Molecular Research and New Therapy in Melanoma and Other Skin Cancers: 2nd Edition

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, titled “Molecular Research and New Therapy in Melanoma and Other Skin Cancers”.

Although we are experiencing increasing success in skin cancer therapy (especially malignant melanoma) by using immune checkpoint inhibition (ICI-) mono as well as combined therapy, skin cancer is still the most frequent cancer in the white population, causing more than 60,000 melanoma-related deaths worldwide each year. The reasons for this are primary and secondary (acquired) resistance against modern ICI therapies, as well as missing information about basic molecular events that induce skin cancer and therapy resistance. Therefore, there is an urgent need to increase evidence-based knowledge in molecular oncology, personalized diagnostics, precision medicine, and predictive assays to find early diagnostic, progression, and predictive molecular biomarkers to monitor skin cancer. Topics that should be focused on in the future (in addition to others) include tumor heterogeneity, tumor-microenvironment interaction (e.g., via exosomes), skin cancer biomarkers, transcriptomics, proteomics, epigenomics, immunomodulation, and the use of high throughput technologies. The main feature of this Special Issue is to provide a recent overview of ongoing molecular research by top experts in skin cancer development and therapy.

Dr. Rüdiger Greinert
Guest Editor

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