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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Therapeutic Advances in Vaccines

edited by Dorota Kopciuch

submission deadline 31 Jan 2026 | Viewed by 138 | Submission Open

Keywords: therapeutic vaccines; mRNA vaccines; DNA-based vaccines; viral vector vaccines; protein-based vaccines; peptide vaccines; personalized cancer vaccines; antigen persistence; immune activation mechanisms

(This special issue belongs to the Section Molecular Immunology)

Molecular Research in Renal Endocrinology

edited by

Natalija Filipović

submission deadline 31 Jan 2026 | Viewed by 137 | Submission Open

Keywords: renin– angiotensin system; natriuretic peptides; calcitriol; erythropoietin; prostaglandins; endothelins; adrenomedullin

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Advances in Striated Muscle Physiology

edited by Xuesong Feng

submission deadline 31 Jan 2026 | Viewed by 136 | Submission Open

Keywords: striated muscle; physiology; myopathies; mitochondria; mechanotransduction; epigenetics regulation; muscle aging; muscle regeneration

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Effects of Natural Products on Neurological Diseases

edited by

Maytal Shabat-Simon

submission deadline 31 Jan 2026 | Viewed by 136 | Submission Open

Keywords: natural products; neurodegenerative diseases; oxidative stress; neuroinflammation; amyloid β ; TAU pathology; PI3K/AKT; BDNF-TrkB-CREB; phytochemicals; neuroprotection; cannabinoids; psilocybin/psilocyn; mitochondrial dysfunction; blood– brain barrier; high-throughput screening; animal models; structure– activity relationship; pharmacokinetics; bioavailability

(This special issue belongs to the Section Molecular Neurobiology)

Fibrous Proteins: Latest Developments in Molecular Study

edited by Priscila Casado

submission deadline 31 Jan 2026 | Viewed by 131 | Submission Open

Keywords: fibrous proteins; molecular studies; translational applications; inflammatory markers; biomolecular expression; immunological pathways; personalized treatments; diagnostics; clinical practice; etiopathogenies

(This special issue belongs to the Section Molecular Biology)

Recent Progress in 3D Cellular Models of the Tumor Microenvironment

edited by

Kalpana Mandal

submission deadline 31 Jan 2026 | Viewed by 116 | Submission Open

Keywords: 3D tumor models; immunotherapy; organ-on-a-chip; cell mechanics and mechanotransduction; drug delievery; tumor heterogenity; organoids/spheroids; biomaterials; hydrogels/scaffolds

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Mechanisms Underlying Kidney Disease

edited by

Dong-Jun Park

submission deadline 31 Jan 2026 | Viewed by 115 | Submission Open

Keywords: acute kidney injury; molecular mechanisms; therapeutic agents; experimental model; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery: 2nd Edition

edited by Fei Guo

submission deadline 31 Jan 2026 | Viewed by 104 | Submission Open

Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications

(This special issue belongs to the Section Molecular Informatics)

Applications of Molecular Imaging in Nanomedicine

edited by

Manuela Malatesta

submission deadline 31 Jan 2026 | Viewed by 83 | Submission Open

Keywords: nanoparticles; biodistribution; magnetic resonance imaging; positron emission tomography; computed tomography; ultrasound imaging; optical imaging; light microscopy; electron microscopy

(This special issue belongs to the Section Molecular Nanoscience)

Exploring UV-Induced Disease: Insights into Mechanisms and Innovative Strategies for Prevention and Therapy

edited by Hui Xu and

Ying Huang

submission deadline 1 Feb 2026 | 1 articles | Viewed by 1341 | Submission Open

Keywords: ultraviolet radiation; skin; DNA damage; DNA repair; immunosuppression; inflammatory disease; autoimmune disease; melanoma; non-melanoma skin cancers; genetic susceptibility; chemopre-vention; tumor immunotherapy; skin organoids for UV study; new animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Female and Male Fertility: From Diseases to Current Trends and Research Developments

edited by Fabio Barra

submission deadline 4 Feb 2026 | Viewed by 156 | Submission Open

Keywords: female infertility; male infertility; reproductive health; reproductive outcomes; assisted reproductive technologies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Mechanisms for the Prevention and Treatment of Stroke

edited by

Cesare Patrone

submission deadline 10 Feb 2026 | 1 articles | Viewed by 1283 | Submission Open

Keywords: stroke; pathophysiology; mechanisms; comorbidities; treatments

(This special issue belongs to the Section Molecular Neurobiology)

Current Research for Ovarian Cancer Biology and Therapeutics (Second Edition)

edited by

Carmela Ricciardelli

submission deadline 10 Feb 2026 | Viewed by 155 | Submission Open

Keywords: ovarian cancer; chemotherapy resistance; metastasis; novel therapeutic agents; immunotherapy; CAR-T cells; cancer chemotherapy; pre-clinical models

(This special issue belongs to the Section Molecular Oncology)

Cardiovascular Calcification: New Insights into Degenerative Mechanisms and Therapeutic Perspectives

edited by Antonella Bonetti

submission deadline 10 Feb 2026 | Viewed by 154 | Submission Open

Keywords: ectopic calcification; tissue calcinosis; cardiovascular calcification; anti-calcific effect; calcification reduction; anti-calcific model

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Driving Liver Disease: From Cellular Stress to Therapeutic Targets

edited by

Konstantinos Arvanitakis

submission deadline 18 Feb 2026 | 2 articles | Viewed by 2376 | Submission Open

Keywords: liver disease; molecular mechanisms; hepatocellular stress; fibrosis; non-coding RNAs; metabolism; MASLD; liver fibrosis; hepatocellular carcinoma; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Molecular Markers in Prostate Cancer

edited by Thaidy Moreno-Rodriguez

submission deadline 19 Feb 2026 | Viewed by 128 | Submission Open

Keywords: prostate cancer; genetic markers; androgen receptor signaling; molecular biomarkers; therapy resistance mechanisms; liquid biopsy; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Mechanisms of Spinal Cord Injury and Repair

edited by Victoria Moreno-Manzano

submission deadline 20 Feb 2026 | 10 articles | Viewed by 33445 | Submission Open

Keywords: spinal cord injury; molecular changes; neuronal degeneration; circuit regeneration; transcriptomics; cell imaging; single-cell analysis; cell communication; behavior; functional outputs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Dysbiosis in Chronic Diseases

edited by

Ana Isabel Beltrán-Velasco

submission deadline 20 Feb 2026 | 5 articles | Viewed by 31595 | Submission Open

Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; microorganism; metabolites; clinical practices; prebiotics; probiotics

(This special issue belongs to the Section Molecular Microbiology)

Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases

edited by

Niels Schaft

submission deadline 20 Feb 2026 | 10 articles | Viewed by 29050 | Submission Open

Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen

(This special issue belongs to the Section Molecular Immunology)

Probiotics in Health and Disease

edited by

Jasna Novak

submission deadline 20 Feb 2026 | 3 articles | Viewed by 28233 | Submission Open

Keywords: probiotic; microbiota; quality; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

Tumor Microenvironments: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression

edited by Sonam Mittal

submission deadline 20 Feb 2026 | 8 articles | Viewed by 27089 | Submission Open

Keywords: tumor microenvironment; metastasis; metabolism; cytokines; cancer-derived extracellular vesicles; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Advancements in Cancer Biomarkers

edited by

Christos Mikropoulos

submission deadline 20 Feb 2026 | 11 articles | Viewed by 26288 | Submission Open

Keywords: biomarkers; ctDNA; mircroRNA; proteomics; gene methylation; TIL; transcriptomics; micro RNA; tumor microenvironment; gene methylation; proteomics

(This special issue belongs to the Section Molecular Oncology)

Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites

edited by

Jen-Tsung Chen

submission deadline 20 Feb 2026 | 12 articles | Viewed by 26156 | Submission Open

Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Research in Prediction of Protein Structure and Function, 2nd Edition

edited by

Shuai Cheng Li

submission deadline 20 Feb 2026 | 5 articles | Viewed by 25956 | Submission Open

Keywords: prediction; protein structure; protein function; protein complex; machine learning; deep learning; multiple sequence alignment

(This special issue belongs to the Section Molecular Informatics)

Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers

edited by Alessandra Bettiol

submission deadline 20 Feb 2026 | 11 articles | Viewed by 25279 | Submission Open

Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Alzheimer’s Disease

edited by Sudip Dhakal

submission deadline 20 Feb 2026 | 12 articles | Viewed by 22707 | Submission Open

Keywords: Alzheimer’ s disease; amyloid beta; tauopathy; autophagy; stress response; mitochondrial dysfunction; cognitive decline; biomarkers; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights in Steroid Biosynthesis and Metabolism

edited by Amanda C. Swart

submission deadline 20 Feb 2026 | 6 articles | Viewed by 22205 | Submission Open

Keywords: steroid biosynthesis; steroid metabolism; aldo-keto reductase (AKR); cytochrome P450; steroid reductase (SRD5A); 17β -hydroxysteroid dehydrogenases (17β HSD); 11β -hydroxysteroid dehydrogenase (11β HSD); reproduction and sexual differentiation; endogenous cardiac steroids; anabolic steroids; prostate cancer; gut microbiome; immune system; inflammation; cardiovascular disease (CVD); kidney function; hormone replacement therapy (HRT)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Anti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 3rd Edition

edited by

Ming-Ju Hsieh

submission deadline 20 Feb 2026 | 13 articles | Viewed by 19991 | Submission Open

Keywords: anti-inflammatory; anti-cancer; antioxidants; antiproliferative; antiviral; antibacterial; antibodies; molecular mechanism; chemoresistance; molecular biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Molecular Trends and Prospects in Kidney Diseases

edited by

Federico Greco

and

Carlo A. Mallio

submission deadline 20 Feb 2026 | 6 articles | Viewed by 18991 | Submission Open

Keywords: nephrology; molecular biology; renal disease; genomic research; kidney molecular pathways; biomarkers in renal disease; transcriptomics of renal dysfunction; omics approaches in kidney research; molecular diagnostics for renal diseases; pharmacogenomics in kidney treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products from Plants: Association with Human Health and Therapeutic Benefits

edited by

Andrey Marchev

and

Nikolina Mihaylova

submission deadline 20 Feb 2026 | 8 articles | Viewed by 18712 | Submission Open

Keywords: botanical products; phytochemicals; bio/pharmacological compounds; cellular and molecular targets; molecular and physiological mechanism; human health; disease prevention and treatment; inflammatory diseases; age-related disorders; chronic and (auto)immune diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Therapeutic Strategies in Allergic Diseases

edited by

Sylwia Smolińska

submission deadline 20 Feb 2026 | 6 articles | Viewed by 18507 | Submission Open

Keywords: molecular allergy diagnostics; allergen identification; allergen neutralization/elimination strategies; allergen immunotherapy; impact of pollution on allergies; new allergens; cross-reactivity; unexpected allergen sources

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammatory Bowel Diseases: Molecular Mechanism and Therapeutics

edited by

Woon Kyu Lee

submission deadline 20 Feb 2026 | 4 articles | Viewed by 17221 | Submission Open

Keywords: inflammatory bowel disease; IBD; ulcerative colitis; Crohn’ s disease; animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Bioactive Nutrients Promoting Health Through Gut Microbiota: 3rd Edition

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Feb 2026 | 3 articles | Viewed by 16891 | Submission Open

Keywords: phytochemicals; complex carbohydrates; gut microbiota; prebiotics; probiotics; inflammation; molecular mechanisms; human health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Organoids and Organs-on-Chip for Medical Research

edited by

Miguel Hueso

submission deadline 20 Feb 2026 | 5 articles | Viewed by 16682 | Submission Open

Keywords: organoids; organs-on-chip; tissue engineering; disease modeling; biomarkers; molecular pathways; nanotechnology; preclinical models; artificial organs; artificial intelligence; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Postharvest Biology and Molecular Research of Fruits

edited by

Xiangbin Xu

submission deadline 20 Feb 2026 | 6 articles | Viewed by 16521 | Submission Open

Keywords: postharvest biology; fruit; storage technologies; molecular mechanisms; senescence; chilling injury; browning; nutrition; disease; toxin

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Omics: Sensing, Signaling, Regulation and Homeostasis

edited by

Margherita-Gabriella De Biasi

submission deadline 20 Feb 2026 | 6 articles | Viewed by 15619 | Submission Open

Keywords: plant homeostasis; omics; transcriptomics; metabolomics; proteomics; genomics; ionomics; environmental stress; regulatory mechanisms; metabolic processes; systems biology

(This special issue belongs to the Section Molecular Plant Sciences)

Mitochondrial Function in Health and Diseases

edited by Sally P. Wheatley

submission deadline 20 Feb 2026 | 6 articles | Viewed by 15466 | Submission Open

Keywords: mitochondria; metabolism; lipid; ATP; respiration; calcium; iron; inheritance; apoptosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurodegenerative Diseases: From Molecular Mechanisms to Pathophysiology (Second Edition)

edited by

Anne Vejux

submission deadline 20 Feb 2026 | 2 articles | Viewed by 14897 | Submission Open

Keywords: neurodegenerative diseases; molecular mechanisms; physiology; cell death; autophagy; oxidative stress; inflammation; genetic factors; diet; cognitive functions; exosomes; blood– brain barrier; immunity

(This special issue belongs to the Section Molecular Neurobiology)

Genomics and Proteomics of Cancer

edited by

Raffaella Lazzarini

submission deadline 20 Feb 2026 | 6 articles | Viewed by 14640 | Submission Open

Keywords: cancer; carcinogenesis; genetic; epigenetic modification; protein expression; protein phosphorylation; proteomic

(This special issue belongs to the Section Molecular Oncology)

Antioxidants as Regulators of Metabolic Pathways: Potential and Therapeutic Strategies

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Feb 2026 | 2 articles | Viewed by 14624 | Submission Open

Keywords: antioxidants; metabolic pathways; oxidative stress; cellular homeostasis; redox signaling; energy metabolism; lipid metabolism; therapeutic strategies; chronic diseases

(This special issue belongs to the Section Molecular Biology)

New Insights into Aquaporins: 2nd Edition

edited by

Graça Soveral

and

Inês Vieira Da Silva

submission deadline 20 Feb 2026 | 7 articles | Viewed by 13779 | Submission Open

Keywords: aquaporin; membrane channel; regulation; pathophysiology; drug target

(This special issue belongs to the Section Molecular Biology)

Cheminformatics in Drug Discovery and Green Synthesis

edited by

Ana Amić

submission deadline 20 Feb 2026 | 7 articles | Viewed by 13742 | Submission Open

Keywords: cheminformatics; drug discovery; databases; in silico methods; green chemistry

(This special issue belongs to the Section Molecular Informatics)

New Insights in Antibody Therapy

edited by

Loredana Frasca

submission deadline 20 Feb 2026 | 4 articles | Viewed by 13623 | Submission Open

Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease

(This special issue belongs to the Section Molecular Immunology)

New Molecular Mechanisms in the Development of Brain Tumors and Metastases

edited by

Raffaele Addeo

Michele Caraglia

and

Marianna Abate

submission deadline 20 Feb 2026 | 5 articles | Viewed by 12734 | Submission Open

Keywords: brain tumor; brain metastasis; blood– brain barrier; target therapy; cancer molecular biology; brain tumor microenvironment; molecular biomarkers

(This special issue belongs to the Section Molecular Oncology)

Role of MicroRNAs in Human Diseases: 2nd Edition

edited by

Lorenzo F. Sempere

submission deadline 20 Feb 2026 | 8 articles | Viewed by 12365 | Submission Open

Keywords: microRNAs; miRNAs; miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials

(This special issue belongs to the Section Molecular Genetics and Genomics)

Chronic Rhinosinusitis: Aetiology, Immunology and Treatment, 3rd Edition

edited by

Seung-Heon Shin

submission deadline 20 Feb 2026 | 3 articles | Viewed by 12170 | Submission Open

Keywords: innate immunity; adaptive immunity; protease; cytokine; inflammation; epithelial cells; fibroblasts; eosinophils; lymphocytes; biologics

(This special issue belongs to the Section Molecular Immunology)

Machine Learning and Bioinformatics in Human Health and Disease: 2nd Edition

edited by

Andreas Leiherer

submission deadline 20 Feb 2026 | 6 articles | Viewed by 11951 | Submission Open

Keywords: machine learning; bioinformatics; deep learning; multi-omics approaches; genetic risk factors; drug interactions; precision medicine; neurodegenerative diseases; disease diagnosis; epidemic prediction

(This special issue belongs to the Section Molecular Informatics)

Genes and Human Diseases: 3rd Edition

edited by

Mikhail I. Churnosov

submission deadline 20 Feb 2026 | 9 articles | Viewed by 11938 | Submission Open

Keywords: genes; human diseases; genetic-epidemiological studies; genetic factors; susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

Heterocyclic Compounds: Synthesis, Design, and Biological Activity

edited by

Josef Jampilek

submission deadline 20 Feb 2026 | 9 articles | Viewed by 11842 | Submission Open

Keywords: heterocycles; bioactive molecules and materials; pharmacophore; design; targeting; computer studies; synthesis and analysis; natural compounds; carbohydrates; physicochemical properties; biological screening

(This special issue belongs to the Section Biochemistry)

Advances in Insulin Resistance Research: 2nd Edition

edited by

Byungyong Ahn

submission deadline 20 Feb 2026 | 2 articles | Viewed by 11804 | Submission Open

Keywords: insulin resistance; obesity; metabolic diseases; diabetes; metabolism; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

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