Genetic and Genomic Insights in Kidney Diseases: Mechanisms, Diagnosis and Therapeutics

Dear Colleagues,

Genetic kidney diseases encompass a broad spectrum of inherited disorders affecting renal structure and function, including cystic, glomerular, and tubulointerstitial conditions. These diseases represent a significant cause of chronic kidney disease and are characterized by remarkable genetic and phenotypic heterogeneity.

This Special Issue aims to provide a comprehensive overview of the genetic architecture and molecular mechanisms underlying inherited kidney diseases, promoting integration between basic science, translational research, and clinical practice.

The identification of disease-causing genes and the development of advanced sequencing technologies have progressively transformed the diagnosis and classification of hereditary kidney disorders, enabling more precise patient stratification.

Recent advances in multi-omics approaches, gene editing technologies, and novel disease models are reshaping our understanding of pathogenesis and opening new avenues for targeted and personalized therapies.

We welcome original research articles, reviews, and short communications that address genetics, molecular mechanisms, disease modeling, diagnostics, biomarkers, and innovative therapeutic strategies across the spectrum of inherited kidney diseases, including cystic disorders.

Dr. Maria Amicone
Dr. Ersilia Nigro
Guest Editors

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