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Special Issue "Development of Responsive Nanoparticles for Cancer Therapy"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 February 2020.

Special Issue Editor

Prof. Dr. Jordi Puiggalí
E-Mail Website
Guest Editor
Chemical Engineering Department. Universitat Politècnica de Catalunya, c/Eduard Maristany, 08019 Barcelona, Spain
Interests: structure of synthetic polymers; development of biodegradable polymers; study of nanocomposites; polymer physics; polymer crystallization

Special Issue Information

Dear Colleagues,

Cancer is the second leading cause of death worldwide with over 10 million cases each year. Surgery, radiotherapy, chemotherapy, and, to a lesser degree, immunotherapy and hyperthermia are typical treatments for malignant tumors. Nevertheless, the limitations of such therapies are evident. For example, conventional chemotherapeutic drugs have a short blood circulation time, very low specificity and a high risk of damaging healthy tissues.

Nanoscale polymeric systems have a great potential to fight against cancer and currently do not seem to have a sufficiently competitive alternative. Nanoparticles can preferentially leak into carcinogenic tissues taking advantage of the enhanced permeability and retention effect of malignant tumors. Nanosized systems can be designed with a great drug loading capacity, the ability to protect the payload from the immune system, a large surface to attach targeting ligands, stimuli responsiveness, and controlled release. Internal and external stimuli (e.g., pH, redox potential, enzyme expression, temperature, magnetic field, ultrasound, and light) can be used to target tumors and deliver the payload after administration. The potential of cancer nanomedicine is becoming enormous considering the versatility of polymer chemistry, which enables the development of complex architectures as well as simple hydrophilic nanogels.

This Special Issue of International Journal of Molecular Sciences will discuss, collect, and offer recent highlights and advances on the design of stimuli-responsive nanoparticles for cancer treatment.

Prof. Dr. Jordi Puiggalí
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanogels
  • stimuli responsiveness
  • smart polymers
  • drug release
  • cancer therapy

Published Papers (1 paper)

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Research

Open AccessArticle
Incorporation of Chloramphenicol Loaded Hydroxyapatite Nanoparticles into Polylactide
Int. J. Mol. Sci. 2019, 20(20), 5056; https://doi.org/10.3390/ijms20205056 - 11 Oct 2019
Abstract
Chloramphenicol (CAM) has been encapsulated into hydroxyapatite nanoparticles displaying different morphologies and crystallinities. The process was based on typical precipitation of solutions containing phosphate and calcium ions and the addition of CAM once the hydroxyapatite nuclei were formed. This procedure favored a disposition [...] Read more.
Chloramphenicol (CAM) has been encapsulated into hydroxyapatite nanoparticles displaying different morphologies and crystallinities. The process was based on typical precipitation of solutions containing phosphate and calcium ions and the addition of CAM once the hydroxyapatite nuclei were formed. This procedure favored a disposition of the drug into the bulk parts of the nanoparticles and led to a fast release in aqueous media. Clear antibacterial activity was derived, being slightly higher for the amorphous samples due to their higher encapsulation efficiency. Polylactide (PLA) microfibers incorporating CAM encapsulated in hydroxyapatite nanoparticles were prepared by the electrospinning technique and under optimized conditions. Drug release experiments demonstrated that only a small percentage of the loaded CAM could be delivered to an aqueous PBS medium. This amount was enough to render an immediate bacteriostatic effect without causing a cytotoxic effect on osteoblast-like, fibroblasts, and epithelial cells. Therefore, the prepared scaffolds were able to retain CAM-loaded nanoparticles, being a reservoir that should allow a prolonged release depending on the polymer degradation rate. The studied system may have promising applications for the treatment of cancer since CAM has been proposed as a new antitumor drug. Full article
(This article belongs to the Special Issue Development of Responsive Nanoparticles for Cancer Therapy)
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