kamil Gill

submission deadline 20 Dec 2025 | 15 articles | Viewed by 32819 | Submission Open

Keywords: reproductive; endocrinology; reproductive hormones; embryology; molecular research; IVF; obesity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Retinal Diseases: 2nd Edition

edited by Minzhong Yu

submission deadline 20 Dec 2025 | 10 articles | Viewed by 30117 | Submission Open

Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cell; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Responses to Biotic and Abiotic Stresses

edited by

Shu Yuan

submission deadline 20 Dec 2025 | 21 articles | Viewed by 26836 | Submission Open

Keywords: plant enzymes and metabolites; abiotic stress; stress response; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen response

(This special issue belongs to the Section Molecular Plant Sciences)

High-Density Lipoproteins in Health and Disease

edited by

Ilaria Zanotti

submission deadline 20 Dec 2025 | 7 articles | Viewed by 24768 | Submission Open

Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy

(This special issue belongs to the Section Molecular Biology)

Exosomes and Extracellular Vesicles in Health and Diseases: 3rd Edition

edited by

Manuela Zavatti

and

Francesca Beretti

submission deadline 20 Dec 2025 | 8 articles | Viewed by 24201 | Submission Open

Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Basis of Neuropsychiatric Disorders: Recent and Future Developments

edited by

Konstantinos Tsamakis

submission deadline 20 Dec 2025 | 5 articles | Viewed by 22070 | Submission Open

Keywords: molecular; schizophrenia; depression; genetic; autism; mechanisms; genetic

(This special issue belongs to the Section Molecular Neurobiology)

Plant Biodiversity and Molecular Marker Technology: Discovery and Application of DNA Polymorphisms

edited by

Luigi De Masi

submission deadline 20 Dec 2025 | 14 articles | Viewed by 21824 | Submission Open

Keywords: plant biodiversity; plant genetic resources; genetic variability; molecular characterization; biomolecular resources; DNA-based molecular markers; DNA sequencing; next generation sequencing; biosequences; DNA polymorphisms; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Biomimetic Materials Applied in the Analytical and Biomedical Fields

edited by

Iacob Bogdan-Cezar

and

Ede Bodoki

submission deadline 20 Dec 2025 | 6 articles | Viewed by 21318 | Submission Open

Keywords: biomimetics; molecular recognition; imprinted polymers; smart materials; molecular complexes; polymeric biomaterials; biomedical materials; analytical methods; molecular interactions; artificial receptors

(This special issue belongs to the Section Materials Science)

Bacteriophages Biology and Bacteriophage-Derived Technologies

edited by Wilfried Moreira

submission deadline 20 Dec 2025 | 5 articles | Viewed by 21088 | Submission Open

Keywords: bacteriophage; antibiotic resistance; biofilm; molecular biology; genetic engineering; synthetic biology

(This special issue belongs to the Section Biochemistry)

The Relationship, Mechanisms, and Treatment Strategies of Diabetes Mellitus and Related Diseases

edited by Maria Kokozidou

submission deadline 20 Dec 2025 | 6 articles | Viewed by 20795 | Submission Open

Keywords: diabetes mellitus; molecular mechanisms; related diseases; genetic basis; microRNAs; incretins; targeted therapies; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Molecular Mechanisms Underlying Tumorigenesis and Innovative Therapeutic Approaches for Cancer-Fighting, 3rd Edition

edited by

Annapina Russo

, Giulia Russo and

Annalisa Pecoraro

submission deadline 20 Dec 2025 | 9 articles | Viewed by 19447 | Submission Open

Keywords: cancer; nucleolus; nucleolar stress; tumorigenesis; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Natural Bioactives and Inflammation, 2nd Edition

edited by

Juan Gambini

submission deadline 20 Dec 2025 | 6 articles | Viewed by 18887 | Submission Open

Keywords: inflammation; bioactive compounds; polyphenols; nutraceutical; diet; nutrition; pharmacology; health; lifespan; healthspan; aging; inflammaging

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Therapeutic Approaches to Osteoarthritis

edited by

Masato Sato

submission deadline 20 Dec 2025 | 8 articles | Viewed by 18743 | Submission Open

Keywords: mode of action; molecular mechanisms; pathogenesis; drug delivery; disease-modifying drug; translational research; cell therapy; regenerative medicine

(This special issue belongs to the Section Molecular Pharmacology)

The Importance of Molecular Circadian Rhythms in Health and Disease

edited by

Telma Quintela

and

Diana Rita Barata Costa

submission deadline 20 Dec 2025 | 7 articles | Viewed by 18435 | Submission Open

Keywords: molecular clock; circadian dysfunction; health; chronotherapy; circadian rhythms

(This special issue belongs to the Section Molecular Biology)

Impact of Diet on the Endocrine System: Insights into Cellular and Molecular Mechanisms

edited by

Gaia Favero

and

Luca Vanella

submission deadline 20 Dec 2025 | 4 articles | Viewed by 18257 | Submission Open

Keywords: antioxidants; diet; endocrine system; ROS; lifestyle; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Updates on Synthetic and Natural Antioxidants

edited by

Izabela Sadowska-Bartosz

and

Grzegorz Bartosz

submission deadline 20 Dec 2025 | 10 articles | Viewed by 18198 | Submission Open

Keywords: antioxidants; synthetic; natural compounds

(This special issue belongs to the Section Biochemistry)

Role of Natural Compounds in Human Health and Disease

edited by Jaewon Shim and

Wook-bin Lee

submission deadline 20 Dec 2025 | 8 articles | Viewed by 17925 | Submission Open

Keywords: natural compound; therapeutic applications; action mechanisms of natural compounds; traditional medicine

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights of Fungal and Plant Lipids: Structural Diversity, Metabolism and Applications

edited by

Ekaterina Kotlova

submission deadline 20 Dec 2025 | 8 articles | Viewed by 17811 | Submission Open

Keywords: lipidomics; fatty acids; glycerolipids; sphingolipids; sterols; oxylipins; fungal and plant lipid metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

Computational Approaches in Drug Design: Novel Methodologies and Applications

edited by

Serena Vittorio

submission deadline 20 Dec 2025 | 7 articles | Viewed by 17767 | Submission Open

Keywords: drug design; computational approaches; molecular docking; molecular dynamics; pharmacophore modeling; homology modeling; computer aided drug design; ADME/Tox predictions; artificial intelligence

(This special issue belongs to the Section Molecular Informatics)

Current Research on Bioactives from Natural Products

edited by

Carmen Lizette Del-Toro-Sánchez

submission deadline 20 Dec 2025 | 5 articles | Viewed by 17256 | Submission Open

Keywords: antioxidants; molecular models; natural products; bioactive compounds; food; materials; antimicrobials; mechanisms of action; extraction techniques; health benefits

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapies in Skeletal Muscle Diseases

edited by Valeria Guglielmi

submission deadline 20 Dec 2025 | 4 articles | Viewed by 17224 | Submission Open

Keywords: skeletal muscle; skeletal muscle diseases; pathogenesis; molecular mechanism; muscle degeneration; muscle regeneration; myokines; cell therapy; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recombinant Proteins, Protein Folding and Drug Discovery

edited by

Mohamed Raafat El-Gewely

submission deadline 20 Dec 2025 | 7 articles | Viewed by 17209 | Submission Open

Keywords: heterologous hosts for gene expression; recombinant therapeutic proteins; antigens; and antibodies; large scale production of recombinant proteins; recombinant protein bioreactor; downstream processing of recombinant proteins; codon optimization for protein expression; refolding of misfolded recombinant proteins; solubilization of aggregated and inclusion bodies of recombinant proteins; protein target validation for drug discovery and development; protein target expression for drug discovery and development; metabolic engineering of recombinant protein production; regulatory noncoding RNAs to boost the expression of protein; the use of foldases & conformases in recombinant protein expression; delivery of therapeutic proteins; therapeutic protein Vs mRNA therapeutics

(This special issue belongs to the Section Biochemistry)

Advanced Research on HIV Virus and Infection

edited by

Patricia Price

submission deadline 20 Dec 2025 | 5 articles | Viewed by 17083 | Submission Open

Keywords: HIV; viral proteins; immunogenetics; pathogenesis

(This special issue belongs to the Section Molecular Immunology)

Mass Spectrometry Approaches as Clinical Diagnostic/Prognostic Tools

edited by

Federica Iavarone

submission deadline 20 Dec 2025 | 3 articles | Viewed by 16932 | Submission Open

Keywords: mass spectrometry; quantitative analysis; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Immunity and Inflammation in Cardiovascular Diseases

edited by

David J. Vigerust

submission deadline 20 Dec 2025 | 6 articles | Viewed by 16733 | Submission Open

Keywords: pathogens; oxidative stress; cytokines; chemokines; immunity; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Molecular Targets for Treatment and Drug Delivery in Tumors

edited by

Emily Capone

submission deadline 20 Dec 2025 | 11 articles | Viewed by 16612 | Submission Open

Keywords: targeted therapy; tumor; molecular target; drug delivery; drug design

(This special issue belongs to the Section Molecular Oncology)

(Meta)Genomic, Functional, Structural and Evolutionary Analysis of Transport Systems

edited by

Arturo Medrano-Soto

, Milton Saier and Gabriel Moreno-Hagelsieb

submission deadline 20 Dec 2025 | 3 articles | Viewed by 15471 | Submission Open

Keywords: molecular transport; transport mechanisms; evolution; families and superfamilies; genomics; metagenomics; 3D structural insights; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Biomarkers and Early Detection Strategies of Ovarian Tumors

edited by Lukasz Szafron

submission deadline 20 Dec 2025 | 8 articles | Viewed by 15144 | Submission Open

Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment

(This special issue belongs to the Section Molecular Oncology)

Breast Cancer: From Pathophysiology to Novel Therapies

edited by Jennifer Sims-Mourtada

submission deadline 20 Dec 2025 | 9 articles | Viewed by 15070 | Submission Open

Keywords: breast cancer; genetics; tumor microenvironment; model systems; organoids; immune cells; tumor stroma; therapeutic resistance; novel therapies

(This special issue belongs to the Section Molecular Oncology)

Plant Genome Editing

edited by Lei Gao

submission deadline 20 Dec 2025 | 5 articles | Viewed by 14459 | Submission Open

Keywords: plant genome editing; Cas9/Cas12a; CRISPR/CRISPRa/CRISPRi; anti-CRISPR; gene editing; off target impact; prime editing; bioinformatics/database

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Natural Products in Drug Discovery

edited by

Luciana Scotti

and

Marcus Tullius Scotti

submission deadline 20 Dec 2025 | 8 articles | Viewed by 13562 | Submission Open

Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Phytochemicals of Natural Products: Source, Analysis, and Bioactivities

edited by

Yu-Kuo Chen

, Chi-I Chang and Chi-Chien Lin

submission deadline 20 Dec 2025 | 5 articles | Viewed by 13530 | Submission Open

Keywords: phytochemicals; bioactive compounds; natural products; bioactivities; purification; chemoprevention; chemotherapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

In Honor of Elie Metchnikoff, a Nobel Prize Winner, Who Discovered Macrophages as Phagocyte Cells Involved in the Process of Innate Immunity

edited by

Pierre Tennstedt

submission deadline 20 Dec 2025 | 5 articles | Viewed by 13523 | Submission Open

Keywords: macrophages; monocytes; phagocytes; fibroblast; cytokines; chronic disease; autoimmune disease; inflammatory disease; immune response; disease treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Primary and Secondary Bladder Disorders in Neurourology and Inflammatory Diseases

edited by

Wei-Chia Lee

and

Yung-Shun Juan

submission deadline 20 Dec 2025 | 6 articles | Viewed by 13390 | Submission Open

Keywords: bladder ischemia; bladder pain syndrome; interstitial cystitis; irradiation cystitis; ketamine cystitis; microbiota; overactive bladder; underactive bladder; botulinum toxin for bladder disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarker Discovery and Validation for Precision Oncology

edited by

Luís Lima

submission deadline 20 Dec 2025 | 5 articles | Viewed by 12171 | Submission Open

Keywords: biomarker discovery; biomarker validation; precision oncology; cancer screening; cancer diagnostics; liquid biopsy; multi-omics integration; targeted therapies; immunotherapy biomarkers; translational cancer research

(This special issue belongs to the Section Molecular Oncology)

Targeting Glioblastoma Metabolism

edited by

José M. Matés

and

José Ángel Campos Sandoval

submission deadline 20 Dec 2025 | 4 articles | Viewed by 12113 | Submission Open

Keywords: glioblastoma; metabolic heterogeneity; metabolic reprogramming; cancer stem cells; therapeutic resistance; metabolic vulnerabilities; IDH1/2 mutations; tumor microenvironment; epigenetic regulation

(This special issue belongs to the Section Molecular Oncology)

Topoisomerase Inhibitors: Future Perspectives and Challenges

edited by

Ben Bax

and Mark Mitton-Fry

submission deadline 20 Dec 2025 | 3 articles | Viewed by 11962 | Submission Open

Keywords: antibiotic; topoisomerase; inhibitor; anticancer; resistance; safety

(This special issue belongs to the Section Molecular Pharmacology)

Pathophysiology of Hair Loss

edited by

Kwang-Hyun Park

submission deadline 20 Dec 2025 | 1 articles | Viewed by 11935 | Submission Open

Keywords: Hair Loss; Pathophysiology; Molecular Mechanisms; Genetic Mutations; Signaling Pathways; Nutrient Interactions; Personalized Therapies; Targeted Drug Delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

RNA Vaccines and Therapeutics: Challenges and Opportunities

edited by

Seong-Wook Lee

submission deadline 20 Dec 2025 | 3 articles | Viewed by 11846 | Submission Open

Keywords: RNA-based therapy; RNA vaccine; mRNA; circRNA; saRNA; non-coding RNA/sRNA; microRNA/siRNA/antisense RNA; RNA aptamer; ribozyme; RNA editing/genome editing

(This special issue belongs to the Section Molecular Pharmacology)

Genetic Engineering of Plants for Stress Tolerance, Second Edition

edited by

Moxian Chen

submission deadline 20 Dec 2025 | 7 articles | Viewed by 11793 | Submission Open

Keywords: CRISPR-Cas system; RNA interference; abiotic and biotic stresses; transcriptional regulation; post-transcriptional regulation; post-translational modification; genetic evolution; biotechnology; molecular mechanisms; regulatory circuits

(This special issue belongs to the Section Molecular Plant Sciences)

Atherosclerosis: From Molecular Mechanisms, Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Antonio Barbato

submission deadline 20 Dec 2025 | 3 articles | Viewed by 11756 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and New Therapy in Melanoma and Other Skin Cancers: 2nd Edition

edited by

Rüdiger Greinert

submission deadline 20 Dec 2025 | 4 articles | Viewed by 11396 | Submission Open

Keywords: epigenetics; cancer stem cells; noncoding RNA (miRNA); personalized diagnostic (medicine); personalized medicine; DNA repair; skin cancer biomarker; skin cancer prevention; genomics; transcriptomics; immunomodulation; ctDNA; circulating tumor cells; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Advances in Molecular Modeling, Docking and Simulations of Protein Structure, 2nd Edition

edited by

Lorant Janosi

submission deadline 20 Dec 2025 | 6 articles | Viewed by 11266 | Submission Open

Keywords: molecular modeling; protein structure; molecular mechanisms; protein interactomics; ligand design; peptides; molecular dynamics; molecular docking

(This special issue belongs to the Section Macromolecules)

The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases

edited by

Eugenia Piragine

submission deadline 20 Dec 2025 | 5 articles | Viewed by 10957 | Submission Open

Keywords: sulfur compounds; sulfur metabolism; hydrogen sulfide; H2S-donors; human health; human disease; nutraceuticals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nutrition as a Tool for Modulating Cellular Metabolism

edited by

Francesca Oppedisano

Anna Spagnoletta

and

Salvatore Nesci

submission deadline 20 Dec 2025 | 2 articles | Viewed by 10856 | Submission Open

Keywords: cell metabolism; mitochondria; ROS; RNS; proliferation and cell death; metabolic pathways; transporters; natural compounds; bioactive molecules; novel foods; metabolic diseases; human pathology

(This special issue belongs to the Section Biochemistry)

Molecular Research in Infective Mycobacteria

edited by

Giovanni Stelitano

submission deadline 20 Dec 2025 | 5 articles | Viewed by 10782 | Submission Open

Keywords: infections; mycobacteria; molecular biology; antimicrobials; bacteria biochemistry

(This special issue belongs to the Section Molecular Microbiology)

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