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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Neuropharmacology in Neurodegenerative Disorders

edited by

Ichiro Kawahata

submission deadline 31 Dec 2025 | Viewed by 159 | Submission Open

Keywords: neuropharmacology; neurodegenerative disorders; cognitive dysfunction; motor dysfunction; drug discovery; neuroprotection; neurogenesis; brain plasticity; biomarkers; AI (artificial intelligence)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Discoveries in Virus–Cytoskeleton Regulation

edited by

Agustín Valenzuela-Fernández

submission deadline 31 Dec 2025 | Viewed by 158 | Submission Open

Keywords: viruses; cytoskeleton dynamics; actin; tubulin and intermediate filaments; infection; pathogenesis; therapies

(This special issue belongs to the Section Molecular Biology)

Natural Products in Cancer Prevention and Treatment—Second Edition

edited by

Simona Serini

and

Gabriella Calviello

submission deadline 31 Dec 2025 | Viewed by 158 | Submission Open

Keywords: natural products; cancer; therapeutic strategies; novel molecular pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Targeted Peptide Drugs for Metabolic Diseases

edited by

Lukasz Buldak

submission deadline 31 Dec 2025 | Viewed by 154 | Submission Open

Keywords: metabolic disorders; peptide drugs; MASLD; receptor targeting; lipid regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Adaptations of Arthropod Vectors to Oxidative Stress

edited by

Francisco José Alves Lemos

submission deadline 31 Dec 2025 | Viewed by 154 | Submission Open

Keywords: oxidative stress; arthropod vectors; molecular adaptation; redox biology; proteomics; stress response mechanisms

(This special issue belongs to the Section Molecular Biology)

Epigenetic Mechanisms in Pain

edited by Hsien-Yu Peng

submission deadline 31 Dec 2025 | Viewed by 151 | Submission Open

Keywords: chronic pain; epigenetics; molecular biomarkers; neural plasticity; ion channel function; synaptic transmission; therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Micro/Nano-Structure Regulation of Two-Dimensional Materials

edited by

Ning Wang

submission deadline 31 Dec 2025 | Viewed by 150 | Submission Open

Keywords: 2D materials; micro/nano-engineering; structure– property relationships

(This special issue belongs to the Section Materials Science)

Gut Microbiota in Human Disease and Health: 2nd Edition

edited by

Silvia Turroni

and

Federica D'Amico

submission deadline 31 Dec 2025 | Viewed by 148 | Submission Open

Keywords: gut microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation

(This special issue belongs to the Section Molecular Microbiology)

Cellular, Immune and Molecular Pathways of Injury and Disease in Forensic and Legal Medicine

edited by

Sorin Hostiuc

submission deadline 31 Dec 2025 | Viewed by 147 | Submission Open

Keywords: molecular autopsy; cellular injury pathways; ischemia and hypoxia markers; molecular profiling of fatal injuries; forensic genetics and toxicogenomic

(This special issue belongs to the Section Molecular Biology)

Pathogenesis of Central Nervous System Disorders, Interplay and Multifaceted Role of Glial Cells and Neuroprotective Mechanisms

edited by Matilde Balbi

submission deadline 31 Dec 2025 | Viewed by 147 | Submission Open

Keywords: neurodegenerative disease; CNS disorders; glial cells; glia-cross talk; extracellular vesicles; calcium pathway; neuroinflammation; autophagy; excitotoxicity; glial phenotype

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Underlying the Involvement of Cytomegalovirus in the Progression of Multiple Sclerosis

edited by

Marco Miceli

submission deadline 31 Dec 2025 | Viewed by 145 | Submission Open

Keywords: multiple sclerosis; central nervous system; autoimmune; genetic and environmental factors; herpesviruses; CMV; immunopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endometrial Cancer: From Molecular Insights to Treatment

edited by Giuseppe Angelico

submission deadline 31 Dec 2025 | Viewed by 142 | Submission Open

Keywords: endometrial cancer; molecular classification; TCGA; precision oncology; immunotherapy; targeted therapy; biomarkers; tumor microenvironment; genomics; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Penetrating Peptides: Novel Therapeutic Tools for Drug Delivery

edited by

Betty Revon Liu

submission deadline 31 Dec 2025 | Viewed by 142 | Submission Open

Keywords: cell-penetrating peptides; peptide design; drug delivery; controlled and release; clinical applica-tions; penetration mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Innovative Approaches to RNA-Based Therapeutics

edited by

Elzbieta Kierzek

submission deadline 31 Dec 2025 | Viewed by 140 | Submission Open

Keywords: RNA therapeutic; RNA drug; antisense therapy; siRNA; delivery; oligonucleotides; mRNA vaccine

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Skin Allergies: Cross-Disciplinary Approaches to Diagnosis and Therapy

edited by

Montserrat Fernández-Guarino

, Belén De la Hoz and

Javier Martínez-Botas

submission deadline 31 Dec 2025 | Viewed by 139 | Submission Open

Keywords: skin allergy; dermatology; allergy management; allergic reaction; topical immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapeutic Strategies for Cystic Fibrosis

edited by Kavisha Arora

submission deadline 31 Dec 2025 | Viewed by 138 | Submission Open

Keywords: cystic fibrosis; CFTR; modulator therapy; non-responder mutations; mRNA therapy; gene editing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Biochemical, Genetic, and Molecular Biology Approaches in Human Reproduction

edited by Athanasios Zikopoulos

submission deadline 31 Dec 2025 | Viewed by 138 | Submission Open

Keywords: reproductive biology; infertilit; epigenetics in reproduction; maternal-fetal health; precision medicine

(This special issue belongs to the Section Molecular Biology)

Anti-Cancer Effects of Natural Products: 2nd Edition

edited by

Moon Nyeo Park

submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open

Keywords: cancer; natural products; herbal medicine; anticancer therapies; metastasis; recurrence; resistance mechanism; novel biomarker

(This special issue belongs to the Section Molecular Pharmacology)

Emerging Therapeutic Approaches and Novel Targets in Fibrosis Treatment

edited by

Akrivi Chrysanthopoulou

submission deadline 31 Dec 2025 | Viewed by 136 | Submission Open

Keywords: organ fibrosis; tissue fibrosis; regenerative medicine; fibroblasts; chronic inflammation; immune mechanisms; wound healing; injured epithelium or endothelium; epithelial– mesenchymal transformation; treatment; therapies; therapeutic approaches; diagnosis; prognosis; antifibrotic agents

(This special issue belongs to the Section Molecular Immunology)

RNA Biology: Unraveling the Complex Interplay Between Proteins and RNAs in Gene Expression and Regulation, 2nd Edition

edited by

Rosemary Kiernan

submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open

Keywords: RNA biology; protein– RNA interplay; gene expression; post-transcriptional modifications; non-coding RNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Pharmacology for Neuropathic and Chronic Pain Management

edited by

Kuthati Yaswanth

and

Chih-Shung Wong

submission deadline 31 Dec 2025 | Viewed by 132 | Submission Open

Keywords: neuropathic pain; diabetic neuropathy; chronic pain; DPP-4 inhibitors; SGLT2 inhibitors; pain pharmacology; neuroinflammation; glial activation; ion channels; cannabinoids; endogenous peptides; epigenetic modulation; extended-release formulations; drug repurposing; analgesic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Applications of Microbial and Marine-Derived Natural Products with Health Benefits

edited by Simona Negreş

submission deadline 31 Dec 2025 | Viewed by 129 | Submission Open

Keywords: microbial products; marine-derived products; pharmacological activity; key molecules; molecular mechanisms; drug discovery; nutraceuticals; therapy; prophylaxis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Endocrine–Immune Crosstalk in Human Reproductive Health and Pathology

edited by Juan Pablo Mackern-Oberti

submission deadline 31 Dec 2025 | Viewed by 127 | Submission Open

Keywords: T cells; B cells; autoimmune disease; reproduction; immunemodulation; inflammation; endocrinology; lactation

(This special issue belongs to the Section Molecular Immunology)

Hidradenitis Suppurativa: Molecular Mechanisms and Therapeutic Strategies

edited by

Lucas André Cavalcanti Brandão

submission deadline 31 Dec 2025 | Viewed by 126 | Submission Open

Keywords: hidradenitis suppurativa; molecular mechanisms; therapeutic strategies; pathophysiology; autoinflammatory disorders; immunology; dermatology inflammation; skin disease; molecular pathways; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targets in Brain Tumor Pathogenesis

edited by Mugurel Petrinel Radoi

submission deadline 31 Dec 2025 | Viewed by 125 | Submission Open

Keywords: brain tumors; molecular pathogenesis; glioma biomarkers; tumor microenvironment; neuro-oncology; targeted therapy; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Environmental Exposures and Molecular Disruption Mechanisms in Human Health

edited by

David Lozano-Paniagua

submission deadline 31 Dec 2025 | Viewed by 121 | Submission Open

Keywords: environmental exposure; epigenetic; exposome; molecular biomarkers; molecular toxicology

(This special issue belongs to the Section Molecular Toxicology)

Pharmacological Agents for Soft Tissue and Articular Injections: From Mechanisms to Clinical Applications

edited by

Carmelo Pirri

submission deadline 31 Dec 2025 | Viewed by 120 | Submission Open

Keywords: injectable pharmacological agents; musculoskeletal disorders; injection therapies; platelet-rich plasma (PRP); hyaluronic acid

(This special issue belongs to the Section Molecular Pharmacology)

Current Research on Phenolic Profiles and Anti-Inflammatory Activities of Plants

edited by Chi-Rei Wu and Li-Wei Lin

submission deadline 31 Dec 2025 | Viewed by 118 | Submission Open

Keywords: plants; phenolic profiles; inflammation; cardiovascular disorders; cancer; diabetes; neurodegenerative disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Multiple Myeloma: Cancer Therapy and the Tumour Microenvironment

edited by Ruba Al Abdulla

submission deadline 31 Dec 2025 | Viewed by 116 | Submission Open

Keywords: multiple myeloma; cancer resistance; therapeutic strategies; stroma cells; cancer microenvironment; cancer immunity

(This special issue belongs to the Section Molecular Oncology)

Oxidative–Inflammatory Crosstalk in Retinal Pigment Epithelium: Models, Mechanisms, and Modulators

edited by

Min-Yen Hsu

submission deadline 31 Dec 2025 | Viewed by 114 | Submission Open

Keywords: retinal pigment epithelium (RPE); oxidative stress; inflammation; immunometabolism; mitochondrial dysfunction; inflammasome; IL-8/VEGF signaling; heavy-metal toxicity; extracellular vesicles; antioxidant therapy

(This special issue belongs to the Section Molecular Immunology)

RNA-Mediated Post-Transcriptional Regulation in Bacteria Roles of Small RNAs, Small Proteins, and RNA Modifications

edited by Karl M Thompson

submission deadline 31 Dec 2025 | Viewed by 114 | Submission Open

Keywords: bacterial post-transcriptional regulation; small RNAs (sRNAs); small open reading frames (smORFs); RNA modifications; epitranscriptomics

(This special issue belongs to the Section Molecular Biology)

Molecular Perspective of Alzheimer’s Disease

edited by

Philippe Poindron

submission deadline 31 Dec 2025 | Viewed by 113 | Submission Open

Keywords: Alzheimer’ s disease; amyloid peptide (toxic conformation); mutations (gamma-secretase); GWAS; risk factors; new treatment (monoclonal antibodies)

(This special issue belongs to the Section Molecular Neurobiology)

Gene Regulation and Neurotoxicity in Alcohol Related Pathologies

edited by

Stefano Casalotti

submission deadline 31 Dec 2025 | Viewed by 104 | Submission Open

Keywords: alcohol; ethanol; gene expression; neurotoxicity; epigenetics; polymorphisms; neu-rons; glial cell; plasticity

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Engineering in Insoluble Antibacterial Particle for Medical Devices

edited by Ole T. Jensen

submission deadline 31 Dec 2025 | Viewed by 103 | Submission Open

Keywords: antibacterial; quaternary ammonium silica particles; bactericidal mechanism; antibacterial particle; medical devices

(This special issue belongs to the Section Materials Science)

Structural and Functional Analysis of Amino Acids and Proteins: 2nd Edition

edited by

Wenying Yan

submission deadline 31 Dec 2025 | Viewed by 103 | Submission Open

Keywords: protein structure; protein function; amino acids network; deep learning; bioinformatics; protein– protein interaction; drug discovery; biomarker

(This special issue belongs to the Section Molecular Informatics)

Gene Variants and Phenotypic Diversity: Insights into CFTR, SLC Transporters and Disease

edited by Veronique Ladeveze

submission deadline 31 Dec 2025 | Viewed by 101 | Submission Open

Keywords: mutations; polymorphisms; alternative splicing; exon skipping; intron retention; CFTR (ABCC7); cystic fibrosis; SLC16a3; Alzheimer’ s disease; pulmonary and brain cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances in Diagnosis and Treatment of Gynaecological Cancers

edited by

Chenhsuan Wu

submission deadline 31 Dec 2025 | Viewed by 97 | Submission Open

Keywords: gynecological oncology; molecular biomarkers; precision medicine; tumor microenvironment; targeted therapy; early detection; immunotherapy; genomic profiling; drug resistance; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Epigenetic and Transcriptional Regulation in Aquaculture: Immunity, Stress and Disease Prevention

edited by

Chan-Hee Kim

submission deadline 31 Dec 2025 | Viewed by 93 | Submission Open

Keywords: epigenetics; transcriptional regulation; trained immunity; DNA methylation; histone modifications; non-coding RNAs; disease prevention; aquaculture

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genome Editing and Biotechnology in Fruit Improvement

edited by Hongxia Miao

submission deadline 31 Dec 2025 | Viewed by 92 | Submission Open

Keywords: fruit improvement; horticultural crops; genome editing; biotechnology; molecular biology; plant genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Nanomaterials for Cancer Treatment and Translational Medicine

edited by

Mingzhen Zhang

submission deadline 31 Dec 2025 | Viewed by 91 | Submission Open

Keywords: nanozymes; extracellular vesicles; drug delivery systems; cancer treatment; oxidative stress-related diseases; translational medicine

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms and Pathways Involved in Toxicant-Induced Stress

edited by

Maria Giulia Lionetto

and

Maria Elena Giordano

submission deadline 31 Dec 2025 | Viewed by 89 | Submission Open

Keywords: oxidative stress; cell death; biomarkers; toxicant exposure; environmental toxicology; cell signaling pathways

(This special issue belongs to the Section Molecular Toxicology)

Genetic Variants Involved in Breast and Ovarian Cancers

edited by

Chakravarthy Garlapati

submission deadline 31 Dec 2025 | Viewed by 86 | Submission Open

Keywords: breast and ovarian cancers; genetics; genomics; biomarkers; mutations; genetic variants; translational markers

(This special issue belongs to the Section Molecular Oncology)

Cancer Stem Cells as Key Immunotherapy Targets

edited by Cosmin Andrei Cismaru

submission deadline 31 Dec 2025 | Viewed by 62 | Submission Open

Keywords: cancer stem cells; immunotherapy; immune escape; tumor antigens; cancer recurrence

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research on Chronic Heart Failure

edited by

Marco Tana

submission deadline 1 Jan 2026 | 3 articles | Viewed by 6981 | Submission Open

Keywords: chronic heart failure (CHF); cardiovascular medicine; cardiac amyloidosis; biomarkers; translational ap-proaches; molecular approaches; pharmacological treatment; molecular mechanisms; molecular pathways; prognosis; clinical practice in CHF management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Poly- and Oligo-Saccharides as Pharmaceutical Agents in Biology and Medicine

edited by

Kevin H. Mayo

submission deadline 1 Jan 2026 | Viewed by 272 | Submission Open

Keywords: polysaccharides; oligosaccharides; isolation and purification; structural and functional analyses; biological mechanisms of action; cellular & molecular targets and interactions; pharmaceutical drug development; cancer; cardiovascular disease; diabetes

(This special issue belongs to the Section Molecular Biology)

Checkpoint Antibodies at the Crossroads: From Mechanisms to Multi-Modal Cancer Therapy

edited by Li Ye and Xuyao Zhang

submission deadline 10 Jan 2026 | 1 articles | Viewed by 2345 | Submission Open

Keywords: immune checkpoint inhibitors; tumor microenvironment; computational immunology; resistance mechanisms; multifunctional antibodies; rational combination design

(This special issue belongs to the Section Molecular Immunology)

From Microbes to Humans: Unveiling the Dynamic World of Carbonic Anhydrases (CAs)

edited by

Clemente Capasso

submission deadline 10 Jan 2026 | Viewed by 710 | Submission Open

Keywords: metalloenzymes; bacteria; pathogens; sulfonamides; inhibitors; activators; anti-infective agents; medicine; anticancer; neurodegenerative diseases; biomedical applications; biotechnology

(This special issue belongs to the Section Biochemistry)

Advances in Allergen Immunotherapy: Current Concepts and Future Directions

edited by

Constantinos Pitsios

submission deadline 10 Jan 2026 | Viewed by 142 | Submission Open

Keywords: allergen immunotherapy; oral immunotherapy; Hymenoptera venom; allergy extracts; adjuvants

(This special issue belongs to the Section Molecular Immunology)

Plant Epigenetic Memory Under Abiotic Stress

edited by

Md Mezanur Rahman

submission deadline 11 Jan 2026 | Viewed by 165 | Submission Open

Keywords: plant epigenetics; epigenetic memory; abiotic stress; DNA methylation; histone modification; chromatin remodeling; transgenerational inheritance; stress-responsive genes

(This special issue belongs to the Section Molecular Plant Sciences)

From Electronic Structure to Application: Computational Insights into Bioactive and Functional Molecules

edited by

Karolina Kula

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2299 | Submission Open

Keywords: molecular design; molecular modeling; substituent effect; reactivity descriptors; biological potential; in silico study; physicochemical properties; ADME; PASS; QSAR

(This special issue belongs to the Section Molecular Informatics)

Displaying special issue 451-500 on page 10 of 68.

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