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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease

edited by Alessandra Porcu

submission deadline 20 Jun 2026 | Viewed by 121 | Submission Open

Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Underlying the Pathogenesis and Treatment of Gastrointestinal Disorders

edited by

Andrzej Pławski

submission deadline 20 Jun 2026 | Viewed by 116 | Submission Open

Keywords: gastrointestinal disorders; molecular mechanisms; diagnosis; treatment; precision medicine; biomarkers; gastrointestinal cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence and Data Science for the Discovery of Anticancer Targets and Decision Support

edited by

Soumia Ziti

submission deadline 20 Jun 2026 | Viewed by 110 | Submission Open

Keywords: artificial intelligence in oncology; data science and decision support in cancer therapy; target discovery and biomarker identification; machine learning and multi-omics integration; predictive modeling in precision medicine

(This special issue belongs to the Section Molecular Informatics)

Deciphering the Molecular Mechanisms That Regulate Plant Disease and Immunity

edited by Bourlaye Fofana and

Champa Wijekoon

submission deadline 20 Jun 2026 | Viewed by 92 | Submission Open

Keywords: plants; biotic stressors; molecular mechanisms; omics technologies; plant immunity

(This special issue belongs to the Section Molecular Plant Sciences)

Medicinal Plants, Animal-Derived Products, and Natural Compounds: Roles in Health and Disease

edited by

Vitor Engrácia Valenti

submission deadline 20 Jun 2026 | Viewed by 29 | Submission Open

Keywords: natural bioactive compounds; medicinal plants; animal-derived products; marine natural products; chronic diseases; inflammation; oxidative stress; molecular mechanisms; therapeutic peptides; natural toxins; antioxidant activity; anti-inflammatory agents; nanoformulations; nanodelivery systems; drug delivery; pharmacological properties; translational research; integrative medicine; natural therapeutics; disease prevention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Evolution, Genetics and Pathogenesis of Viruses, 2nd Edition

edited by

Marta Szabat

submission deadline 20 Jun 2026 | Viewed by 20 | Submission Open

Keywords: viruses; genome structure; viral RNA/DNA; replication viral cycle; recombination; viral infection; antiviral agents

(This special issue belongs to the Section Molecular Microbiology)

New Molecular Mechanisms and Markers in Inflammatory Disorders, 4th Edition

edited by

Elena Vianello

submission deadline 20 Jun 2026 | Viewed by 19 | Submission Open

Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling

(This special issue belongs to the Section Molecular Immunology)

Functions and Applications of Natural Products: 2nd Edition

edited by

Seung-Hong Lee

submission deadline 25 Jun 2026 | 1 articles | Viewed by 470 | Submission Open

Keywords: natural products; biomedicine/phytomedicine; biologically active extracts and compounds; pharmacological and toxicological mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research in Pregnancy-Related Complications

edited by Kallirhoe Kalinderi

submission deadline 25 Jun 2026 | Viewed by 232 | Submission Open

Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Colorectal Cancer: A Molecular Genetics Perspective (2nd Edition)

edited by

Ehsan Gharib

submission deadline 25 Jun 2026 | Viewed by 93 | Submission Open

Keywords: colorectal cancer; chromosomal and microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Function in Human Health and Disease: 3rd Edition

edited by

Yumay Chen

submission deadline 25 Jun 2026 | Viewed by 74 | Submission Open

Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT

(This special issue belongs to the Section Biochemistry)

Molecular Progression of Gut Microbiota—2nd Edition

edited by

Emina Pustijanac

submission deadline 25 Jun 2026 | Viewed by 66 | Submission Open

Keywords: gut microbiota; microbiome; differences in gut microflora; molecular techniques; gut microbiota’ s role and composition; healthy state; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

Current Research on Cancer Biology and Therapeutics: Fourth Edition

edited by

Rafael Coveñas Rodríguez

submission deadline 29 Jun 2026 | 4 articles | Viewed by 1626 | Submission Open

Keywords: cancer and anticancer peptides; substance P/neurokinin-1 receptor system; neurokinin-1 receptor antagonists

(This special issue belongs to the Section Molecular Oncology)

Plant Growth: Molecular Mechanisms

edited by

Zulfiqar Ali Sahito

and

Afsheen Zehra

submission deadline 29 Jun 2026 | Submission Open

Keywords: plant growth; hormonal crosstalk; epigenetics; CRISPR/Cas9 genome editing technologies; metabolomics; transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

State-of-the-Art Molecular Immunology in Chile, 2nd Edition

edited by

Marcela Hernandez Ríos

Juan C. Aguillon

, María Rosa Bono,

Nicolas Dutzan

Rolando Vernal

and

Leandro J. Carreño

submission deadline 30 Jun 2026 | 7 articles | Viewed by 14848 | Submission Open

Keywords: innate immunity; adaptive immunity; host– pathogen interactions; immunopathology; osteoimmunology; immunosenescence; immunotherapy; antibody; vaccines; Chile

(This special issue belongs to the Section Molecular Immunology)

Wnt/β-Catenin Signaling in Cancer

edited by

Teresa Catalano

and

Gitana Maria Aceto

submission deadline 30 Jun 2026 | 1 articles | Viewed by 6520 | Submission Open

Keywords: Wnt/β -catenin pathway; tumors; gene expression; molecular targets; tumor microenvironment; carcinogenesis and metastasis; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Oncology)

Cirrhosis: From Molecular Mechanisms to Therapeutic Strategies

edited by

Hongqun Liu

submission deadline 30 Jun 2026 | 4 articles | Viewed by 6221 | Submission Open

Keywords: liver; fibrogenesis; cirrhosis; portal hypertension; complications; molecular mechanisms; pathway; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Preclinical and Translational Research in Thyroid Cancer

edited by

Marialuisa Appetecchia

and

Giulia Puliani

submission deadline 30 Jun 2026 | 2 articles | Viewed by 5762 | Submission Open

Keywords: thyroid cancers; pathogenesis; molecular bases of thyroid cancer; precision medicine; gender medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Natural Products for Cancer Therapy

edited by María Jesus Rodríguez-Yoldi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 3198 | Submission Open

Keywords: apoptosis; antioxidant; anti-inflammatory; cancer; cell viability; food-by-products; natural products; polyphenols

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections

edited by

Luciana Barros de Arruda

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2852 | Submission Open

Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormone Receptor in Breast Cancer: 2nd Edition

edited by

Rocío García-Becerra

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2430 | Submission Open

Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors

(This special issue belongs to the Section Molecular Oncology)

Oxidative Stress Unveiled: Mechanisms and Implications in Cardiac Pathologies

edited by Sukkum Ngullie Chang and Vernat Exil

submission deadline 30 Jun 2026 | Viewed by 476 | Submission Open

Keywords: reactive oxygen species (ROS); electron transport chain (ETC); mitochondrial permeability transition pore (mPTP); endothelial– cardiomyocyte– fibroblast crosstalk; metabolic adaptation; inflammation; cardiovascular disease (CVD)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic Regulation of Plant Growth and Protection (2nd Edition)

edited by

Yuxuan Hou

and

Zhiyong Li

submission deadline 30 Jun 2026 | Viewed by 194 | Submission Open

Keywords: molecular regulation; genetic resources; functional genomics; plant growth and development; abiotic and biotic stresses; plant– microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Molecular Genetics and Molecular Therapy for Gastric Cancers

edited by

Binnari Kim

submission deadline 30 Jun 2026 | Viewed by 167 | Submission Open

Keywords: gastric cancer; molecular genetics; targeted therapy; tumor microenvironment; immunotherapy; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials and Nanotechnology in Cancer Therapy and Regenerative Medicine

edited by Manoochehr Rasekh

submission deadline 30 Jun 2026 | Viewed by 150 | Submission Open

Keywords: biomaterials; nanoparticle drug delivery; cancer therapy; stimuli-responsive nanocarriers; targeted therapeutics; regenerative medicine; tissue engineering; theranostics

(This special issue belongs to the Section Materials Science)

Unraveling Neurodevelopmental Disorders: A Molecular Perspective

edited by Marija-Magdalena Petrinovic

submission deadline 30 Jun 2026 | Viewed by 94 | Submission Open

Keywords: neurodevelopmental disorders; molecular neuroscience; genetics; epigenetics; functional MRI (fMRI); magnetic resonance spectroscopy (MRS); PET imaging; imaging biomarkers; translational neuroscience; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

From DNA Damage to Cell Death: Emerging Drug Targets and Therapeutic Opportunities

edited by

Mateusz Kciuk

and Beata Marciniak

submission deadline 30 Jun 2026 | Viewed by 91 | Submission Open

Keywords: apoptosis; cancer therapy; cell death pathways; chemoresistance; DNA damage response (DDR); DNA repair inhibitors; drug discovery; ferroptosis; genomic instability; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Molecular Discoveries in Pharmacogenetics: From Bench to Bedside

edited by

Kumaraswamy Naidu Chitrala

submission deadline 30 Jun 2026 | Viewed by 85 | Submission Open

Keywords: pharmacogenetics; clincial practice; artficial intelligence; bioinformatics; personalized medicine; drug response; genetic variations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Human Liver Diseases: 3rd Edition

edited by

Elena Grossini

submission deadline 30 Jun 2026 | Viewed by 80 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); alcoholic steatohepatitis (ASH); Wilson’ s disease; hemochromatosis; viral hepatitis; autoimmune hepatitis; hepatocellular carcinoma; signaling pathways; molecular mechanisms; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitigating Metal Toxicity: Contaminated Environment, Animal Studies and Human Health

edited by

Agnieszka Scibior

Manuel Aureliano

and

Juan Llopis

submission deadline 30 Jun 2026 | Viewed by 76 | Submission Open

Keywords: heavy metal toxicity; heavy metal pollution; heavy metal bioaccumulation and interactions; health risk; mechanistic analysis; dysregulation of cellular homeostasis; natural plant bioactive compounds; human diseases; environmental pollution; in vitro/animal studies; innovative strategies; polyoxometalates (POMs); metal-organic frameworks (MOFs)

(This special issue belongs to the Section Molecular Toxicology)

Thermogenic Adipocytes and Skeletal Muscle: Novel Molecular Targets for the Treatment of Diabetes and Obesity

edited by

Hiroshi Sakaue

submission deadline 30 Jun 2026 | Viewed by 73 | Submission Open

Keywords: metabolic diseases; obesity; type 2 diabetes; molecular signaling pathway

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Latest Research Progress of Biomaterial Modification

edited by

Manuel José Lis

submission deadline 30 Jun 2026 | Viewed by 71 | Submission Open

Keywords: functionalization of carbohydrates; molecular aggregation; simulation of biopolymers; biopolymeric microcapsules; biopolymeric devices

(This special issue belongs to the Section Materials Science)

Preparation and Applications of Colloidal Emulsions

edited by

Bakht Ramin Shah

submission deadline 30 Jun 2026 | Viewed by 60 | Submission Open

Keywords: emulsions; fabrication; characterization; applications; encapsulation; delivery systems

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into the Stability and Degradation of Perovskite Solar Cells

edited by

Amal Bouich

submission deadline 30 Jun 2026 | Viewed by 55 | Submission Open

Keywords: perovskite; thin films; solar cells; PCE; stability; molecular structure evolution (perovskite); perovskite precursor molecular design

(This special issue belongs to the Section Materials Science)

Anesthetics and Neurovascular Health: Molecular Pathways

edited by Gabriele Melegari

submission deadline 30 Jun 2026 | Viewed by 43 | Submission Open

Keywords: neurovascular paths; blood– brain barrier (BBB) and anesthesia; neurovascular coupling; perioperative neuroprotection; neuroinflammation; endothelial dysfunction; cerebral autoregulation; cerebral blood flow; perioperative brain health

(This special issue belongs to the Section Molecular Neurobiology)

Leukemia in the Omics Era: From Mechanisms to Therapies

edited by Marco Rossi

submission deadline 30 Jun 2026 | Viewed by 38 | Submission Open

Keywords: FLT3 inhibitors; JAK inhibitors; BTK inhibitors; BCL 2 inhibitors; BTK degraders; menin inhibitors; IDH inibitors

(This special issue belongs to the Section Molecular Oncology)

Recent Trends in Metal-Organic and Covalent Organic Frameworks

edited by

Muhammad Asad

submission deadline 30 Jun 2026 | Viewed by 36 | Submission Open

Keywords: metal– organic frameworks; covalent organic frameworks; porous materials; electrocatalysis; sustainable energy systems; adsorption; supercapacitors

(This special issue belongs to the Section Materials Science)

Gynaecological Diseases: From Emergence to Translational Medicine

edited by

Pawel Kordowitzki

submission deadline 30 Jun 2026 | Viewed by 35 | Submission Open

Keywords: gynaecological diseases; reproductive biology; endometriosis; ovarian dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Alzheimer’s Disease

edited by

Giulia Bivona

submission deadline 30 Jun 2026 | Viewed by 31 | Submission Open

Keywords: Alzheimer’ s Disease; amyloid beta; molecular target

(This special issue belongs to the Section Molecular Neurobiology)

Reproductive Endocrinology Research: 2nd Edition

edited by

Tsung-Hsien Lee

submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open

Keywords: molecular endocrinology; reproductive genetics; hormonal signaling pathways; fertility and infertility; epigenetics in reproduction; environmental impact on reproduction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Polymeric Nanomaterials in Medicine

edited by Prabhanjan Giram

submission deadline 30 Jun 2026 | Viewed by 27 | Submission Open

Keywords: nanomaterials; nanocomposites; biomolecules; nano pharmaceuticals; nanoparticles; applications of nanomaterials; nanoformulation design; characterization; nanodrug delivery system; targeted and controlled release therapies

(This special issue belongs to the Section Molecular Nanoscience)

Exploring the Crossroads of Autoimmunity, Inflammatory Diseases, and Cancer

edited by Xuming Mao

submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open

Keywords: autoimmune disorders; tumor microenvironment; chronic inflammation; immune checkpoint inhibitors; machine learning; epidemiology

(This special issue belongs to the Section Molecular Immunology)

Viral Infections and Host Antiviral Responses: Molecular Mechanisms and Molecular Regulation

edited by Hong Jia

submission deadline 30 Jun 2026 | Viewed by 25 | Submission Open

Keywords: antiviral immunity; viral entry; host– virus interaction; innate immunity; interferon signaling; viral immune evasion; non-coding RNAs; post-translational modifications; molecular therapeutics; viral pathogenesis

(This special issue belongs to the Section Molecular Microbiology)

Advanced Functional Materials for Catalysis and Storage

edited by

Kaixin Zhu

submission deadline 30 Jun 2026 | Viewed by 21 | Submission Open

Keywords: functional materials; energy catalysis; small molecule conversion; energy storage

(This special issue belongs to the Section Materials Science)

Liposome-Related Nanotechnology and Lipid-Based Nanocarriers

edited by

Carla Matos

submission deadline 30 Jun 2026 | Viewed by 15 | Submission Open

Keywords: liposomes; lipid nanoparticles; solid lipid nanoparticles; nanostructured lipid carriers; nanocarriers; drug delivery; controlled release

(This special issue belongs to the Section Molecular Nanoscience)

Plant Secondary Metabolites and Their Regulatory Mechanisms

edited by

Daniela Trono

submission deadline 30 Jun 2026 | Viewed by 13 | Submission Open

Keywords: secondary metabolites; plant growth and development; response to biotic and abiotic stresses; biosynthesis and degradation; gene and enzyme regulation; metabolic engineering; omics approaches

(This special issue belongs to the Section Molecular Plant Sciences)

From Drug Design to Mechanistic Understanding and Resistance

edited by

Yuan Ma

submission deadline 30 Jun 2026 | Viewed by 7 | Submission Open

Keywords: drug resistance; drug discovery; targeted protein degradation; systems pharmacology; structural biology

(This special issue belongs to the Section Molecular Pharmacology)

Next-Generation Disease Models for Neuropsychiatric Disorders: Organoids, iPSC-Derived Circuits, and Gene Editing

edited by Masaru Tanaka

submission deadline 30 Jun 2026 | Viewed by 3 | Submission Open

Keywords: brain organoids; induced pluripotent stem cells (iPSC); neural stem cells; CRISPER-CAS systems (CRISPR); neuropsychiatric disorders; neurodevelopmental disorders; synaptic transmission; neuroinflammation; drug discovery; animal disease models

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights and Therapeutic Advances in Atherosclerosis

edited by

Zhu Bo

submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open

Keywords: atherosclerosis; molecular mechanisms; lipid metabolism; inflammation; endothelial dysfunction; RNA therapeutics; nanomedicine; cardiovascular disease; biomarkers; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ovarian Insufficiency: From Molecular Pathology to Novel Therapeutic Approach

edited by Aleksandar Ljubić

submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open

Keywords: ovarian insufficiency; premature ovarian insufficiency; molecular pathology; regenerative medicine; stem cell therapy; platelet-rich plasma; epigenetics; intraovarian treatment; ovarian stem cells; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3151-3200 on page 64 of 66.

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