Occupational/Residential Exposure to Toxic Xenobiotics

Dear Colleagues,

Occupational and/or residential exposure to toxic/genotoxic/carcinogenic xenobiotics represents a serious threat to human health. Causal relationships between exposure to these pollutants—often in complex mixtures—and acute and/or chronic diseases are well reported in literature. Moreover, aside from exposure occurring in the workplace or in the general environment, exposure to toxic/genotoxic/carcinogenic xenobiotics might also occur because of individual lifestyle (e.g., smoking habits, alcohol consumption, diet, etc.).

In addition to chemical analysis, adverse health effects of xenobiotics can be studied on living organisms in ecosystems (e.g., ecogenotoxicology) or in humans. Overall, these approaches play a pivotal role in addressing public health challenges and supporting public health policy aiming to reduce exposure to xenobiotics and prevent adverse human health impacts.

In the last few decades, numerous epidemiological studies have used a molecular approach for improving measurement of exposure and for early detection of health effects. Biomonitoring of genotoxic hazards has been reported in several studies by the use of different genotoxicity endpoints, such as analysis of primary DNA damage (e.g., comet assay), or cytogenetic effects (e.g., micronuclei, chromosomal aberrations, and sister chromatid exchanges).

This Special Issue of the International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge regarding the links between exposure to toxic/genotoxic/carcinogenic xenobiotics and human health. Original research papers (in vitro, in vivo, and human studies), reviews, meta-analyses, are welcome in this issue. Other manuscript types accepted include methodological papers, position papers, brief reports, and commentaries.

We will accept manuscripts from different disciplines, including exposure assessment science, epidemiology, intervention studies, risk and health impact assessment, risk management.

Papers dealing with new biotoxicological approaches aimed at identifying early effects and individual susceptibility through “omics”, including epigenetics, and at measuring and characterizing biological effects from gene–environment interactions will be particularly appreciated.

Prof. Dr. Massimo Moretti
Dr. Milena Villarini
Dr. Mattia Acito
Guest Editors

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