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Molecular Advances in Heart Disease: Genomics, Proteomics, and Bioinformatics of Heart Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 966

Special Issue Editor


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Guest Editor
Cedars-Sinai Medical Center, Cedars-Sinai, 127 San Vicente Blvd #A9100, Los Angeles, CA 90048, USA
Interests: cardiovascular disease; cardiac fibrosis; peptidylarginine deiminase; citrullination; posttranslational modifications

Special Issue Information

Dear Colleagues,

We are welcoming submissions for our new Special Issue titled Molecular Advances in Heart Disease. This Special Issue aims to present publications that elucidate heart disease’s etiology and pathophysiology. We will accept articles focusing on the study and interpretation of molecular, genetic, proteomic, and metabolomic changes in tissues and cells to aid in the diagnosis, pathogenesis, prognosis, and treatment of heart diseases. In addition to basic science, we welcome translational research and clinical evidence that supports biomolecular experiments. Every year, approximately 647,000 Americans die from heart disease, which is 1 in every 4 deaths, making it the leading cause of death and an important unmet medical need. We hope that this Special Issue will collate papers that foster a comprehensive understanding of this condition and breakthroughs in the field of heart disease research.

Dr. Justyna Fert-Bober
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • heart disease
  • cardiovascular disease
  • coronary artery disease (CAD)
  • heart attack
  • heart failure
  • arrhythmia (abnormal heart rhythms)
  • valve disease
  • high blood pressure
  • congenital heart conditions
  • inherited heart conditions
  • fibrosis
  • pathobiology of fibrosis
  • aging
  • chronic inflammation
  • inflammatory and cardiovascular diseases
  • myocarditis
  • extracellular matrix biology

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Published Papers (1 paper)

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Research

12 pages, 1826 KiB  
Communication
Postmortem-Derived Exosomal MicroRNA 486-5p as Potential Biomarkers for Ischemic Heart Disease Diagnosis
by So-Yeon Kim, Sookyoung Lee, Jong-Tae Park, Su-Jin Lee and Hyung-Seok Kim
Int. J. Mol. Sci. 2024, 25(17), 9619; https://doi.org/10.3390/ijms25179619 - 5 Sep 2024
Viewed by 468
Abstract
Exosomes are nanovesicles 30–150 nm in diameter released extracellularly. Those isolated from human body fluids reflect the characteristics of their cells or tissues of origin. Exosomes carry extensive biological information from their parent cells and have significant potential as biomarkers for disease diagnosis [...] Read more.
Exosomes are nanovesicles 30–150 nm in diameter released extracellularly. Those isolated from human body fluids reflect the characteristics of their cells or tissues of origin. Exosomes carry extensive biological information from their parent cells and have significant potential as biomarkers for disease diagnosis and prognosis. However, there are limited studies utilizing exosomes in postmortem diagnostics. In this study, we extended our initial research which identified the presence and established detection methodologies for exosomes in postmortem fluids. We analyzed exosomal miRNA extracted from plasma and pericardial fluid samples of a control group (n = 13) and subjects with acute myocardial infarction (AMI; n = 24). We employed next-generation sequencing (NGS) to investigate whether this miRNA could serve as biomarkers for coronary atherosclerosis leading to acute myocardial infarction. Our analysis revealed 29 miRNAs that were differentially expressed in the AMI group compared to the control group. Among these, five miRNAs exhibited more than a twofold increase in expression across all samples from the AMI group. Specifically, miR-486-5p levels were significantly elevated in patients with high-grade (type VI or above) atherosclerotic plaques, as per the American Heart Association criteria, highlighting its potential as a predictive biomarker for coronary atherosclerosis progression. Our results indicate that postmortem-derived exosomal microRNAs can serve as potential biomarkers for various human diseases, including cardiovascular disorders. This finding has profound implications for forensic diagnostics, a field critically lacking diagnostic markers. Full article
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