Old and New Players in Inflammatory Disorders as Tools for Prevention, Diagnosis, and Treatment

Dear colleagues,

Inflammation participates in host defenses against infectious agents and injury, but it also contributes to the development of many diseases that collectively represent the leading causes of disability and mortality worldwide. In particular, multiple lines of evidence have suggested that chronic diseases such as obesity, cardiovascular disease, type 2 diabetes mellitus, nonalcoholic fatty liver disease, autoimmunity, cancer, and neurodegenerative disorders recognize inflammation as a common trigger for pathophysiological conditions. However, the mechanisms underlying the inflammatory regulation of these disorders are not fully understood. The interplay of cells involved in the immune system and inflammatory mediators orchestrates molecular pathways that contribute to tissue injury, oxidative stress, remodeling of the extracellular matrix, angiogenesis, and fibrosis in target tissues.

As the control of inflammation seems to be an attractive target for healthcare improvement, a thorough knowledge of molecular profiles and the detection of new biomarkers of inflammatory processes can support the development of new approaches to early diagnosis, treatment, and monitoring of inflammation-related disorders, and also provide tools to predict disease susceptibility.

This Special Issue “Old and New Players in Inflammatory Disorders as Powerful Tools for Prevention, Diagnosis, and Treatment” welcomes original research and review articles in the field, with a focus on but not limited to molecular players in inflammation that hold the potential for making advancements in the management of inflammatory diseases.

Dr. Nadia Ferlazzo
Dr. Monica Currò
Guest Editors

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