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3 April 2026
Colorectal Cancer Awareness Month–March 2026

As part of its ongoing commitment to advancing cancer research and knowledge exchange, MDPI highlights colorectal cancer in the March edition—one of the most prevalent and deadly cancers worldwide. It ranks as the third most diagnosed cancer and the second leading cause of cancer-related deaths globally, with an estimated 1.9 million new cases and over 900,000 deaths each year.

Of growing concern is the steady rise in incidence among individuals under 50, a trend observed over the past two to three decades. This underscores the urgent need to better understand underlying risk factors, strengthen early detection strategies, and develop innovative diagnostic tools.

Through curated research, Special Issues, and expert-led webinars, MDPI journals continue to support collaboration across researchers, clinicians, and policymakers. Such collective efforts are essential to accelerate discoveries and translate them into meaningful action—advancing toward more effective prevention, earlier detection, and improved patient outcomes.

Keynote Speakers
Prof. Dr. Paola Patrignani,
“G. d’Annunzio” University School of Medicine, Italy
Prof. Dr. William Gmeiner,
Wake Forest University, USA

Dr. Eva Martínez-Balibrea,
Catalan Institute of Oncology, Spain

Dr. Zoltán Wiener,
Semmelweis University,
Hungary

Register for this webinar for free here!

Integrative Mechanistic Investigation of the Anticancer Effects of Panax notoginseng in Colorectal Cancer
by Jaemoo Chun, Sarah Shin and Jeeyoun Jung
Molecules 2026, 31(5), 807; https://doi.org/10.3390/molecules31050807  

Integrated Multi-Omics Analysis Identifies Novel Prognostic and Diagnostic Hub Genes in Colorectal Cancer
by Devi Lal and Himani Pandey
Onco 2025, 5(4), 50; https://doi.org/10.3390/onco5040050

A Multimodal MRI-Based Model for Colorectal Liver Metastasis Prediction: Integrating Radiomics, Deep Learning, and Clinical Features with SHAP Interpretation
by Xin Yan, Furui Duan, Lu Chen, Runhong Wang, Kexin Li, Qiao Sun and Kuang Fuby Xin Yan, Furui Duan, Lu Chen, Runhong Wang, Kexin Li, Qiao Sun and Kuang Fu
Curr. Oncol. 2025, 32(8), 431; https://doi.org/10.3390/curroncol32080431  

Exploring Experimental Models of Colorectal Cancer: A Critical Appraisal from 2D Cell Systems to Organoids, Humanized Mouse Avatars, Organ-on-Chip, CRISPR Engineering, and AI-Driven Platforms—Challenges and Opportunities for Translational Precision Oncology”
by Ahad Al-Kabani, Bintul Huda, Jewel Haddad, Maryam Yousuf, Farida Bhurka, Faika Ajaz, Rajashree Patnaik, Shirin Jannati and Yajnavalka Banerjee
Cancers 2025, 17(13), 2163; https://doi.org/10.3390/cancers17132163

The Gut Microbiota and Colorectal Cancer: Understanding the Link and Exploring Therapeutic Interventions
by Imen Zalila-Kolsi, Dhoha Dhieb, Hussam A. Osman and Hadjer Mekideche
Biology 2025, 14(3), 251; https://doi.org/10.3390/biology14030251

A Novel Bacteriophage with the Potential to Inhibit Fusobacterium nucleatum-Induced Proliferation of Colorectal Cancer Cells
by Ho Yin Pekkle Lam, Meng-Jiun Lai, Pin-Chun Wang, Wen-Jui Wu, Li-Kuang Chen, Hsiang-Wei Fan, Chun-Chieh Tseng, Shih-Yi Peng and Kai-Chih Chang
Antibiotics 2025, 14(1), 45; https://doi.org/10.3390/antibiotics14010045

A New Blood-Based Epigenetic Diagnostic Biomarker Test (EpiSwitch®® NST) with High Sensitivity and Positive Predictive Value for Colorectal Cancer and Precancerous Polyps
by Ewan Hunter, Heba Alshaker, Cicely Weston, Mutaz Issa, Shekinah Bautista, Abel Gebregzabhar, Anya Virdi, Ann Dring, Ryan Powell, Jayne Green et al.
Cancers 2025, 17(3), 521; https://doi.org/10.3390/cancers17030521

The Role of KRAS Mutations in Colorectal Cancer: Biological Insights, Clinical Implications, and Future Therapeutic Perspectives
by Mitsunobu Takeda, Shoma Yoshida, Takuya Inoue, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mamoru Uemura, Hirofumi Yamamoto, Yuichiro Doki and Hidetoshi Eguchi
Cancers 2025, 17(3), 428; https://doi.org/10.3390/cancers17030428

Network Pharmacology and Bioinformatics Study of Six Medicinal Food Homologous Plants Against Colorectal Cancer
by Xinyue Zhao, Jian Xiu, Hengzheng Yang, Weiwei Han and Yue Jin
Int. J. Mol. Sci. 2025, 26(3), 930; https://doi.org/10.3390/ijms26030930

A Review of Potential Agents for Colon Cancer Interception in FAP Patients: Evidence from Preclinical Studies in APCMin/+ Mice
by Karthikkumar Venkatachalam, Krishnendu Goswami, Venkateshwar Madka and Chinthalapally V. Rao
Targets 2025, 3(1), 4; https://doi.org/10.3390/targets3010004

Colorectal Cancer: Epidemiology, Risk Factors, and Prevention
by Gholamreza Roshandel, Fatemeh Ghasemi-Kebria and Reza Malekzadeh
Cancers 2024, 16(8), 1530; https://doi.org/10.3390/cancers16081530

Symptom Burden and Time from Symptom Onset to Cancer Diagnosis in Patients with Early-Onset Colorectal Cancer: A Multicenter Retrospective Analysis
by Victoria A. Baronas, Arif A. Arif, Eric Bhang, Gale K. Ladua, Carl J. Brown, Fergal Donnellan, Sharlene Gill, Heather C. Stuart and Jonathan M. Loree
Curr. Oncol. 2024, 31(4), 2133-2144; https://doi.org/10.3390/curroncol31040158

 

Recent Advances in Surgical Strategies for Managing Metastatic Colorectal Cancer
Guest Editors: Dr. Fabrizio D'Acapito and Dr. Marco Vaira
Deadline for manuscript submissions: 15 June 2026

Novel Strategies in the Prevention/Treatment of Colorectal Cancer: 2nd Edition
Guest Editor: Prof. Dr. William H. Gmeiner
Deadline for manuscript submissions: 20 June 2026

Molecular Mechanisms and Therapeutic Strategies of Colorectal Cancer
Guest Editor: Dr. Daniel Gabriel Pons
Deadline for manuscript submissions: 20 September 2026

Gut Microbiota and Inflammation in Colorectal Tumor Development and Progression
Guest Editors: Prof. Dr. Giovanni Monteleone and Dr. Irene Marafini
Deadline for manuscript submissions: 30 September 2026

       

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