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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic and Epigenetic Drivers of Lung Cancer Heterogeneity and Therapy Resistance

edited by Maria Palmieri and Viola Bianca Serio

submission deadline 25 Sep 2026 | Viewed by 290 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); intratumor heterogeneity; acquired resistance; DNA methylation; histone modifications; non-coding RNAs (ncRNAs); epithelial–mesenchymal transition (EMT); single-cell sequencing; liquid biopsy; targeted therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic Mutations and Susceptibility in Breast Cancer

edited by Balaji Virassamy

submission deadline 25 Sep 2026 | Viewed by 281 | Submission Open

Keywords: genetic variants; somatic mutation landscape; morphological variation; oncogenic timing; next-generation sequencing; targeted therapies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic Responses to Rapid Environmental Change in Biodiversity Hotspots

edited by Diana Daniela Moreno-Santillan and Diana Aguilar Gomez

submission deadline 25 Sep 2026 | Viewed by 236 | Submission Open

Keywords: population genetics; phylogenetics; adaptation; environmental change; conservation genetics

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Corn Breeding for Disease Resistance

edited by Xuanjun Feng

submission deadline 25 Sep 2026 | Viewed by 211 | Submission Open

Keywords: maize; disease resistance; corn breeding; resistance gene; QTL mapping; genomic-assisted breeding; gene functional analysis; plant–pathogen interaction; genetic diversity; molecular genetics; crop genetic improvement; cereal crop

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics, Breeding and Genomic Improvement of Aquaculture Fish

edited by Tianqing Huang

submission deadline 25 Sep 2026 | Viewed by 194 | Submission Open

Keywords: aquaculture; fish breeding; genetics; polyploidy; molecular biology; gonadal development

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Aspects of Autoimmune Diseases

edited by Cheuk Wun Li

submission deadline 10 Oct 2026 | 7 articles | Viewed by 9466 | Submission Open

Keywords: autoimmune diseases; genetics; genetic variants; polygenic; therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Abiotic Stress in Crop: Molecular Genetics and Genomics

edited by Xuke Lu

submission deadline 10 Oct 2026 | 2 articles | Viewed by 1587 | Submission Open

Keywords: plants; abiotic stresses; molecular mechanism; differentially expressed genes (DEGs); regulatory network

(This special issue belongs to the Section Plant Genetics and Genomics)

Sperm DNA Changes: Causes, Diagnostics, and Implications for Fertility and Offspring Health

edited by

Jonatan Axelsson

and

Humaira Gowher

submission deadline 10 Oct 2026 | 1 articles | Viewed by 1324 | Submission Open

Keywords: sperm DNA; sperm DNA fragmentation; germ cell mutations; de novo mutations; offspring effects; infertility; sperm chromatin structure; epigenetics; lifestyle; environmental effects; error-corrected sequencing; aneuploidy; chromosome aberrations; pregnancy; child

(This special issue belongs to the Section Genetic Diagnosis)

Identifying Fertility Biomarkers Using Omics Approach

edited by

Muhammet Rasit Ugur

submission deadline 10 Oct 2026 | 1 articles | Viewed by 1086 | Submission Open

Keywords: fertility; infertility; biomarker; omics; multi-omics; genomics; transcriptomics; proteomics; metabolomics; epigenomics; lipidomic; microbiomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genome Sequencing and Genetic Testing for Cancer

edited by

Kapila Gunasekera

submission deadline 10 Oct 2026 | 1 articles | Viewed by 698 | Submission Open

Keywords: next-generation sequencing (NGS); precision oncology; liquid biopsy and ctDNA; whole-genome sequencing (WGS); cancer susceptibility genes; somatic mutation profiling; pharmacogenomics; machine learning and AI in omics; multi-omics integration; biomarker discovery; targeted therapy; molecular diagnostics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Utilizing Animal Disease Models to Understand Human Genetics

edited by

Tiziana Orsini

submission deadline 10 Oct 2026 | Viewed by 301 | Submission Open

Keywords: animal models of human disease; genotype-phenotype correlation; functional genomics; developmental biology; translational genetics; variant validation; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Cancer Driver Mutations and Tumor Evolution

edited by Yusi Fu

submission deadline 10 Oct 2026 | Viewed by 235 | Submission Open

Keywords: driver mutations; tumor evolution; clonal dynamics; intratumor heterogeneity; somatic mosaicism; single-cell genomics; mutational signatures; clonal hematopoiesis; tumor microenvironment

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Diagnosis, Management and Therapy of Rare Diseases

edited by Giorgia Girotto

submission deadline 15 Oct 2026 | 8 articles | Viewed by 8838 | Submission Open

Keywords: rare and ultrarare genetic diseases; genetic mechanisms; gene-tailored management; personalized therapeutic approaches

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Morphological Diversity in Plants

edited by

P. Roxanne Kellar

submission deadline 15 Oct 2026 | 7 articles | Viewed by 8657 | Submission Open

Keywords: biodiversity; conservation; genetic structure; genetics; genotype; germplasm; haplotype; high-throughput sequencing; invasive species; microsatellites; molecular markers; morphological characters; morphology; morphometrics; morphotype; next-generation sequencing; phenotype; systematics; taxonomy; variation

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Epigenetic Factors for Autoimmune Diseases

edited by

Ulises De La Cruz-Mosso

submission deadline 15 Oct 2026 | 2 articles | Viewed by 4439 | Submission Open

Keywords: single nucleotide variants; polymorphism; mutations; microRNAs; HLA genes; cytokine gene; DNA methylation; rheumatoid arthritis; systemic lupus erythematosus; exposome

(This special issue belongs to the Section Epigenomics)

The Function and Molecular Mechanism for Immune Responses in Human Diseases

edited by Zsofia Banlaki

submission deadline 15 Oct 2026 | 3 articles | Viewed by 3510 | Submission Open

Keywords: leukocyte; cytokine; immune receptor; signal transduction; gene expression; antibody-antigen; major histocompatibility complex; complement system; inflammation

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Human Reproductive and Prenatal Genetics

edited by Edith Said

submission deadline 15 Oct 2026 | 1 articles | Viewed by 2287 | Submission Open

Keywords: reproductive genetics; female infertility; male infertility; recurrent pregnancy loss; preconception genetic testing; pre-implantation genetic testing; prenatal genetics; non-invasive prenatal testing; molecular genetics; cytogenetics; molecular cytogenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Mechanisms and Applications of Forensic Genetics

edited by Sara C Zapico

submission deadline 15 Oct 2026 | 2 articles | Viewed by 1889 | Submission Open

Keywords: forensic biology ; forensic genetic genealogy; next-generation sequencing (NGS); epigenetic markers/DNA methylation/non-coding RNAs; microbiome forensics; biomarker detection; DNA phenotyping; DNA degradation and preservation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Aquatic Germplasm Resources and Genetic Breeding

edited by Wei Song

submission deadline 15 Oct 2026 | 2 articles | Viewed by 1501 | Submission Open

Keywords: fish; shrimp; shellfish; algae; geographical population; morphological difference; cytochrome oxidase subunit I (COI); microsatellites; genetic structure; genetic diversity; gene cloning; cellular localization; RNAi; gene overexpression

(This special issue belongs to the Section Animal Genetics and Genomics)

Chromatin Modifications and RNA-Based Regulation of Gene Expression

edited by Alonso Javier Pardal

submission deadline 15 Oct 2026 | 1 articles | Viewed by 1018 | Submission Open

Keywords: chromatin modifications; RNA; gene expression; transcription; chromatin boundaries; RNA-binding proteins

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genomics for Smart and Greener Agriculture

edited by Loan Nguyen and Christie Warburton

submission deadline 15 Oct 2026 | 1 articles | Viewed by 773 | Submission Open

Keywords: genomics; transcriptomics; metagenomics; microbiome; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Spatial Organisation of Chromosomes and Genes

edited by Yu Liu and Lingluo Chu

submission deadline 15 Oct 2026 | Viewed by 612 | Submission Open

Keywords: 3D genome; cohesin; CTCF; TAD; compartment; loop extrusion; gene regulation; enhancer–promoter interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

From Genes to Systems: Genetic and Epigenetic Control of the Metastatic Cascade

edited by

Eric Rahrmann

submission deadline 15 Oct 2026 | Viewed by 454 | Submission Open

Keywords: cancer metastasis; genetic alterations; epigenetic reprogramming; tumor heterogeneity; lineage plasticity; metastatic niche formation; dormancy; circulating tumor cells (CTCs); immune evasion; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Epigenomics)

Gene Editing Technology for Xenotransplantation in Human Genetic Diseases

edited by Brendan J. Keating

submission deadline 15 Oct 2026 | Viewed by 306 | Submission Open

Keywords: xenotransplantation; gene editing; CRISPR/Cas; genetically modified donor animals; genome engineering; immunologic incompatibility

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Mechanisms of Inflammation and Immune Regulation in Tumors

edited by

Fuduan Peng

submission deadline 15 Oct 2026 | Viewed by 247 | Submission Open

Keywords: bioinformatics; computational biology; tumor microenvironment; single-cell RNA sequencing; spatial omics; microbiome–immune interaction; immunotherapy targets; pan-cancer; machine learning

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Genomic Basis of Agronomical, Quality and Functional Traits in Plants

edited by

Limin Zhang

submission deadline 15 Oct 2026 | Viewed by 227 | Submission Open

Keywords: agronomic traits; quality traits; functional genomics; quantitative trait loci (QTL); genome-wide association study (GWAS); gene editing; crop improvement; molecular breeding; transcriptomics; plant development

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Epidemiology, Genomics and Drug Resistance Mechanisms of Pathogenic Bacteria

edited by Ming Jiang

submission deadline 15 Oct 2026 | Viewed by 226 | Submission Open

Keywords: molecular epidemiology; antimicrobial resistance; pathogenic bacteria; drug resistance mechanisms; bacterial evolution; multi-omics integration; metabolomics; antibiotic tolerance and persistence

(This special issue belongs to the Section Microbial Genetics and Genomics)

Research on Genomics and Genetics of Parasites

edited by

Kapila Gunasekera

and

Xinzhuan Su

submission deadline 15 Oct 2026 | Viewed by 218 | Submission Open

Keywords: comparative genomics; host–parasite interactions; drug resistance mechanisms; functional genomics (CRISPR-Cas9); transcriptomics and proteomics; population genetics; molecular epidemiology; vaccine target discovery; machine learning in parasitology; molecular diagnostics

(This special issue belongs to the Section Microbial Genetics and Genomics)

Unraveling the Genetic Landscape of Colorectal Cancer: The Latest Breakthroughs and Insights

edited by Nadia Saoudi Gonzalez

submission deadline 20 Oct 2026 | 4 articles | Viewed by 5470 | Submission Open

Keywords: personalized medicine; target therapy; metastatic colorectal cancer; precision oncology; biomarker discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Epidemiology and Gene-Environment Interactions

edited by Fen Yang

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1213 | Submission Open

Keywords: genetic epidemiology; gene–environment interaction; polygenic risk scores; exposome; genome-wide association studies; whole-genome sequencing; multi-omics integration; mendelian randomization; causal inference; population diversity; translational genetics; artificial intelligence in genomics

(This special issue belongs to the Section Genes & Environments)

Genetic and Molecular Mechanisms in Animal Reproduction

edited by

Xianfeng Yu

submission deadline 20 Oct 2026 | Viewed by 488 | Submission Open

Keywords: gamete; embryo; gene regulation; epigenetics; cloning; IVP; ET

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular Genetics and Breeding in Pigs

edited by

Linyuan Shen

submission deadline 20 Oct 2026 | Viewed by 247 | Submission Open

Keywords: pig genetics; molecular breeding; genotype-by-environment interaction; genomic selection; gene editing; intelligent phenotyping; sustainable livestock production

(This special issue belongs to the Section Animal Genetics and Genomics)

3D Chromatin Architecture: From Computational Algorithms to Biological Functions

edited by

Minji Kim

submission deadline 20 Oct 2026 | Viewed by 235 | Submission Open

Keywords: 3D genomics; computational algorithm; genome organization; gene regulation; molecular mechanism; functional elements

(This special issue belongs to the Section Bioinformatics)

Genetic Insights into Species Evolution: From Phylogeny to Adaptation

edited by Wei Zhang

submission deadline 20 Oct 2026 | Viewed by 222 | Submission Open

Keywords: phylogeny; phylogenomics; adaptive traits; population genomics; species diversity; economic species; marine biology; organellar genome; nuclear genome

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genetic Diagnosis and Therapeutics of Eye Diseases

edited by

Suzana Konjevoda

and

Snježana Kaštelan

submission deadline 25 Oct 2026 | 5 articles | Viewed by 5979 | Submission Open

Keywords: genetic eye diseases; inherited retinal disorders; ophthalmic genetics; gene therapy; genetic diagnosis; retinitis pigmentosa; leber congenital amaurosis; personalised medicine; ocular therapeutics; genomic medicine; molecular diagnostics; precision ophthalmology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Pharmacogenomics and Pharmacoepigenomics in Autoimmune Diseases: How Close We Are to Personalised Medicine

edited by

Yiannis Vasilopoulos

and

Ioannis S. Vizirianakis

submission deadline 25 Oct 2026 | 2 articles | Viewed by 2797 | Submission Open

Keywords: pharmacogenomics; pharmacoepigenomics; drug efficacy; drug toxicity; molecular pharmacology; autoimmune diseases

(This special issue belongs to the Section Pharmacogenetics)

Recent Progress in Forensic Genetics and Molecular Identification

edited by

Maria Saiz

submission deadline 25 Oct 2026 | 2 articles | Viewed by 2451 | Submission Open

Keywords: forensic genetics; molecular identification; next generation sequencing; trace DNA analysis; challenging samples

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Mechanisms of Synaptic Plasticity in Neuropsychiatric Disorders

edited by Lace Riggs

submission deadline 25 Oct 2026 | 2 articles | Viewed by 2144 | Submission Open

Keywords: synaptic plasticity; neuropsychiatric disorders; autism spectrum disorder; schizophrenia; depression; epigenetic regulation; synaptic signaling; circuit dysfunction; gene–circuit interactions; molecular neuroscience; translational neurogenetics; epigenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genes, Genomes, and Systems Biology in Agriculture

edited by Nick Hudson and

Pâmela A. Alexandre

submission deadline 25 Oct 2026 | 2 articles | Viewed by 1480 | Submission Open

Keywords: systems biology; modelling; omics technologies; big data; machine learning; genetics; genomics; transcriptomics; microbiome; metabolomics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetic and Genomic Analysis of Inflammatory Bowel Disease

edited by Mario Gorenjak and

Gregor Jezernik

submission deadline 25 Oct 2026 | 2 articles | Viewed by 1274 | Submission Open

Keywords: inflammatory bowel disease; crohn’s disease; ulcerative colitis; genomics; transcriptomics; biologicals; small-molecule drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Diagnosis and Treatment of Rare Diseases

edited by

Miao Sun

submission deadline 25 Oct 2026 | 2 articles | Viewed by 1161 | Submission Open

Keywords: rare genetic diseases; clinical genomics; next-generation sequencing (NGS); exome and whole-genome sequencing; mitochondrial DNA (mtDNA) disorders; epigenetics and DNA methylation; RNA modification and transcriptomics; gene expression profiling; genotype–phenotype correlation; disease mechanisms; functional genomics; bioinformatics and variant interpretation; molecular diagnosis; precision medicine; gene- and RNA-based therapies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Plant Stress Tolerance: Genetic and Genomic Mechanisms and Expression Regulation

edited by Chao Ma

submission deadline 25 Oct 2026 | 1 articles | Viewed by 736 | Submission Open

Keywords: plant stress tolerance; gene expression regulation; epigenetics; functional genomics; non-coding RNA; abiotic and biotic stress; multi-omics integration; transcriptional regulation; signal transduction; secondary metabolism

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Mechanisms and Functional Insights in Microbiome Research

edited by

Tsute Chen

submission deadline 25 Oct 2026 | Viewed by 461 | Submission Open

Keywords: microbiome; marker genes; genomics; meta-genomics; meta-transcriptomics; proteomics; meta-proteomics; metabolomics; functional microbiome; microbiome-host interaction; microbiome-environment interaction; genetic mechanism

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetic and Genomic Insights in Kidney Diseases: Mechanisms, Diagnosis and Therapeutics

edited by Maria Amicone and

Ersilia Nigro

submission deadline 25 Oct 2026 | Viewed by 304 | Submission Open

Keywords: cystic kidney disease; ADPKD; kidney stones; nephronophtisis; ADTKD; cystinuria; primary hyperoxaluria; NGS; MLPA; CGH array

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Tropical Plant Genetics and Breeding

edited by Jiaming Zhang

submission deadline 25 Oct 2026 | Viewed by 278 | Submission Open

Keywords: tropical crops; genomic selection; abiotic stress tolerance; disease resistance; CRISPR/Cas9; genome-wide association study (GWAS); molecular markers

(This special issue belongs to the Section Plant Genetics and Genomics)

Rice Genome Dissection and Molecular Breeding Innovation

edited by Wei Hu

submission deadline 25 Oct 2026 | Viewed by 65 | Submission Open

Keywords: rice genomics; molecular breeding; map-based cloning; genome-wide association study (GWAS); functional gene characterization

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Insights into Diseases Related to Mitochondrial Dysfunction: From Diagnosis to Treatment

edited by Luigi Citrigno and Annamaria Cerantonio

submission deadline 5 Nov 2026 | 1 articles | Viewed by 934 | Submission Open

Keywords: mitochondrial dysfunction; mtDNA mutations; genetic diagnosis; next-generation sequencing; neurodegeneration; metabolic disorders; mitochondrial therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Emerging Insights in Single-Cell and Spatial Omics for Disease Mechanisms

edited by

Yang Liu

submission deadline 5 Nov 2026 | 1 articles | Viewed by 731 | Submission Open

Keywords: single-cell omics; spatial omics; disease mechanisms; tissue microenvironment; cell–cell communication; multi-omics integration; cellular heterogeneity; systems biology; computational biology; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic Landscapes and Precision Therapeutics of Central Nervous System Malignancies

edited by