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Cancer Diagnosis through SERS and Other Related Techniques

Department of Physical Chemistry and EMaS, Universitat Rovira i Virgili, 43007 Tarragona, Spain
ICREA, Passeig Lluís Companys 23, 08010 Barcelona, Spain
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 2253;
Received: 26 February 2020 / Revised: 17 March 2020 / Accepted: 20 March 2020 / Published: 24 March 2020
(This article belongs to the Special Issue Development of Responsive Nanoparticles for Cancer Therapy)
Cancer heterogeneity increasingly requires ultrasensitive techniques that allow early diagnosis for personalized treatment. In addition, they should preferably be non-invasive tools that do not damage surrounding tissues or contribute to body toxicity. In this context, liquid biopsy of biological samples such as urine, blood, or saliva represents an ideal approximation of what is happening in real time in the affected tissues. Plasmonic nanoparticles are emerging as an alternative or complement to current diagnostic techniques, being able to detect and quantify novel biomarkers such as specific peptides and proteins, microRNA, circulating tumor DNA and cells, and exosomes. Here, we review the latest ideas focusing on the use of plasmonic nanoparticles in coded and label-free surface-enhanced Raman scattering (SERS) spectroscopy. Moreover, surface plasmon resonance (SPR) spectroscopy, colorimetric assays, dynamic light scattering (DLS) spectroscopy, mass spectrometry or total internal reflection fluorescence (TIRF) microscopy among others are briefly examined in order to highlight the potential and versatility of plasmonics. View Full-Text
Keywords: cancer; diagnosis; liquid biopsy; miRNA; circulating tumor cells; plasmonic nanoparticles; SERS; SPR; DLS; TIRF cancer; diagnosis; liquid biopsy; miRNA; circulating tumor cells; plasmonic nanoparticles; SERS; SPR; DLS; TIRF
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Blanco-Formoso, M.; Alvarez-Puebla, R.A. Cancer Diagnosis through SERS and Other Related Techniques. Int. J. Mol. Sci. 2020, 21, 2253.

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